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Science
Vo
l.
11
,
No
.
3
,
Sep
tem
b
er
201
8
,
p
p
.
1
2
2
3
~
1
2
2
7
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SS
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2502
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4752
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co
m
1.
I
NT
RO
D
UCT
I
O
N
Mic
r
o
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tec
h
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r
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tech
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m
s
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t
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ex
p
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o
f
g
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s
f
r
o
m
t
h
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ce
ll
[
1
]
.
I
t
p
l
ac
es
th
e
g
e
n
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s
eq
u
en
ce
s
o
n
a
g
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ip
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esig
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eq
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s
o
f
d
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cle
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ac
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DNA
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o
r
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R
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p
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ase
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e.
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f
m
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w
s
r
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s
to
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al
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t
h
o
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s
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o
f
g
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x
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p
r
o
f
iles
s
i
m
u
lta
n
eo
u
s
l
y
[
2
-
5
]
.
T
h
e
d
atasets
p
r
o
d
u
ce
d
b
y
m
icr
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r
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tech
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g
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is
k
n
o
w
n
as
g
e
n
e
e
x
p
r
ess
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n
d
at
aset
[
2
]
.
Mu
ch
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m
ed
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r
esear
ch
,
esp
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y
ca
n
ce
r
o
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s
r
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c
h
,
h
as
b
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n
i
n
cr
ea
s
ed
.
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w
e
v
er
,
th
e
p
r
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p
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ties
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lar
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s
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w
o
u
ld
af
f
ec
t
th
e
r
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lt
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f
r
esear
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as
w
ell.
Si
n
ce
t
h
e
m
i
cr
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ar
r
ay
d
ataset
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s
lar
g
e
d
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m
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n
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e
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x
p
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h
ar
ac
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is
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[
6
]
.
B
esid
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at,
m
icr
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r
a
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d
ata
s
ets
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av
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a
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m
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t
o
cc
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r
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ter
th
e
f
ir
s
t
co
llectio
n
o
f
d
ataset.
T
h
e
ac
cu
r
ac
y
o
f
t
h
e
clas
s
i
f
icatio
n
a
lg
o
r
it
h
m
w
o
u
ld
b
e
af
f
ec
ted
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
5
0
2
-
4752
I
n
d
o
n
esia
n
J
E
lec
E
n
g
&
C
o
m
p
Sci,
Vo
l
.
11
,
No
.
3
,
Sep
tem
b
er
201
8
:
1
2
2
3
–
1
2
2
7
1224
Hen
ce
,
d
ata
p
r
e
-
p
r
o
ce
s
s
i
n
g
is
o
n
e
o
f
th
e
m
a
n
d
ato
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ce
s
s
es
to
u
n
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er
g
o
b
ef
o
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t
h
e
d
at
aset
ca
n
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e
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lied
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to
o
th
er
m
a
in
s
tr
ea
m
r
esear
c
h
alg
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r
it
h
m
s
[
7
]
.
I
n
th
e
n
e
x
t
s
ec
tio
n
,
w
e
w
o
u
ld
lik
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to
in
tr
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s
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atas
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et
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s
t
h
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ataset.
W
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tio
n
3
,
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tco
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p
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s
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ata
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ll
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p
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s
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f
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ataset.
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a
s
tl
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w
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ld
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2
.
RE
SE
ARCH
M
AT
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AL
& M
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T
H
O
DO
L
O
G
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I
n
th
is
s
ec
tio
n
,
t
h
e
m
ater
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al
an
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m
et
h
o
d
o
lo
g
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ap
p
lie
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in
t
h
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s
t
u
d
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ill
b
e
ex
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lain
ed
.
Gen
e
e
x
p
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d
ataset
is
a
p
p
lied
as
in
p
u
t
d
atase
t
f
o
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t
h
e
d
ata
p
r
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-
p
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s
s
in
g
p
u
r
p
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s
e.
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n
t
h
i
s
s
tu
d
y
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B
io
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u
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d
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s
s
t
h
e
d
ata
b
ef
o
r
e
it h
as b
ee
n
u
s
ed
to
p
r
ed
ict
an
d
class
i
f
ied
th
e
g
en
e
s
.
2
.
1
.
M
icro
a
rr
a
y
Da
t
a
Gen
e
ex
p
r
es
s
io
n
d
ataset
i
s
th
e
d
ataset
p
r
o
d
u
ce
d
b
y
m
icr
o
ar
r
ay
tec
h
n
o
lo
g
y
.
I
t
ca
n
b
e
ac
ce
s
s
ed
f
r
o
m
Natio
n
al
C
e
n
ter
f
o
r
B
io
tech
n
o
lo
g
y
I
n
f
o
r
m
atio
n
(
N
C
B
I
)
.
I
n
th
i
s
r
esear
ch
,
GSE1
0
0
7
2
[
8
]
is
d
o
w
n
lo
ad
ed
in
r
a
w
f
i
le.
T
h
e
p
latf
o
r
m
to
p
r
ep
ar
e
th
is
Af
f
y
m
etr
i
x
m
icr
o
ar
r
a
y
g
e
n
e
ex
p
r
ess
io
n
d
ataset
is
G
P
L
9
6
.
T
h
e
s
am
p
le
s
id
en
ti
f
icatio
n
(
I
D)
o
f
lu
n
g
ca
n
ce
r
d
ataset
ar
e
b
et
w
ee
n
GSM
2
5
4
6
2
5
t
o
GSM2
5
4
7
3
1
.
GSE
1
0
0
7
2
is
o
n
e
o
f
th
e
lu
n
g
ca
n
ce
r
t
y
p
e
s
a
m
p
les
s
et.
I
t
h
as
1
0
7
s
a
m
p
les,
o
f
w
h
ic
h
5
8
ar
e
ca
n
ce
r
o
u
s
s
a
m
p
les
an
d
4
9
ar
e
n
o
r
m
al
s
a
m
p
les.
I
n
o
v
er
all,
GSE1
0
0
7
2
h
as 1
3
7
8
8
g
en
es.
2
.
2
.
M
et
ho
do
lo
g
y
A
r
a
w
f
ile
o
f
g
e
n
e
e
x
p
r
ess
io
n
d
ata
is
s
at
u
r
ated
w
it
h
a
n
ab
u
n
d
an
ce
o
f
i
n
f
o
r
m
atio
n
e
x
tr
ac
te
d
f
r
o
m
t
h
e
ce
ll.
T
h
is
r
a
w
f
ile
n
ee
d
s
to
b
e
p
r
o
ce
s
s
ed
in
o
r
d
er
f
o
r
th
e
r
ig
h
t
attr
ib
u
te
s
to
b
e
ex
tr
ac
ted
f
o
r
th
e
n
e
x
t
r
esear
c
h
s
tu
d
y
.
R
p
r
o
g
r
a
m
m
i
n
g
la
n
g
u
a
g
e
is
c
h
o
s
e
n
an
d
h
e
n
ce
p
ac
k
a
g
es
t
h
at
ar
e
b
u
i
ld
u
p
b
y
R
p
r
o
g
r
a
m
m
i
n
g
lan
g
u
ag
e
w
il
l
b
e
u
s
ed
to
p
r
e
-
p
r
o
ce
s
s
t
h
e
d
ataset.
I
n
o
u
r
s
t
u
d
y
,
t
h
e
B
i
o
co
n
d
u
cto
r
p
ac
k
ag
e
i
s
d
o
w
n
l
o
ad
ed
an
d
i
m
p
o
r
ted
f
o
r
th
e
p
u
r
p
o
s
ed
o
f
d
ata
p
r
e
-
p
r
o
ce
s
s
in
g
[
9
]
.
T
h
e
B
io
co
n
d
u
cto
r
w
ill
a
n
al
y
s
e
th
e
e
x
p
r
ess
io
n
v
a
lu
e
a
n
d
f
u
r
t
h
er
ar
r
an
g
e
t
h
e
d
ataset
u
s
i
n
g
n
o
r
m
aliza
tio
n
w
h
ich
n
ar
r
o
w
s
t
h
e
r
an
g
e
o
f
d
ata
to
b
e
s
t
u
d
ied
.
I
n
th
is
s
t
u
d
y
,
th
e
d
ataset
w
ill
u
n
d
er
g
o
3
p
r
e
-
p
r
o
ce
s
s
i
n
g
s
ta
g
es
b
e
f
o
r
e
b
ein
g
ap
p
lied
in
to
t
h
e
r
ea
l
cla
s
s
if
icatio
n
al
g
o
r
ith
m
s
s
u
c
h
as
g
e
n
etic
a
lg
o
r
it
h
m
[
1
0
]
,
p
ath
w
a
y
b
ased
ca
n
ce
r
cla
s
s
i
f
icatio
n
[
1
1
]
,
an
d
s
ig
n
i
f
ica
n
t
d
ir
ec
ted
r
an
d
o
m
w
al
k
(
s
D
R
W
)
[
1
2
]
.
Fig
u
r
e
1
illu
s
tr
ate
t
h
e
p
h
a
s
es i
n
d
ata
p
r
e
-
p
r
o
ce
s
s
in
g
s
ta
g
e.
Fig
u
r
e
1
.
Data
p
r
e
-
p
r
o
ce
s
s
in
g
o
f
g
e
n
e
ex
p
r
ess
io
n
d
ataset
T
h
e
f
ir
s
t
2
s
tep
s
w
il
l
r
u
n
u
n
d
er
B
io
co
n
d
u
cto
r
w
h
ile
th
e
last
s
tep
w
ill
r
u
n
u
n
d
er
s
DR
W
.
First,
u
n
w
a
n
ted
attr
ib
u
tes,
m
i
s
s
in
g
v
al
u
e
an
d
p
r
o
p
er
ar
r
an
g
e
m
en
ts
o
f
d
ataset
w
ill
b
e
ap
p
li
ed
in
o
r
d
er
to
clea
n
th
e
d
ata.
Fi
g
u
r
e
2
s
h
o
w
s
th
e
d
etails
o
f
t
h
e
f
ir
s
t
s
tep
o
f
d
ata
p
r
e
-
p
r
o
ce
s
s
in
g
.
U
n
w
an
ted
attr
ib
u
tes
a
n
d
t
h
e
s
a
m
p
les
th
at
h
a
v
e
m
is
s
in
g
v
a
lu
es
w
i
ll
b
e
r
e
m
o
v
ed
.
R
ea
r
r
a
n
g
e
m
e
n
t
o
f
d
ata
ac
co
r
d
in
g
to
th
e
r
eq
u
ir
e
m
e
n
t
o
f
f
o
r
m
at
w
i
ll
b
e
r
u
n
t
h
r
o
u
g
h
b
e
f
o
r
e
p
r
o
ce
ed
in
g
to
th
e
n
e
x
t
p
h
ase
s
.
Oth
er
t
h
an
e
x
p
r
ess
io
n
v
alu
e,
t
h
er
e
is
o
t
h
er
in
f
o
r
m
atio
n
(
attr
ib
u
tes)
s
u
c
h
as
p
atien
t
b
io
lo
g
ical
in
f
o
r
m
at
i
o
n
an
d
d
ataset
i
n
f
o
r
m
atio
n
wh
ich
in
cl
u
d
ed
in
t
h
e
g
en
e
e
x
p
r
ess
io
n
d
ataset.
A
ll
o
f
th
i
s
in
f
o
r
m
a
tio
n
i
s
n
o
t
g
o
in
g
to
ap
p
ly
i
n
s
DR
W
f
o
r
c
an
ce
r
class
i
f
icat
io
n
p
u
r
p
o
s
es
[
1
3
]
.
Hen
ce
,
th
ese
attr
ib
u
tes
ar
e
co
n
s
id
er
ed
as
u
n
w
a
n
ted
attr
ib
u
te
s
an
d
w
i
ll
b
e
r
e
m
o
v
e
f
r
o
m
th
e
d
ataset.
On
l
y
w
a
n
ted
attr
ib
u
t
es
w
il
l
b
e
k
ep
t
f
o
r
th
e
ca
n
ce
r
class
if
icat
io
n
p
u
r
p
o
s
es
[
1
4
]
,
[
1
5
]
.
E
x
am
p
le
o
f
w
a
n
ted
attr
ib
u
te
s
ar
e
ex
p
r
ess
i
o
n
v
al
u
es,
t
h
e
p
o
s
itio
n
o
f
g
en
e
s
,
th
e
m
ea
n
s
o
f
g
e
n
e
’
s
w
ei
g
h
t,
an
d
s
o
o
n
.
A
ttrib
u
tes
t
h
at
h
av
e
m
is
s
i
n
g
v
al
u
es
w
ill
b
e
p
r
o
h
ib
ited
b
ec
au
s
e
w
i
th
o
u
t
t
h
e
ex
p
r
ess
io
n
v
alu
e
,
th
e
d
eo
x
y
r
ib
o
n
u
cleic
ac
id
(
DNA
)
s
eq
u
e
n
ce
s
co
u
ld
n
o
t
d
eter
m
in
e
t
h
e
ac
tu
al
ex
p
r
es
s
io
n
v
alu
e
a
n
d
th
e
r
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lt
w
il
l
b
e
a
f
f
ec
ted
if
p
r
ed
icted
v
alu
e
is
ap
p
lied
to
it.
Hen
ce
,
attr
ib
u
tes
th
at
co
n
tai
n
m
i
s
s
i
n
g
v
al
u
e
s
w
ill
b
e
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in
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fo
r
Gen
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C
la
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ifica
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(
C
h
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ea
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)
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eli
m
i
n
ated
.
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esid
es
t
h
at,
p
r
o
p
er
ar
r
an
g
e
m
e
n
t
o
f
d
ataset
s
w
il
l
b
e
ap
p
lied
.
DNA
s
eq
u
en
ce
s
ar
e
af
ter
ea
ch
o
t
h
er
an
d
th
e
“
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d
“
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v
al
u
e
w
i
ll
d
eter
m
i
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e
t
h
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p
lacin
g
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h
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a
x
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s
w
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ll
d
eter
m
i
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e
t
h
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p
o
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f
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t
h
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s
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q
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en
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s
o
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T
h
is
is
i
m
p
o
r
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t
f
o
r
t
h
e
n
e
x
t
p
r
o
ce
s
s
i
n
s
DR
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b
ec
au
s
e
t
h
i
s
co
u
ld
h
elp
in
d
eter
m
in
in
g
th
e
n
ex
t
g
e
n
e
an
d
h
e
n
ce
,
f
u
r
th
er
r
ef
er
en
cin
g
co
u
ld
b
e
m
ad
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b
y
co
m
p
ar
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w
it
h
o
th
er
r
ef
er
en
ce
d
ata
s
u
c
h
a
s
K
y
o
to
E
n
c
y
clo
p
ed
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o
f
Ge
n
e
s
an
d
Ge
n
o
m
e
s
(
KE
GG)
p
at
h
w
a
y
an
d
p
r
o
tein
-
p
r
o
tein
in
ter
ac
tio
n
(
P
P
I
)
s
eq
u
en
ce
s
.
Oth
er
t
h
an
t
h
is
,
an
ad
d
itio
n
al
o
f
3
v
alu
es
(
m
ea
n
,
s
ta
n
d
ar
d
d
ev
iatio
n
an
d
n
p
ix
el
s
)
ar
e
u
s
ed
as
ad
d
itio
n
a
l
attr
ib
u
tes
i
n
ca
n
ce
r
p
r
ed
ic
tio
n
an
d
cla
s
s
i
f
icatio
n
p
r
o
ce
s
s
.
T
h
e
m
ea
n
i
s
d
ef
i
n
ed
as
th
e
a
v
er
ag
e
o
f
t
h
e
s
u
m
o
f
th
e
w
ei
g
h
t
o
f
t
h
e
g
en
e.
S
tan
d
ar
d
d
ev
iatio
n
is
t
h
e
p
ar
a
m
ete
r
w
h
ich
is
u
s
ed
to
q
u
an
ti
f
y
t
h
e
a
m
o
u
n
t
o
f
v
ar
iat
io
n
i
n
t
h
e
g
en
e
’
s
w
ei
g
h
t.T
h
e
n
p
ix
el
s
ar
e
t
h
e
l
in
ea
r
d
i
m
e
n
s
i
o
n
o
f
th
e
g
e
n
es
i
n
p
ix
els.
Fig
u
r
e
2
.
Step
1
,
r
em
o
v
e
u
n
wan
ted
attr
ib
u
tes,
m
i
s
s
i
n
g
v
al
u
e
&
p
r
o
p
er
ar
r
an
g
e
m
e
n
t
Seco
n
d
,
n
o
r
m
aliza
tio
n
is
ap
p
lied
to
d
eg
r
ad
e
th
e
b
ig
v
alu
e
an
d
ca
u
s
e
s
th
e
w
ei
g
h
t
o
f
t
h
e
g
en
e
s
f
al
l
in
to
t
h
e
r
an
g
e
b
et
w
ee
n
0
–
1
0
[
1
6
]
.
Du
r
in
g
th
e
n
o
r
m
a
l
iza
tio
n
p
h
ase,
g
e
n
e’
s
w
ei
g
h
t,
m
ea
n
s
,
a
n
d
s
ta
n
d
ar
d
d
ev
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n
i
s
u
s
ed
to
ca
lc
u
late
t
h
e
n
o
r
m
alize
d
v
alu
e.
Fo
r
th
e
n
o
r
m
alize
d
v
al
u
es
t
h
at
ar
e
g
r
e
ater
th
a
n
1
0
,
it
w
ill
b
e
r
em
o
v
ed
as
w
e
j
u
s
t
w
a
n
t
to
k
ee
p
th
e
d
ig
it
w
it
h
in
0
t
o
1
0
.
T
h
is
is
to
r
e
m
o
v
e
t
h
e
in
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11
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3
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Sep
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201
8
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–
1
2
2
7
1226
Af
ter
h
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o
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SUL
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ataset,
GSE1
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2
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s
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u
r
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5
s
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atase
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g
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e
3
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r
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ith
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4
.
CO
NCLUS
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Fo
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ata
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r
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r
o
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i
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ex
a
m
p
le
o
f
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en
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ex
p
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io
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d
ata
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et.
Ge
n
e
ex
p
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ataset
co
n
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m
an
y
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ttrib
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io
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ical
i
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f
o
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m
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ab
o
u
t
th
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s
a
m
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le
s
.
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ce
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ch
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in
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h
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attr
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th
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n
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lecte
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Data
p
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ataset
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ed
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s
s
ta
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ata
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ata
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at
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
d
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N:
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f
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atasets
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n
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ter
p
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ee
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Fu
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R
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Stu
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s
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HM
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RE
F
E
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NC
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S
[1
]
Ba
ir,
E.
Id
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rra
y
d
a
ta.
W
il
e
y
In
ter
d
isc
ip
li
n
a
ry
Rev
iews
:
Co
mp
u
t
a
ti
o
n
a
l
S
ta
t
i
stics
.
2
0
1
3
;5
(
4
):3
0
9
-
3
2
5
.
[2
]
Ka
si
m
,
S
.
,
F
u
d
z
e
e
,
M
.
F
.
,
S
a
l
a
m
a
t,
M
.
A
.
,
Ra
m
li
,
A
.
A
.
,
M
a
h
d
i
n
,
H.,
&
A
b
d
u
ll
a
h
,
M
.
H.
An
imp
ro
v
e
d
c
o
mp
u
t
a
ti
o
n
a
l
fra
me
wo
rk
u
si
n
g
o
n
e
sta
g
e
fi
lt
r
a
ti
o
n
b
y
in
c
o
r
p
o
r
a
ti
n
g
k
n
o
wled
g
e
i
n
g
e
n
e
e
x
p
re
ss
io
n
c
lu
ste
ri
n
g
.
P
r
o
c
e
e
d
in
g
s
o
f
th
e
I
n
te
rn
a
ti
o
n
a
l
Co
n
f
e
re
n
c
e
o
n
A
rti
f
icia
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In
telli
g
e
n
c
e
a
n
d
Ro
b
o
ti
c
s
a
n
d
t
h
e
In
tern
a
ti
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n
a
l
Co
n
f
e
re
n
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e
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A
u
to
m
a
ti
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,
Co
n
t
ro
l
a
n
d
Ro
b
o
ti
c
s E
n
g
in
e
e
rin
g
-
IC
A
IR
-
C
A
CRE
1
6
.
2
0
1
6
.
[3
]
S
e
v
u
g
a
p
a
n
d
i,
N.
a
n
d
Ch
a
n
d
ra
n
,
C.
Clas
sif
i
c
a
ti
o
n
A
lg
o
rit
h
m
f
o
r
G
e
n
e
Ex
p
re
ss
io
n
G
r
a
p
h
a
n
d
M
a
n
h
a
tt
a
n
Dista
n
c
e
.
In
d
o
n
e
sia
n
J
o
u
rn
a
l
o
f
El
e
c
trica
l
En
g
i
n
e
e
rin
g
a
n
d
C
o
mp
u
ter
S
c
ien
c
e
.
2
0
1
7
;
5
(2
):
4
7
2
.
[4
]
L
iu
W
,
L
i
C,
X
u
Y,
Ya
n
g
H,
Ya
o
Q,
Ha
n
J et al.
T
o
p
o
lo
g
ica
ll
y
in
f
e
rrin
g
risk
-
a
c
ti
v
e
p
a
th
wa
y
s to
w
a
rd
p
re
c
ise
c
a
n
c
e
r
c
las
si
f
ica
ti
o
n
b
y
d
irec
ted
ra
n
d
o
m
w
a
l
k
.
Bi
o
in
f
o
rm
a
ti
c
s.
2
0
1
3
;
2
9
(1
7
):2
1
6
9
-
2
1
7
7
.
[5
]
Ch
o
o
n
S
e
n
,
S
.
,
Ka
sim
,
S
.
,
M
d
F
u
d
z
e
e
,
M
.
,
A
b
d
u
l
lah
,
R.
a
n
d
A
ta
n
,
R.
Ra
n
d
o
m
Walk
F
ro
m
Di
ff
e
r
e
n
t
P
e
rsp
e
c
ti
v
e
.
Acta
El
e
c
tro
n
ica
M
a
l
a
y
sia
.
2
0
1
7
;
1
(2
):
2
6
-
27.
[6
]
S
e
a
h
C,
Ka
sim
S
,
M
o
h
a
m
a
d
M
.
S
p
e
c
if
ic
T
u
n
in
g
P
a
ra
m
e
ter
f
o
r
Dire
c
ted
Ra
n
d
o
m
W
a
lk
A
l
g
o
rit
h
m
Ca
n
c
e
r
Clas
sif
ic
a
ti
o
n
.
In
ter
n
a
ti
o
n
a
l
J
o
u
rn
a
l
o
n
Ad
v
a
n
c
e
d
S
c
ien
c
e
,
En
g
i
n
e
e
rin
g
a
n
d
I
n
fo
rm
a
ti
o
n
T
e
c
h
n
o
lo
g
y
.
2
0
1
7
;
7
(1
):
1
7
6
.
[7
]
Re
v
a
th
y
N,
Am
a
lraj
D.
A
c
c
u
ra
t
e
Ca
n
c
e
r
Clas
sif
ic
a
ti
o
n
Us
i
n
g
Ex
p
re
ss
io
n
s
o
f
V
e
ry
F
e
w
Ge
n
e
s.
In
ter
n
a
ti
o
n
a
l
J
o
u
rn
a
l
o
f
Co
m
p
u
ter
A
p
p
l
ica
ti
o
n
s
.
2
0
1
1
;
1
4
(
4
):
1
9
-
22.
[8
]
L
a
n
d
i
M
,
Dra
c
h
e
v
a
T
,
Ro
tu
n
n
o
M
,
F
ig
u
e
ro
a
J,
L
iu
H,
Da
s
g
u
p
ta
A
e
t
a
l.
Ge
n
e
Ex
p
re
ss
io
n
S
ig
n
a
tu
re
o
f
Cig
a
re
tt
e
S
m
o
k
in
g
a
n
d
Its
Ro
le i
n
L
u
n
g
A
d
e
n
o
c
a
rc
in
o
m
a
De
v
e
lo
p
m
e
n
t
a
n
d
S
u
rv
iv
a
l.
PL
o
S
ONE
.
2
0
0
8
;3
(
2
):e
1
6
5
1
.
[9
]
Da
i,
Y.,
G
u
o
,
L
.
,
L
i,
M
.
a
n
d
Ch
e
n
,
Y.
M
icro
a
rra
y
Я
US:
a
u
se
r
-
f
r
ien
d
ly
g
ra
p
h
ica
l
in
terf
a
c
e
to
Bio
c
o
n
d
u
c
to
r
to
o
ls
th
a
t
e
n
a
b
les
a
c
c
u
ra
te
m
icro
a
rra
y
d
a
ta
a
n
a
ly
sis
a
n
d
e
x
p
e
d
it
e
s
c
o
m
p
re
h
e
n
siv
e
f
u
n
c
ti
o
n
a
l
a
n
a
ly
sis
o
f
m
icro
a
rra
y
re
su
lt
s.
BM
C
Res
e
a
rc
h
No
te.
2
0
1
2
;5
(
1
):2
8
2
.
[1
0
]
Od
e
h
,
A
.
No
v
e
l
G
e
n
e
ti
c
A
l
g
o
rit
h
m
f
o
r
Earl
y
P
re
d
icti
o
n
a
n
d
De
tec
ti
o
n
o
f
L
u
n
g
Ca
n
c
e
r.
J
o
u
rn
a
l
o
f
C
a
n
c
e
r
T
re
a
tme
n
t
a
n
d
Res
e
a
rc
h
.
2
0
1
7
;
5
(
2
):1
5
.
[1
1
]
G
ra
u
d
e
n
z
i,
A
.
P
a
th
w
a
y
-
b
a
se
d
c
las
sif
ic
a
ti
o
n
o
f
b
re
a
st
c
a
n
c
e
r
su
b
ty
p
e
s.
Fro
n
ti
e
rs
in
Bi
o
sc
ien
c
e
.
2
0
1
7
;2
2
(1
0
):1
6
9
7
-
1
7
1
2
.
[1
2
]
S
e
a
h
,
C.
,
Ka
sim
,
S
.
,
F
u
d
z
e
e
,
M
.
,
L
a
w
Tze
P
in
g
,
J.,
M
o
h
a
m
a
d
,
M
.
,
S
a
e
d
u
d
in
,
R.
a
n
d
Ism
a
il
,
M
.
A
n
e
n
h
a
n
c
e
d
to
p
o
lo
g
ica
ll
y
sig
n
if
i
c
a
n
t
d
irec
ted
ra
n
d
o
m
wa
lk
in
c
a
n
c
e
r
c
las
si
f
ica
ti
o
n
u
sin
g
g
e
n
e
e
x
p
re
ss
io
n
d
a
tas
e
ts.
S
a
u
d
i
J
o
u
rn
a
l
o
f
Bi
o
lo
g
ica
l
S
c
ien
c
e
s.
2
0
1
7
;2
4
(8
):
1
8
2
8
-
1
8
4
1
.
[1
3
]
S
e
a
h
C,
Ka
si
m
S
,
F
u
d
z
e
e
M
,
M
o
h
a
m
a
d
M
.
A
Dire
c
t
P
ro
o
f
o
f
S
ig
n
if
ica
n
t
Dire
c
ted
Ra
n
d
o
m
W
a
l
k
.
IOP
Co
n
fer
e
n
c
e
S
e
rie
s: M
a
ter
ia
ls
S
c
ien
c
e
a
n
d
En
g
in
e
e
rin
g
.
2
0
1
7
;
2
3
5
:0
1
2
0
0
4
.
[1
4
]
W
u
,
J.
F
e
a
tu
re
S
e
lec
ti
o
n
f
o
r
Ca
n
c
e
r
Clas
si
f
ica
ti
o
n
Us
in
g
M
icro
a
rra
y
Ge
n
e
Ex
p
re
ss
io
n
Da
ta.
Bi
o
sta
ti
stics
a
n
d
Bi
o
me
trics
Op
e
n
Acc
e
ss
J
o
u
rn
a
l.
2
0
1
7
;
1
(2
).
[1
5
]
L
i,
J.,
M
e
n
g
,
X
.
,
W
e
n
,
J.
a
n
d
X
u
,
Y.
A
n
I
m
p
ro
v
e
d
M
e
th
o
d
o
f
S
V
M
-
B
P
S
O
F
e
a
tu
re
S
e
lec
ti
o
n
B
a
se
d
o
n
Clo
u
d
M
o
d
e
l.
T
EL
KOM
NIKA
I
n
d
o
n
e
sia
n
J
o
u
r
n
a
l
o
f
El
e
c
trica
l
E
n
g
i
n
e
e
rin
g
.
2
0
1
4
;1
2
(5
).
[1
6
]
S
h
i
Jin
g
,
L
.
,
F
a
th
iah
M
u
z
a
f
f
a
r
S
h
a
h
,
F
.
,
S
a
b
e
ri
M
o
h
a
m
a
d
,
M
.
,
M
o
o
rth
y
,
K.,
De
ris,
S
.
,
Zak
a
ri
a
,
Z.
a
n
d
Na
p
is,
S
.
A
Re
v
ie
w
o
n
Bio
in
f
o
rm
a
ti
c
s
En
rich
m
e
n
t
A
n
a
l
y
sis
T
o
o
ls
T
o
w
a
rd
s
F
u
n
c
ti
o
n
a
l
A
n
a
ly
sis
o
f
Hig
h
T
h
ro
u
g
h
p
u
t
G
e
n
e
S
e
t
Da
ta.
Cu
rr
e
n
t
Pro
teo
mic
s
.
2
0
1
5
;1
2
(1
):
1
4
-
27.
[1
7
]
Kim
,
Y.
a
n
d
Yo
o
n
,
Y.
A
g
e
n
e
ti
c
f
il
ter
f
o
r
c
a
n
c
e
r
c
las
si
f
ica
ti
o
n
o
n
g
e
n
e
e
x
p
re
ss
io
n
d
a
ta.
Bio
-
M
e
d
ica
l
M
a
ter
ia
ls
a
n
d
En
g
i
n
e
e
rin
g
.
2
0
1
5
;2
6
(s1
):
S
1
9
9
3
-
S
2
0
0
2
.
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