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H
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Vo
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3
,
Sep
tem
b
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201
6
,
p
p
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3
2
5
~
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8
I
SS
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2252
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w
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3
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4
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[
1
]
.
P
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w
it
h
tu
b
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cu
lo
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is
h
av
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d
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2
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[
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RE
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ARCH
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8806
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Sep
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1
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at
t
h
e
t
h
ir
d
w
ee
k
.
Data
a
n
al
y
s
is
w
a
s
p
er
f
o
r
m
ed
u
s
in
g
p
air
ed
t
tes
t
i
f
th
e
d
ata
n
o
r
m
all
y
d
is
tr
ib
u
ted
,
b
u
t
i
f
it
is
n
o
t
th
e
n
it
wi
l
l b
e
test
ed
w
ith
W
ilco
x
o
n
t
est [
6
]
.
3.
RE
SU
L
T
S
A
ND
AN
AL
Y
SI
S
C
h
ar
ac
ter
is
tics
o
f
r
esp
o
n
d
en
t
s
p
r
esen
ted
in
T
ab
le
1
.
T
h
e
ch
ar
ac
ter
is
tics
i
n
clu
d
ed
g
e
n
d
er
,
ag
e,
ed
u
ca
tio
n
,
a
n
d
o
cc
u
p
atio
n
.
I
n
T
ab
le
1
it
is
k
n
o
w
n
th
a
t
m
o
s
t
m
ale
r
e
s
p
o
n
d
en
ts
1
8
(
5
8
.
1
%);
t
h
e
lar
g
est
a
g
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g
r
o
u
p
is
th
e
2
6
-
4
5
y
ea
r
s
o
ld
,
1
5
(
4
8
.
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%)
;
m
o
s
t
ed
u
ca
tio
n
o
f
r
esp
o
n
d
en
t
s
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s
Hi
g
h
Sc
h
o
o
l
1
7
(
5
4
.
8
%
)
;
an
d
m
o
s
t r
esp
o
n
d
en
ts
w
er
e
p
r
iv
ate
e
m
p
lo
y
ee
s
t
h
at
w
as
9
(
2
9
%).
Ta
b
le
1
.
C
h
ar
ac
ter
is
tics
o
f
R
e
s
p
o
n
d
en
ts
C
h
a
r
a
c
t
e
r
i
st
i
c
s o
f
r
e
sp
o
n
d
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n
t
s
F
r
e
q
u
e
n
c
y
P
e
r
c
e
n
t
G
e
n
d
e
r
a.
M
a
l
e
18
5
8
.
1
b.
F
a
mal
e
13
4
1
.
9
A
g
e
a.
15
-
2
5
y
e
a
r
s o
l
d
8
2
5
.
8
b.
26
-
4
5
y
e
a
r
s o
l
d
15
4
8
.
4
c.
47
-
6
0
y
e
a
r
s o
l
d
8
2
5
.
8
Ed
u
c
a
t
i
o
n
a.
El
e
me
n
t
a
r
y
S
c
h
o
o
l
5
1
6
.
1
b.
Ju
n
i
o
r
H
i
g
h
S
c
h
o
o
l
9
2
9
.
0
c.
H
i
g
h
sc
h
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l
17
5
4
.
8
O
c
c
u
p
a
t
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n
a.
P
r
i
v
a
t
e
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mp
l
o
y
e
e
s
9
2
9
.
0
b.
En
t
r
e
p
r
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n
e
u
r
5
1
6
.
1
c.
L
a
b
o
r
4
1
2
.
9
d.
H
o
u
sew
i
f
e
3
9
.
7
e.
S
t
u
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t
4
1
2
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f.
Et
c
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2
6
.
5
g.
D
o
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s n
o
t
w
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k
4
1
2
.
9
So
u
r
ce
s
: P
r
i
m
ar
y
d
ata,
in
2
0
1
6
.
3
.
1
.
No
r
m
a
lity
da
t
a
t
est
I
n
T
ab
le
2
,
th
e
r
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lt
o
f
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h
ap
ir
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W
ilk
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alit
y
test
s
h
o
w
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ican
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.
T
h
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s
,
it
ca
n
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th
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an
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p
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t
test
d
ata
w
as
n
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is
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s
o
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at
t
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is
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f
th
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T
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Data
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
P
HS
I
SS
N:
2252
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8806
Dee
p
B
r
ea
th
in
g
R
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x
a
tio
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Te
ch
n
iq
u
es I
mp
r
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ve
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m
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tio
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l
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mia
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s
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mu
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327
3
.
2
.
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m
o
t
io
n c
o
ntr
o
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T
ab
le
3
p
r
esen
ts
th
e
r
esu
l
t
o
f
b
iv
ar
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test
.
I
n
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ab
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3
i
t
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k
n
o
w
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t
h
at
t
h
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s
ig
n
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ly
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if
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ce
s
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ea
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)
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d
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ter
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ela
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et
w
ee
n
5
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5
to
1
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2
8
.
T
ab
le
3
.
C
o
m
p
ar
is
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o
f
Mea
n
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d
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d
ar
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Dev
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B
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r
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d
Af
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Dee
p
B
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R
elax
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Emo
t
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c
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4.
DIS
CU
SS
I
O
N
I
n
th
is
s
t
u
d
y
r
esear
c
h
er
s
w
a
n
t
ed
to
ex
a
m
in
e
th
e
ef
f
ec
t
o
f
r
e
lax
atio
n
tech
n
iq
u
es
to
co
n
tr
o
l
e
m
o
tio
n
s
o
f
p
atien
t
s
w
it
h
tu
b
er
cu
lo
s
is
.
T
h
e
r
esu
lts
i
n
T
ab
le
2
c
o
n
f
ir
m
ed
th
at
t
h
e
v
alu
e
o
f
m
ea
n
a
n
d
s
tan
d
ar
d
d
ev
iatio
n
w
a
s
3
0
.
0
3
(
±
5
.
7
2
)
b
ef
o
r
e
th
e
tr
ea
t
m
e
n
t
of
d
ee
p
b
r
ea
th
i
n
g
r
elax
atio
n
tec
h
n
iq
u
es
,
a
n
d
a
f
te
r
th
e
tr
ea
t
m
e
n
t
t
h
e
m
ea
n
a
n
d
s
ta
n
d
ar
d
d
ev
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n
w
a
s
3
8
.
0
0
(
±
6
.
0
5
)
w
it
h
p
v
al
u
e
=
0
.
0
0
1
.
T
h
e
r
esu
lts
o
f
t
h
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s
s
tu
d
y
in
d
icate
d
t
h
at
d
ee
p
b
r
ea
th
in
g
r
el
a
x
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n
t
ec
h
n
iq
u
es
s
i
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n
i
f
ica
n
tl
y
e
f
f
ec
t
ed
o
n
co
n
tr
o
l
lin
g
e
m
o
tio
n
s
o
f
p
atien
t
s
w
it
h
tu
b
er
cu
lo
s
i
s
.
T
h
is
r
esu
lts
is
s
u
p
p
o
r
ted
b
y
th
e
r
esear
ch
r
es
u
lts
co
n
d
u
cted
b
y
Yil
m
az
,
GS
et
al
(
2
0
1
5
)
in
p
atien
t
s
w
it
h
b
r
ea
s
t
ca
n
ce
r
w
h
ich
m
e
n
tio
n
ed
th
at
b
e
f
o
r
e
th
e
i
n
ter
v
en
tio
n
g
r
o
u
p
h
a
v
in
g
r
ela
x
atio
n
e
x
er
cises
,
th
e
m
ea
n
an
d
s
tan
d
ar
d
d
ev
iatio
n
w
a
s
4
2
.
2
6
(
±
7
.
4
9
)
an
d
af
ter
th
e
ex
er
cises
w
as
3
6
.
2
0
(
±
7
.
4
9
)
,
w
i
th
p
-
v
al
u
e
=
0
0
1
[
7
].
T
h
e
r
esu
lts
ar
e
also
s
i
m
i
lar
to
th
e
s
tu
d
y
co
n
d
u
cted
b
y
M.
J
.
Nav
ee
n
[
5
]
to
w
ar
d
s
p
atien
t
s
w
ith
C
h
r
o
n
ic
Ob
s
tr
u
cti
v
e
P
u
l
m
o
n
ar
y
Di
s
ea
s
e
(
C
OP
D)
.
I
t
w
a
s
s
tated
th
at
th
e
p
r
e
t
est
r
esu
lt
s
ag
ai
n
s
t
in
te
r
v
en
tio
n
g
r
o
u
p
w
as
1
4
(
7
0
%)
f
r
o
m
th
e
p
atien
ts
wh
o
h
ad
s
ev
er
e
an
x
iet
y
a
n
d
6
(
3
0
%)
f
r
o
m
p
atien
t
s
w
h
o
h
a
d
m
o
d
er
ate
an
x
iet
y
.
I
n
p
o
s
ttes
t
,
a
f
ter
w
ar
d
,
th
er
e
w
er
e
o
n
l
y
f
o
u
n
d
2
(
1
0
%)
p
atie
n
t
s
w
it
h
m
ild
a
n
x
iet
y
an
d
1
8
(
9
0
%)
p
atien
ts
w
i
th
m
o
d
er
ate
a
n
x
ie
t
y
[
5
]
.
T
h
e
o
th
er
s
i
m
ilar
s
tu
d
y
was
p
er
f
o
r
m
ed
b
y
L
i
n
MF
et
al
(
2
0
1
0
)
to
w
ar
d
s
th
e
u
n
d
er
g
o
i
n
g
ch
e
m
o
t
h
er
ap
y
p
atie
n
ts
w
it
h
c
an
ce
r
.
T
h
e
s
tu
d
y
f
o
u
n
d
th
at
b
ef
o
r
e
v
er
b
al
r
elax
atio
n
to
t
h
e
in
ter
v
e
n
tio
n
g
r
o
u
p
,
th
e
a
n
x
ie
t
y
lev
el
r
ea
ch
ed
t
h
e
m
ea
n
an
d
s
tan
d
ar
d
d
ev
iatio
n
o
f
4
1
.
0
7
(
1
3
.
7
1
)
an
d
af
ter
v
e
r
b
al
r
elax
atio
n
t
h
e
an
x
ie
t
y
lev
e
l
o
b
tain
ed
t
h
e
m
e
an
a
n
d
s
ta
n
d
ar
d
d
ev
iatio
n
o
f
3
1
.
6
3
(
1
0
.
9
6
)
,
w
it
h
p
v
al
u
e
0
,
0
0
1
[
8
]
.
T
h
is
s
tu
d
y
w
a
s
also
r
elate
d
to
th
e
s
tu
d
y
o
f
Sep
asi,
N
et
al
[
9
]
.
to
b
r
ea
s
t
ca
n
ce
r
p
atie
n
ts
.
I
t
w
a
s
s
tat
ed
th
at
th
e
v
alu
e
o
f
m
ea
n
an
d
s
tan
d
ar
d
d
ev
iatio
n
t
o
w
ar
d
s
i
n
ter
v
e
n
tio
n
g
r
o
u
p
o
f
r
elax
atio
n
e
x
er
cise
s
o
f
th
e
ir
e
m
o
tio
n
al
w
ell
-
b
ein
g
p
r
e
-
test
w
as 9
.
9
0
(
3
.
6
8
)
an
d
in
th
e
p
o
s
t te
s
t it
o
b
tain
ed
1
9
.
4
0
(
2
:4
1
)
w
it
h
P
v
alu
e
<0
.
0
0
1
[
9
]
.
E
m
o
tio
n
is
a
s
it
u
atio
n
t
h
at
is
v
o
latile
in
t
h
e
i
n
d
iv
id
u
al
t
h
at
s
e
r
v
es
a
s
a
n
i
n
n
er
ad
j
u
s
t
m
e
n
t
(
ad
j
u
s
t
m
e
n
t
f
r
o
m
in
s
id
e)
to
th
e
en
v
ir
o
n
m
e
n
t
to
ac
h
iev
e
w
e
ll
-
b
ein
g
an
d
s
af
et
y
o
f
p
atie
n
ts
[
1
0
]
.
T
h
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p
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ch
o
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atien
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e
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esear
c
h
co
n
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u
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b
y
Ma
r
ti
n
.
L
.
R
et
al
[
1
1
]
in
d
icate
d
t
h
at
o
n
e
o
f
t
h
e
s
tr
o
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g
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t
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o
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-
ad
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t
p
atie
n
t
s
on
t
ak
in
g
tu
b
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cu
lo
s
is
m
ed
icatio
n
is
d
ep
r
ess
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r
ess
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p
atien
t
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h
a
v
e
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o
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-
co
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p
lian
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is
k
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A
cc
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d
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g
to
Ma
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tin
et
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[
1
1
]
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p
atien
ts
w
it
h
tu
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er
cu
lo
s
is
w
i
ll
ex
p
er
ien
ce
co
g
n
i
ti
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m
p
a
ir
m
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t,
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ess
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m
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tic
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d
w
it
h
d
r
a
w
f
r
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m
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v
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t t
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at
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au
s
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cin
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ab
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t
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to
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o
llo
w
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t
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t r
eg
i
m
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n
s
.
E
m
o
tio
n
al
co
n
tr
o
l
i
s
t
h
e
ten
d
en
c
y
to
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ca
l
m
t
h
e
e
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n
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o
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n
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c
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as
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n
o
r
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lex
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t
r
at
eg
ies
f
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r
co
p
in
g
w
it
h
s
tr
e
s
s
[
3
]
.
T
h
e
h
ig
h
ca
p
ab
ilit
y
o
f
co
n
tr
o
llin
g
e
m
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tio
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s
w
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n
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i
n
f
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m
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s
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th
e
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n
k
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in
g
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ter
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a
l
r
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io
n
s
[
1
2
]
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T
h
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ab
ilit
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to
co
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tr
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tio
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s
r
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f
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u
lu
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in
to
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p
o
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tiv
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s
ti
m
u
l
u
s
[
1
3
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I
t
ca
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e
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e
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g
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th
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le
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n
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Ma
h
m
u
d
in
So
b
u
r
[
1
0
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m
en
t
io
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ed
s
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r
u
les
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co
n
tr
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llin
g
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m
o
tio
n
s
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t
h
e
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ar
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:
Dea
l
w
it
h
th
e
e
m
o
ti
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n
s
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f
p
eo
p
le,
r
e
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in
ter
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r
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it
u
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ev
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p
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s
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o
f
h
u
m
o
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an
d
a
r
ea
lis
tic
attit
u
d
e.
Mean
w
h
ile
,
ac
co
r
d
in
g
to
B
ast
in
Har
d
iy
a
n
i
,
t
h
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w
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y
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co
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tr
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l
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g
r
y
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m
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in
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p
leasa
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t
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r
estru
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r
in
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d
b
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m
m
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tio
n
.
5.
CO
NCLU
SI
O
N
T
u
b
er
cu
lo
s
is
p
atien
ts
h
a
v
e
a
t
en
d
en
c
y
to
e
x
p
er
ien
ce
e
m
o
tio
n
al
d
is
tu
r
b
an
ce
d
u
e
to
t
h
e
ill
n
ess
.
Deep
b
r
ea
th
in
g
r
elax
atio
n
tech
n
iq
u
es
co
n
d
u
cted
o
v
er
th
r
ee
w
ee
k
s
is
ef
f
ec
t
iv
e
to
co
n
tr
o
l
e
m
o
ti
o
n
s
o
f
p
atie
n
ts
w
it
h
tu
b
er
cu
lo
s
i
s
.
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