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[
2
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.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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2.
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f
r
a
m
e
w
o
r
k
ar
e
o
p
en
to
th
e
ap
p
r
o
v
ed
clien
ts
w
h
e
n
ev
er
t
h
e
y
r
eq
u
ir
e
th
e
in
f
o
r
m
atio
n
.
Sec
u
r
it
y
ap
p
r
o
ac
h
es
m
u
s
t
b
e
ad
eq
u
ate
to
h
an
d
le
th
e
co
n
s
t
an
tl
y
c
h
a
n
g
i
n
g
in
f
o
r
m
atio
n
r
u
p
t
u
r
es [
3
]
.
T
h
is
is
t
h
e
p
lace
w
h
er
e
th
e
in
f
o
r
m
a
tio
n
s
ec
u
r
it
y
,
en
cr
y
p
tio
n
o
f
i
n
f
o
r
m
at
io
n
v
er
y
s
till
a
n
d
in
m
o
v
e
m
en
t,
ex
ec
u
ti
n
g
clie
n
t a
cc
e
s
s
co
n
tr
o
l b
ec
o
m
e
p
o
s
s
ib
l
y
th
e
m
o
s
t i
m
p
o
r
tan
t
f
ac
to
r
.
Wo
rld o
f
Cry
pto
g
ra
ph
y
Dif
f
er
en
t
cr
y
p
to
g
r
ap
h
ic
tech
n
iq
u
e
s
ar
e
u
t
ilized
f
o
r
s
ec
u
r
in
g
th
e
i
n
f
o
r
m
atio
n
o
v
er
a
n
d
o
v
er
.
C
r
y
p
to
g
r
ap
h
y
is
th
e
s
p
ec
ialt
y
o
f
c
h
an
g
i
n
g
o
v
er
th
e
m
es
s
ag
e
in
to
h
u
m
a
n
d
is
j
o
in
ted
co
d
e,
w
h
ic
h
ca
n
'
t
b
e
tu
r
n
ed
ar
o
u
n
d
to
t
h
e
m
es
s
ag
e
w
ith
o
u
t
p
r
o
p
er
co
d
e.
C
r
y
p
to
g
r
ap
h
y
as
s
u
m
es
an
es
s
en
t
ial
p
ar
t
in
i
n
f
o
r
m
atio
n
h
o
n
es
t
y
.
T
h
is
ca
n
b
e
r
ep
r
es
en
ted
in
t
h
e
th
r
ee
s
e
g
m
e
n
ts
o
f
th
e
C
I
A
tr
iad
(
C
o
n
f
id
e
n
tialit
y
,
I
n
te
g
r
it
y
,
Av
ailab
ilit
y
)
.
C
I
A
is
t
h
e
p
r
in
c
ip
al
id
ea
in
th
e
s
ec
u
r
ed
d
ata
tr
an
s
m
i
s
s
io
n
.
3.
DNA
CRYP
T
O
G
RAP
H
Y
DN
A
cr
y
p
to
g
r
ap
h
y
i
s
o
n
e
o
f
t
h
e
f
a
s
test
g
r
o
w
i
n
g
in
n
o
v
atio
n
s
w
h
ic
h
tak
e
a
s
h
o
t
at
th
o
u
g
h
t
s
o
f
DN
A
f
i
g
u
r
i
n
g
.
An
o
th
er
f
r
a
m
e
w
o
r
k
f
o
r
s
ec
u
r
in
g
d
ata
w
a
s
d
is
p
la
y
e
d
u
s
in
g
t
h
e
r
eg
u
lar
s
tr
u
ct
u
r
e
o
f
DN
A
ca
lled
DN
A
Fig
u
r
in
g
o
r
s
u
b
-
n
u
c
lear
p
r
ep
a
r
in
g
o
r
n
atu
r
al
en
r
o
lli
n
g
.
I
t
w
as
cr
ea
ted
b
y
L
eo
n
ar
d
Ma
x
Ad
le
m
an
i
n
th
e
y
ea
r
1
9
9
4
,
f
o
r
h
an
d
lin
g
t
h
e
b
r
ain
b
o
g
g
li
n
g
i
s
s
u
es.
A
d
le
m
an
is
u
s
u
all
y
ca
lled
as
"
An
"
in
th
e
R
S
A
es
ti
m
atio
n
–
a
co
m
p
u
tatio
n
w
h
ich
is
p
r
ese
n
t
in
a
co
u
p
le
c
ir
cles
t
h
at
h
as
t
r
an
s
f
o
r
m
ed
it
i
n
to
an
ac
k
n
o
wled
g
ed
s
ta
n
d
ar
d
f
o
r
m
ec
h
a
n
ical
q
u
a
lit
y
e
n
cr
y
p
tio
n
o
f
in
f
o
r
m
at
io
n
s
e
n
t
o
v
er
t
h
e
W
eb
.
T
h
e
tech
n
iq
u
e
later
o
n
r
ea
ch
ed
o
u
t
b
y
d
if
f
er
e
n
t
b
o
s
s
es
f
o
r
en
co
d
in
g
an
d
d
i
m
in
is
h
i
n
g
t
h
e
p
o
in
t
o
f
co
n
f
i
n
e
m
en
t
s
ize
o
f
i
n
f
o
r
m
a
tio
n
th
at
m
ad
e
th
e
in
f
o
r
m
atio
n
tr
a
n
s
m
i
s
s
io
n
o
v
er
th
e
s
tr
u
c
tu
r
e
s
p
ee
d
ier
an
d
s
e
c
u
r
ed
[
4
]
.
DNA
I
n
s
er
t
io
n
M
et
ho
d
:
T
h
e
f
ir
s
t
m
e
th
o
d
w
h
ic
h
i
s
d
o
n
e
w
i
th
th
e
DN
A
cr
y
p
to
g
r
ap
h
y
tec
h
n
iq
u
e
.
W
e
m
ai
n
l
y
co
n
ce
n
tr
ated
i
n
th
is
ar
ea
i
n
w
h
ic
h
t
h
e
m
e
th
o
d
as
th
is
o
n
e
h
av
e
s
o
m
e
m
o
r
e
ex
tr
a
f
ea
t
u
r
es
an
d
s
o
m
e
m
o
r
e
s
ec
u
r
it
y
t
h
an
co
m
p
ar
ed
to
o
th
er
s
.
DNA
en
cr
y
p
tio
n
a
n
d
d
ec
r
y
p
tio
n
t
ec
h
n
iq
u
es
a
r
e
v
ice
-
v
er
s
a
tech
n
iq
u
es.
I
n
s
er
tio
n
t
ec
h
n
iq
u
e
u
s
es
DN
A
s
eq
u
en
ce
s
f
o
r
s
e
n
d
in
g
m
e
s
s
a
g
es
s
e
cu
r
el
y
to
t
h
e
r
ec
eiv
er
.
T
h
e
en
cr
y
p
tio
n
i
s
k
n
o
w
n
w
id
e
l
y
a
s
th
e
d
ata
h
id
i
n
g
p
r
o
ce
s
s
.
E
n
cr
y
p
tio
n
tech
n
iq
u
e
u
s
es
th
e
DN
A
s
eq
u
en
ce
,
w
h
ich
co
m
p
r
is
e
s
o
f
A
,
C
,
G,
an
d
T
n
u
cleo
tid
es
w
h
ic
h
ar
e
th
e
m
ai
n
co
m
p
o
n
e
n
t
s
in
t
h
e
DN
A
s
eq
u
e
n
ci
n
g
tec
h
n
iq
u
e
[
1
]
.
E
ncry
ptio
n
:
E
n
cr
y
p
tio
n
i
s
a
p
r
o
ce
s
s
o
f
h
id
in
g
d
ata
f
r
o
m
th
e
o
t
h
er
s
,
w
h
ic
h
ar
e
to
b
e
v
ie
w
ed
o
n
l
y
b
y
s
o
m
e
p
ar
ticu
lar
an
d
ap
p
r
o
p
r
iate
v
ie
w
er
s
.
I
n
a
n
e
n
cr
y
p
tio
n
s
c
h
e
m
e,
th
e
e
n
cr
y
p
ted
co
m
m
u
n
icati
o
n
in
f
o
r
m
a
tio
n
o
r
m
es
s
ag
e
s
ar
e
r
ef
er
r
ed
to
as
p
lain
tex
t
an
d
t
h
e
e
n
cr
y
p
tio
n
is
d
o
n
e
u
s
i
n
g
a
p
ar
ticu
lar
e
n
cr
y
p
tio
n
al
g
o
r
ith
m
tech
n
iq
u
e
,
w
h
ic
h
g
e
n
er
ates a
c
ip
h
er
-
te
x
t
th
at
ca
n
b
e
r
ea
d
o
n
l
y
i
f
it i
s
d
ec
r
y
p
ted
.
T
o
s
i
m
p
li
f
y
t
h
e
d
i
s
cu
s
s
io
n
on
th
e
i
n
s
er
t
io
n
m
et
h
o
d
,
th
e
m
o
s
t
b
asic
v
er
s
io
n
is
ta
k
en
an
d
s
o
l
v
ed
w
it
h
t
h
e
b
est
a
n
d
s
i
m
p
le
ex
a
m
p
le.
T
h
e
m
o
s
t
co
m
p
le
x
v
er
s
io
n
is
also
p
r
ese
n
t
b
u
t
t
h
is
o
n
e
g
i
v
es
y
o
u
th
e
b
est
k
n
o
w
led
g
e
o
n
th
e
m
et
h
o
d
.
E
v
er
y
m
et
h
o
d
u
s
e
s
a
DN
A
s
eq
u
e
n
ce
as
r
ef
er
e
n
ce
w
h
ic
h
i
s
P
in
th
i
s
ca
s
e
[
9
]
.
Su
p
p
o
s
e
th
e
s
ec
r
et
m
es
s
ag
e
M
i
s
0
1
1
0
0
1
1
1
.
L
et
P
b
e
A
G
GT
C
A
GT
C
C
T
T
A
.
T
h
e
m
eth
o
d
w
o
r
k
s
as
s
h
o
w
n
b
elo
w
:
Fo
r
an
clea
r
v
ie
w
a
f
lo
w
ch
a
r
t
is
d
r
a
w
n
f
o
r
t
h
e
en
cr
y
p
tio
n
tec
h
n
iq
u
e,
s
h
o
w
n
i
n
Fi
g
u
r
e
1.
Step
1
.
C
o
n
v
er
t
P
in
to
th
e
b
in
ar
y
s
eq
u
e
n
ce
b
y
u
s
i
n
g
th
e
b
in
ar
y
co
d
in
g
r
u
le.
T
h
u
s
t
h
e
s
eq
u
en
ce
P
w
il
l
n
o
w
b
ec
o
m
e
0
0
1
0
1
0
1
1
0
1
0
0
1
0
1
1
0
1
0
1
1
1
1
1
0
0
.
Step
2
.
Div
id
e
t
h
e
ab
o
v
e
s
eq
u
en
ce
P
in
to
s
eg
m
e
n
ts
,
w
h
er
e
b
y
ea
ch
s
e
g
m
e
n
t
co
n
tai
n
s
k
b
its
.
S
u
p
p
o
s
e
k
is
3
.
T
h
en
th
e
f
o
llo
w
i
n
g
ar
e
th
e
s
e
g
m
e
n
t
s
w
e
g
et:
0
0
1
,
0
1
0
,
1
1
0
,
1
0
0
,
1
0
1
,
1
0
1
,
0
1
1
,
1
1
1
,
a
n
d
0
0
.
T
h
is
ca
n
b
e
o
b
s
er
v
ed
in
Fi
g
u
r
e
3.
Step
3
.
I
n
s
er
t
th
e
m
es
s
ag
e
M
b
its
,
o
n
e
at
a
ti
m
e,
i
n
to
th
e
b
eg
in
n
i
n
g
o
f
ea
ch
a
n
d
ev
er
y
s
eg
m
e
n
ts
o
f
P
.
T
h
e
r
esu
lt i
s
as s
h
o
w
n
:
0
0
0
1
,
1
0
1
0
,
1
1
1
0
,
0
1
0
0
,
0
1
0
1
,
1
1
0
1
,
1
0
1
1
,
1
1
1
1
,
0
0
.
T
h
is
ca
n
b
e
o
b
s
er
v
ed
in
Fi
g
u
r
e
4.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
0
8
9
-
4864
IJ
R
E
S
Vo
l.
5
,
No
.
3
,
No
v
em
b
er
201
6
:
1
3
7
–
14
2
139
T
h
e
s
eg
m
en
ts
w
h
ic
h
d
o
n
o
t
c
ar
r
y
a
n
y
h
id
d
en
m
es
s
ag
e
i
n
it
ar
e
to
b
e
ig
n
o
r
ed
.
T
h
u
s
,
t
h
e
f
o
llo
w
i
n
g
s
e
g
m
e
n
t
s
ar
e
o
b
tain
ed
af
ter
th
e
eli
m
in
a
ti
o
n
o
f
all
th
e
e
x
tr
a
b
its
:
0
0
0
1
,
1
0
1
0
,
1
1
1
0
,
0
1
0
0
,
0
1
0
1
,
1
1
0
1
,
1
0
1
1
,
1
1
1
1
,
0
0
C
o
n
ca
ten
ate
t
h
e
ab
o
v
e
s
eq
u
en
ce
s
,
a
n
d
th
e
n
w
e
g
et
t
h
e
s
eq
u
en
ce
r
eq
u
ir
ed
:
0
0
0
1
1
0
1
0
1
1
1
0
0
1
0
0
0
1
0
1
1
1
0
1
1
0
1
1
1
1
1
1
.
T
h
is
ca
n
b
e
o
b
s
er
v
ed
in
Fig
u
r
e
5.
Step
4.
B
y
u
s
in
g
t
h
e
i
n
v
er
s
e
b
in
ar
y
co
d
i
n
g
f
u
n
c
tio
n
r
u
le
to
p
r
o
d
u
ce
th
e
f
o
llo
w
i
n
g
f
a
k
ed
a
n
d
en
cr
y
p
ted
D
N
A
s
eq
u
en
ce
:
P
0
1
/4
A
C
GGT
GC
A
C
C
T
C
GT
T
T
.
A
s
t
h
e
r
ea
d
er
ca
n
s
ee
,
th
i
s
s
eq
u
en
ce
i
s
q
u
ite
d
i
f
f
er
e
n
t f
r
o
m
P
.
[
5
]
Step
5
.
T
h
e
en
cr
y
p
ted
s
eq
u
e
n
ce
a
s
s
h
o
w
n
ab
o
v
e
is
th
e
n
s
e
n
t
to
th
e
r
ec
eiv
er
.
Fig
u
r
e
6
,
s
h
o
w
s
t
h
e
to
tal
en
cr
y
p
tio
n
p
r
o
ce
s
s
.
Fig
u
r
e
1
.
Flo
w
c
h
ar
t f
o
r
E
n
cr
y
p
tio
n
Dec
ry
ptio
n
:
T
h
e
p
r
o
ce
s
s
o
f
ex
tr
ac
ti
n
g
t
h
e
d
ata
f
r
o
m
th
e
r
ec
eiv
ed
cip
h
er
-
tex
t
f
r
o
m
t
h
e
tr
a
n
s
m
itter
i
s
ca
lled
a
s
d
ec
r
y
p
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n
.
Me
s
s
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g
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ar
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e
n
t
to
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e
r
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ei
v
er
b
y
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s
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ce
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tain
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cr
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p
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n
p
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s
s
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d
b
y
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o
in
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eq
u
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ale
n
t
d
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p
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p
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s
s
o
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l
y
w
e
ca
n
r
eg
e
n
er
ate
t
h
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h
id
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en
m
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s
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g
e
f
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m
th
e
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ed
.
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h
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g
e
n
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ated
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es
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ag
e
w
ill
b
e
t
h
e
r
eq
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m
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e.
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h
is
i
s
o
n
l
y
o
b
s
er
v
e
d
b
y
t
h
e
p
ar
ticu
lar
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ec
ei
v
er
t
o
w
h
o
m
w
e
s
e
n
d
th
e
m
es
s
ag
e.
T
h
er
e
ar
e
s
o
m
e
in
ter
r
u
p
ter
s
,
w
h
o
tr
y
to
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ter
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p
t
t
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e
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ata
in
b
et
w
ee
n
th
e
tr
a
n
s
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is
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,
th
i
s
h
elp
s
to
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en
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th
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m
ess
a
g
e
s
ec
u
r
e
w
it
h
o
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t
an
y
in
ter
r
u
p
ts
.
Fo
r
th
e
s
eq
u
en
ce
th
a
t
is
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eiv
ed
,
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e
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g
ets
a
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b
s
eq
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o
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t
o
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it,
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s
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g
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e
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ec
h
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i
s
m
s
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h
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itter
\
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ep
ar
ated
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u
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eq
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ce
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s
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o
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th
e
p
r
ef
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x
o
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th
e
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e
n
ce
g
r
o
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p
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f
P
,
o
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k
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n
t
h
e
e
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e
n
t
th
at
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i
s
,
th
e
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ip
ie
n
t
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lize
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h
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icate
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ter
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ess
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M
as
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h
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p
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ce
d
u
r
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g
i
v
en
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n
t
h
e
f
lo
w
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h
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t
d
r
a
w
n
i
n
Fi
g
u
r
e
2.
Step
1
.
C
o
d
e
g
o
t
P0
in
to
a
p
a
ir
ed
g
r
o
u
p
in
g
b
y
u
tili
z
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g
t
h
e
p
ar
allel
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d
in
g
g
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id
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e.
T
h
e
s
eq
u
en
ce
P0
w
ill
n
o
w
b
ec
o
m
e:
0
0
0
1
1
0
1
0
1
1
1
0
0
1
0
0
0
1
0
1
1
1
0
1
1
0
1
1
1
1
1
1
b
y
u
s
i
n
g
th
e
b
i
n
ar
y
co
d
in
g
r
u
le.
T
h
e
d
ec
r
y
p
tio
n
is
clea
r
l
y
s
h
o
w
n
i
n
Fi
g
u
r
e
7.
Step
2
.
R
e
m
o
v
e
t
h
e
p
r
in
cip
al
b
its
f
r
o
m
ev
er
y
4
-
b
it
f
r
a
g
m
en
t
in
t
h
e
ab
o
v
e
p
o
r
tio
n
s
.
T
h
e
o
u
tco
m
e
is
as
p
er
t
h
e
f
o
llo
w
in
g
p
ar
titi
o
n
:0
,
1
,
1
,
0
,
0
,
1
,
1
,
1
.
Sep
ar
ate
th
e
last
th
r
ee
b
its
f
r
o
m
e
v
er
y
4
-
b
it
p
o
r
tio
n
.
T
h
e
o
u
tco
m
e
i
s
as
p
er
th
e
f
o
llo
w
in
g
:
0
0
1
,
0
1
0
,
1
1
0
,
1
0
0
,
1
0
1
,
1
0
1
,
0
1
1
,
an
d
1
1
1
.
Step
3
.
C
o
n
ca
te
n
ate
th
e
s
ep
ar
ated
b
its
a
n
d
th
e
ab
o
v
e
r
e
m
ai
n
in
g
s
ec
tio
n
s
,
w
h
ic
h
r
es
u
lt
s
i
n
t
h
e
ac
co
m
p
a
n
y
in
g
t
w
o
f
o
ld
ar
r
an
g
e
m
e
n
t
s
:
0
1
1
0
0
1
1
1
an
d
0
0
1
0
1
0
1
1
0
1
0
0
1
0
1
1
0
1
0
1
1
1
1
1
0
0
.
T
h
e
co
n
v
er
s
e
ca
p
ac
it
y
o
f
t
h
e
t
w
o
f
o
ld
co
d
in
g
g
u
id
eli
n
e
is
u
til
ized
to
ch
an
g
e
th
e
ac
c
o
m
p
an
y
i
n
g
d
o
u
b
le
ar
r
an
g
e
m
en
t.
T
h
is
f
in
al
v
alu
es
ar
e
s
h
o
w
n
in
Fig
u
r
e
8.
Step
4
:
0
0
1
0
1
0
1
1
0
1
0
0
1
0
1
1
0
1
0
1
1
1
1
1
0
0
.
U
s
er
ca
n
s
ee
,
th
i
s
ar
r
an
g
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m
en
t
w
i
ll
b
e
ch
a
n
g
ed
as
A
G
GT
C
A
GT
C
C
T
T
A
.
T
h
is
D
NA
ar
r
an
g
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m
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n
t
is
t
h
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p
r
ef
i
x
o
f
P
an
d
it
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g
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b
ac
k
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s
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b
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r
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a
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d
icate
d
b
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P
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C
o
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eq
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t
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tr
ac
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p
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0
1
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1
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is
th
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w
a
n
ted
m
y
s
ter
y
m
e
s
s
a
g
e
F
L
O
WCH
ART F
O
R
DE
CRYP
T
I
O
N
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
R
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S
I
SS
N:
2
0
8
8
-
8708
F
P
GA
B
a
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Da
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(
C
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d
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)
140
Fig
u
r
e
2
.
Flo
w
c
h
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f
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r
Dec
r
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p
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n
T
h
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ab
o
v
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d
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s
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m
g
r
a
p
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6
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t
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lizes
th
at
th
e
m
y
s
ter
y
m
e
s
s
a
g
e
h
as
b
ee
n
r
e
m
o
v
ed
.
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h
e
co
llecto
r
u
tili
ze
s
t
h
e
ac
co
m
p
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n
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lcu
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to
r
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u
p
th
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s
h
r
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ed
m
es
s
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g
e:
Oth
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DN
A
C
r
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p
to
g
r
ap
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es
1
.
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2
.
Su
b
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M
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:
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eth
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p
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m
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tar
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s
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h
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o
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w
i
n
g
ar
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th
e
co
m
p
li
m
en
tar
y
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s
(
(
AC
)
(
C
G)
(
GT
)
(
T
A
)
)
.
T
h
e
co
m
p
li
m
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n
tar
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p
air
o
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th
e
s
tr
in
g
AACT
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e
C
C
G
A
T
.
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m
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m
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et
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n
tar
y
p
air
s
ar
e
u
s
ed
f
o
r
th
e
d
ec
r
y
p
tio
n
tec
h
n
iq
u
e
w
h
ic
h
is
a
v
ice
v
er
s
a
o
f
t
h
e
e
n
cr
y
p
tio
n
tech
n
iq
u
e
[
7
]
.
Su
bs
t
it
utio
n
M
et
ho
d
:
T
h
is
is
also
o
n
e
o
f
t
h
e
DN
A
tr
an
s
m
is
s
io
n
p
r
o
ce
s
s
w
h
ic
h
wo
r
k
s
o
n
s
u
b
s
tit
u
tio
n
b
asis
,
as
th
e
n
a
m
e
its
el
f
in
d
icate
s
th
at.
Her
e
w
e
d
o
n
’
t
elab
o
r
ate
th
is
m
et
h
o
d
as
it
is
a
v
er
y
le
n
g
th
y
o
n
e
a
n
d
if
w
e
s
tar
t
d
escr
ib
i
n
g
th
is
i
t
w
o
u
ld
b
e
a
v
er
y
le
n
g
t
h
y
as o
u
r
m
ai
n
to
p
ic
is
th
e
I
n
s
er
t
io
n
m
et
h
o
d
w
e
co
n
ce
n
tr
ate
o
n
th
e
m
et
h
o
d
.
W
e
m
a
in
l
y
co
n
ce
n
t
r
ated
o
n
t
h
e
I
NSERT
I
ON
ME
T
HOD
w
e
s
i
m
u
la
ted
th
e
r
es
u
lt
s
u
s
i
n
g
FP
G
A
b
y
Ver
ilo
g
co
d
in
g
.
T
h
e
r
esu
lt
s
m
en
tio
n
ed
b
elo
w
ar
e
t
h
e
DN
A
i
n
s
er
tio
n
m
et
h
o
d
tech
n
iq
u
e
b
as
ed
r
esu
lts
[
8
]
.
4.
SI
M
UL
AT
I
O
N
R
E
S
UL
T
S
T
h
e
b
elo
w
ar
e
th
e
r
es
u
lt
s
o
b
tain
ed
f
r
o
m
t
h
e
i
n
s
er
tio
n
m
et
h
o
d
in
t
h
e
v
er
i
lo
g
s
i
m
u
latio
n
to
o
l c
o
d
in
g
.
E
ncry
ptio
n:
First
th
e
g
i
v
en
ASC
I
I
DN
A
s
eq
u
en
ce
is
co
n
v
er
ted
in
to
b
in
ar
y
s
eq
u
en
ce
a
n
d
th
e
s
eq
u
e
n
ce
is
th
e
n
d
iv
id
ed
in
to
s
eg
m
e
n
ts
u
s
in
g
k
v
alu
e
h
er
e
K=
3
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
0
8
9
-
4864
IJ
R
E
S
Vo
l.
5
,
No
.
3
,
No
v
em
b
er
201
6
:
1
3
7
–
14
2
141
Fig
u
r
e
3
.
E
n
cr
y
p
tio
n
1
,
b
in
ar
y
co
n
v
er
s
io
n
I
n
s
er
t
t
h
e
m
es
s
ag
e
i
n
to
t
h
e
s
eg
m
e
n
t
s
e
v
er
y
b
it
i
s
to
b
e
in
s
er
ted
in
f
r
o
n
t
o
f
t
h
e
P
s
eg
m
en
t
b
its
w
h
ic
h
ar
e
d
iv
id
ed
u
s
i
n
g
k
v
a
lu
e
ab
o
v
e
.
q
in
th
e
ab
o
v
e
f
ig
u
r
e
is
t
h
e
s
e
g
m
en
ted
p
ar
ts
w
h
ic
h
ar
e
d
iv
id
ed
in
to
s
eg
m
e
n
ts
u
s
i
n
g
K
v
al
u
e
.
Fig
u
r
e
4
.
Me
s
s
ag
e
s
eq
u
e
n
ce
i
n
s
er
tio
n
i
n
to
s
eq
u
en
ce
C
o
n
ca
te
n
ate
th
e
s
eq
u
en
ce
s
af
ter
th
e
in
s
er
tio
n
m
ess
a
g
e
is
in
ter
ce
p
ted
in
to
th
e
co
d
e
a
n
d
n
o
w
in
s
er
t
th
e
m
es
s
ag
e
i
n
f
r
o
n
t o
f
e
v
er
y
s
e
g
m
en
ts
i
n
q
th
e
n
th
e
q
n
o
w
b
ec
o
m
e
s
q
1
as seen
i
n
t
h
e
ab
o
v
e
f
ig
u
r
e.
Fig
u
r
e
5
.
C
o
n
ca
ti
n
atio
n
o
f
s
eg
m
en
ts
C
o
n
c
ate
n
ate
t
h
e
s
eq
u
e
n
ce
q
1
,
MSG_
SEQ
i
s
g
en
er
ated
w
h
ic
h
i
s
a
b
i
n
ar
y
s
eq
u
e
n
ce
w
i
th
th
e
h
id
d
en
m
e
s
s
a
g
e
i
n
th
e
DN
A
s
eq
u
en
ce
.
C
o
n
v
er
t th
e
co
n
ca
te
n
ated
b
in
a
r
y
s
eq
u
e
n
ce
ag
ai
n
to
A
S
C
I
I
v
a
lu
e
Fig
u
r
e
6
.
C
o
n
v
er
s
io
n
o
f
co
n
ca
ten
ated
s
eq
u
e
n
ce
i
n
to
b
in
ar
y
C
R
YP
1
th
e
s
eq
u
e
n
ce
is
g
e
n
er
ated
b
y
th
e
co
n
v
er
s
io
n
o
f
th
e
ab
o
v
e
MSG_
SEQ
in
to
th
e
b
in
ar
y
s
eq
u
en
ce
u
s
in
g
t
h
e
b
i
n
ar
y
co
d
in
g
r
u
le.
T
h
is
p
ar
ticu
lar
s
eq
u
en
ce
is
s
en
t
alo
n
g
w
it
h
m
a
n
y
o
th
er
s
u
c
h
b
i
n
ar
y
s
eq
u
en
ce
s
to
th
e
r
ec
ei
v
er
.
W
ith
th
i
s
th
e
en
cr
y
p
tio
n
p
ar
t
is
co
m
p
leted
th
e
s
a
m
e
r
ev
er
s
al
w
a
y
g
iv
e
s
y
o
u
t
h
e
d
ec
r
y
p
ted
o
u
tp
u
t
an
d
th
e
r
eq
u
ir
ed
m
es
s
ag
e.
W
h
ich
ca
n
o
n
l
y
d
o
n
e
b
y
th
e
p
ar
tic
u
la
r
r
ec
eiv
er
.
Dec
ry
ptio
n:
C
o
n
v
er
t th
e
ASC
I
I
v
al
u
e
s
r
ec
e
iv
ed
in
to
b
in
ar
y
s
eq
u
e
n
ce
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
R
E
S
I
SS
N:
2
0
8
8
-
8708
F
P
GA
B
a
s
ed
Da
ta
Hid
in
g
Meth
o
d
s
u
s
in
g
DN
A
C
r
yp
to
g
r
a
p
h
y
Tech
n
iq
u
es
(
C
H.
S
u
r
en
d
r
a
)
142
Fig
u
r
e
7
.
Dec
r
y
p
t,
C
o
n
v
er
s
io
n
o
f
B
I
NA
R
Y
to
ASC
I
I
th
e
r
ec
eiv
ed
s
eq
u
en
ce
s
ar
e
n
o
w
d
ec
r
y
p
ted
o
n
e
a
f
ter
t
h
e
o
th
er
f
o
r
g
etti
n
g
th
e
o
r
ig
in
al
a
n
d
d
esire
d
s
eq
u
en
ce
w
it
h
w
h
ic
h
t
h
e
y
ca
n
e
x
tr
ac
t
t
h
e
m
ess
a
g
e
s
ig
n
al.
T
h
e
s
eq
u
e
n
ce
h
a
v
i
n
g
t
h
e
p
r
o
p
er
ties
s
a
m
e
as
th
e
ir
d
eser
v
ed
o
n
es is
k
n
o
w
n
as t
h
eir
r
eq
u
ir
e
d
s
eq
u
en
ce
f
r
o
m
w
h
ich
t
h
e
m
e
s
s
a
g
e
is
ex
tr
ac
ted
/d
ec
r
y
p
ted
.
Fig
u
r
e
8
.
Fin
al
o
u
tco
m
e
s
ep
ar
atio
n
o
f
m
ess
a
g
e
b
its
f
r
o
m
s
eq
u
en
ce
T
h
e
s
eq
u
en
ce
i
s
d
iv
id
ed
in
to
t
h
e
s
e
g
m
en
t
s
o
f
4
b
its
.
T
h
ese
4
ar
e
d
iv
id
ed
in
to
3
b
its
an
d
1
b
it.
First
b
it o
f
ev
er
y
s
e
g
m
e
n
t is ta
k
en
a
s
m
e
s
s
a
g
e
an
d
th
e
la
s
t 3
b
its
a
s
th
e
DN
A
s
eq
u
e
n
ce
.
First
b
it
s
ar
e
co
n
ca
ten
a
ted
an
d
th
at
is
th
e
r
eq
u
ir
ed
m
es
s
ag
e
s
eq
u
e
n
ce
w
h
ic
h
is
MSG
.
T
h
e
last
3
b
it
s
ar
e
co
n
ca
ten
ated
an
d
th
e
s
e
ar
e
ca
lled
as th
e
DN
A
s
eq
u
en
ce
w
h
ic
h
is
u
s
ed
in
t
h
e
en
cr
y
p
tio
n
it is
q
1
.
T
h
e
m
e
s
s
a
g
e
s
eq
u
e
n
ce
is
t
h
e
s
eq
u
en
ce
w
h
ic
h
is
v
is
ib
le
o
n
l
y
to
th
e
r
ec
ei
v
er
.
T
h
is
p
r
o
tects
th
e
s
eq
u
en
ce
f
r
o
m
o
th
er
s
.
T
h
e
m
e
s
s
a
g
e
is
e
n
cr
y
p
ted
i
n
s
u
c
h
a
w
a
y
t
h
at
t
h
e
i
n
ter
ce
p
to
r
s
w
h
o
h
ac
k
s
t
h
e
m
es
s
ag
e
s
ar
e
k
ep
t secu
r
ed
.
5.
CO
NCLU
SI
O
N
DN
A
cr
y
p
to
g
r
ap
h
y
s
y
s
te
m
a
p
p
r
o
ac
h
is
a
n
e
w
ap
p
r
o
ac
h
,
w
h
ic
h
u
til
izes
th
e
d
eo
x
y
r
ib
o
n
u
cleic
ac
id
ar
r
an
g
e
m
en
t
p
r
o
p
er
ty
f
o
r
k
e
y
en
cr
y
p
tio
n
a
n
d
cr
y
p
to
g
r
ap
h
y
m
eth
o
d
.
T
h
e
u
n
u
s
u
al
p
r
o
p
er
ties
o
f
d
eo
x
y
r
ib
o
n
u
cle
ic
ac
id
s
u
cc
e
s
s
io
n
r
es
u
lt
in
u
s
a
g
e
o
f
d
eo
x
y
r
i
b
o
n
u
cleic
ac
id
s
u
cc
es
s
io
n
f
o
r
in
f
o
cr
y
p
to
g
r
ap
h
y
fo
r
m
s
.
T
h
e
k
e
y
cr
ea
ted
w
i
th
i
n
th
e
m
e
th
o
d
g
o
es
to
a
lev
el
cr
y
p
to
g
r
ap
h
y
m
et
h
o
d
an
d
co
n
j
o
in
tl
y
th
e
f
i
g
u
r
e
co
n
ten
t
cr
ea
ted
lik
e
w
i
s
e
g
o
es
2
lev
el
cr
y
p
to
g
r
ap
h
y
m
et
h
o
d
s
.
E
lab
o
r
atio
n
an
d
s
ec
u
r
it
y
i
s
ac
co
m
p
lis
h
ed
b
y
ir
r
eg
u
lar
er
a
o
f
t
h
e
k
e
y
t
h
at
i
s
u
s
ed
to
c
y
p
h
er
an
d
d
ec
ip
h
er
i
n
f
o
.
Deo
x
y
r
ib
o
n
u
cleic
ac
id
cr
y
p
to
s
y
s
te
m
i
s
s
a
f
er
an
d
s
o
lid
t
h
a
n
t
h
e
cu
s
to
m
ar
y
cr
y
p
to
g
r
ap
h
y
s
y
s
te
m
s
b
ec
au
s
e
th
e
p
r
o
ce
s
s
m
a
n
y
-
s
id
ed
q
u
a
lit
y
w
o
u
ld
p
o
s
s
ib
l
y
h
ig
h
f
o
r
d
eo
x
y
r
ib
o
n
u
cle
ic
ac
i
d
in
n
o
v
at
io
n
.
RE
F
E
R
E
NC
E
S
[1
]
H.J.
S
h
i
u
,
K.L
.
Ng
,
J.F
.
F
a
n
g
,
R.
C.
T
.
L
e
e
,
C.
H.
Hu
a
n
g
,
Da
ta h
id
i
n
g
m
e
th
o
d
s b
a
se
d
u
p
o
n
DN
A
se
q
u
e
n
c
e
s.
[2
]
S
.
M
a
n
n
a
S
.
Ro
y
P
.
Ro
y
S
.
K.
Ba
n
d
y
o
p
a
d
h
y
a
y
:
M
o
d
if
ied
tec
h
n
i
q
u
e
s o
f
in
se
rti
o
n
m
e
th
o
d
.
[3
]
C.
C.
Ch
a
n
g
,
T
.
C.
L
u
,
Y.F
.
Ch
a
n
g
a
n
d
C
.
T
.
L
e
e
,
Re
v
e
r
sib
le
d
a
ta
h
i
d
in
g
sc
h
e
m
e
s
f
o
r
d
e
o
x
y
rib
o
n
u
-
c
leic
a
c
id
(
DN
A
)
m
e
d
iu
m
,
In
ter
n
a
ti
o
n
a
l
J
o
u
rn
a
l
o
f
In
n
o
v
a
ti
v
e
Co
m
p
u
t
in
g
,
I
n
fo
rm
a
ti
o
n
a
n
d
Co
n
tro
l
,
v
o
l.
3
,
n
o
.
5
,
p
p
.
1
1
4
5
-
1
1
6
0
,
[4
]
I.
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