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vi
c
a
l
a
n
d
b
r
e
a
s
t
c
a
n
c
e
r
s
we
r
e
s
i
g
nif
i
c
a
n
t
l
y
d
if
f
e
r
e
n
t
(
p=
.
000)
[
6]
.
C
a
n
c
e
r
d
i
a
g
n
o
s
i
s
a
n
d
i
t
s
t
r
e
a
t
m
e
n
t
s
i
n
duc
e
s
t
r
e
s
s
i
n
c
a
n
c
e
r
s
ur
vi
v
o
r
s
w
i
t
h
im
pa
c
t
s
o
n
a
nxi
e
t
y
a
n
d
de
pr
e
s
s
i
o
n;
w
hi
l
e
d
i
a
g
n
o
s
t
i
c
t
e
s
t
,
t
h
e
po
s
s
i
bil
i
t
y
o
f
a
dd
i
t
i
o
na
l
c
a
nc
e
r
,
c
a
n
c
e
r
r
e
c
ur
r
e
n
c
e
a
n
d
m
e
t
a
s
t
a
s
i
s
i
n
duc
e
f
e
a
r
i
n
c
a
n
c
e
r
s
ur
vi
v
o
r
s
im
pa
c
t
i
n
g
pe
r
c
e
i
ve
d
li
f
e
n
o
r
m
a
l
i
t
y
(
P
L
N)
[
7]
.
T
h
e
r
e
i
s
a
s
pe
c
if
i
c
ne
ur
o
c
i
r
c
u
i
t
r
y
i
n
o
ur
b
r
a
i
n
w
hi
c
h
li
nk
i
n
g
s
t
r
e
s
s
to
f
e
a
r
a
n
d
a
nxi
e
t
y
i
nv
o
l
vi
ng
a
my
gda
l
e
a
n
d
i
ns
u
l
a
r
c
o
r
t
e
x
a
c
t
i
v
a
t
i
o
n
[
8]
.
T
h
e
r
e
a
r
e
t
h
r
e
e
pa
r
t
s
o
f
b
r
a
in
whi
c
h
u
n
de
r
go
s
tr
e
s
s
-
i
n
duc
e
d
s
t
r
uc
t
ur
a
l
r
e
m
o
de
l
in
g
a
n
d
c
a
us
e
t
h
e
c
h
a
n
ge
s
i
n
b
e
h
a
vi
o
r
a
l
a
n
d
phy
s
i
o
l
o
g
i
c
a
l
r
e
s
po
n
s
e
s
:
t
h
e
hi
ppo
c
a
m
pu
s
,
a
m
y
gda
l
a
,
a
n
d
pr
e
f
r
o
n
t
a
l
c
o
r
t
e
x
[
9]
.
S
t
r
e
s
s
e
v
e
n
c
o
u
l
d
l
im
i
t
t
h
e
e
f
f
i
c
a
c
y
o
f
b
e
ha
vi
o
r
a
l
t
h
e
r
a
p
i
e
s
a
im
e
d
a
t
l
im
i
t
i
ng
pa
t
h
o
l
o
g
i
c
a
l
f
e
a
r
[
10]
.
T
h
e
e
x
pe
r
t
o
f
s
t
r
e
s
s
r
e
s
e
a
r
c
h
,
Ha
n
s
S
e
ly
e
,
de
f
i
n
e
d
s
t
r
e
s
s
a
s
a
n
o
ns
pe
c
i
f
i
c
b
o
d
y
r
e
s
po
n
s
e
t
o
a
n
y
de
m
a
n
d
[
11]
.
E
v
e
r
y
s
t
r
e
s
s
m
a
y
l
e
a
v
e
a
n
i
ne
r
a
d
i
c
a
bl
e
s
c
a
r
,
a
n
d
i
nd
i
vi
du
a
l
s
ur
vi
ve
s
f
r
o
m
s
t
r
e
s
s
by
b
e
i
n
g
o
l
de
r
.
H
i
s
s
t
r
e
s
s
m
o
de
l
,
t
h
e
Ge
ne
r
a
l
A
da
pt
a
t
i
o
n
S
y
ndr
o
m
e
(
G
A
S
)
,
s
t
a
t
e
d
t
h
a
t
t
h
e
r
e
we
r
e
t
h
r
e
e
s
t
a
ge
s
o
f
b
o
d
y
r
e
s
po
n
s
e
to
wa
r
ds
s
tr
e
s
s
:
a
l
a
r
m
,
r
e
s
i
s
t
a
n
c
e
,
a
n
d
e
xha
us
t
i
o
n
[
12]
.
A
da
pt
a
t
i
o
n
a
n
d
s
t
r
e
s
s
a
r
e
t
wo
i
m
po
r
t
a
n
t
c
o
n
c
e
pts
to
b
e
u
n
de
r
s
t
oo
d
i
n
o
r
de
r
to
un
de
r
s
t
a
n
d
b
e
t
t
e
r
a
b
o
ut
i
n
d
i
v
i
dua
l
b
e
h
a
vi
o
r
,
e
s
pe
c
i
a
l
ly
f
o
r
u
n
de
r
s
t
a
n
d
i
ng
t
h
e
p
h
a
s
e
s
o
f
il
l
ne
s
s
[
13]
.
A
da
pt
a
t
i
o
n
c
o
ul
d
b
e
s
e
e
n
a
s
a
pr
o
duc
t
a
n
d
a
pr
o
c
e
s
s
;
a
s
a
pr
o
duc
t,
a
da
ptat
i
o
n
c
a
nn
o
t
r
e
m
a
i
n
e
n
t
i
r
e
ly
f
a
i
t
hf
u
l
t
o
i
t
s
o
r
i
g
in
a
l
f
o
r
m
,
whil
e
a
s
a
pr
o
c
e
s
s
,
a
da
pt
a
t
i
o
n
b
e
c
o
m
e
s
a
n
a
c
t
o
f
a
ppr
o
pr
i
a
t
i
n
g
a
n
d
s
a
l
va
g
i
ng
w
hil
e
t
r
y
i
ng
t
o
g
i
v
e
ne
w
m
e
a
ni
ng
[
14]
.
A
we
ll
-
k
n
o
wn
a
da
pt
a
t
i
o
n
t
h
e
o
r
y
i
n
t
h
e
n
ur
s
i
ng
wo
r
l
d
i
s
t
h
e
a
da
pt
a
t
i
o
n
m
o
de
l
o
f
n
ur
s
in
g
w
hi
c
h
wa
s
de
v
e
l
o
pe
d
by
S
i
s
t
e
r
C
a
ll
i
s
t
a
R
o
y
i
n
1976.
S
he
a
s
s
u
m
e
d
t
h
a
t
a
pe
r
s
o
n
i
s
a
bi
o
-
ps
y
c
h
o
-
s
o
c
i
a
l
b
e
i
ng
w
h
o
i
s
i
n
c
o
ns
t
a
n
t
i
n
t
e
r
a
c
t
i
o
n
w
i
t
h
a
c
h
a
n
g
i
ng
e
nvi
r
o
nm
e
n
t
c
o
n
s
i
de
r
e
d
a
s
a
n
a
da
pt
i
v
e
s
y
s
t
e
m
.
A
pe
r
s
o
n
o
r
g
r
o
ups
wh
o
d
i
d
a
da
pt
a
t
i
o
n
m
e
a
ns
t
h
e
y
us
e
c
o
n
s
c
i
o
u
s
a
wa
r
e
n
e
s
s
,
s
e
lf
-
r
e
f
l
e
c
t
i
o
n
a
n
d
c
h
o
i
c
e
t
o
c
r
e
a
t
e
h
um
a
n
a
n
d
e
nvi
r
o
nm
e
n
t
a
l
i
n
t
e
gr
a
t
i
o
n
[
15]
.
T
h
e
l
o
n
ge
r
pe
o
pl
e
l
i
ve
w
i
t
h
c
a
n
c
e
r
,
t
h
e
m
o
r
e
e
x
po
s
ur
e
to
wa
r
ds
v
a
r
i
o
us
t
y
pe
s
o
f
s
t
r
e
s
s
o
r
t
h
e
y
e
n
c
o
un
t
e
r
phy
s
i
c
a
ll
y
a
n
d
ps
y
c
h
o
l
o
g
i
c
a
ll
y
.
T
h
e
l
o
n
ge
r
t
h
e
e
x
po
s
ur
e
to
wa
r
ds
s
t
r
e
s
s
w
i
ll
b
e
t
h
e
s
h
o
r
t
e
r
t
h
e
i
n
d
i
v
i
dua
l
li
f
e
s
p
a
n
[
16]
.
I
n
un
he
a
l
t
hy
i
nd
i
v
i
d
ua
l
s
,
wo
m
e
n
li
vi
ng
w
i
t
h
c
a
n
c
e
r
f
o
r
i
ns
t
a
n
c
e
,
t
h
e
l
o
n
gt
i
m
e
e
x
po
s
ur
e
t
o
wa
r
ds
s
tr
e
s
s
m
a
y
wo
r
s
e
n
t
h
e
i
r
h
e
a
l
t
h
s
t
a
t
us
.
C
o
r
r
e
l
a
t
i
o
n
b
e
t
we
e
n
ps
y
c
h
o
s
o
c
i
a
l
s
t
r
e
s
s
o
r
s
a
n
d
d
i
s
e
a
s
e
i
s
i
n
f
l
ue
n
c
e
d
by
t
he
s
t
r
e
s
s
o
r
s
(
i
t
s
n
a
t
ur
e
,
n
u
m
be
r
,
a
n
d
pe
r
s
i
s
t
e
n
c
e
)
a
n
d
t
h
e
i
n
d
i
v
i
dua
l
’
s
bi
o
l
o
g
i
c
a
l
v
u
l
ne
r
a
bil
i
t
y
(
e
.
g.
ge
n
e
t
i
c
s
,
c
o
n
s
t
i
t
ut
i
o
n
a
l
f
a
c
t
or
s
)
,
ps
y
c
h
o
s
o
c
i
a
l
r
e
s
o
ur
c
e
s
,
a
n
d
c
o
p
i
n
g
s
t
r
a
t
e
g
y
[
17]
.
Ge
n
de
r
a
l
s
o
h
a
s
s
i
g
ni
f
i
c
a
n
t
e
f
f
e
c
t
to
wa
r
ds
s
tr
e
s
s
a
n
d
i
t
s
m
a
n
a
ge
m
e
n
t
.
W
o
m
e
n
a
r
e
f
r
e
que
n
t
l
y
r
e
po
r
t
t
h
e
e
l
e
v
a
t
e
d
s
t
r
e
s
s
l
e
v
e
l
c
o
m
pa
r
e
d
t
o
m
e
n
w
i
t
h
mo
r
e
phy
s
i
c
a
l
a
n
d
e
m
o
t
i
o
n
a
l
s
ym
pto
m
s
a
pp
e
a
r
,
b
ut
t
h
e
y
a
r
e
do
i
n
g
a
b
e
t
t
e
r
j
o
b
t
h
a
n
m
e
n
by
c
o
nn
e
c
t
i
n
g
w
i
t
h
oth
e
r
s
b
e
t
t
e
r
;
t
hi
s
c
o
nn
e
c
t
i
o
n
i
s
i
m
po
r
t
a
n
t
f
o
r
m
a
k
i
ng
s
t
r
e
s
s
m
a
n
a
ge
m
e
n
t
s
t
r
a
t
e
gi
e
s
[
18]
.
T
h
e
r
e
i
s
a
bi
g
que
s
t
i
o
n
a
b
o
u
t
h
o
w
l
o
n
g
a
da
pt
a
t
i
on
pr
o
c
e
s
s
h
a
pp
e
n
,
i
s
t
h
e
r
e
a
ny
m
a
xim
u
m
li
mi
t
f
o
r
t
h
a
t,
i
n
a
ny
c
o
n
t
e
x
t
o
f
li
f
e
.
T
h
e
p
e
r
i
o
d
o
f
e
x
po
s
ur
e
to
wa
r
ds
s
t
r
e
s
s
o
r
s
c
o
ul
d
de
t
e
r
m
i
ne
i
nd
i
vi
du
a
l
s
t
r
e
s
s
to
l
e
r
a
n
c
e
due
t
o
a
da
p
t
a
t
i
o
n
pr
o
c
e
s
s
.
I
n
c
r
e
a
s
e
s
ur
viv
o
r
s
hi
p
o
r
l
o
n
ge
r
l
if
e
e
x
pe
c
t
a
n
c
y
i
n
c
a
n
c
e
r
s
ur
vi
v
o
r
s
h
a
v
e
im
p
li
c
a
t
i
o
n
o
n
l
o
n
ge
r
s
t
r
e
s
s
o
r
e
x
po
s
ur
e
s
by
im
pa
c
t
o
f
pr
o
l
o
n
g
e
d
ps
y
c
h
o
l
o
g
i
c
a
l
p
a
i
n
/
s
u
f
f
e
r
i
ng
due
to
s
tr
e
s
s
a
n
d
f
e
a
r
,
e
s
pe
c
i
a
l
ly
i
n
l
o
n
g
-
t
e
r
m
c
a
n
c
e
r
s
ur
vi
v
o
r
s
.
Al
t
h
o
ugh
s
t
r
e
s
s
o
r
e
x
po
s
ur
e
s
m
a
y
h
a
ppe
n
y
e
a
r
ly
i
n
C
C
S
a
n
d
B
C
S
,
whe
t
h
e
r
t
h
e
i
r
s
t
r
e
s
s
/
f
e
a
r
to
l
e
r
a
n
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e
s
s
i
g
nif
i
c
a
n
t
l
y
im
pr
o
v
e
o
v
e
r
t
i
m
e
a
l
o
n
g
w
i
t
h
t
h
e
s
ur
vi
v
o
r
s
hi
p
s
t
a
ge
s
or
n
ot,
i
t
i
s
s
t
i
l
l
a
bi
g
que
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t
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o
n
m
a
r
k.
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a
s
e
d
o
n
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h
e
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e
1
e
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l
a
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t
h
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m
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gr
a
phy
c
h
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r
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t
a
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h
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m
a
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o
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t
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w
as
l
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n
g
t
e
r
m
s
ur
vi
v
o
r
s
;
t
h
e
r
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f
o
r
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t
h
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s
ur
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l
r
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f
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a
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t
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d
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l
c
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r
t
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c
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l
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y
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o
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g
.
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ur
ge
y
w
a
s
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op
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h
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i
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o
f
t
h
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r
a
p
y
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o
r
B
C
S
,
whil
e
C
C
S
wa
s
m
o
s
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l
y
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r
we
n
t
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ge
r
y
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n
d
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h
e
m
o
-
r
a
d
i
o
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r
a
p
y
.
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o
t
h
c
a
n
c
e
r
a
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d
i
t
s
t
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a
t
m
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n
t
s
we
r
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b
e
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ng
l
o
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g
t
e
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m
s
t
r
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s
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o
r
s
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o
r
m
o
s
t
r
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s
po
n
de
n
t
s
.
T
a
bl
e
2
e
x
p
l
a
i
ns
t
h
e
pr
i
m
a
r
y
d
a
t
a
o
f
s
t
ud
y
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s
po
n
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n
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s
i
n
de
t
a
i
l
s
.
Ge
n
e
r
a
ll
y
,
c
e
r
vi
c
a
l
c
a
n
c
e
r
r
e
s
u
l
t
e
d
i
n
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r
s
t
s
t
r
e
s
s
a
n
d
f
e
a
r
c
o
m
pa
r
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d
t
o
b
r
e
a
s
t
c
a
nc
e
r
,
b
ut
l
uc
k
il
y
hi
g
h
P
L
N
wa
s
f
o
un
d
m
o
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t
i
n
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ot
h
c
a
s
e
s
.
B
C
S
e
x
p
e
r
i
e
n
c
e
d
l
e
s
s
s
t
r
e
s
s
a
n
d
f
e
a
r
c
o
m
pa
r
e
d
to
C
C
S
,
e
v
e
n
“
n
o
ne
”
l
e
v
e
l
wa
s
f
o
u
n
d
i
n
m
o
s
t
v
a
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bl
e
s
.
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e
pr
e
s
s
i
o
n
a
n
d
a
nxi
e
t
y
we
r
e
f
o
un
d
t
o
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e
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r
s
t
i
n
C
C
S
t
h
a
n
B
C
S
.
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h
e
m
a
j
or
i
t
y
o
f
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oth
r
e
s
p
on
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e
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ts
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g
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e
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th
a
t
a
m
on
g
a
l
l
c
a
u
s
e
s
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a
gn
os
ti
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te
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t
w
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s
th
e
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l
y
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a
r
i
a
b
l
e
wh
i
c
h
w
a
s
l
e
s
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e
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r
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d
b
y
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m
e
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l
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vi
n
g
wi
th
c
a
n
c
e
r
.
T
a
b
l
e
3
e
x
pl
a
i
n
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th
e
s
p
e
c
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f
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c
d
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ta
of
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tu
d
y
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s
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on
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e
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ts
i
n
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e
tai
l
s
.
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tr
e
s
s
due
to
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a
n
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r
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g
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o
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n
d
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r
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t
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nt
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c
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n
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if
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e
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n
t
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n
c
a
s
e
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(
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a
n
d
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e
s
pe
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t
i
ve
ly
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,
i
m
pa
c
t
i
n
g
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g
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c
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n
t
d
i
f
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n
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e
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nxi
e
t
y
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pr
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s
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o
n
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n
d
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L
N
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we
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n
c
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s
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n
d
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e
s
pe
c
t
i
ve
ly
)
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hil
e
f
e
a
r
t
o
wa
r
ds
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n
c
e
r
r
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c
ur
r
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n
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e
,
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e
t
a
s
t
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s
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s
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dd
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t
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o
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n
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r
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n
d
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i
a
g
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o
s
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i
c
t
e
s
t
we
r
e
n
o
t
s
i
g
ni
f
i
c
a
n
t
l
y
d
i
f
f
e
r
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n
t
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e
t
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e
n
c
a
s
e
s
(
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=
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=
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=
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,
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n
d
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=
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338
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e
s
pe
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t
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ly
)
.
T
a
bl
e
4
e
x
p
l
a
i
ns
t
h
e
s
i
g
nif
i
c
a
n
t
d
i
f
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e
r
e
n
c
e
s
o
f
s
t
r
e
s
s
,
a
n
xi
e
t
y
,
de
pr
e
s
s
i
o
n
,
a
n
d
P
L
N
i
n
b
o
t
h
gr
oups
.
S
tr
e
s
s
due
t
o
c
a
n
c
e
r
d
i
a
g
n
o
s
i
s
a
n
d
t
r
e
a
t
m
e
n
t
s
,
a
nxi
e
t
y
,
de
pr
e
s
s
i
o
n
,
a
n
d
P
L
N
w
e
r
e
n
ot
s
i
g
nif
i
c
a
n
t
l
y
d
i
f
f
e
r
e
n
t
b
e
t
we
e
n
s
ur
vi
v
o
r
s
h
i
p
s
t
a
ge
s
i
n
b
o
t
h
c
a
s
e
s
(
C
C
S
:
p
=
0.
918,
p
=
0.
244
,
p
=
0.
337
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p
=
0.
257,
a
n
d
p
=
0.
518
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e
s
pe
c
t
i
ve
l
y
;
B
C
S
:
p
=
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476,
p
=
0.
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p
=
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,
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=
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n
d
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=
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e
s
pe
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t
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v
e
ly
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.
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e
a
r
t
o
wa
r
ds
c
a
n
c
e
r
r
e
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ur
r
e
nc
e
,
m
e
t
a
s
t
a
s
i
s
,
a
dd
i
t
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o
n
a
l
c
a
n
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e
r
,
a
n
d
d
i
a
g
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o
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i
c
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s
t
we
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l
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n
o
t
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g
nif
i
c
a
n
t
ly
d
i
f
f
e
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n
t
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e
t
we
e
n
s
ur
vi
v
o
r
s
hi
p
s
t
a
ge
s
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n
b
ot
h
c
a
s
e
s
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S
:
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=
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=
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432
,
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=
0
.
704,
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n
d
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=
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e
s
pe
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t
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ve
ly
;
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=
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p
=
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645
,
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=
0.
43
0,
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n
d
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=
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e
s
pe
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t
i
v
e
ly
)
.
All
s
t
ud
y
pa
r
a
m
e
t
e
r
s
we
r
e
n
o
t
s
i
g
n
i
f
i
c
a
n
t
l
y
d
if
f
e
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n
t
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e
t
we
e
n
s
ur
vi
v
o
r
s
hi
p
s
t
a
ge
s
i
n
b
o
t
h
c
a
s
e
s
,
i
n
d
i
c
a
t
i
n
g
a
v
e
r
y
s
l
o
w
i
m
pr
o
v
e
m
e
n
t
o
f
s
t
r
e
s
s
/
f
e
a
r
t
o
l
e
r
a
n
c
e
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n
t
he
l
o
n
g
r
u
n
o
f
s
ur
vi
v
o
r
s
hi
p
pe
r
i
o
d
.
T
a
bl
e
5
(
A
a
n
d
B
)
e
x
p
l
a
i
ns
t
h
e
r
e
s
u
l
t
o
f
s
t
a
t
i
s
t
i
c
a
l
a
n
a
ly
s
i
s
i
n
d
e
t
a
i
l
s
.
T
h
e
r
e
a
r
e
m
a
ny
li
f
e
e
v
e
n
t
s
i
nduc
i
ng
i
nd
i
v
i
dua
l
s
t
r
e
s
s
,
o
n
e
o
f
t
h
e
m
i
s
p
hy
s
i
c
a
l
d
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s
e
a
s
e
,
e
s
pe
c
i
a
ll
y
t
h
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c
h
r
o
ni
c
o
n
e
[
19]
.
R
e
s
u
l
t
s
s
h
o
we
d
t
h
a
t
s
tr
e
s
s
du
e
to
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n
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g
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s
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n
d
t
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t
m
e
n
t
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g
nif
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c
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n
t
l
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d
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f
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n
t
b
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t
we
e
n
C
C
S
a
n
d
B
C
S
(
p=
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n
d
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=
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003
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e
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pe
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t
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v
e
ly
)
,
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m
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a
c
t
i
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g
s
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g
nif
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c
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n
t
di
f
f
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nxi
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c
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(
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n
d
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t
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e
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n
t
h
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o
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h
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r
h
a
n
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e
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r
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r
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t
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s
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a
dd
it
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o
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l
c
a
n
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r
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n
d
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i
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g
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o
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t
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s
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g
nif
i
c
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n
t
ly
d
i
f
f
e
r
e
n
t
b
e
t
we
e
n
c
a
s
e
s
(
a
ll
p
>
α
)
.
T
h
e
s
e
f
i
nd
i
ngs
i
nd
i
c
a
t
e
t
h
a
t
s
t
r
e
s
s
due
t
o
c
a
n
c
e
r
d
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a
g
n
o
s
i
s
a
n
d
t
r
e
a
t
m
e
n
t
s
,
a
nxi
e
t
y
,
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pr
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s
s
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o
n
,
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n
d
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L
N
a
r
e
m
o
r
e
de
t
e
r
m
i
n
e
d
by
c
a
s
e
s
c
o
m
pa
r
e
d
to
f
e
a
r
to
wa
r
ds
c
a
n
c
e
r
r
e
c
ur
r
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n
c
e
,
m
e
t
a
s
t
a
s
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s
,
a
dd
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t
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o
na
l
c
a
nc
e
r
,
a
n
d
d
i
a
g
n
o
s
t
i
c
t
e
s
t
w
hi
c
h
a
r
e
f
o
un
d
to
b
e
r
e
l
a
t
i
v
e
ly
s
im
il
a
r
i
n
C
C
S
a
n
d
B
C
S
.
S
tr
e
s
s
due
t
o
c
e
r
vi
c
a
l
c
a
nc
e
r
d
i
a
g
n
o
s
i
s
(
80.
85%
s
e
v
e
r
e
s
t
r
e
s
s
)
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s
f
o
u
n
d
t
o
b
e
m
o
r
e
s
e
v
e
r
e
t
h
a
n
s
t
r
e
s
s
due
to
b
r
e
a
s
t
c
a
n
c
e
r
d
i
a
g
n
o
s
i
s
(
48.
28%
s
e
v
e
r
e
s
t
r
e
s
s
)
.
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ot
h
c
e
r
vi
c
a
l
a
n
d
b
r
e
a
s
t
c
a
n
c
e
r
a
r
e
c
h
r
o
ni
c
d
i
s
e
a
s
e
,
b
ut
t
h
e
y
c
o
u
l
d
i
nduc
e
d
i
f
f
e
r
e
n
t
s
t
r
e
s
s
l
e
v
e
l
i
n
wo
m
e
n
.
M
o
r
e
s
e
v
e
r
e
s
t
r
e
s
s
w
a
s
f
o
u
n
d
i
n
wo
m
e
n
li
v
i
ng
w
i
t
h
c
e
r
vi
c
a
l
c
a
n
c
e
r
(
C
C
S
)
.
T
hi
s
po
s
s
i
b
ly
ha
ppe
n
e
d
b
e
c
a
u
s
e
m
a
ny
C
C
S
pe
r
c
e
i
ve
d
t
h
a
t
s
e
x
ua
l
pr
o
bl
e
m
c
o
u
l
d
h
a
ppe
n
due
t
o
c
e
r
vi
c
a
l
c
a
n
c
e
r
.
A
s
t
udy
a
b
o
ut
di
s
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8806
Str
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ar
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275
r
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20]
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[
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6]
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(
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T
a
bl
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1
.
De
m
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gr
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ph
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h
a
r
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c
C
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c
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r
(
n=
47)
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r
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s
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r
(
n=
58)
Fr
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c
y
%
Fr
e
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n
c
y
%
1.
A
ge
(
y
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s
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ld
)
a.
<
21
0
0
1
1.72
b.
21
-
30
0
0
5
8.62
c.
31
-
40
d.
41
-
50
e.
51
-
60
f.
61
-
70
g.
>
70
5
11
17
13
1
10.64
23.40
36.17
27.66
2.13
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15
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4
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25.86
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13.79
6.90
2.
R
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hr
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1
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46
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18.97
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3.
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t
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40
6
1
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12.76
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57
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4.
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d
u
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at
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al
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ac
k
gr
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.
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r
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s
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15
31.91
11
18.97
b.
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e
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s
c
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.
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ig
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ip
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ne
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c
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t
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d
14
13
2
3
29.79
27.66
4.25
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5
26
15
1
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44.83
25.86
1.72
5.
M
ar
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s
a
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in
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d
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d.
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e
3
39
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1
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8.51
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8
36
14
0
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24.14
0
6. L
iv
in
g at
h
o
m
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it
h
a
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b.
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hi
ld
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n
c
.
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l
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d.
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a
r
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s
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.
S
ib
li
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7.
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c
c
u
p
at
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on
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s
t
at
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s
a
.
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ul
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-
tim
er
b.
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t
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ti
m
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r
c
.
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ti
r
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d
d.
H
ous
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w
if
e
e
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in
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a
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o
b
f
.
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m
pl
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e
d
39
17
3
0
0
2
3
0
40
0
2
82.98
36.17
6.38
0
0
4.25
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0
85.11
0
4.25
30
35
2
11
2
11
2
4
37
1
3
51.72
60.34
3.45
18.97
3.45
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3.45
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5.17
8. GDP
p
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r
m
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a
.
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s
th
a
n m
in
im
um
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in
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5 m
il
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.
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or
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n
d.
N
o
i
n
c
o
m
e
34
8
3
2
72.34
17.02
6.38
4.25
34
14
6
3
58.62
24.14
10.34
5.17
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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N:
2252
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8806
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T
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2
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Ye
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1
st
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F
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ly
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d
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2018
b.
2017
c
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2016
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e
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2014
f
. <
2014
0
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5
18
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14.89
25.53
8.62
8.62
38.30
4
16
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31.03
2.
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+
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.
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p
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g.
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+
c
h
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m
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r
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+
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di
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a
lg
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c
h.
S
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ge
r
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+
c
h
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+
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+
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or
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m
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d
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j.
O
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a
l
m
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c
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(
v
a
r
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t
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p
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s
)
k.
U
nt
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a
t
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d
5
13
2
0
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1
1
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8.62
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0
14.89
36.17
2.13
2.13
0
0
2.13
26
8
11
1
1
5
0
0
1
4
1
44.83
13.79
18.97
1.72
1.72
8.62
0
0
1.72
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1.72
T
a
bl
e
3
.
S
t
r
e
s
s
,
a
n
xi
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t
y
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de
pr
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s
s
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n
,
P
L
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a
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d
f
e
a
r
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n
C
C
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a
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d
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C
C
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r
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r
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ti
c
C
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r
v
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c
a
l
c
a
n
c
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r
(
n=
47)
B
r
e
a
s
t
c
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nc
e
r
(
n=
58)
Fr
e
qu
e
n
c
y
%
Fr
e
qu
e
n
c
y
%
1. S
t
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e
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e
38
8
1
0
80.85
17.02
2.13
0
28
20
7
3
48.28
34.48
12.07
5.17
2. S
t
r
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.
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M
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.
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il
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d.
N
o
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e
26
18
3
0
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0
20
16
17
5
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27.59
29.31
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3. An
xi
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t
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a
.
S
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ve
r
e
b.
M
o
de
r
a
te
c
.
M
il
d
d.
N
o
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e
25
18
4
0
53.19
38.30
8.51
0
22
16
14
6
37.93
27.59
24.14
10.34
4.
D
e
p
r
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s
s
io
n
a
.
S
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ve
r
e
b.
M
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de
r
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il
d
d.
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o
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e
26
12
6
3
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25.53
12.77
6.38
10
5
20
23
17.24
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34.48
39.66
5. P
L
N
a
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H
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h
b. M
o
de
r
a
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c
.
L
o
w
30
14
3
63.83
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49
8
1
84.48
13.79
1.72
6. F
e
ar
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t
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c
a
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c
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d. No
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27
16
4
0
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34.04
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11
8
6
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29
14
4
0
61.70
29.79
8.51
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11
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6
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18.97
13.79
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8. F
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14
9
7
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24.14
15.52
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d
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N
o
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9
27
9
2
19.15
57.45
19.15
4.26
16
14
20
8
27.59
24.14
34.48
13.79
*
C
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Evaluation Warning : The document was created with Spire.PDF for Python.
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6.51
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B
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5.80(
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5.41(
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4.56(
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0.664
0.519
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3.05(
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F
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6.05(
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F
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[
33]
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R
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[
6]
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Al
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[
19]
.
I
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d
B
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(
p<
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001)
[
34]
.
B
y
l
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v
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ng
w
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h
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f
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d
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30
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[
35]
.
An
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49%
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[
36]
.
L
a
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a
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us
&
F
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m
a
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s
ugge
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t
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d
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[
19]
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Evaluation Warning : The document was created with Spire.PDF for Python.
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N:
2252
-
8806
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due
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o
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li
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w
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r
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us
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to
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s
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a
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e
a
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.
AC
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be
r
:
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hi
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RE
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[1
]
M.
K
ap
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an
,
“
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[2
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b
u
rg
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al
.
,
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’s
Can
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ran
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[3
]
R.
A
.
Ca
m
p
o
,
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t
al
.
,
“
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e
at
h
e
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as
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s
o
f
Ca
n
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r
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r
v
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h
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p
:
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i
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s
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p
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p
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.
[4
]
Mi
n
i
s
t
ry
o
f
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al
t
h
,
R
e
p
u
b
l
i
c
o
f
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d
o
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s
i
a
,
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n
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Re
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fr
o
m
:
h
t
t
p
:
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[5
]
M.
M.
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emme
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t
,
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al
.
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o
p
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s
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fo
r
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c
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,
”
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Lo
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l
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[6
]
N
.
P.
W
.
P.
Sari
,
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W
o
men
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w
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6
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4
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D
.
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.
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5
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s
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.
[2
6
]
D
.
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m
p
-
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arb
ro
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H
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k
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H
o
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me
s
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B,
(
e
d
s
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).
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Ca
n
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Nu
r
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:
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rl
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A
:
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Bart
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,
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.
1
6
,
pp.
4
9
7
-
5
5
4
,
2
0
1
8
.
[2
7
]
L
.
Mo
rs
e,
“
Sk
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n
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d
N
a
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e
d
Ch
a
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.
,
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,
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.
,
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o
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s
,
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,
(e
d
s
.
),
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n
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t
o
m
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a
n
a
g
em
en
t
,
4
th
E
d
i
t
i
o
n
,
Bu
rl
i
n
g
t
o
n
,
M
A
:
J
o
n
e
s
&
Bart
l
e
t
t
L
e
ar
n
i
n
g
,
v
o
l
.
2
8
,
p
p
.
5
8
7
-
6
1
6
,
2
0
1
4
.
[2
8
]
V
.
M.
D
e
s
t
,
“
Rad
i
at
i
o
n
T
h
e
rap
y
:
T
o
x
i
c
i
t
i
e
s
an
d
Ma
n
ag
emen
t
,
”
Y
arb
ro
,
CH
.
,
W
u
j
c
k
i
,
D
.
,
H
o
l
me
s
,
G
B.
,
(ed
s
.
).
Ca
n
ce
r
Nu
r
s
i
n
g
:
P
r
i
n
c
i
p
l
es
a
n
d
P
r
a
ct
i
ce
,
8
th
E
d
i
t
i
o
n
,
Bu
rl
i
n
g
t
o
n
,
MA
:
J
o
n
e
s
an
d
Bart
l
e
t
t
L
e
ar
n
i
n
g
,
v
o
l
.
1
3
,
p
p
.
333
-
3
7
4
,
2
0
1
8
.
[2
9
]
M.
L
i
,
L
.
W
an
g
,
“
T
h
e
A
s
s
o
c
i
at
i
o
n
s
o
f
Ps
y
ch
o
l
o
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i
c
a
l
St
re
s
s
w
i
t
h
D
e
p
re
s
s
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v
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an
d
A
n
x
i
e
t
y
S
y
m
p
t
o
m
s
a
mo
n
g
Ch
i
n
e
s
e
B
l
ad
d
e
r
a
n
d
R
en
al
Can
ce
r
Pat
i
e
n
t
s
:
T
h
e
M
e
d
i
at
i
n
g
R
o
l
e
o
f
R
e
s
i
l
i
en
ce
,
”
P
Lo
S
O
NE
,
v
o
l
.
1
1
,
n
o
.
4
,
p
p
.
e
0
1
5
4
7
2
9
,
2
0
1
6
.
[3
0
]
Y
-
L
.
Y
an
g
,
e
t
a
l
.
,
“
Pre
v
al
en
ce
a
n
d
A
s
s
o
ci
at
ed
P
o
s
i
t
i
v
e
Ps
y
ch
o
l
o
g
i
c
al
V
ar
i
ab
l
e
s
o
f
D
e
p
re
s
s
i
o
n
an
d
A
n
x
i
e
t
y
amo
n
g
Ch
i
n
e
s
e
C
e
r
v
i
c
a
l
Can
ce
r
Pat
i
e
n
t
s
:
A
Cro
s
s
-
Sec
t
i
o
n
a
l
St
u
d
y
,
”
P
Lo
S
O
N
E
,
v
o
l
.
9
,
n
o
.
4
,
p
p
.
e
9
4
8
0
4
,
2
0
1
4
.
[3
1
]
C.
K
w
o
k
,
K
.
W
h
i
t
e,
“
Pe
r
ce
i
v
e
d
I
n
f
o
r
m
at
i
o
n
N
ee
d
s
an
d
S
o
c
i
a
l
S
u
p
p
o
rt
o
f
C
h
i
n
e
s
e
-
A
u
s
t
ral
i
an
Br
e
as
t
Can
ce
r
Su
rv
i
v
o
rs
,
”
S
u
p
p
o
r
t
Ca
r
e
Ca
n
cer
,
v
o
l
.
2
2
,
n
o
.
1
0
,
p
p
.
2
6
5
1
-
2
6
5
9
,
2
0
1
4
.
[3
2
]
G
.
J
.
Y
o
o
,
e
t
al
.
,
“
O
l
d
e
r
W
o
me
n
,
Br
e
as
t
Can
ce
r,
an
d
So
c
i
a
l
S
u
p
p
o
rt
,
”
S
u
p
p
o
r
t
C
a
r
e
Ca
n
cer
,
v
o
l
.
1
8
,
n
o
.
1
2
,
pp.
1
5
2
1
-
1
5
3
0
,
2
0
1
0
.
[3
3
]
J
.
Y
o
u
,
Q
.
L
u
,
“
So
u
rce
s
o
f
So
ci
al
Su
p
p
o
rt
an
d
A
d
j
u
s
t
me
n
t
a
m
o
n
g
Ch
i
n
e
s
e
Can
ce
r
Su
r
v
i
v
o
rs
:
G
en
d
e
r
a
n
d
A
g
e
D
i
ff
e
r
e
n
ce
s
,
”
S
u
p
p
o
r
t
Ca
r
e
Ca
n
cer
,
v
o
l
.
22,
n
o
.
3
,
p
p
.
6
9
7
-
7
0
4
,
2
0
1
4
.
[3
4
]
N
.
P.
W
.
P.
Sar
i
,
“
Ph
y
s
i
c
al
W
e
l
l
b
e
i
n
g
i
n
C
e
r
v
i
c
a
l
an
d
Br
e
as
t
Can
ce
r
Su
r
v
i
v
o
rs
:
A
Cr
o
s
s
-
Sec
t
i
o
n
al
St
u
d
y
i
n
S
u
rab
a
y
a,
In
d
o
n
e
s
i
a,
”
In
d
o
n
e
s
i
a
n
J
o
u
r
n
a
l
o
f
Ca
n
cer
,
v
o
l
.
1
2
,
n
o
.
3
,
p
p
.
8
0
-
8
7
,
2
0
1
8
.
[3
5
]
B.
T
h
ew
e
s
,
e
t
al
.
,
“
A
Q
u
al
i
t
at
i
v
e
E
x
p
l
o
rat
i
o
n
o
f
F
ear
o
f
Can
ce
r
R
ec
u
rr
e
n
ce
(FCR)
a
m
o
n
g
s
t
A
u
s
t
ral
i
an
an
d
Can
ad
i
a
n
Br
e
as
t
Can
ce
r
S
u
rv
i
v
o
rs
,
”
S
u
p
p
o
r
t
Ca
r
e
Ca
n
c
er
,
v
o
l
.
2
4
,
p
p
.
2
2
6
9
-
2
2
7
6
,
2
0
1
6
.
[3
6
]
J
.
D
e
V
r
i
e
s
,
e
t
al
.
,
“
H
o
w
Br
e
as
t
Can
ce
r
Su
rv
i
v
o
rs
Co
p
e
w
i
t
h
F
e
ar
o
f
R
e
cu
rr
e
n
ce:
A
Fo
cu
s
G
ro
u
p
St
u
d
y
,
”
S
u
p
p
o
r
t
C
a
r
e
Ca
n
ce
r
,
v
o
l
.
2
2
,
n
o
.
3
,
p
p
.
705
-
7
1
2
,
2
0
1
4
.
[3
7
]
C.
V
ri
n
t
en
,
e
t
al
.
,
“
W
h
at
D
o
P
e
o
p
l
e
F
e
ar
A
b
o
u
t
Can
ce
r?
A
S
y
s
t
em
at
i
c
R
e
v
i
ew
a
n
d
M
e
t
a
-
S
y
n
t
h
e
s
i
s
o
f
Can
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r
F
ears
i
n
T
h
e
G
e
n
e
ra
l
P
o
p
u
l
at
i
o
n
,
”
P
s
ych
o
-
O
n
co
l
o
g
y
, v
o
l
.
2
6
,
n
o
.
8
,
p
p
.
1
0
7
0
-
1
0
7
9
,
2
0
1
7
.
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