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I
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8806
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h
o
li
s
tic
m
ed
ical.
2.
RE
S
E
ARCH
M
E
T
H
O
D
2
.
1
.
G
ro
up
i
ng
t
he
s
ub
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t
Six
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m
ale
m
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o
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s
w
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s
s
s
tr
ain
,
±
2
0
g
r
am
s
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y
w
ei
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h
t,
2
m
o
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t
h
s
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ld
,
w
er
e
d
iv
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d
ed
in
to
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g
r
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p
s
to
tr
ea
t
w
it
h
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s
a
n
ctu
m
in
f
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d
if
f
er
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d
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d
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r
in
g
1
0
d
a
y
s
.
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h
e
ac
li
m
atitat
io
n
f
o
r
m
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w
a
s
a
w
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k
.
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o
u
p
s
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d
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w
er
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tr
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ted
as
f
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w
s
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5
0
m
g
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y
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5
0
0
m
g
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d
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Gr
o
u
p
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w
as
p
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s
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tr
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l,
tr
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llected
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h
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of
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d
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lth
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h
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hro
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P
PT
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n
iv
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j
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d
a.
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h
e
ca
lcu
latio
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o
f
th
r
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m
b
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c
y
te
n
u
m
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b
ased
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n
th
e
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h
ase
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co
n
tr
ast
m
et
h
o
d
s
.
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h
e
ca
lcu
latio
n
w
as r
ep
ea
ted
5
ti
m
e
s
.
2
.
3
.
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nfusi
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prepa
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on
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w
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n
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f
i
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m
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l
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ater
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f
ter
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s
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ater
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s
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lter
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h
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r
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p
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w
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NOV
A
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h
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v
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G
r
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(
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a
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1
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[
1
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,
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3
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an
d
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to
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ip
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m
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[
6
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.
Oscimu
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also
h
a
v
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f
lav
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id
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as
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Melo
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1
1
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I
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h
i
s
s
tu
d
y
s
h
o
w
ed
th
at
O
s
cimu
m
s
a
n
ctu
m
h
av
e
a
f
u
n
ctio
n
as a
n
al
ter
n
ativ
e
an
ti th
r
o
m
b
o
c
y
tes
m
ed
ic
in
e
[
1
0
]
.
4.
CO
NCLU
SI
O
N
Oscimu
m
s
a
n
ctu
m
h
av
e
a
t
h
r
o
m
b
o
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y
tes
an
ti
ag
e
g
g
r
atio
n
s
b
y
lo
w
er
i
n
g
t
h
e
th
r
o
m
b
o
c
y
te
s
n
u
m
b
er
.
T
h
e
d
o
s
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o
f
Osci
mu
m
s
a
n
ctu
m
m
o
r
e
t
h
a
n
5
0
0
m
g
/d
a
y
co
u
ld
h
av
e
t
h
e
s
i
m
i
lar
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f
ec
t
to
c
l
o
p
id
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g
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el
o
n
th
e
lo
w
er
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n
g
o
f
th
r
o
m
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tes
n
u
m
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.
O
s
cimu
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s
a
n
ctu
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co
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l
d
as
th
e
alter
n
at
iv
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m
ed
icin
e
as
th
e
t
h
r
o
m
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o
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y
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s
an
ti a
g
eg
g
r
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n
.
W
e
s
u
g
g
est
f
o
r
f
u
r
t
h
er
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esear
ch
: (
1
)
to
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p
lo
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an
5
0
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m
g
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d
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to
f
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th
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s
i
m
ilar
p
o
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tial
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y
w
i
th
s
tan
d
ar
d
d
o
s
e
o
n
cl
o
p
id
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g
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el,
(
2
)
to
ex
p
lo
r
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th
e
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th
er
liq
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id
th
a
n
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ater
to
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tr
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t
Oscimu
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s
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n
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m
to
p
r
o
d
u
ce
th
e
co
n
ce
n
tr
ated
ex
tr
ac
tio
n
,
(
3
)
t
h
e
m
ec
h
a
n
i
s
m
e
o
f
d
ec
r
ea
s
in
g
t
h
e
th
r
o
m
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t
n
u
m
b
er
s
till
n
ee
d
ex
p
lr
o
r
ed
.
ACK
NO
WL
E
D
G
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M
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NT
S
We
ar
e
th
an
k
s
to
A
n
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m
al
L
ab
o
r
ato
r
y
U
n
i
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s
itas
Mu
h
a
m
m
ad
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a
h
Yo
g
y
ak
ar
ta
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n
d
L
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PT
Un
i
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ita
s
Gad
j
ah
Ma
d
a
to
h
elp
o
u
r
r
ese
ar
ch
.
RE
F
E
R
E
NC
E
S
[1
]
De
w
i,
S
P
.
,
“
Os
c
im
u
m
sa
n
tu
m
”,
Tan
a
m
a
n
Ob
a
t
In
d
o
n
e
sia
,
2
0
0
7
.
t
o
i
u
sd
.
m
u
lt
ip
ly
.
c
o
m
.
[2
]
Kh
a
n
,
IN.
,
Ha
b
ib
,
R.
,
Ra
h
m
a
n
,
R.
,
M
a
n
n
a
n
,
A
.
,
S
a
rk
e
r,
M
I
,
Ha
w
lad
e
r
S
.
,
“
T
h
ro
m
b
o
li
ti
c
P
o
ten
ti
a
l
o
f
Os
c
i
m
u
n
sa
c
tu
m
L
,
Cu
rc
u
m
a
L
o
n
g
a
,
L
,
A
z
a
d
irac
h
tain
d
ica
L
,
a
n
d
A
n
a
c
a
rd
iu
m
o
c
c
id
e
n
tale
L”
,
J
o
u
rn
a
l
Of
Ba
sic
a
n
d
Cli
n
ica
l
Ph
a
rm
a
c
y
, v
ol
/i
ss
u
e
:
2
(
3
)
,
p
p
.
1
2
5
-
1
2
7
,
2
0
1
1
.
[3
]
P
ra
k
a
sh
,
H.
,
G
u
p
ta,
N.,
“
T
h
e
ra
p
e
u
ti
c
Us
e
s
o
f
Os
c
i
m
u
m
sa
n
c
tu
m
L
in
n
(T
u
lsi)
w
it
h
a
No
te
o
n
Eu
g
e
n
o
l
a
n
d
Its
P
h
a
rm
a
lco
lo
g
ica
l
A
c
ti
o
n
s”
,
In
d
i
a
n
J
o
u
r
n
a
l
Ph
y
si
o
lo
g
y
Ph
a
rm
a
c
o
l
o
g
y
,
v
ol
/i
ss
u
e
:
49
(
2
),
pp
.
1
2
5
-
31
,
2
0
0
5
.
[4
]
S
in
g
h
,
S
.
,
Re
h
a
n
,
HMS
.
,
M
a
ju
m
d
a
r,
DK
.
,
“
Eff
e
c
t
o
f
O
sc
i
m
u
m
s
a
n
c
tu
m
f
ix
e
d
o
il
o
n
b
lo
o
d
p
re
ss
u
r
e
,
b
lo
o
d
c
lo
tt
i
n
g
ti
m
e
a
n
d
p
e
n
to
b
a
rb
it
o
n
e
-
in
d
u
c
e
d
sle
e
p
in
g
ti
m
e
”
,
J
o
u
rn
a
l
o
f
Et
h
n
o
p
h
a
rm
a
c
o
l
o
g
y
,
v
o
l/
issu
e
:
7
8
(
2
-
3)
,
pp
.
1
3
9
-
14
3
,
2
0
0
1
.
[5
]
T
o
h
ti
,
I.
,
T
u
rsu
n
,
M
.
,
Um
a
r,
A
.
,
T
u
rd
i,
S
.
,
Im
in
,
H.
,
M
o
o
re
,
N.,
“
A
q
u
e
o
u
s
e
x
trac
ts
o
f
Oc
i
m
u
m
b
a
si
li
c
u
m
L
.
(s
we
e
t
b
a
sil)
d
e
c
re
a
se
p
late
let
a
g
g
re
g
a
ti
o
n
in
d
u
c
e
d
b
y
AD
P
a
n
d
t
h
ro
m
b
in
i
n
v
it
ro
a
n
d
ra
ts
a
rteri
o
–
v
e
n
o
u
s sh
u
n
t
th
r
o
m
b
o
sis
in
v
iv
o
”
,
T
h
ro
mb
o
sis Res
e
a
rc
h
,
v
o
l/
issu
e
:
1
1
8
(6
)
,
p
p
.
7
3
3
-
7
3
9
,
2
0
0
6
.
[6
]
M
a
ry
,
N
K.
,
Ba
b
u
,
B
H.
,
P
a
d
ik
k
a
la,
J.,
“
A
n
ti
a
th
e
ro
g
e
n
ic
e
ff
e
c
t
o
f
Ca
p
s
H
T
2
,
a
h
e
rb
a
l
Ay
u
r
v
e
d
ic
m
e
d
icin
e
f
o
r
m
u
latio
n
”
,
P
h
y
to
me
d
ici
n
e
,
v
o
l
/i
ss
u
e
:
1
0
(6
-
7)
,
p
p
.
4
7
4
-
4
8
2
,
2
0
0
3
.
[7
]
S
a
m
a
,
S
N
.,
“
A
M
in
e
o
f
M
e
d
ica
l
Us
e
s
:
Oc
i
m
u
m
S
a
n
c
tu
m
,
T
h
e
Ho
ly
Ba
sil”
,
I
n
ter
n
a
sio
n
a
l
J
o
u
rn
a
l
Rev
iew
a
n
d
Res
e
a
rc
h
, v
ol
/i
ss
u
e
:
2
(
2
)
,
p
p
.
6
9
-
74
,
2
0
1
2
.
[8
]
El
-
S
a
d
e
k
M
EH.
,
M
o
u
sta
f
a
S
M.
,
Ka
d
i
HO
.
,
Al
-
Ha
k
a
m
i
A
M
A
.
,
“
De
ter
m
in
a
ti
o
n
o
f
Clo
p
id
o
g
re
l
Ca
rb
o
x
y
li
c
A
c
id
in
Hu
m
a
n
P
las
m
a
b
y
L
C
-
M
S
/M
S
”,
Ame
ric
a
n
J
o
u
r
n
a
l
o
f
An
a
lytica
l
C
h
e
mistry
,
v
o
l.
2,
p
p
.
4
4
7
-
4
5
5
,
2
0
1
1
.
[9
]
Ka
tzu
n
g
,
B
G
.,
“
Ba
sic
a
n
d
Cli
n
ic
a
l
P
h
a
rm
a
c
o
lo
g
y
(8
th
e
d
)
”
,
(
D.
S
jab
a
n
a
,
E.
Isb
a
n
d
iati,
A
.
Ba
so
ri
,
M
.
S
o
e
d
jak
,
I.
Un
o
,
Ra
m
a
d
h
a
n
i,
S
.
Zak
a
ria,
p
e
n
e
rje
m
a
h
)
,
Ja
k
a
rta
,
S
a
le
m
b
a
M
e
d
ik
a
,
2
0
0
2
.
[1
0
]
Ch
e
n
,
S
J.
,
W
a
n
g
,
M
H.
,
Ch
e
n
,
IJ.
,
“
A
n
ti
p
late
let
a
n
d
c
a
lciu
m
in
h
ib
it
o
ry
p
ro
p
e
rti
e
s
o
f
e
u
g
e
n
o
l
a
n
d
so
d
i
u
m
e
u
g
e
n
o
l
a
c
e
tate
”
,
Ge
n
Ph
a
rm
a
c
o
l
o
g
y
,
v
ol
/i
ss
u
e
:
27
(
4
)
,
p
p
.
6
2
9
-
33
,
1
9
9
6
.
[1
1
]
Im
a
n
R
A
.
,
“
T
h
e
e
ff
e
c
t
o
f
M
e
lo
th
ria
ma
d
e
ra
sp
a
ta
n
a
i
n
h
ib
it
in
p
late
let
a
g
g
re
g
a
ti
o
n
”
,
In
d
i
a
n
J
o
u
rn
a
l
o
f
Ph
a
rm
a
c
e
u
t
ica
l
S
c
ien
c
e
s
,
v
ol
/i
ss
u
e
:
68
(
5
)
,
p
p
.
6
6
8
-
6
7
0
,
2
0
0
6
.
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