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Vo
l.
5
,
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.
4
,
Dec
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er
201
6
,
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p
.
43
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~
44
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SS
N:
2252
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2
5
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8806
I
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HS
Vo
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5
,
No
.
4
,
Dec
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b
er
20
1
6
:
43
7
–
44
3
438
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th
er
e
w
er
e
f
o
u
n
d
a
r
s
en
ic
lev
els
i
n
w
ater
0
.
0
9
8
m
g
/
L
,
an
d
f
is
h
o
f
3
.
8
6
7
m
g
/
k
g
.
Fu
r
t
h
er
m
o
r
e,
th
e
ac
q
u
ir
ed
d
iag
n
o
s
i
s
ca
s
es
o
f
d
is
ea
s
e
i
n
th
e
p
o
p
u
latio
n
s
h
o
w
ed
n
o
t
s
t
r
o
n
g
d
o
se
-
r
esp
o
n
s
e
r
elatio
n
s
h
ip
ar
s
en
ic
ca
u
s
es
s
k
i
n
lesi
o
n
s
[
6
]
.
T
h
ese
r
esu
lts
w
er
e
co
n
s
i
s
ten
t
w
it
h
h
i
g
h
co
n
ce
n
tr
atio
n
s
o
f
ar
s
e
n
ic
f
o
u
n
d
e
d
w
h
ich
2
5
w
e
lls
in
s
p
ec
ted
th
e
w
a
ter
,
th
e
n
u
m
b
er
o
f
ca
s
es
a
s
m
an
y
as
5
4
p
eo
p
le
w
h
o
s
u
f
f
er
f
r
o
m
d
is
o
r
d
er
s
o
f
th
e
s
k
i
n
(
k
er
ato
s
i
s
o
r
h
y
p
er
k
er
ato
s
is
)
.
T
h
e
r
esu
lt
s
o
b
tain
ed
,
9
0
%
o
f
w
a
ter
w
ell
s
p
o
llu
ted
B
u
y
a
t
v
illa
g
e
w
i
th
m
i
n
i
m
u
m
co
n
ce
n
tr
atio
n
s
(
0
.
0
0
6
3
m
g
/l),
m
ax
i
m
u
m
(
0
.
1
0
4
0
m
g
/
l
)
a
n
d
th
e
m
ea
n
±
SD
(
0
.
0
4
0
±
0
.
0
3
0
m
g
/
l)
.
Hea
l
th
r
is
k
(
R
Q)
h
a
s
e
x
ce
ed
ed
1
,
d
u
r
atio
n
ti
m
e
w
a
s
1
.
5
y
ea
r
s
a
n
d
a
m
a
x
i
m
u
m
c
o
n
s
u
m
p
tio
n
r
ate
o
f
5
3
m
l/d
a
y
/
p
er
s
o
n
w
ei
g
h
in
g
3
5
k
g
.
B
ased
o
n
th
e
s
e
d
ata
f
i
n
d
in
g
s
,
B
u
y
at
co
m
m
u
n
it
y
s
h
o
u
ld
n
o
t
d
r
in
k
w
ater
f
r
o
m
w
el
ls
ex
ce
ed
s
5
3
m
l/p
er
s
o
n
/
d
a
y
a
s
an
e
n
v
ir
o
n
m
en
tal
h
ea
lt
h
r
is
k
m
a
n
ag
e
m
e
n
t [
7
]
.
T
h
e
E
n
v
ir
o
n
m
e
n
tal
P
r
o
tectio
n
A
g
e
n
c
y
(
E
P
A
)
h
as
d
eter
m
i
n
e
d
th
at
th
e
m
e
tal
ar
s
e
n
ic
w
as
h
ar
m
f
u
l
to
h
u
m
a
n
h
ea
lt
h
an
d
i
t
ca
n
lead
to
n
on
-
ca
r
cin
o
g
en
ic
an
d
ca
r
ci
n
o
g
e
n
ic
ill
n
e
s
s
.
I
n
o
r
g
a
n
ic
ar
s
en
ic
ca
n
ca
u
s
e
s
k
i
n
ca
n
ce
r
,
lu
n
g
,
li
v
er
a
n
d
b
lad
d
er
.
Hig
h
le
v
els
o
f
ex
p
o
s
u
r
e
ca
n
ca
u
s
e
th
e
d
ea
th
o
f
h
u
m
a
n
,
w
h
ile
lo
n
g
-
ter
m
ex
p
o
s
u
r
e
ca
n
ca
u
s
e
d
ar
k
e
n
i
n
g
o
f
th
e
s
k
i
n
,
w
ar
ts
o
n
t
h
e
p
al
m
s
,
s
o
les,
an
d
to
r
s
o
[
8
-
9
]
.
Hea
v
y
m
etal
p
o
llu
tio
n
i
n
th
e
w
ater
s
a
t
t
h
e
L
o
s
ar
i
Ma
k
as
s
ar
(
n
ea
r
Ma
k
as
s
ar
Go
ld
e
n
Ho
tel)
an
d
L
o
s
ar
i
(
f
r
o
n
t
o
f
Fo
r
t
R
o
tter
d
a
m
)
s
a
m
p
li
n
g
p
o
in
t
h
a
s
e
x
ce
ed
ed
s
af
e
l
i
m
its
.
I
n
Sep
te
m
b
er
2
0
1
2
th
e
r
esu
lts
o
b
tain
ed
s
u
cc
e
s
s
i
v
el
y
a
t
t
h
e
t
w
o
p
o
in
ts
[
i.e
.
0
.
0
0
8
1
m
g
/
L
;
0
.
0
3
7
2
m
g
/
L
;
0
.
0
1
8
5
m
g
/
L
]
an
d
[
0
,
0
0
4
5
m
g
/
L
;
0
.
0
6
5
9
m
g
/
L
;
0
.
0
1
4
1
m
g
/
L
]
.
Hea
v
y
m
etal
le
v
el
s
h
av
e
e
x
c
ee
d
ed
th
e
s
ta
n
d
ar
d
o
f
So
u
t
h
Su
la
w
e
s
i
Go
v
er
n
o
r
R
eg
u
latio
n
No
.
6
9
Yea
r
2
0
1
0
r
eg
ar
d
in
g
Sta
n
d
ar
d
an
d
E
n
v
i
r
o
n
m
e
n
tal
Da
m
a
g
e
C
r
iter
ia
Ap
p
en
d
ix
No
.
I
.
c.
2
.
Sea
W
ater
Qu
alit
y
Sta
n
d
ar
d
f
o
r
Ma
r
in
e
to
u
r
is
m
[
1
0
]
,
w
h
er
ein
0
.
0
0
2
m
g
/
L
f
o
r
th
e
m
e
tal
m
er
cu
r
y
(
H
g
)
,
0
.
0
0
2
m
g
/
L
f
o
r
He
x
av
ale
n
t
C
h
r
o
m
i
u
m
(
C
r
VI
)
,
an
d
0
.
0
0
5
m
g
/
L
f
o
r
lead
(
P
b
)
[
1
1
]
.
C
h
ar
ac
ter
is
tics
o
f
m
etal
s
in
an
aq
u
atic
en
v
ir
o
n
m
e
n
t
w
er
e
h
ig
h
l
y
d
ep
en
d
e
n
t
o
n
t
h
e
s
p
ec
iatio
n
o
f
m
etal
s
.
I
t
h
ad
af
f
ec
ted
th
e
p
r
esen
ce
o
f
t
h
ese
m
etal
s
in
b
io
lo
g
ical
tis
s
u
es
(
b
io
av
ailab
ilit
y
)
an
d
to
x
icit
y
to
b
io
ta,
tr
an
s
p
o
r
tatio
n
a
n
d
m
o
b
il
izatio
n
,
as
w
e
ll
as
i
n
ter
ac
tio
n
w
i
th
s
ed
i
m
e
n
t
o
r
s
o
il
[
1
2
]
.
Hea
v
y
m
etal
s
s
et
tle
to
t
h
e
s
ed
i
m
e
n
t
h
a
s
a
r
esid
en
ce
ti
m
e
to
th
o
u
s
a
n
d
s
y
ea
r
s
w
h
ile
t
h
e
in
s
id
e
o
f
li
v
i
n
g
o
r
g
a
n
i
s
m
s
,
h
e
av
y
m
etal
s
w
ill
b
e
co
n
ce
n
tr
ated
t
h
r
o
u
g
h
th
e
b
io
ac
cu
m
u
lat
io
n
p
r
o
ce
s
s
.
Hea
v
y
m
etal
s
ca
n
p
r
ese
n
ce
i
n
to
t
h
e
b
o
d
y
o
r
g
a
n
i
s
m
i
n
th
r
ee
w
a
y
s
ite
m
s
,
n
a
m
el
y
f
o
o
d
ch
ain
,
g
i
lls
a
n
d
d
if
f
u
s
io
n
t
h
r
o
u
g
h
t
h
e
s
k
i
n
s
u
r
f
ac
e.
T
h
u
s
,
in
d
icato
r
s
o
f
h
ea
v
y
m
etal
p
o
llu
tio
n
i
n
co
as
tal
w
a
ter
s
u
s
e
th
e
s
ed
i
m
en
t
a
n
d
m
ar
in
e
li
f
e
th
a
t
p
r
ese
n
ce
in
t
h
e
w
ater
s
ar
o
u
n
d
th
e
s
ea
[
1
3
-
14]
.
P
r
esen
ce
o
f
h
ea
v
y
m
etal
s
in
c
o
astal
Ma
k
as
s
ar
w
il
l
b
e
lo
w
er
in
g
t
h
e
en
v
ir
o
n
m
en
t
q
u
alit
y
a
n
d
to
x
ic
to
m
ar
in
e
li
f
e
e
v
en
to
h
u
m
a
n
s
.
T
y
p
e
s
o
f
m
ar
in
e
li
f
e
s
u
ch
a
s
f
i
s
h
an
d
s
h
ell
f
is
h
co
n
s
u
m
ed
b
y
c
o
m
m
u
n
it
y
b
ec
a
u
s
e
o
f
t
h
e
h
ig
h
p
r
o
tein
co
n
te
n
t.
T
h
e
m
u
s
s
el
s
w
er
e
f
o
u
n
d
i
n
t
h
e
co
astal
ar
ea
an
d
s
o
ld
b
y
f
is
h
er
m
en
o
n
t
h
e
ed
g
e.
I
n
ad
d
itio
n
,
taf
f
o
r
d
ab
le
p
r
ices
b
y
th
e
co
m
m
u
n
it
y
.
T
h
e
h
i
g
h
le
v
el
o
f
f
is
h
a
n
d
s
h
ell
f
i
s
h
co
n
s
u
m
p
tio
n
w
h
ich
m
etal
co
n
ta
m
i
n
a
n
ts
i
m
p
ac
t
to
p
u
b
li
c
h
ea
lt
h
i
n
ac
u
te
a
n
d
ch
r
o
n
ic
d
is
ea
s
e.
Me
tal
ac
cu
m
u
lated
in
m
ar
in
e
li
f
e
a
n
d
h
u
m
a
n
tis
s
u
e
[
1
4
-
1
6
]
.
T
h
e
co
astal
co
m
m
u
n
it
y
as
a
p
eo
p
leaf
f
ec
ted
th
er
i
s
k
o
f
h
ea
v
y
m
eta
l
p
o
l
lu
tio
n
i
n
t
h
e
w
a
ter
s
.
T
h
er
e
w
er
e
1
4
d
is
tr
ict
s
i
n
Ma
k
as
s
a
r
cit
y
,
b
u
t
th
e
s
elec
ted
ar
ea
j
u
s
t
t
w
o
s
u
b
-
d
i
s
tr
ict
w
h
ic
h
h
a
v
e
co
astal
co
m
m
u
n
i
t
y
,
p
o
ten
tiall
y
e
x
p
o
s
ed
to
ar
s
en
ic
d
u
e
to
in
d
u
s
tr
ia
l
ac
tiv
i
tie
s
,
m
ar
iti
m
e
i
n
teg
r
ated
r
eg
io
n
,
y
a
g
ag
r
ic
u
lt
u
r
al
p
esti
cid
es
an
d
co
m
m
er
cial
f
er
tili
ze
r
s
n
a
m
el
y
Kal
u
k
u
B
o
d
o
a
C
o
astal
i
n
T
allo
s
u
b
-
d
is
tr
ict
a
n
d
Un
tia
C
o
astal
i
n
B
ir
in
g
k
an
a
y
a
s
u
b
-
d
i
s
tr
ict.
B
ased
o
n
d
ata
ab
o
u
t
p
r
ese
n
ce
o
f
h
ea
v
y
m
eta
ls
i
n
Ma
k
a
s
s
ar
,
a
s
o
u
r
ce
o
f
h
ea
v
y
m
etal
p
o
llu
tio
n
,
as
w
ell
a
s
th
e
n
a
tu
r
e
o
f
t
h
e
ca
r
cin
o
g
e
n
ic
an
d
n
o
n
-
ca
r
ci
n
o
g
e
n
ic
in
h
u
m
a
n
s
,
t
h
e
r
e
s
ea
r
ch
er
s
i
n
ter
ested
to
m
ea
s
u
r
e
th
e
le
v
els
o
f
ar
s
e
n
ic
co
n
tai
n
ed
in
f
i
s
h
an
d
s
h
el
lf
is
h
c
o
n
s
u
m
ed
b
y
Kal
u
k
u
B
o
d
o
a
an
d
U
n
tia
co
astal
C
o
m
m
u
n
i
t
y
.
Ob
s
er
v
a
s
io
n
al
s
t
u
d
y
w
as
u
s
in
g
E
n
v
ir
o
n
m
e
n
tal
Hea
lth
R
i
s
k
An
al
y
s
i
s
ap
p
r
o
ac
h
r
elate
d
to
A
r
s
e
n
ic
(
A
s
)
.
T
h
ese
ap
p
r
o
ac
h
b
ec
o
m
e
li
m
ited
r
esear
ch
s
t
u
d
y
a
n
d
n
e
v
er
b
ee
n
d
o
n
e
b
ef
o
r
e
in
th
is
c
o
astal
r
eg
io
n
.
T
h
is
s
tu
d
y
ai
m
ed
to
d
eter
m
in
e
t
h
e
h
ea
lt
h
r
i
s
k
o
f
ar
s
en
ic
co
n
t
a
m
i
n
atio
n
in
f
is
h
a
n
d
s
h
ell
f
i
s
h
d
u
e
to
s
ea
f
o
o
d
co
n
s
u
m
p
tio
n
f
o
r
Kalu
k
u
B
o
d
o
a
an
d
Un
tia
co
astal c
o
m
m
u
n
it
y
in
Ma
k
as
s
ar
C
it
y
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
P
HS
I
SS
N:
2252
-
8806
A
r
s
en
ic
E
xp
o
s
u
r
e
to
F
is
h
a
n
d
S
h
ellfis
h
C
o
n
s
u
mp
tio
n
a
mo
n
g
C
o
mmu
n
ity
in
K
a
lu
ku
B
o
d
o
a
.
.
.
.
(
Mu
s
fir
a
h
)
439
2.
RE
S
E
ARCH
M
E
T
H
O
D
2
.
1
.
Resea
rc
h
des
ig
n
T
h
is
t
y
p
e
o
f
r
esear
ch
w
as
a
n
o
b
s
er
v
atio
n
al
s
tu
d
y
w
it
h
a
n
E
n
v
ir
o
n
m
e
n
tal
Hea
lt
h
R
i
s
k
An
al
y
s
i
s
(
E
HR
A
)
ap
p
r
o
ac
h
w
h
ic
h
r
is
k
f
ac
to
r
s
w
er
e
m
ea
s
u
r
ed
at
th
e
s
a
m
e
ti
m
e
to
p
r
o
v
id
e
a
m
a
g
n
it
u
d
e
p
r
ed
ictio
n
o
f
th
e
h
ea
l
th
r
is
k
s
ca
u
s
ed
b
y
A
r
s
en
ic
in
f
i
s
h
a
n
d
s
h
e
llfis
h
.
2
.
2
.
L
o
ca
t
io
n a
nd
t
i
m
e
re
s
ea
rc
h
T
h
e
s
tu
d
y
co
n
d
u
cted
on
Ma
y
-
J
u
n
e
2
0
1
4
in
Ma
k
a
s
s
ar
co
as
t,
s
a
m
p
li
n
g
s
ite
ar
e
T
allo
Dis
tr
ic
t
(
Kalu
k
u
B
o
d
o
a
C
o
astal)
an
d
B
ir
in
g
k
a
n
a
y
a
(
Un
t
ia
C
o
astal),
So
u
th
Su
l
a
w
e
s
i,
I
n
d
o
n
es
ia.
T
h
e
s
elec
ted
lo
ca
tio
n
b
ased
o
n
th
e
co
n
s
id
er
atio
n
t
h
at
t
h
e
co
a
s
tal
ar
ea
s
h
ad
ex
p
er
ie
n
ce
d
s
e
d
i
m
en
ta
tio
n
a
n
d
w
ater
p
o
llu
t
i
o
n
f
r
o
m
t
w
o
r
iv
er
s
n
a
m
e
l
y
,
J
en
eb
er
an
g
an
d
T
allo
r
iv
er
.
T
h
er
e
w
er
ea
l
s
o
a
v
ar
iet
y
o
f
ac
tiv
ities
t
h
at
p
o
ten
tiall
y
co
n
ta
m
i
n
ate
aq
u
atic
en
v
ir
o
n
m
en
t
s
s
u
ch
as
in
d
u
s
tr
ial,
m
ar
iti
m
e
in
te
g
r
at
ed
ar
ea
,
r
esid
en
tial,
h
o
s
p
italit
y
a
n
d
ag
r
icu
ltu
r
a
l
ac
tiv
itie
s.
2
.
3
.
P
o
pu
la
t
io
n a
nd
s
a
m
pl
e
T
h
e
en
v
ir
o
n
m
en
ta
l
p
o
p
u
latio
n
w
er
e
f
is
h
an
d
s
h
ell
f
is
h
i
n
t
h
e
Ma
k
a
s
s
ar
co
astal.
T
h
e
s
am
p
le
in
t
h
is
s
tu
d
y
ta
k
en
f
r
o
m
Kal
u
k
u
B
o
d
o
a
an
d
Un
tia
C
o
as
tal.
T
h
e
tis
s
u
e
s
a
m
p
le
s
o
f
f
is
h
/
s
h
el
lf
is
h
th
at
h
a
s
b
ee
n
o
b
tain
ed
,
th
en
ta
k
en
to
t
h
e
la
b
o
r
a
to
r
y
an
d
R
esear
c
h
C
e
n
te
r
f
o
r
Fo
o
d
T
ec
h
n
o
lo
g
y
o
f
Ma
r
o
s
as
lab
o
r
ato
r
y
an
al
y
s
is
o
f
A
r
s
e
n
.
Sa
m
p
ela
n
al
y
ze
w
as
u
s
i
n
g
A
E
S (
A
to
m
ic
E
m
w
as
s
io
n
Sp
ec
tr
o
s
co
p
y
)
.
T
h
e
h
u
m
a
n
p
o
p
u
latio
n
w
as
all
th
e
f
is
h
er
m
a
n
w
h
o
li
v
e
in
Un
tia
an
d
Kalu
k
u
B
o
d
o
a
C
o
astal
ar
ea
.
T
h
e
s
a
m
p
le
i
n
th
i
s
s
tu
d
y
w
a
s
a
f
i
s
h
er
m
e
n
p
o
p
u
latio
n
as
m
u
c
h
a
s
4
9
p
eo
p
le.
Sa
m
p
lin
g
w
as
d
o
n
e
b
y
p
r
o
p
o
r
tio
n
al
r
an
d
o
m
s
a
m
p
l
in
g
m
eth
o
d
.
2
.
4
.
Da
t
a
a
na
l
y
s
is
T
h
is
s
t
u
d
y
u
s
ed
E
n
v
ir
o
n
m
en
tal
Hea
lt
h
R
is
k
An
al
y
s
is
(
E
R
H
A
)
an
d
E
x
ce
l
p
r
o
g
r
a
m
m
e.
E
n
v
ir
o
n
m
e
n
tal
h
ea
lt
h
r
i
s
k
an
a
l
y
s
i
s
ca
r
r
ied
o
u
t
b
y
t
h
e
r
is
k
c
h
ar
ac
ter
izatio
n
p
r
o
ce
d
u
r
es
w
h
i
ch
ca
lc
u
lated
u
s
i
n
g
th
e
f
o
r
m
u
la
:
(
1
)
An
n
o
tatio
n
:
RQ
:
R
is
k
Q
u
o
tien
t (
No
n
-
ca
r
ci
n
o
g
e
n
ic
R
i
s
k
c
h
ar
ac
ter
izatio
n
)
R
f
D
:
An
al
y
s
i
s
o
f
d
o
s
e
-
r
esp
o
n
s
e
I
:
I
n
tak
e
T
h
e
lev
el
o
f
h
ea
lt
h
r
i
s
k
s
f
o
r
c
ar
cin
o
g
e
n
ic
e
f
f
ec
ts
ex
p
r
es
s
ed
in
n
o
tatio
n
E
x
ce
s
s
C
a
n
ce
r
R
is
k
(
E
C
R
)
.
T
o
ch
ar
ac
ter
ize
th
e
r
is
k
f
o
r
ca
r
cin
o
g
e
n
ic
e
f
f
ec
ts
ca
lc
u
lat
io
n
b
y
f
o
ld
i
n
g
i
n
tak
e
w
it
h
Slo
p
e
Facto
r
(
SF
)
.
T
h
e
f
o
r
m
u
la
f
o
r
d
eter
m
i
n
i
n
g
t
h
e
E
C
R
w
a
s
as f
o
llo
w
s
:
(
2
)
An
n
o
tatio
n
:
E
C
R
=
E
x
ce
s
s
C
a
n
ce
r
R
is
k
(
ca
r
cin
o
g
en
ic
r
is
k
ch
ar
ac
ter
izatio
n
)
SF
=
r
ef
er
en
ce
v
a
lu
e
r
is
k
a
g
en
t
w
i
t
h
ca
r
cin
o
g
e
n
ic
e
f
f
ec
ts
(
m
g
/
k
g
/
h
ar
i)
I
=
I
n
tak
e
(
m
g
/
k
g
/
h
ar
i)
A
r
s
e
n
ic
h
a
s
a
v
al
u
e
o
f
SF
a
cc
o
r
d
in
g
to
i
n
ter
n
atio
n
al
s
ta
n
d
ar
d
s
th
at
w
as
eq
u
al
to
1
.
5
m
g
/k
g
/
d
a
y
,
eq
u
iv
ale
n
t
to
th
e
r
ef
er
e
n
ce
d
o
s
e
(
0
.
0
0
0
1
/
SF
=
0
.
0
0
0
1
/
1
.
5
=
6
.
6
6
6
6
7
E
-
0
5
)
.
T
h
e
r
is
k
ch
ar
ac
ter
is
tics
e
x
p
r
ess
ed
b
y
t
h
e
le
v
el
o
f
r
is
k
(
R
is
k
Q
u
o
tien
t
“RQ”)
f
o
r
t
h
e
e
f
f
ec
ts
o
f
n
o
n
-
ca
r
cin
o
g
en
ic
w
asd
i
v
id
i
n
g
b
et
w
ee
n
in
ta
k
e
(
I
)
an
d
r
ef
r
en
ce
d
o
s
e
(
R
FD)
w
h
il
e
th
e
ca
r
cin
o
g
e
n
ic
r
is
k
lev
el
s
ex
p
r
ess
ed
in
n
o
tatio
n
E
x
ce
s
s
C
an
ce
r
R
i
s
k
(
E
C
R
)
,
w
h
ic
h
w
as
t
h
e
m
u
lt
ip
licatio
n
o
f
in
ta
k
e
(
I
)
an
d
th
e
s
lo
p
e
f
ac
to
r
(
SF
)
.
R
is
k
e
x
is
t
s
an
d
n
ee
d
s
to
b
e
co
n
tr
o
lled
if
RQ
>
1
an
d
E
C
R
>
E
-
4
[
1
7
]
.
3.
RE
SU
L
T
S
A
ND
AN
AL
Y
SI
S
T
h
e
r
esu
lts
o
f
t
h
is
s
tu
d
y
s
h
o
w
ed
th
at
th
e
r
is
k
o
f
A
r
s
e
n
ic
in
l
o
ca
tio
n
s
tu
d
y
ar
ea
s
w
as
v
er
y
h
ig
h
le
v
el
s
b
ec
au
s
e
t
h
e
f
is
h
a
n
d
s
h
ell
f
i
s
h
co
n
s
u
m
p
t
io
n
a
s
w
ell
as
s
u
p
p
o
r
ted
b
y
t
h
e
c
h
ar
ac
ter
is
tic
s
o
f
r
esp
o
n
d
e
n
ts
w
h
o
co
n
tr
ib
u
te
to
o
cc
u
r
th
e
h
ea
lt
h
p
r
o
b
lem
s
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8806
I
J
P
HS
Vo
l.
5
,
No
.
4
,
Dec
em
b
er
20
1
6
:
43
7
–
44
3
440
3
.
1
.
Dis
t
ribu
t
io
n o
f
re
s
po
n
dents
cha
ra
ct
er
is
t
ics
in t
he
K
a
lu
ku
B
o
do
a
a
nd
Unt
ia
Co
a
s
t
a
l
T
h
e
d
is
tr
ib
u
tio
n
o
f
r
e
s
p
o
n
d
en
ts
c
h
ar
ac
ter
is
tics
in
t
h
e
Kal
u
k
u
B
o
d
o
a
an
d
U
n
tia
C
o
ast
al
ca
n
b
e
s
h
o
w
ed
b
elo
w
i
n
T
ab
le
1
.
T
h
e
n
u
m
b
er
o
f
f
is
h
er
m
en
w
h
o
f
r
eq
u
en
tl
y
ea
t
f
i
s
h
a
n
d
s
h
ell
f
is
h
c
atch
ed
o
f
ab
o
u
t
4
9
p
eo
p
le
w
i
th
t
h
e
m
aj
o
r
ity
a
g
e
an
d
len
g
t
h
o
f
s
ta
y
f
o
r
r
esp
o
n
d
en
ts
b
o
th
in
t
h
e
r
an
g
e
o
f
3
0
-
4
0
y
ea
r
s
w
i
th
a
p
er
ce
n
tag
e
o
f
5
7
.
1
%.
T
ab
le
1
also
s
h
o
w
s
t
h
at
r
esp
o
n
d
en
ts
w
h
o
h
ad
ele
m
e
n
tar
y
ed
u
ca
tio
n
as
m
u
c
h
as
4
9
%.
Hea
lth
p
r
o
b
le
m
s
w
er
e
o
f
te
n
ex
p
er
ien
ce
d
b
y
th
e
m
aj
o
r
ity
o
f
r
esp
o
n
d
en
ts
ar
e
s
k
i
n
co
m
p
lai
n
ts
o
f
itc
h
i
n
g
an
d
d
iar
r
h
ea
as
m
u
c
h
a
s
2
8
.
6
%
o
f
r
esp
o
n
d
e
n
ts
to
th
e
n
at
u
r
e
o
f
t
h
e
d
is
ea
s
e
co
n
s
ta
n
tl
y
as
m
u
ch
as
9
5
.
9
%.
T
h
e
ef
f
o
r
t
s
tr
ea
t
m
en
t
o
f
t
h
e
m
aj
o
r
it
y
r
esp
o
n
d
en
ts
w
a
s
do
in
g
t
h
eir
o
w
n
tr
ea
t
m
e
n
t.
C
o
m
m
u
n
it
y
s
h
o
u
ld
n
o
t
b
e
allo
w
ed
if
t
h
e
s
y
m
p
to
m
s
h
a
v
e
ap
p
ea
r
e
d
alr
ea
d
y
.
W
e
r
ec
o
m
m
en
d
t
h
at
th
e
r
esp
o
n
d
en
t
s
h
o
u
ld
ch
ec
k
to
a
d
o
cto
r
th
eir
h
ea
lth
o
r
th
e
n
ea
r
est
h
ea
lth
ca
r
e.
L
o
w
ed
u
ca
tio
n
le
v
el
o
f
r
esp
o
n
d
en
ts
lead
to
a
lac
k
o
f
a
w
ar
e
n
es
s
o
r
in
itiat
iv
e
s
to
r
ep
o
r
t
h
ea
lth
co
m
p
lain
ts
to
h
ea
lth
s
er
v
ices.
T
h
u
s
,
t
h
e
co
m
m
u
n
it
y
d
ec
id
ed
t
o
tr
ea
t
th
e
m
s
elv
e
s
t
o
a
g
en
er
ic
d
r
u
g
w
it
h
d
o
s
e
n
o
t
f
it
ev
e
n
i
g
n
o
r
i
n
g
co
m
p
lai
n
ts
.
Ma
j
o
r
c
o
m
m
u
n
it
y
w
as
co
n
s
id
er
a
co
m
m
o
n
d
is
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20
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d
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r
[
2
2
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2
3
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.
T
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e
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in
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6
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w
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ter
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u
r
r
en
ce
o
f
s
p
o
n
ta
n
eo
u
s
ab
o
r
tio
n
an
d
n
er
v
o
u
s
s
y
s
te
m
d
a
m
ag
e
(
i
f
in
h
i
g
h
d
o
s
es)
[
2
3
-
2
5
]
.
A
r
s
e
n
ic
ca
n
b
e
ea
s
il
y
ab
s
o
r
b
ed
r
o
u
g
h
l
y
9
5
p
er
ce
n
t
i
f
it
s
w
allo
w
ed
.
A
r
s
en
ic
w
ill
d
is
tr
i
b
u
ted
an
d
s
to
r
ed
in
al
l ti
s
s
u
es
o
f
th
e
b
o
d
y
a
n
d
m
etab
o
lized
an
d
el
i
m
in
ated
th
r
o
u
g
h
t
w
o
s
eq
u
e
n
tial
p
r
o
ce
s
s
.
T
h
e
f
ir
s
t
w
as
th
e
o
x
id
atio
n
/
r
ed
u
ctio
n
w
er
e
ar
s
en
ate
i
n
to
ar
s
en
ite
a
n
d
ar
s
en
ite
i
n
to
ar
s
en
ate.
R
ed
u
ctio
n
o
f
ar
s
en
ate
(
A
s
V
)
to
ar
s
en
ite
(
As
I
I
I
)
r
eq
u
ir
ed
b
e
f
o
r
e
m
et
h
y
la
tio
n
o
cc
u
r
s
.
T
h
is
r
ea
ctio
n
r
eq
u
ir
es
g
l
u
tat
h
io
n
e
(
GSH)
.
Glu
tat
h
io
n
e
w
a
s
k
n
o
w
n
to
f
o
r
m
co
m
p
le
x
e
s
w
it
h
ar
s
en
ic
an
d
m
ed
iates
t
h
e
r
ed
u
ctio
n
o
f
ar
s
e
n
ate
i
n
to
ar
s
en
ite.
G
lu
ta
th
io
n
e
co
m
p
le
x
ca
n
b
e
eli
m
i
n
ated
i
n
t
h
e
b
ile
an
d
a
p
o
s
iti
v
e
co
r
r
elatio
n
h
as
b
ee
n
f
o
u
n
d
b
et
w
e
en
g
l
u
tat
h
io
n
e
an
d
ar
s
en
ic
i
n
th
e
b
ile
[
2
2
-
2
3
]
.
T
h
e
s
ec
o
n
d
s
ta
g
e
w
a
s
t
h
e
m
e
tilatio
n
,
w
h
ic
h
o
cc
u
r
s
m
ai
n
l
y
in
th
e
li
v
er
,
r
eq
u
ir
e
s
-
a
d
en
o
s
y
m
e
tio
n
i
n
(
SA
Me
)
an
d
p
o
s
s
ib
l
y
o
t
h
er
m
et
h
y
l
d
o
n
o
r
s
(
ch
o
li
n
e,
c
y
s
te
in
e,
g
l
u
tat
h
io
n
e,
lip
o
ic
ac
id
r
ed
u
ce
d
)
to
p
r
o
d
u
ce
m
o
n
o
m
etilar
s
e
n
ic
ac
id
(
MM
A
)
an
d
d
i
m
et
ilar
s
e
n
ic
ac
id
(
DM
A
)
.
B
o
th
MM
A
an
d
DM
A
ar
e
f
o
u
n
d
in
h
u
m
a
n
u
r
in
e
an
d
ar
e
e
x
p
ec
ted
as t
h
e
en
d
p
r
o
d
u
ct
o
f
t
h
e
m
etab
o
lis
m
o
f
ar
s
e
n
ic.
B
ec
au
s
e
DM
A
w
a
s
r
e
m
o
v
ed
f
r
o
m
t
h
e
ce
ll
f
aster
th
a
n
MM
A
o
r
in
o
r
g
an
ic
ar
s
en
ic,
a
n
d
ar
s
en
ic
m
et
h
y
latio
n
r
ed
u
ce
s
th
e
a
m
o
u
n
t
r
etain
ed
in
th
e
ti
s
s
u
es
b
y
th
e
in
cr
ea
s
ed
s
o
lu
b
ili
t
y
in
w
ater
ar
s
e
n
ite,
m
et
h
y
lati
o
n
w
as
co
n
s
id
er
ed
b
y
s
o
m
e
r
esear
ch
er
s
as
a
m
ec
h
a
n
i
s
m
d
eto
x
icatio
n
[
1
6
]
,
[
2
2
]
.
Sp
ec
iatio
n
s
tu
d
ies
o
f
h
u
m
a
n
e
x
p
o
s
u
r
e
to
ar
s
e
n
ic
i
n
th
e
u
r
in
e
i
n
d
icate
s
th
at
t
h
e
m
etab
o
lite
w
as
co
m
p
o
s
ed
o
f
1
0
-
1
5
%
in
o
r
g
an
ic
ar
s
en
ic
a
n
d
ac
id
m
o
n
o
m
et
h
y
lar
s
en
ic
a
n
d
m
o
s
t
(
6
0
-
8
0
%)
o
f
d
im
eti
lar
s
en
ic
ac
i
d
[
1
3
].
T
h
e
r
is
k
le
v
el
o
f
ca
r
ci
n
o
g
e
n
ic
an
d
n
o
n
-
ca
r
cin
o
g
en
ic
ca
u
s
ed
b
y
f
is
h
a
n
d
s
h
ell
f
i
s
h
co
n
s
u
m
p
t
io
n
co
n
tain
A
r
s
e
n
ic
s
h
o
w
i
n
g
s
ig
n
s
o
f
in
s
ec
u
r
i
t
y
s
o
t
h
e
y
w
er
e
n
ee
d
r
eq
u
ir
ed
r
is
k
m
a
n
a
g
e
m
e
n
t
.
R
is
k
m
a
n
a
g
e
m
e
n
t
w
a
s
d
o
n
e
in
an
ef
f
o
r
t
to
r
ed
u
ce
o
f
h
ea
lth
r
is
k
f
o
r
lo
ca
lly
a
n
d
s
y
s
te
m
icall
y
e
f
f
ec
t
.
T
h
er
e
ar
e
s
ev
er
al
w
a
y
s
to
r
ed
u
ce
lev
els
(
C
)
o
f
ar
s
e
n
ic
in
f
i
s
h
an
d
s
h
e
ll
f
is
h
,
s
u
c
h
u
s
r
ed
u
cin
g
t
h
e
in
tak
e
(
R
)
f
is
h
an
d
s
h
ell
f
i
s
h
r
ate,
r
ed
u
cin
g
th
e
f
r
eq
u
e
n
c
y
o
f
ar
s
e
n
ic
ex
p
o
s
u
r
e
(
FE)
an
d
r
ed
u
cin
g
th
e
d
u
r
atio
n
o
f
ar
s
e
n
ic
ex
p
o
s
u
r
e
(
Dt)
.
4.
CO
NCLU
SI
O
N
T
h
e
h
i
g
h
er
m
ea
n
lev
el
s
o
f
A
r
s
en
ic
(
A
s
)
i
n
f
is
h
a
n
d
s
h
ell
f
i
s
h
co
n
s
u
m
ed
b
y
co
m
m
u
n
itie
s
w
er
e
f
o
u
n
d
in
Un
t
ia
th
a
n
Kalu
k
u
B
o
d
o
a
c
o
astal
ar
ea
s
.
C
ar
cin
o
g
e
n
ic
r
is
k
lev
el
v
a
lu
e
w
as
m
o
r
e
th
a
n
ex
p
o
n
en
t
4
(
E
C
R
>
E
-
4
)
an
d
n
o
n
-
car
ci
n
o
g
e
n
ic
r
i
s
k
m
o
r
e
th
a
n
1
(
R
Q
>
1
)
at
all
s
t
u
d
y
s
ites
.
I
t
ca
n
b
e
co
n
c
lu
d
ed
th
at
f
i
s
h
an
d
s
h
ell
f
i
s
h
w
er
e
n
o
t
s
af
e
f
o
r
co
n
s
u
m
p
tio
n
an
d
i
m
p
ac
t
h
e
alth
p
r
o
b
le
m
s
th
at
ar
e
n
o
n
-
ca
r
cin
o
g
e
n
ic
ev
e
n
c
ar
cin
o
g
e
n
ic.
R
i
s
k
m
a
n
a
g
e
m
en
t
n
ee
d
to
b
e
co
n
tr
o
l
it.
W
e
r
ec
o
m
m
e
n
d
ed
th
at
p
eo
p
le,
esp
ec
iall
y
co
m
m
u
n
it
y
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As ex
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f
E
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d
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u
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u
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ti
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t
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m
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Sta
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d
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izatio
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Ma
r
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s
R
esear
c
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C
en
ter
f
o
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o
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T
ec
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n
o
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n
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o
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m
en
tal
Ag
e
n
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o
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Ma
k
as
s
ar
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e
g
io
n
s
,
an
d
t
h
e
D
i
s
tr
ict
Hea
lt
h
O
f
f
ice
o
f
Ma
k
as
s
ar
,
I
n
d
o
n
esia
f
o
r
t
h
eir
s
u
p
p
o
r
tin
g
a
n
d
ass
i
s
ta
n
ce
d
u
r
in
g
d
ata
co
llectio
n
an
d
an
a
l
y
s
i
s
.
RE
F
E
R
E
NC
E
S
[1
]
W
.
W
id
o
wa
ti
,
e
t
a
l.
,
“
T
h
e
E
f
fe
c
t
s
o
f
T
o
x
i
c
M
e
tals:
P
o
ll
u
t
io
n
P
re
v
e
n
ti
o
n
a
n
d
Co
n
tro
l
,”
Yo
g
y
a
k
a
rt
a
,
A
n
d
i
Off
s
e
t;
200
8
.
[2
]
Ro
m
p
a
s
,
“
T
o
x
i
c
o
lo
g
y
M
a
rin
e
:
M
a
rin
e
Bo
a
rd
S
e
c
re
taria
t
,”
Eas
t
Ja
k
a
rta
,
W
a
lau
Be
n
k
u
len
,
2
0
1
0
.
[3
]
Bh
u
p
a
n
d
e
r
P
.
a
n
d
M
u
k
h
e
rjee
D.
P
.
,
“
A
ss
e
ss
m
e
n
t
o
f
Hu
m
a
n
He
a
lt
h
Risk
f
o
r
A
rse
n
ic,
Co
p
p
e
r,
Nic
k
e
l,
M
e
rc
u
ry
a
n
d
Zi
n
c
in
F
ish
C
o
ll
e
c
ted
f
ro
m
T
r
o
p
ica
l
W
e
tl
a
n
d
s
in
In
d
ia
,
”
Ad
v
L
if
e
S
c
i
T
e
c
h
n
o
l
,
v
o
l.
2
,
2
0
1
1
.
Av
a
il
a
b
le
f
ro
m
:
h
tt
p
:
//
ww
w
.
i
i
ste
.
o
rg
/Jo
u
rn
a
ls/i
n
d
e
x
.
p
h
p
/A
L
S
T
/
a
rti
c
le/v
ie
w
F
il
e
/9
6
1
/8
8
2
.
[4
]
F
o
o
d
a
n
d
Dr
u
g
A
d
m
in
istratio
n
o
f
In
d
o
n
e
si
a
Re
g
u
lati
o
n
s
,
“
De
ter
m
in
a
ti
o
n
L
im
it
o
f
M
icro
b
ial
Co
n
tam
in
a
ti
o
n
a
n
d
Ch
e
m
ic
a
ls
i
n
F
o
o
d
,”
2
0
0
9
.
No
.
H
K.0
0
.
0
6
.
1
.
5
2
.
4
0
1
1
.
[5
]
A
.
Da
u
d
,
e
t
a
l.
,
“
Risk
M
a
n
a
g
e
m
e
n
t
o
f
Ca
d
m
iu
m
(
Cd
),
d
u
e
t
o
L
e
io
g
n
a
to
h
u
s
sp
.,
Po
rt
u
n
u
s
Pela
g
icu
s
,
An
a
d
a
r
a
sp
.
,
d
a
n
Pen
a
e
u
s,
sp
.
,
Co
n
su
m
p
ti
o
n
Am
o
n
g
Co
m
m
u
n
it
y
in
Tallo
S
u
b
d
i
stric
t
,
M
a
k
a
ss
a
r,
In
d
o
n
e
sia
,
”
In
te
rr
n
a
ti
o
n
a
l
J
S
c
i
Res
Pu
b
l
.
,
v
o
l/
issu
e
:
3
(
1
1
)
,
2
0
1
3
.
[6
]
Da
u
d
A
.
,
“
M
a
teria
l
P
o
l
lu
tan
ts
A
r
se
n
ic
in
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o
d
a
n
d
Urin
e
a
s
a
Hy
p
e
r
k
e
ra
to
sis
Bio
m
a
rk
e
rs
a
t
Bu
y
a
t
Co
m
m
u
n
it
y
,”
M
a
k
a
ss
a
r
,
Un
iv
e
rsit
y
o
f
Ha
s
a
n
u
d
d
in
,
2
0
0
9
.
[7
]
Da
u
d
A
.
,
“
He
a
v
y
M
e
tal
T
o
x
ico
lo
g
y
o
f
A
rse
n
ic
in
En
v
iro
n
m
e
n
tal
Risk
He
a
lt
h
A
n
a
l
y
z
e
P
e
rsp
e
c
ti
v
e
s
,”
M
a
k
a
ss
a
r
,
Un
iv
e
rsit
y
o
f
Ha
s
a
n
u
d
d
in
,
2
0
1
4
.
[8
]
IRI
S
,
“
A
rse
n
ic In
o
rg
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n
ic
,
”
2
0
1
0
.
Av
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il
a
b
le f
ro
m
:
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tt
p
:/
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ww
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.
g
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v
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r
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s/su
b
st/
0
2
7
8
.
h
tm
.
[9
]
S
o
u
t
h
S
u
law
e
si
P
ro
v
in
c
ial
G
o
v
e
r
n
m
e
n
t
,
“
Qu
a
li
t
y
S
tan
d
a
rd
s
a
n
d
En
v
iro
n
m
e
n
tal
Da
m
a
g
e
Crit
e
r
ia
,”
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h
e
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o
u
t
h
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u
law
e
s
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G
o
v
e
rn
o
r
S
tan
d
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r
d
Re
g
u
latio
n
s
No
.
6
9
.
S
o
u
th
S
u
law
e
s
i
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ro
v
in
c
ial
G
o
v
e
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n
m
e
n
t
,
2
0
1
0
.
[1
0
]
T
h
e
Ce
n
ter
f
o
r
He
a
lt
h
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n
d
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c
u
p
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ti
o
n
a
l
S
a
f
e
t
y
o
f
M
a
k
a
ss
a
r
,
“
M
a
rin
e
W
a
ter
Qu
a
li
ty
In
sp
e
c
ti
o
n
f
o
r
M
a
k
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ss
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r
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p
o
rt
,”
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h
e
Ce
n
ter f
o
r
He
a
lt
h
a
n
d
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c
u
p
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t
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l
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f
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a
k
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s
sa
r
,
2
0
1
2
.
[1
1
]
Da
r
m
o
n
o
,
“
En
v
iro
n
m
e
n
t
a
n
d
P
o
ll
u
ti
o
n
:
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ts
Re
latio
n
to
T
o
x
ico
lo
g
ic
a
l
o
f
M
e
tal
Co
m
p
o
u
n
d
s
,”
Ja
k
a
rta
,
Un
iv
e
rsit
y
o
f
In
d
o
n
e
sia
P
re
ss
,
2
0
1
0
.
[1
2
]
T
a
h
ir
A
.
,
“
Eco
to
x
ico
lo
g
y
in
th
e
He
a
lt
h
P
e
rsp
e
c
ti
v
e
o
f
M
a
rin
e
Eco
s
y
ste
m
s
,”
Ba
n
d
u
n
g
,
Ka
ry
a
P
u
tra D
a
rwa
ti
,
2
0
1
2
.
[1
3
]
P.
Bh
a
tt
a
c
h
a
ry
a
,
e
t
a
l
.,
“
A
rse
n
ic i
n
th
e
e
n
v
iro
n
m
e
n
t
:
Bio
lo
g
y
a
n
d
Ch
e
m
i
str
y
,
”
S
c
i
T
o
ta
l
En
v
iro
n
,
v
o
l.
3
7
9
,
p
p
.
1
0
9
–
1
2
0
.
[1
4
]
Ju
n
a
id
i
I.
,
“
Ca
n
c
e
r
,”
Ja
k
a
rta
,
Bh
u
a
n
a
P
o
p
u
lar S
c
ien
c
e
,
2
0
0
7
.
[1
5
]
C.
Un
e
y
a
m
a
,
e
t
a
l.
,
“
A
rse
n
ic i
n
Va
rio
u
s F
o
o
d
s: Cu
m
u
lativ
e
Da
ta
,
”
Fo
o
d
A
d
d
it
Co
n
ta
m
,
v
o
l.
24
,
p
p
.
447
–
5
3
4
,
2
0
0
7
.
[1
6
]
P
.
A
.
S
in
g
h
,
et
a
l
.
,
“
M
e
c
h
a
n
i
s
m
P
e
rtain
in
g
t
o
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rse
n
ic T
o
x
icit
y
,
”
2
0
1
1
.
[1
7
]
Ra
h
m
a
n
A
.
,
“
In
stru
c
ti
o
n
a
l
o
f
He
a
lt
h
Risk
A
n
a
l
y
z
e
M
a
teria
ls
T
r
a
in
in
g
,”
In
ten
siv
e
Ba
sic
L
e
v
e
l
P
ro
g
ra
m
m
e
,
De
p
o
k
,
2
0
0
7
.
[1
8
]
T
h
e
In
d
o
n
e
sia
n
Na
ti
o
n
a
l
S
tan
d
a
r
d
,
“
L
im
it
f
o
r
He
a
v
y
M
e
tal
Co
n
tam
in
a
ti
o
n
in
F
o
o
d
,”
T
h
e
Na
ti
o
n
a
l
S
tan
d
a
rd
iza
ti
o
n
Ag
e
n
c
y
,
2009.
[1
9
]
P
e
ters
e
n
J
.
a
n
d
Ch
riste
n
se
n
B
.
T
.
,
“
Eco
to
x
ico
lo
g
ica
l
E
v
a
lu
a
ti
o
n
o
f
A
s,
Cd
,
Cr,
P
b
,
Hg
a
n
d
Ni
A
p
p
li
e
d
w
it
h
F
e
rti
l
i
se
rs i
n
De
n
m
a
rk
,
”
In
tern
a
l
re
p
o
rt
n
r
DJ
F
Ra
p
p
o
rt
M
a
rk
b
ru
g
,
p
p
.
9
8
,
2
0
0
9
.
[2
0
]
A
.
M
a
ll
o
n
g
i
a
n
d
A
.
L
.
Ra
n
teta
m
p
a
n
g
,
“
Risk
s
A
ss
e
ss
m
e
n
t
o
f
C
a
d
m
iu
m
t
h
ro
u
g
h
A
q
u
a
ti
c
Bio
ta
Co
n
su
m
p
ti
o
n
f
ro
m
S
e
n
tan
i
L
a
k
e
i
n
P
a
p
u
a
,
In
d
o
n
e
sia
,
”
In
t
J
E
n
g
Res
T
e
c
h
n
o
l
,
v
o
l/
issu
e
:
2
(6
)
,
p
p
.
2
4
9
2
–
2
5
0
0
,
2
0
1
3
.
[2
1
]
T
h
e
G
e
n
e
ra
l
Dire
c
to
ra
te
o
f
En
v
iro
n
m
e
n
tal
He
a
lt
h
a
n
d
Co
n
tr
o
l
Dise
a
se
s
,
“
G
u
id
e
li
n
e
s
f
o
r
En
v
iro
n
m
e
n
tal
He
a
lt
h
Risk
A
n
a
l
y
sis
,
”
Ja
k
a
rta
,
M
in
istry
o
f
He
a
lt
h,
2
0
1
2
.
[2
2
]
“
Ca
se
S
tu
d
ies
i
n
E
n
v
iro
n
m
e
n
tal
M
e
d
icin
e
:
A
rse
n
ic
T
o
x
i
c
it
y
,”
Ag
e
n
c
y
f
o
r
T
o
x
ic
S
u
b
sta
n
c
e
s
a
n
d
D
i
se
a
se
Re
g
is
tr
y
.
Av
a
il
a
b
le f
ro
m
:
h
tt
p
:/
/w
ww
.
a
tsd
r.
c
d
c
.
g
o
v
/cs
e
m
/ar
se
n
ic/d
o
c
s/a
rse
n
ic.p
d
f
.
[2
3
]
V
.
M
u
d
g
a
l,
e
t
a
l
.
,
“
Ef
f
e
c
t
o
f
T
o
x
i
c
M
e
tals o
n
H
u
m
a
n
He
a
lt
h
,
”
Op
e
n
Nu
tr
a
c
e
u
ti
c
a
ls
J
.
,
v
o
l.
3
,
p
p
.
94
–
9
9
,
2
0
1
0
.
[2
4
]
C.
Vie
ira,
e
t
a
l.
,
“
M
e
rc
u
ry
,
Ca
d
m
iu
m
,
L
e
a
d
a
n
d
A
rse
n
ic
L
e
v
e
ls
i
n
T
h
re
e
P
e
lag
ic
F
ish
S
p
e
c
ies
f
ro
m
t
h
e
A
tl
a
n
ti
c
Oc
e
a
n
:
In
tra
-
a
n
d
In
ter
-
S
p
e
c
if
ic
V
a
riab
il
i
ty
a
n
d
Hu
m
a
n
He
a
lt
h
Risk
s
F
o
r
Co
n
su
m
p
ti
o
n
,
”
Fo
o
d
Ch
e
m
T
o
x
ico
l
.
,
v
o
l.
49
,
p
p
.
9
2
3
–
9
32
,
2
0
1
1
.
[2
5
]
Kr
i
sh
n
a
P
.
V
.
,
e
t
a
l.
,
“
Hu
m
a
n
H
e
a
lt
h
Risk
A
s
se
ss
m
e
n
t
o
f
H
e
a
v
y
M
e
tal
A
c
c
u
m
u
latio
n
t
h
r
o
u
g
h
F
is
h
Co
n
su
m
p
ti
o
n
,
f
ro
m
M
a
c
h
il
ip
a
tn
a
m
Co
a
st,
A
n
d
h
ra
P
ra
d
e
sh
,
I
n
d
ia
,
”
In
t
Res
J
Pu
b
li
c
En
v
iro
n
He
a
l
,
v
o
l/
issu
e
:
1
(
5
)
,
p
p
.
1
2
1
–
1
2
5
,
2
0
1
4
.
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