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Dec
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[
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.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8806
I
J
P
HS
Vo
l.
5
,
No
.
4
,
Dec
em
b
er
20
1
6
:
367
–
3
7
4
368
C
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p
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m
b
i
n
atio
n
w
it
h
o
r
w
it
h
o
u
t
co
n
v
en
t
io
n
al
m
ed
ical
tr
e
at
m
e
n
t
f
o
r
ch
r
o
n
ic
d
is
ea
s
es
[
7
]
.
T
r
ea
tm
en
t
f
o
r
d
iab
etes
as
a
ch
r
o
n
ic
d
is
ea
s
e
is
co
n
ti
n
o
u
s
l
y
co
n
d
u
c
ted
,
m
ai
n
l
y
b
y
m
ai
n
tai
n
i
n
g
g
lu
co
s
e
le
v
els
w
it
h
i
n
n
o
r
m
a
l
to
ler
an
ce
.
A
lt
h
o
u
g
h
th
er
e
is
co
n
v
en
t
io
n
al
t
h
er
ap
y
s
o
m
e
ti
m
e
s
it
s
till
ca
u
s
es
co
m
p
l
i
ca
tio
n
s
.
T
h
er
ef
o
r
e,
m
ed
icin
e
d
ev
e
lo
p
m
en
t
is
c
o
n
tin
u
o
s
l
y
co
n
d
u
cted
i.e
b
y
u
s
i
n
g
h
er
b
al
m
e
d
icin
e
a
s
an
alter
n
ati
v
e
o
r
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e.
C
A
M
th
at
i
s
w
id
el
y
u
s
ed
b
y
d
ia
b
etes
p
atien
t
s
ar
e
h
er
b
al,
v
ita
m
i
n
,
an
d
p
r
a
y
er
.
I
n
th
e
US,
C
A
M
t
h
at
m
o
s
t
w
id
el
y
u
s
ed
b
y
p
atien
ts
w
i
th
d
i
ab
etes
w
er
e
h
er
b
al,
s
u
p
p
le
m
en
ts
(
v
ita
m
i
n
s
a
n
d
m
i
n
er
als),
m
i
n
d
b
o
d
y
t
h
e
r
ap
ies [
8
]
.
Hea
lth
-
s
ee
k
i
n
g
b
e
h
av
io
u
r
as
in
d
icate
d
b
y
d
iab
etes
p
atie
n
t
w
as
a
h
ier
ar
ch
y
t
h
at
s
ta
r
ted
f
r
o
m
s
elf
-
tr
ea
t
m
e
n
t,
t
h
en
lead
to
m
ed
ical
tr
ea
t
m
e
n
t
o
r
co
n
v
en
tio
n
al
m
ed
icin
e.
So
u
r
ce
s
o
f
tr
ea
t
m
en
t
i
n
clu
d
e
th
r
e
e
in
ter
r
elate
d
s
ec
to
r
s
,
f
a
m
il
y
/
s
elf
-
tr
ea
t
m
en
t,
co
n
v
e
n
tio
n
al
tr
e
at
m
e
n
t,
an
d
p
r
o
f
ess
io
n
al
m
ed
i
ca
l
tr
ea
t
m
en
t.
T
h
e
s
elec
ted
tr
ea
t
m
e
n
t
ca
n
b
e
co
m
b
in
i
n
g
u
tili
ze
d
,
li
k
e
m
ed
ica
l
an
d
co
n
v
en
t
io
n
al
tr
ea
t
m
e
n
t
[
9
]
.
A
cc
o
r
d
in
g
to
Kr
o
eg
er
(
1
9
8
3
)
h
ea
lth
-
s
ee
k
i
n
g
b
eh
av
io
u
r
w
as
k
n
o
w
n
a
s
a
h
ea
ler
s
h
o
p
p
in
g
w
h
ich
w
i
ll
b
e
u
tili
ze
d
b
y
p
atien
t
s
to
d
ea
l
w
it
h
co
m
p
lai
n
t
s
o
f
il
l
n
es
s
.
Hea
lt
h
-
s
ee
k
in
g
b
eh
a
v
io
u
r
w
as
i
n
f
l
u
en
ce
d
b
y
m
a
n
y
t
h
in
g
s
,
o
n
e
o
f
w
h
ic
h
w
a
s
t
h
e
s
tatu
s
o
f
t
h
e
p
atie
n
ts
’
d
is
ea
s
e:
ac
u
te
o
r
c
h
r
o
n
ic.
P
ati
en
ts
w
it
h
c
h
r
o
n
ic
d
i
s
ea
s
es
te
n
d
to
s
ee
k
tr
ea
t
m
e
n
t
m
o
r
e
t
h
a
n
o
n
e
[
10
-
1
1
]
.
T
h
er
e
w
a
s
a
ten
d
en
c
y
th
at
e
m
er
g
ed
ar
o
u
n
d
t
h
e
w
o
r
ld
f
o
r
DM
T
2
p
atien
ts
to
u
s
e
o
r
s
elec
t
C
A
M
i
n
o
r
d
er
to
in
cr
ea
s
e
th
eir
h
ea
lt
h
s
tat
u
s
.
T
h
e
p
r
ev
alen
ce
o
f
C
A
M
u
s
ed
in
t
h
e
US
s
h
o
wed
co
n
s
is
te
n
t
h
i
g
h
p
er
ce
n
tag
e
at
7
2
.
8
%
in
2
0
0
6
an
d
8
6
.
6
%
in
2
0
1
0
[
1
2
-
1
3
]
.
L
i
k
e
w
i
s
e
in
Ma
la
y
s
ia,
t
h
e
p
r
ev
alen
ce
o
f
DM
p
atien
ts
w
h
o
u
s
ed
C
A
M
i
n
2
0
1
1
w
a
s
4
9
.
6
0
%,
an
d
an
in
cr
ea
s
ed
to
6
2
.
5
0
% in
2
0
1
3
[
1
4
-
1
5
]
.
C
o
m
p
le
m
en
tar
y
a
n
d
A
l
ter
n
ati
v
e
Me
d
ici
n
e
i
n
I
n
d
o
n
esia
h
a
s
b
ee
n
r
eg
u
lated
in
t
h
e
Hea
lt
h
Min
i
s
ter
R
eg
u
latio
n
o
f
I
n
d
o
n
esia
R
ep
u
b
lic,
Nu
m
b
er
1
1
0
9
/
ME
N
KE
S
/
P
E
R
/
IX
/
2
0
0
7
o
n
I
m
p
le
m
e
n
tatio
n
o
f
C
o
m
p
le
m
en
tar
y
a
n
d
A
l
ter
n
at
iv
e
Me
d
icin
e
i
n
Hea
l
th
C
ar
e
Facilities
.
C
o
m
p
le
m
e
n
tar
y
m
ed
icin
e
to
d
a
y
h
a
s
b
ee
n
ap
p
lied
to
th
e
h
ea
lth
s
er
v
ices
in
S
u
r
ab
a
y
a
w
h
ich
a
lr
ea
d
y
h
av
e
tr
ad
itio
n
al
m
ed
i
cin
e
s
er
v
ice
s
at
2
0
co
m
m
u
n
it
y
h
ea
lt
h
ce
n
ter
s
in
Su
r
ab
a
y
a
an
d
R
e
g
io
n
a
l
P
u
b
lic
Hea
lth
d
r
.
So
eto
m
o
Su
r
ab
a
y
a.
A
cc
o
r
d
in
g
to
d
r
.
E
s
ti
Ma
r
tia
n
a
(
2
0
1
1
)
,
p
eo
p
le
w
h
o
to
o
k
m
ed
ical
tr
ea
t
m
e
n
t
in
co
m
m
u
n
it
y
h
ea
lt
h
ce
n
ter
s
w
o
u
ld
h
a
v
e
t
w
o
tr
ea
t
m
e
n
t
o
p
tio
n
s
.
T
h
e
s
elec
ti
o
n
co
u
ld
b
e
a
m
ed
ici
n
e
f
r
o
m
th
e
d
o
cto
r
o
r
tr
ad
itio
n
al
m
e
d
icin
e.
T
r
ad
itio
n
al
m
ed
icin
e
s
er
v
ices
in
t
h
e
co
m
m
u
n
it
y
h
ea
lt
h
ce
n
ter
s
in
S
u
r
ab
a
y
a
i
n
cl
u
d
ed
ac
u
p
u
n
ct
u
r
e,
ac
u
p
r
ess
u
r
e,
b
ab
y
m
as
s
ag
e,
as
w
e
ll a
s
h
er
b
al
co
n
s
u
lta
tio
n
.
R
eg
io
n
al
P
u
b
lic
Hea
lt
h
Dr
.
So
eto
m
o
S
u
r
ab
a
y
a
also
p
r
o
v
i
d
ed
tr
ad
itio
n
al
m
ed
ici
n
e
s
er
v
ices
i
n
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
ic
in
e
P
o
ly
c
lin
ic
(
P
o
lik
lin
i
k
Ob
at
T
r
a
d
is
io
n
al
I
n
d
o
n
esia
=
OT
I
)
,
w
h
ic
h
ai
m
ed
to
m
ee
t
t
h
e
n
ee
d
s
o
f
p
u
b
lic
h
e
alth
s
er
v
ices.
Hea
lt
h
s
er
v
ice
s
co
n
s
i
s
ted
o
f
h
er
b
al
th
er
ap
y
,
ac
u
p
u
n
ct
u
r
e
a
n
d
m
as
s
ag
e
ar
o
m
at
h
er
ap
y
.
I
t
w
a
s
s
i
m
ilar
w
i
th
o
th
er
co
n
v
e
n
ti
o
n
al
p
o
l
y
cli
n
ics,
I
n
d
o
n
esia
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
cli
n
ic
al
s
o
d
eliv
er
i
n
g
le
v
els
o
f
s
er
v
ices
in
c
lu
d
i
n
g
p
r
o
m
o
ti
v
e,
p
r
ev
e
n
ti
v
e,
cu
r
at
iv
e
,
r
eh
ab
ilit
ati
v
e
an
d
p
alliativ
e.
DM
T
2
p
atien
ts
also
u
tili
ze
d
tr
ad
itio
n
al
h
e
al
th
s
er
v
ices
at
I
n
d
o
n
es
ian
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
cli
n
ic.
I
n
2
0
1
4
th
e
n
u
m
b
e
r
o
f
DM
T
2
p
atien
ts
w
h
o
v
is
it
ed
to
I
n
d
o
n
esian
T
r
ad
itio
n
al
Me
d
icin
e
P
o
l
y
cli
n
ic
r
ea
ch
ed
5
0
p
e
o
p
le.
T
h
e
p
u
r
p
o
s
e
o
f
th
i
s
s
tu
d
y
w
as
to
ex
p
lo
r
e
in
d
ep
th
ab
o
u
t
t
h
e
r
esp
o
n
s
es
o
f
DM
p
atie
n
t
s
w
h
o
v
is
ited
to
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
i
cin
e
P
o
ly
cl
in
ic
i
n
R
e
g
io
n
al
P
u
b
lic
Hea
lth
Dr
.
So
eto
m
o
Su
r
ab
a
y
a
i
n
u
s
i
n
g
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e.
T
h
e
b
eh
av
io
u
r
o
f
co
m
p
le
m
e
n
ta
r
y
m
ed
ici
n
e
u
s
a
g
e
e
x
p
lo
r
ed
in
to
f
i
v
e
t
h
e
m
e
s
,
n
a
m
e
l
y
:
p
s
y
ch
o
lo
g
ical
r
esp
o
n
s
es
a
f
ter
d
ia
g
n
o
s
ed
DM
,
o
p
in
io
n
s
ab
o
u
t
t
h
e
d
is
ea
s
e,
co
m
p
l
e
m
en
tar
y
m
ed
ici
n
e
u
s
a
g
e
p
atter
n
s
,
t
h
e
r
ea
s
o
n
f
o
r
u
s
i
n
g
co
m
p
le
m
en
tar
y
m
ed
ici
n
e,
an
d
th
e
r
esp
o
n
s
e
to
th
e
tr
ea
t
m
en
t.
2.
RE
S
E
ARCH
M
E
T
H
O
D
T
h
is
s
tu
d
y
u
s
ed
q
u
alitati
v
e
d
esig
n
w
it
h
p
h
e
n
o
m
e
n
o
lo
g
ical
m
et
h
o
d
ap
p
r
o
ac
h
,
w
it
h
t
h
e
f
o
cu
s
o
n
D
M
p
atien
ts
w
h
o
u
s
e
co
m
p
le
m
en
tar
y
m
ed
ici
n
e.
Nin
e
p
ar
ticip
an
ts
w
er
e
s
elec
ted
b
ased
o
n
p
u
r
p
o
s
iv
e
s
a
m
p
lin
g
w
it
h
t
h
e
cr
iter
ia
u
s
i
n
g
co
m
p
le
m
en
tar
y
m
ed
icin
e
at
least
3
m
o
n
th
s
,
s
u
f
f
er
ed
f
r
o
m
DM
f
o
r
m
o
r
e
t
h
an
o
n
e
y
ea
r
,
an
d
th
e
p
atien
t
’
s
ag
e
r
an
g
ed
b
et
w
ee
n
3
0
-
6
5
y
ea
r
s
o
ld
.
T
h
is
s
t
u
d
y
w
as
co
n
d
u
cted
at
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
cl
in
ic
i
n
R
e
g
io
n
al
P
u
b
lic
Hea
lth
d
r
.
So
eto
m
o
Su
r
ab
a
y
a
in
Au
g
u
s
t
an
d
O
cto
b
er
2
0
1
5
.
Data
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
P
HS
I
SS
N:
2252
-
8806
R
esp
o
n
s
es o
f D
ia
b
etes Mellitu
s
P
a
tien
ts
W
h
o
Used
C
o
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leme
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Med
icin
e
(
A
n
ita
Jo
elia
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tin
a
)
369
co
llectio
n
e
m
p
lo
y
ed
in
d
ep
th
i
n
ter
v
ie
w
a
n
d
f
ie
ld
n
o
te.
All
p
ar
ticip
an
ts
h
ad
p
r
eli
m
in
ar
y
ex
p
lan
atio
n
ab
o
u
t
t
h
e
s
tu
d
y
,
t
h
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a
n
d
t
h
e
r
ig
h
ts
o
f
p
ar
ticip
an
ts
b
y
s
i
g
n
in
g
i
n
f
o
r
m
co
n
s
e
n
t.
Data
an
a
l
y
s
i
s
u
s
ed
t
h
e
m
atic
co
n
ten
t
a
n
al
y
s
is
.
T
h
is
s
t
u
d
y
h
ad
th
r
o
u
g
h
et
h
ic
s
tes
t
b
y
et
h
ic
s
s
t
u
d
y
co
m
m
itte
e
s
o
f
R
e
g
io
n
al
P
u
b
lic
Hea
lt
h
d
r
.
So
eto
m
o
Su
r
ab
a
y
a
a
s
n
o
ted
N
u
m
b
er
4
4
9
/
P
an
k
e.
KKE
/
IX
/
2015.
Valid
atio
n
w
as
d
ata
u
s
in
g
co
m
m
u
n
icati
v
e
v
a
lid
it
y
to
co
n
f
i
r
m
th
e
d
ata
th
at
h
as
b
ee
n
o
b
tain
ed
,
an
d
d
escr
ip
tio
n
s
to
th
e
r
e
s
ea
r
ch
s
u
b
j
ec
ts
.
A
n
o
t
h
er
v
alid
atio
n
is
d
o
n
e
b
y
tr
ian
g
u
latio
n
tech
n
iq
u
e
s
th
r
o
u
g
h
a
f
a
m
i
l
y
m
e
m
b
er
o
f
a
p
ar
ticip
an
t
(
h
u
s
b
an
d
o
r
ch
ild
)
,
th
e
ex
p
er
ie
n
c
e
o
f
r
esear
ch
er
s
i
n
t
h
e
f
ield
o
f
m
ed
ical
s
u
r
g
ical
n
u
r
s
in
g
a
n
d
T
r
an
s
cu
lt
u
r
al
n
u
r
s
in
g
,
esp
ec
iall
y
i
n
h
ea
lt
h
ca
r
e
p
atien
t
s
w
it
h
d
iab
etes
m
el
lit
u
s
,
an
d
ass
o
ciate
w
it
h
liter
atu
r
e
r
ev
ie
w
.
3.
RE
SU
L
T
S
A
ND
AN
AL
Y
SI
S
T
h
is
s
t
u
d
y
d
id
n
o
t
e
x
p
lain
ab
o
u
t
t
h
e
r
ea
s
o
n
o
f
w
h
y
p
ar
tici
p
an
ts
s
elec
t
to
g
et
m
ed
ical
tr
ea
t
m
e
n
t
i
n
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
l
y
cli
n
ic,
b
u
t
m
o
r
e
e
m
p
h
asized
o
n
th
e
r
ea
s
o
n
o
f
w
h
y
p
ar
ticip
an
ts
u
s
ed
t
h
e
co
m
p
le
m
e
n
tar
y
m
ed
icin
e.
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
cl
in
ic
w
as
o
n
l
y
u
s
ed
as
to
o
l
to
d
eter
m
i
n
e
p
ar
ticip
an
ts
w
h
o
w
er
e
u
s
i
n
g
o
r
s
elec
ti
n
g
h
er
b
al
m
ed
icin
e,
b
o
th
r
ec
o
m
m
en
d
ed
b
y
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
l
y
cli
n
ic
an
d
al
s
o
o
u
ts
id
e
I
n
d
o
n
e
s
ian
T
r
ad
itio
n
al
Me
d
ici
n
e
P
o
ly
cl
in
ic.
Her
b
al
m
ed
icin
e
s
r
ec
o
m
m
e
n
d
ed
b
y
I
n
d
o
n
es
ian
T
r
a
d
itio
n
al
Me
d
icin
e
P
o
ly
cli
n
ic
w
er
e
p
an
icu
la
ta
ca
p
s
u
le,
b
a
y
lea
f
ca
p
s
u
le,
th
e
co
m
b
i
n
atio
n
o
f
b
o
th
an
d
al
tili
s
lea
f
ca
p
s
u
le.
Her
b
al
m
ed
icin
e
u
s
ed
b
y
p
ar
ticip
an
ts
w
h
o
w
er
e
n
o
t
v
is
ited
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
l
y
cli
n
ic
w
er
e
b
a
y
lea
f
,
ci
n
n
a
m
o
n
,
p
a
n
ic
u
lata,
T
F
s
u
p
p
l
e
m
en
ts
,
a
n
d
r
u
ellia
tu
b
er
o
s
a
leaf
.
T
h
e
n
u
m
b
er
o
f
p
ar
ticip
an
t
i
n
th
i
s
s
t
u
d
y
w
er
e
9
p
eo
p
le,
w
h
er
e
3
p
eo
p
le
u
n
d
er
g
o
i
n
g
tr
e
at
m
e
n
t
i
n
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
ic
in
e
P
o
ly
c
lin
ic
an
d
w
h
i
le
6
p
e
o
p
le
r
em
ai
n
in
g
h
ad
ex
p
er
ien
c
e
in
tak
i
n
g
m
ed
ica
l
tr
ea
t
m
e
n
t
in
t
h
e
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
l
y
clin
ic
in
2
0
1
6
.
A
ll
p
ar
ticip
an
ts
ac
k
n
o
w
led
g
ed
th
a
t
th
e
y
w
er
e
s
u
f
f
er
ed
f
r
o
m
d
iab
etes
f
r
o
m
t
h
e
d
o
cto
r
’
s
d
ia
g
n
o
s
ed
.
Fi
v
e
p
ar
ticip
an
t
s
s
tated
th
a
t
t
h
e
y
v
is
i
ted
d
o
cto
r
f
o
r
a
h
ea
lt
h
ch
ec
k
d
u
e
to
s
o
m
e
h
ea
lth
co
m
p
lai
n
t
s
h
a
n
d
n
u
m
b
n
ess
,
li
m
p
,
t
h
i
n
,
h
a
v
e
f
r
eq
u
en
t
u
r
in
ate,
a
n
d
s
leep
y
.
On
e
p
ar
ticip
an
t d
elib
er
atel
y
c
h
ec
k
ed
o
u
t b
ec
a
u
s
e
o
f
t
h
e
p
o
s
s
ib
ilit
y
s
u
f
f
er
in
g
f
r
o
m
d
iab
etes d
u
e
to
i
n
h
er
ita
n
ce
.
T
h
r
ee
p
ar
ticip
an
ts
d
iag
n
o
s
ed
d
iab
etes
b
y
d
o
cto
r
d
u
r
in
g
h
ea
lt
h
co
n
tr
o
l
f
o
r
o
th
er
d
is
e
ases
(
h
y
p
er
ten
s
io
n
,
ch
o
lest
er
o
l)
an
d
r
es
u
lt
o
f
lab
o
r
ato
r
y
’
s
b
lo
o
d
ch
ec
k
i
n
g
d
u
r
in
g
tr
ea
t
m
en
t
i
n
h
ea
lth
f
ac
i
liti
es
w
h
ic
h
i
n
d
icate
a
n
in
cr
ea
s
e
i
n
g
l
u
co
s
e.
C
h
ar
ac
ter
is
tics
o
f
p
ar
ticip
an
t
s
s
h
o
w
ed
i
n
t
h
is
s
t
u
d
y
d
i
v
i
d
ed
in
to
in
d
iv
id
u
al
c
h
ar
ac
ter
is
tics
a
n
d
d
is
ea
s
e
ch
ar
ac
ter
is
t
ics.
T
h
e
in
d
iv
id
u
al
ch
ar
ac
ter
is
t
ics
i
n
clu
d
ed
g
e
n
d
er
,
ag
e,
an
d
ed
u
ca
tio
n
.
A
ll
t
h
e
p
ar
ticip
an
ts
w
er
e
f
e
m
ale.
T
h
e
ag
e
o
f
p
ar
ticip
an
ts
r
a
n
g
ed
b
et
w
ee
n
4
5
-
6
5
y
ea
r
s
o
ld
,
w
it
h
t
h
e
d
is
tr
ib
u
tio
n
o
f
4
p
ar
ticip
an
ts
ag
ed
ar
o
u
n
d
4
5
-
5
0
y
ea
r
s
o
ld
,
3
p
a
r
ticip
an
ts
ag
e
d
5
1
-
5
5
y
ea
r
s
o
ld
,
an
d
2
p
a
r
ticip
an
ts
ag
ed
ar
o
u
n
d
61
-
6
5
y
ea
r
s
o
ld
.
Data
o
n
p
ar
ticip
an
ts
'
ed
u
ca
tio
n
w
as
o
n
e
p
ar
ticip
an
t
d
id
n
o
t
co
m
p
lete
ele
m
e
n
tar
y
s
ch
o
o
l,
7
p
ar
tici
p
an
ts
g
r
ad
u
ated
f
r
o
m
h
i
g
h
s
ch
o
o
l
(
o
r
eq
u
iv
alen
t)
,
an
d
1
p
ar
ticip
an
t
g
r
ad
u
ated
f
r
o
m
u
n
i
v
er
s
it
y
(
B
ac
h
elo
r
Deg
r
ee
)
.
Dis
ea
s
e
s
ch
ar
ac
ter
is
tics
i
n
cl
u
d
ed
th
e
t
y
p
e
o
f
d
is
ea
s
e
s
,
p
er
io
d
o
f
illn
ess
a
n
d
p
er
io
d
in
u
s
i
n
g
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e.
A
l
l
p
ar
ticip
an
ts
w
er
e
d
ia
g
n
o
s
ed
d
iab
etes
m
ellit
u
s
t
y
p
e
2
an
d
h
av
e
s
u
f
f
er
ed
m
o
r
e
th
an
o
n
e
y
ea
r
,
w
i
th
th
e
ca
te
g
o
r
y
o
f
1
-
5
y
ea
r
s
a
s
m
an
y
a
s
6
p
eo
p
le
an
d
6
-
1
0
y
ea
r
s
as
m
a
n
y
as
3
p
eo
p
le.
W
h
ile
th
e
p
er
io
d
in
u
s
in
g
co
m
p
le
m
e
n
tar
y
m
ed
icin
e
w
as
m
o
r
e
th
a
n
3
m
o
n
th
s
,
w
it
h
th
e
ca
teg
o
r
y
o
f
3
-
12
m
o
n
t
h
s
as
m
an
y
as 4
p
eo
p
le,
1
-
5
y
ea
r
s
a
s
m
an
y
as 4
p
eo
p
le,
an
d
m
o
r
e
t
h
an
5
y
ea
r
s
as
m
a
n
y
as 1
p
eo
p
le.
T
h
e
r
esu
lts
o
f
i
n
-
d
ep
th
i
n
t
er
v
ie
w
w
it
h
p
ar
ticip
a
n
ts
,
o
b
tain
ed
f
i
v
e
t
h
e
m
es
o
n
p
s
y
ch
o
lo
g
ical
r
esp
o
n
s
esa
f
ter
d
iag
n
o
s
ed
DM
.
T
h
e
th
e
m
es
w
er
e
p
s
y
c
h
o
lo
g
ic
al
r
es
p
o
n
s
es
af
ter
d
iag
n
o
s
ed
D
M,
o
p
in
io
n
s
ab
o
u
t
DM
,
m
ed
ical
tr
ea
t
m
en
t
s
ele
ctio
n
p
atter
n
,
t
h
e
r
ea
s
o
n
s
to
s
elec
t
co
m
p
le
m
e
n
tar
y
m
ed
i
cin
e,
r
esp
o
n
s
e
s
to
co
m
p
le
m
e
n
tar
y
m
ed
icin
e,
a
n
d
f
a
m
il
y
s
u
p
p
o
r
t
f
o
r
t
h
e
u
s
e
o
f
co
m
p
le
m
e
n
tar
y
m
ed
icin
e.
B
elo
w
t
h
e
q
u
o
t
an
s
w
er
s
o
f
th
e
p
a
r
ticip
an
ts
:
3
.
1
.
P
s
y
cho
lo
g
ica
l
re
s
po
ns
es a
f
t
er
dia
g
no
s
ed
DM
DM
is
a
ch
r
o
n
ic
d
is
ea
s
e
th
a
t
w
il
l
b
e
s
u
f
f
er
ed
a
lif
eti
m
e.
So
m
eo
n
e
w
h
o
h
ad
a
ch
r
o
n
ic
d
is
e
ase
al
w
a
y
s
d
if
f
ic
u
lt
to
ac
ce
p
t t
h
e
f
ac
t t
h
at
th
e
y
h
av
e
to
ch
a
n
g
e
t
h
eir
li
f
e
s
t
y
le
[
1
6
]
.
P
atien
ts
w
h
o
h
a
v
e
r
ec
eiv
e
d
a
d
iag
n
o
s
i
s
o
f
d
iab
etes
ca
n
m
ak
e
th
e
m
i
n
to
a
lo
s
s
o
f
co
n
tr
o
l
[
1
7
]
.
T
h
e
y
m
u
s
t
ad
h
er
e
an
d
ad
ap
t
w
it
h
n
e
w
d
if
f
er
e
n
t
r
o
u
tin
es,
li
k
e
g
ett
in
g
in
j
ec
tio
n
s
o
f
i
n
s
u
li
n
,
co
n
s
u
m
e
h
ea
lth
y
f
o
o
d
an
d
d
o
p
h
y
s
ical
ex
er
c
is
e.
Stre
s
s
o
n
D
M
p
atien
ts
ca
u
s
ed
b
y
ass
o
r
t
m
en
t
p
r
ess
u
r
e
to
liv
e
n
o
r
m
all
y
.
P
atien
ts
s
h
o
u
ld
b
e
ab
le
to
in
teg
r
ate
th
e
DM
p
r
ess
u
r
e
in
to
d
ail
y
r
o
u
ti
n
it
y
.
C
h
r
o
n
ic
d
is
ea
s
e
r
esu
l
ted
s
en
s
e
s
o
f
lo
s
s
,
s
u
c
h
as
ad
d
in
g
f
i
n
an
c
ial
d
if
f
icu
l
ties
f
o
r
m
o
s
t
in
d
iv
id
u
als
a
n
d
b
r
in
g
i
n
g
ch
a
n
g
ed
in
li
f
est
y
le
a
n
d
d
ep
en
d
en
ce
o
n
o
th
er
s
[
1
8
]
.
Stre
s
s
h
as
t
h
r
ee
f
o
r
m
s
,
n
a
m
el
y
:
s
ti
m
u
l
u
s
,
r
esp
o
n
s
e,
a
n
d
p
r
o
ce
s
s
.
R
esp
o
n
s
e
is
i
n
d
iv
id
u
al
r
ea
ctio
n
s
th
at
ar
is
e
b
ec
a
u
s
e
o
f
ce
r
tain
s
itu
a
tio
n
s
t
h
at
ca
u
s
e
s
tr
es
s
.
R
esp
o
n
s
e
t
h
at
ar
is
es
ca
n
b
e
p
h
y
s
io
lo
g
ical,
s
u
c
h
a
s
:
p
alp
itatio
n
s
,
tr
e
m
b
li
n
g
,
d
izzin
e
s
s
,
a
n
d
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8806
I
J
P
HS
Vo
l.
5
,
No
.
4
,
Dec
em
b
er
20
1
6
:
367
–
3
7
4
370
p
s
y
ch
o
lo
g
ical
r
esp
o
n
s
e
s
s
u
c
h
as
f
ea
r
,
an
x
ie
t
y
,
d
if
f
ic
u
lt
to
co
n
ce
n
tr
ate,
an
d
ea
s
i
l
y
ir
r
itated
.
P
ar
ticip
an
ts
in
th
i
s
s
tu
d
y
s
h
o
w
ed
r
esp
o
n
s
es to
th
e
s
tr
ess
,
m
ain
l
y
p
s
y
ch
o
lo
g
ical
r
esp
o
n
s
es.
P
s
y
c
h
o
lo
g
ica
l
r
esp
o
n
s
e
s
h
o
wed
b
y
9
p
ar
ticip
an
ts
i
n
t
h
i
s
s
tu
d
y
w
a
s
f
ea
r
r
e
s
p
o
n
s
e,
as
e
x
p
r
ess
ed
b
y
3
p
ar
ticip
an
ts
:
“
.
.
.
I
w
a
s
s
ca
r
e
d
w
h
en
th
ey
s
a
id
I
g
o
t
d
ia
b
etes
.
.
.
"
,
d
o
w
n
r
esp
o
n
s
e
e
x
p
r
ess
e
d
b
y
2
p
ar
ticip
an
t
s
:
“
I
w
a
s
d
o
w
n
a
t
fir
s
t,
limp
.
.
.
.
th
a
t
I
g
o
t
d
ia
b
etes
.
.
.
"
,
a
n
x
iet
y
r
esp
o
n
s
e
e
x
p
r
ess
ed
b
y
1
p
ar
ticip
an
t:"
I
feel
a
n
xiety
w
h
en
t
h
ey
s
a
id
i
g
o
t
d
i
a
b
etes
.
.
.
"
,
c
o
n
f
u
s
ed
r
esp
o
n
s
e
ex
p
r
ess
ed
b
y
1
p
ar
ticip
an
t:"
I
a
m
s
o
co
n
fu
s
ed
.
.
.
"
.
On
e
p
ar
ticip
an
t
s
h
o
w
ed
n
o
r
m
a
l
p
s
y
c
h
o
lo
g
ical
r
esp
o
n
s
e
a
g
ai
n
s
t
d
iab
etes
d
ia
g
n
o
s
is
g
i
v
e
n
b
y
t
h
e
d
o
cto
r
.
T
w
o
p
ar
ticip
an
ts
s
h
o
w
ed
t
h
eir
r
ej
ec
tio
n
r
esp
o
n
s
e
a
f
ter
d
iag
n
o
s
ed
DM
.
T
h
e
r
esp
o
n
s
es
co
u
ld
b
e
s
ee
n
f
r
o
m
t
h
e
p
ar
ticip
an
t
ex
p
r
ess
io
n
:"
.
.
.
I
d
o
n
’
t
b
eliev
e
th
a
t
I
’
m
d
ia
g
n
o
s
ed
d
ia
b
etes,
h
o
w
co
u
ld
it
b
e
"
.
T
h
e
r
ea
ctio
n
o
f
th
is
d
en
ial
in
ac
co
r
d
an
ce
w
it
h
t
h
e
th
eo
r
y
o
f
lo
s
s
b
y
K
u
b
ler
R
o
s
e
,
th
e
f
ir
s
t
r
ea
ctio
n
o
f
i
n
d
iv
i
d
u
als
w
h
o
e
x
p
er
ien
ce
lo
s
s
is
s
h
o
ck
,
d
is
b
elief
,
o
r
to
d
en
y
th
e
f
ac
t
th
at
t
h
e
lo
s
s
ac
tu
all
y
o
cc
u
r
s
.
DM
p
atien
ts
e
x
p
er
ien
ce
a
lo
s
s
o
f
p
h
y
s
io
lo
g
y
r
elate
d
to
lo
s
s
o
f
ad
eq
u
ate
p
a
n
cr
ea
tic
f
u
n
cti
o
n
,
w
h
ic
h
f
u
n
c
tio
n
i
n
t
h
e
p
an
cr
ea
s
s
ec
r
ete
th
e
h
o
r
m
o
n
e
i
n
s
u
li
n
n
ee
d
ed
to
r
eg
u
late
b
lo
o
d
g
lu
co
s
e
le
v
els.
A
lt
h
o
u
g
h
i
n
itiall
y
,
8
o
f
9
p
ar
ticip
an
ts
s
h
o
w
ed
p
s
y
ch
o
lo
g
i
ca
l
r
esp
o
n
s
esa
s
f
ea
r
,
a
n
x
ie
t
y
,
co
n
f
u
s
e
,
d
o
w
n
,
an
d
r
ej
ec
tio
n
,
b
u
t
in
t
h
e
en
d
th
e
y
co
u
ld
ac
ce
p
t
th
e
f
ac
t.
T
h
e
ex
p
r
ess
io
n
o
f
r
ec
ep
tio
n
w
a
s
s
h
o
w
ed
:"
.
.
.
F
in
a
lly
I
a
cc
ep
t
it,
a
s
i
t
i
s
.
.
.
"
.
I
n
th
e
ac
ce
p
ta
n
ce
s
tag
e,
p
ar
ticip
an
ts
s
e
n
s
e
o
f
lo
s
s
in
li
f
e
an
d
f
i
n
d
a
w
a
y
to
m
o
v
e
f
o
r
w
ar
d
.
T
h
e
ac
ce
p
tan
ce
p
h
ase
is
r
elate
d
to
th
e
r
eo
r
g
an
iza
tio
n
o
f
t
h
e
f
ee
li
n
g
o
f
lo
s
s
,
th
o
u
g
h
ts
w
er
e
al
w
a
y
s
ce
n
ter
ed
o
n
th
e
m
i
s
s
i
n
g
o
b
j
ec
ts
b
eg
in
to
d
i
m
i
n
is
h
o
r
d
is
ap
p
ea
r
.
I
n
d
iv
id
u
als
h
av
e
to
ac
ce
p
t th
e
f
ac
t t
h
at
ex
p
er
ien
ce
d
lo
s
s
a
n
d
s
tar
t to
lo
o
k
f
o
r
w
ar
d
.
3
.
2
.
O
pin
io
ns
a
bo
ut
DM
Op
in
io
n
s
o
f
D
M
p
atien
t
s
w
er
e
ex
p
lo
r
ed
in
t
h
is
s
tu
d
y
as
s
o
ciate
d
w
i
th
r
i
s
k
f
ac
to
r
s
t
h
at
co
u
ld
ca
u
s
e
DM
T
2
.
So
m
e
r
is
k
f
ac
to
r
s
co
u
l
d
af
f
ec
t
DM
m
o
r
b
id
it
y
.
T
h
e
r
is
k
s
co
n
s
i
s
ted
o
f
g
e
n
etic
a
n
d
lif
est
y
le
s
u
c
h
as
d
iet
an
d
ac
ti
v
it
y
p
atter
n
s
.
T
h
e
li
f
es
t
y
le
w
a
s
a
f
ac
to
r
t
h
at
co
u
ld
b
e
ch
a
n
g
ed
w
i
th
a
g
o
o
d
s
el
f
-
m
a
n
ag
e
m
e
n
t
[
2
]
,
[
1
9
]
.
DM
T
2
is
a
ch
r
o
n
ic
d
is
ea
s
e
th
at
r
eq
u
ir
es
r
o
u
ti
n
e
h
ea
l
th
m
an
a
g
e
m
e
n
t
an
d
s
u
s
tai
n
ab
le
th
u
s
n
ee
d
s
p
r
o
p
er
m
ed
ical
tr
ea
t
m
e
n
t [
2
0
]
.
DM
p
atien
t
s
w
h
o
v
is
i
ted
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
c
lin
ic
co
m
p
r
eh
e
n
d
ab
o
u
t
D
M
d
is
ea
s
e
as
in
h
er
it
d
i
s
ea
s
e,
e
v
e
n
a
m
o
n
g
th
e
m
n
o
t
f
o
u
n
d
a
n
y
h
i
s
to
r
y
o
f
h
er
ed
it
y
,
u
n
h
ea
lth
y
lif
e
s
t
y
le,
u
n
co
n
tr
o
lled
ea
tin
g
,
lack
o
f
e
x
er
cise,
a
n
d
l
ess
ac
ti
v
it
y
.
I
n
ad
d
itio
n
t
h
er
e
w
er
e
p
ar
ticip
an
t
s
w
h
o
s
aid
t
h
at
DM
is
a
d
is
ea
s
e
th
at
i
n
cu
r
ab
le
an
d
m
u
s
t ta
k
e
m
ed
icin
e
i
n
w
h
o
le
li
f
e.
B
elo
w
w
er
e
s
tate
m
e
n
ts
f
r
o
m
p
ar
ticip
an
ts
ab
o
u
t D
M
:
1.
DM
is
in
h
er
ited
: "
DM is kn
o
w
n
to
b
e
i
n
h
erit
ed
.
.
.
"
,
2.
U
n
h
ea
lth
y
li
f
es
t
y
le
a
s
a
r
ea
s
o
n
: “
.
.
.
a
s
u
n
co
n
tr
o
lled
ea
tin
g
,
la
ck
o
f e
xe
r
cise,
a
n
d
va
r
io
u
s
c
a
u
s
es
"
,
3.
DM
d
is
ea
s
e
m
u
s
t
ta
k
e
m
ed
icin
e
f
o
r
w
h
o
le
li
f
e
a
n
d
i
n
cu
r
ab
le,
as
e
x
p
r
ess
ed
:
“
D
ia
b
etes
w
il
l
n
ee
d
med
ica
tio
n
fo
r
w
h
o
le
life a
n
d
in
cu
r
a
b
le,
s
o
ye
s
,
I
’
m
a
fr
a
id
"
.
A
ll
p
ar
ticip
an
ts
e
x
p
r
ess
ed
th
ei
r
o
p
in
io
n
s
o
n
th
e
r
i
s
k
f
ac
to
r
s
o
f
DM
b
ec
au
s
e
t
h
e
y
h
ad
s
u
f
f
e
r
ed
f
r
o
m
it
f
o
r
m
o
r
e
th
a
n
o
n
e
y
ea
r
an
d
g
o
t e
n
o
u
g
h
i
n
f
o
r
m
atio
n
f
r
o
m
h
ea
lth
p
r
o
f
es
s
io
n
al
s
.
3
.
3
.
Co
m
ple
m
e
nta
ry
m
edic
ine us
a
g
e
pa
t
t
er
n
T
h
e
h
ea
lt
h
-
s
ee
k
in
g
p
atter
n
b
e
h
av
io
u
r
s
h
o
w
ed
h
ier
ar
ch
y
s
tar
ted
f
r
o
m
s
el
f
-
tr
ea
t
m
en
t,
s
ee
k
f
o
r
m
ed
ical
tr
ea
t
m
e
n
t
an
d
o
th
er
tr
ea
t
m
e
n
t
s
(
co
m
p
le
m
e
n
tar
y
a
n
d
alter
n
ativ
e
o
r
tr
ad
itio
n
al)
[
9
]
.
I
n
ac
co
r
d
an
ce
w
it
h
th
e
th
eo
r
y
o
f
h
ea
ler
s
h
o
p
p
in
g
d
ev
elo
p
ed
b
y
Kr
o
eg
er
(
1
9
8
3
)
,
d
u
r
in
g
t
h
e
ill
n
es
s
,
t
h
e
p
atien
t
w
a
s
li
k
el
y
to
s
ee
k
a
s
ec
o
n
d
h
ea
ler
,
w
it
h
o
u
t
r
ef
e
r
en
ce
f
r
o
m
t
h
e
f
ir
s
t.
L
i
k
e
w
i
s
e,
DM
T
2
p
atien
t
s
h
ad
a
ten
d
e
n
c
y
to
d
o
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e
to
in
cr
ea
s
e
th
eir
h
ea
lt
h
s
tatu
s
[
1
4
-
1
5
]
,
[
2
1
]
.
T
h
is
s
tu
d
y
ex
p
lo
r
ed
th
e
p
att
er
n
o
f
tr
ea
t
m
en
t
s
elec
ted
b
y
DM
p
atien
ts
.
C
A
M
u
s
a
g
e
p
atter
n
w
as
b
eh
av
io
u
r
ten
d
e
n
c
y
s
h
o
w
ed
b
y
d
iab
etes
p
atie
n
ts
in
u
s
in
g
C
A
M
a
s
a
co
m
p
le
m
e
n
t
to
co
n
v
en
tio
n
al
tr
ea
t
m
e
n
t
b
ein
g
u
n
d
er
tak
e
n
.
I
n
t
h
i
s
lite
r
atu
r
e
s
t
u
d
y
,
t
h
e
p
atter
n
o
f
C
A
M
u
s
a
g
e
s
h
o
w
ed
b
y
d
iab
etes
p
atien
ts
w
er
e,
(
1
)
m
o
s
tl
y
C
A
M
u
s
ed
co
m
b
in
ed
w
ith
co
n
v
e
n
tio
n
a
l
tr
ea
t
m
e
n
t
/
allo
p
ath
y
,
(
2
)
d
id
n
o
t
ch
an
g
e
t
h
eir
tr
ea
t
m
e
n
t,
b
o
th
in
th
e
tr
ea
t
m
e
n
t
s
c
h
ed
u
l
e
o
r
d
o
s
ag
e,
(
3
)
r
e
d
u
ce
d
o
n
e
d
o
s
ag
e
lo
w
er
o
r
m
o
r
e
o
f
co
n
v
en
t
io
n
al
tr
ea
t
m
en
t
,
(
4
)
u
s
ed
co
n
v
e
n
tio
n
al
tr
ea
t
m
en
ts
a
n
d
C
A
M
i
n
d
i
f
f
er
e
n
t
ti
m
es,
a
n
d
(
5
)
s
to
p
p
ed
th
e
co
n
v
en
t
io
n
al
tr
ea
t
m
e
n
t
w
h
e
n
u
s
i
n
g
C
AM
[
2
2
-
2
5
]
.
T
h
is
s
t
u
d
y
r
es
u
lt
s
t
h
at
p
ar
tici
p
an
ts
h
av
e
a
h
ab
it
i
n
u
s
i
n
g
h
e
r
b
al
m
ed
icin
e
b
e
f
o
r
e
v
i
s
iti
n
g
I
n
d
o
n
esia
n
T
r
a
d
itio
n
al
Me
d
icin
e
P
o
ly
c
li
n
ic,
s
till
u
s
in
g
h
er
b
al
m
ed
ic
in
e
e
v
en
th
o
u
g
h
n
o
lo
n
g
er
v
is
iti
n
g
I
n
d
o
n
e
s
ian
T
r
a
d
itio
n
al
Me
d
icin
e
P
o
l
y
clin
ic,
co
m
b
i
n
i
n
g
m
ed
ical
tr
ea
t
m
en
t
w
it
h
h
er
b
al,
ch
a
n
g
in
g
t
h
e
d
o
s
ag
e
o
f
m
ed
ical
tr
ea
t
m
e
n
t
w
h
en
u
s
in
g
h
er
b
al,
n
o
t
i
n
f
o
r
m
i
n
g
to
d
o
cto
r
w
h
o
h
an
d
led
t
h
at
t
h
e
y
u
s
ed
h
er
b
al
m
o
r
e
th
a
n
o
n
e
.
State
m
e
n
t o
f
p
ar
ticip
an
ts
w
h
o
s
h
o
w
ed
co
m
p
le
m
en
tar
y
m
ed
ic
in
e
u
s
ag
e
e
x
p
r
ess
ed
as b
el
o
w
:
1.
So
m
e
p
ar
ticip
an
ts
u
s
ed
co
m
p
l
e
m
en
tar
y
m
ed
ici
n
e
(
h
er
b
al,
s
u
p
p
lem
e
n
t
s
)
af
ter
d
iag
n
o
s
ed
D
M.
T
h
e
p
atter
n
co
u
ld
b
e
s
ee
n
f
r
o
m
t
h
eir
o
p
in
io
n
s
:
"
.
.
.
I
a
ls
o
d
r
in
k
ex
tr
a
cts
o
f
p
a
ce
(
Mo
r
in
d
a
citr
o
fo
lia
)
a
fter
d
ia
g
n
o
s
ed
d
ia
b
etes
"
,
".
.
.
s
tew
o
f
b
a
ylea
f,
b
etel
a
n
d
g
i
n
g
er
.
.
.
"
,
"
.
.
.
s
tew
o
f
cin
n
a
mo
n
.
.
.
"
,
".
.
.
b
itter
h
erb
a
l
(
s
te
w
o
f
p
a
n
icu
la
t
a
)
,
s
tew
o
f le
a
fflo
w
e
r
.
.
.
"
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
P
HS
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N:
2252
-
8806
R
esp
o
n
s
es o
f D
ia
b
etes Mellitu
s
P
a
tien
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W
h
o
Used
C
o
mp
leme
n
ta
r
y
Med
icin
e
(
A
n
ita
Jo
elia
n
tin
a
)
371
2.
So
m
e
p
ar
ticip
an
ts
s
till
u
s
ed
h
er
b
al
ev
en
t
h
o
u
g
h
n
o
lo
n
g
er
v
is
iti
n
g
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
cli
n
ic,
as
e
x
p
r
ess
ed
b
y
p
a
r
ticip
an
t:
"
R
ig
h
t
n
o
w
I
o
n
ly
co
n
s
u
me
p
a
n
ic
u
la
ta
ev
ery
d
a
y
.
.
.
",
"
d
r
in
k
s
tew
o
f
p
in
n
a
ta
a
n
d
cin
n
a
mo
n
"
,
"
.
.
.
d
r
in
k
b
itter
h
erb
a
l
a
lter
n
a
te
ly
w
i
th
g
lib
en
cla
mid
e
...
”
,
"
.
.
.
I
co
n
tin
u
e
to
d
r
in
k
r
u
ellia
tu
b
ero
s
a
lea
f .
.
.
”
3.
P
ar
ticip
an
t
s
elec
ted
co
m
p
le
m
en
tar
y
m
ed
ici
n
e
b
y
co
m
b
in
in
g
m
ed
i
ca
l
tr
ea
t
m
e
n
t
w
it
h
h
er
b
al
o
r
s
u
p
p
le
m
e
n
t
s
.
Ho
w
ev
er
,
s
o
m
e
p
ar
ticip
an
ts
m
ad
e
c
h
an
g
ed
t
o
th
e
m
ed
ical
tr
ea
t
m
e
n
t
w
it
h
o
u
t
r
ep
o
r
tin
g
to
th
eir
d
o
cto
r
s
.
C
h
an
g
ed
in
th
e
t
r
ea
t
m
en
t
w
er
e
b
y
:
r
ed
u
ci
n
g
t
h
e
d
o
s
ag
e
o
f
m
ed
ical
tr
ea
t
m
e
n
t
o
r
d
id
n
o
t
tak
e
it,
y
et
s
til
l
co
n
s
u
m
i
n
g
h
er
b
al
o
r
s
u
p
p
le
m
e
n
ts
.
State
m
e
n
t
o
f
p
ar
ticip
an
ts
t
h
at
in
d
icate
d
t
h
e
y
c
h
an
g
ed
t
h
e
tr
ea
t
m
e
n
t
as
ex
p
r
ess
ed
:
"
I
f
my
g
lu
co
s
e
is
n
o
r
ma
l,
I
d
o
n
o
t
d
r
in
k
metfo
r
min
,
w
i
ll
o
n
ly
d
r
in
k
b
itter
h
erb
a
l
"
.
"
.
.
.
I
ta
ke
p
a
n
icu
l
a
ta
lea
f
ca
p
s
u
le
a
n
d
metfo
r
min
b
u
t
I
d
o
n
’
t
d
r
i
n
k
th
e
metfo
r
min
"
,
"
I
ta
ke
metfo
r
min
a
n
d
g
lib
en
cla
mid
e,
b
u
t
I
d
o
n
’
t
d
r
in
k
metfo
r
min
,
w
h
ile
n
o
t
ev
ery
d
a
y
co
n
s
u
min
g
g
lib
en
cla
mid
e.
I
a
m
s
w
itch
in
g
it w
ith
b
itter
h
erb
a
l
".
T
h
e
h
ea
lth
-
s
ee
k
i
n
g
b
eh
a
v
io
u
r
p
atter
n
w
as
i
n
f
l
u
en
ce
d
b
y
th
e
t
y
p
e
an
d
s
e
v
er
it
y
o
f
s
y
m
p
to
m
s
,
th
e
t
y
p
e
o
f
d
is
ea
s
e
(
ac
u
te
o
r
ch
r
o
n
ic)
.
Ma
in
l
y
d
iab
etes
p
atien
ts
w
h
o
u
s
e
C
A
M
d
id
n
o
t
in
f
o
r
m
to
th
eir
d
o
cto
r
s
o
r
h
ea
lth
p
r
o
f
ess
io
n
al
s
.
T
h
e
r
ea
s
o
n
s
o
f
w
h
y
d
iab
etes
p
atien
ts
o
f
C
AM
u
s
er
s
d
id
n
o
t
i
n
f
o
r
m
t
h
eir
d
o
cto
r
ab
o
u
t
th
eir
C
A
M
u
s
a
g
e
as
f
o
llo
w
s
r
ea
s
o
n
s
:
h
ea
lt
h
p
r
o
f
es
s
io
n
a
ls
w
o
u
ld
p
r
ev
en
t
th
e
u
s
e
o
f
C
A
M
an
d
h
ea
lt
h
p
r
o
f
es
s
io
n
al
s
d
id
n
o
t
h
av
e
ad
eq
u
ate
k
n
o
w
le
d
g
e
ab
o
u
t
C
A
M.
Fro
m
t
h
o
s
e
r
ea
s
o
n
s
r
eq
u
ir
ed
h
ea
l
th
p
o
lic
y
f
r
o
m
g
o
v
er
n
m
e
n
t
o
n
th
e
u
s
e
o
f
C
A
M
i
n
h
ea
lt
h
f
ac
ilit
ies [
2
5
].
3
.
4
.
Rea
s
o
ns
t
o
us
e
co
m
ple
m
e
nta
ry
m
edi
c
ine
So
m
e
r
ea
s
o
n
s
w
h
ic
h
b
ec
a
m
e
b
asic
in
tak
i
n
g
d
ec
is
io
n
to
ch
o
o
s
e
h
er
b
al
m
ed
ici
n
e
o
r
s
u
p
p
lem
en
ts
as
a
co
m
p
a
n
io
n
to
m
ed
ical
tr
ea
t
m
en
t
w
a
s
as
s
ess
ed
i
n
t
h
i
s
s
t
u
d
y
.
I
n
-
d
ep
th
in
ter
v
ie
w
s
t
h
at
h
ad
b
ee
n
co
n
d
u
cted
o
n
6
9
p
ar
ticip
an
ts
,
4
2
%
(
n
=
2
9
)
h
ad
id
en
tifie
d
th
e
b
en
e
f
its
o
f
C
AM
u
s
a
g
e
f
o
r
d
iab
etes
p
atien
ts
,
s
o
m
e
tr
e
m
en
d
o
u
s
i
m
p
r
o
v
e
m
en
t
s
i
n
g
lu
co
s
e
w
h
ich
w
as
a
s
s
o
ciate
d
w
i
th
C
A
M.
T
h
is
co
n
d
itio
n
co
n
s
id
er
ed
p
o
s
itiv
e
l
y
af
f
ec
t
d
iab
etes
b
y
h
elp
in
g
to
'p
r
ev
en
t
h
ar
m
'
f
r
o
m
c
h
r
o
n
ic
co
n
d
itio
n
s
,
s
tab
ilizi
n
g
o
r
lo
w
er
i
n
g
g
l
u
co
s
e,
p
o
s
itiv
e
f
ee
li
n
g
s
th
at
ar
is
ed
an
d
s
a
y
in
g
th
at
ch
r
o
n
ic
d
is
ea
s
e
w
as
'
l
ess
o
f
a
p
r
o
b
lem
'
[
2
6
]
.
T
h
e
r
ea
s
o
n
s
o
f
d
iab
etes
p
atien
ts
u
s
i
n
g
C
A
M
w
i
th
s
tr
o
n
g
b
elie
f
as
s
tated
t
h
at
C
AM
is
s
af
er
,
h
a
v
e
f
e
w
er
s
id
e
ef
f
ec
ts
,
C
AM
w
il
l
m
ai
n
tai
n
t
h
e
h
ea
lt
h
,
a
n
d
t
h
e
u
s
e
o
f
C
A
M
d
u
e
to
les
s
e
f
f
e
ctiv
e
in
allo
p
atic
tr
ea
t
m
e
n
t
[
2
7
]
.
T
h
er
e
w
a
s
al
s
o
b
elief
t
h
at
C
AM
h
ad
s
y
n
er
g
i
s
t
ic
ef
f
ec
t
w
it
h
co
n
v
e
n
tio
n
al
tr
ea
t
m
e
n
t [
2
3
]
.
C
h
an
g
et
al.
,
2
0
1
1
ex
p
lain
ed
t
h
at
th
e
r
ea
s
o
n
f
o
r
d
iab
etes
p
atien
ts
u
s
in
g
C
A
M
w
as
to
co
n
tr
o
l
d
iab
etes,
h
ea
l
co
m
p
l
icatio
n
s
,
an
d
m
o
s
t
(
7
1
.
9
%)
o
th
er
co
n
d
itio
n
s
as
s
o
ciate
d
w
it
h
h
ea
lth
.
So
m
e
o
p
in
io
n
s
o
f
p
ar
ticip
an
ts
r
elate
d
to
th
e
r
ea
s
o
n
s
to
s
elec
t
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e
wer
e
d
u
e
to
co
n
s
id
er
th
at
m
ed
ical
d
r
u
g
c
o
n
tain
ed
ch
e
m
ica
ls
,
co
n
s
id
er
th
e
s
id
e
ef
f
ec
ts
o
f
m
ed
ical
tr
ea
t
m
e
n
t,
an
d
th
e
p
r
esen
ce
o
f
o
th
er
d
is
ea
s
e
s
b
esi
d
es DM
,
as e
x
p
r
ess
ed
in
b
elo
w
s
tate
m
en
t
s
:
1.
Me
d
ical
d
r
u
g
s
co
n
ta
in
ed
ch
e
m
ical
s
: "
I
d
o
a
vo
i
d
d
r
u
g
s
,
a
fr
a
id
to
r
ea
liz
e
its
ch
emic
a
ls
co
n
ta
in
ed
".
2.
Sid
e
ef
f
ec
ts
o
f
d
r
u
g
s
:
"
I
a
m
a
fr
a
id
o
f
s
id
e
effec
ts
w
h
en
ta
kin
g
med
icin
e
fr
o
m
d
o
cto
r
b
ec
a
u
s
e
it
mu
s
t
b
e
co
n
s
u
med
co
n
tin
u
o
u
s
ly
"
,
"
I
a
m
a
fr
a
id
o
f
la
ter
s
id
e
effec
ts
w
h
ich
ca
n
a
tta
ck
h
e
a
r
t
"
.
"
I
g
et
vo
mited
ev
ery
time
d
r
in
kin
g
a
ca
r
b
o
s
e
a
n
d
g
lip
ir
id
med
icin
e,
s
o
I
s
to
p
it
"
,
"
.
.
.
if
I
d
r
in
k
metfo
r
m
in
co
n
tin
u
o
u
s
ly,
it
w
il
l
at
ta
ck
my
kid
n
ey
,
I
b
ec
o
me
a
fr
a
id
th
en
."
3.
T
h
e
p
r
esen
ce
o
f
o
th
er
d
i
s
ea
s
e
s
:
"
I
d
r
in
k
h
erb
a
l
to
min
imi
z
e
d
r
u
g
co
n
s
u
mp
tio
n
b
ec
a
u
s
e
I
a
lr
ea
d
y
n
o
r
va
s
k
fo
r
h
yp
erten
s
io
n
,
th
u
s
I
d
o
n
’
t
w
a
n
t to
co
n
fu
s
e
in
t
a
kin
g
med
i
cin
e
".
Qu
alitat
iv
e
s
tu
d
y
co
n
d
u
cted
i
n
Ho
r
tu
s
Me
d
ic
u
s
Her
b
al
Sai
n
ti
f
icatio
n
C
li
n
ic,
s
h
o
w
ed
s
o
m
e
b
en
e
f
it
s
in
u
s
in
g
h
er
b
al
m
ed
icin
e
f
o
r
DM
T
2
p
atien
ts
,
li
k
e
to
av
o
id
tr
ea
t
m
e
n
t
s
w
i
th
ch
e
m
ical
s
c
o
n
ta
m
i
n
atio
n
,
h
av
e
ef
f
icac
y
a
n
d
lo
w
e
x
p
en
d
it
u
r
e.
P
atien
ts
ex
a
m
i
n
ed
f
ir
s
t
b
y
d
o
cto
r
b
ef
o
r
e
g
ettin
g
t
h
e
h
er
b
a
l
p
r
escr
ip
tio
n
[
2
8
].
A
ll
t
h
e
i
n
g
r
ed
ie
n
ts
t
h
at
p
u
t
i
n
to
th
e
b
o
d
y
w
o
u
ld
h
av
e
p
o
s
s
i
b
ilit
y
to
ca
u
s
e
s
id
e
ef
f
ec
t
s
.
Si
m
ilar
w
it
h
m
ed
ical
tr
ea
t
m
e
n
t,
h
er
b
al
m
ed
ici
n
e
c
o
u
ld
ca
u
s
e
s
id
e
ef
f
ec
t
s
.
T
h
e
s
e
s
id
e
ef
f
ec
t
s
w
er
e
i
n
f
l
u
en
ce
d
b
y
t
h
e
d
o
s
ag
e
co
n
s
u
m
ed
,
b
o
d
y
co
n
d
itio
n
,
an
d
co
m
b
i
n
i
n
g
co
n
s
u
m
p
tio
n
w
i
t
h
m
ed
ical
tr
ea
t
m
en
t.
T
h
e
w
a
y
to
m
i
n
i
m
ize
t
h
ese
s
id
e
ef
f
ec
ts
w
a
s
to
d
eter
m
in
e
t
h
e
ef
f
icac
y
an
d
d
o
s
ag
e
o
f
h
er
b
al
m
ed
icin
e
u
s
ed
[
29
]
.
3
.
5
.
Respo
ns
e
s
t
o
w
a
rds
co
m
ple
menta
ry
m
edici
ne
T
h
e
p
lan
ts
co
n
s
u
m
ed
as
h
er
b
al
m
ed
ici
n
e
f
o
r
d
iab
etes
ar
e
p
an
icu
lata
a
n
d
b
ay
leaf
t
h
a
t
h
av
e
a
h
y
p
o
g
l
y
ce
m
ic
ac
t
iv
it
y
.
B
ased
o
n
s
t
u
d
y
,
p
an
icu
la
ta
h
a
s
b
en
ef
it
to
p
r
ev
en
t
t
h
e
ab
s
o
r
p
tio
n
o
f
g
l
u
co
s
e
f
r
o
m
in
tes
tin
e
an
d
in
cr
ea
s
e
g
lu
co
s
e
m
etab
o
lis
m
,
w
h
ile
b
a
y
lea
f
h
as
h
y
p
o
g
l
y
ce
m
ic
e
f
f
ec
t o
n
DM
T
2
.
T
h
u
s
p
an
icu
lat
a
an
d
b
ay
leaf
h
a
v
e
b
en
ef
it to
lo
w
er
g
lu
co
s
e
le
v
el
s
o
n
DM
T
2
[
3
0
]
.
P
ar
ticip
an
ts
in
th
i
s
s
t
u
d
y
co
n
s
u
m
ed
v
ar
io
u
s
h
er
b
al.
Her
b
al
u
s
ed
in
I
n
d
o
n
e
s
ian
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
cli
n
ic
w
er
e
b
ay
leaf
ca
p
s
u
le,
p
an
icu
lata,
altilis
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d
co
m
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in
at
io
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b
a
y
lea
f
an
d
p
an
icu
lata.
Her
b
al
co
n
s
u
m
ed
o
u
t
s
id
e
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
clin
ic
w
er
e
b
a
y
lea
f
,
cin
n
a
m
o
n
,
p
an
icu
la
ta,
P
ac
e
(
Mo
r
in
d
a
citr
if
o
lia)
,
r
u
ellia
tu
b
er
o
s
a
p
lan
ts
,
a
n
d
A
f
r
ica
leaf
.
P
ar
ticip
an
t
r
esp
o
n
s
e
s
to
co
m
p
le
m
e
n
tar
y
m
ed
icin
e
s
elec
tio
n
w
er
e
s
u
b
j
ec
tiv
e
o
n
t
h
e
ef
f
ec
t
s
ca
u
s
ed
af
ter
co
n
s
u
m
ed
co
m
p
le
m
e
n
tar
y
tr
ea
t
m
e
n
t.
E
f
f
ec
t
s
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
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:
2
2
5
2
-
8806
I
J
P
HS
Vo
l.
5
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No
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4
,
Dec
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b
er
20
1
6
:
367
–
3
7
4
372
ca
u
s
ed
b
y
s
u
b
j
ec
tiv
e
s
tate
m
e
n
ts
o
f
t
h
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p
ar
ticip
an
t
s
co
u
ld
b
e
p
h
y
s
ical
c
h
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g
e
s
p
er
ce
iv
e
d
an
d
g
lu
co
s
e
le
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el
ch
ec
k
i
n
g
.
T
h
e
s
tate
m
e
n
t
as
ex
p
r
ess
ed
,
"
I
f
I
ta
ke
h
erb
a
l
me
d
icin
e,
my
b
o
d
y
feels
g
o
o
d
,
m
y
g
lu
co
s
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erin
g
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my
Hb
A
1
c
a
ls
o
b
ec
o
mes n
o
r
ma
l
"
So
m
e
h
er
b
al
w
er
e
s
a
f
e
an
d
e
f
f
ec
tiv
e
to
u
s
e
f
o
r
m
a
n
y
co
n
d
iti
o
n
s
.
Desp
ite
th
e
in
cr
ea
s
ed
u
s
e
o
f
h
er
b
al
p
r
o
d
u
cts,
th
er
e
w
er
e
n
o
i
n
cr
e
asin
g
r
ep
o
r
ts
o
f
to
x
icit
y
[
1
8
]
.
I
n
c
h
o
o
s
in
g
tr
ea
t
m
e
n
t
an
d
m
ed
icin
e
u
s
ed
,
eit
h
er
he
r
b
al
o
r
ch
e
m
ical,
it
m
u
s
t
c
o
n
s
id
er
th
e
n
ee
d
s
,
cir
cu
m
s
ta
n
ce
s
,
an
d
co
n
d
it
io
n
s
f
ac
ed
.
I
t
w
a
s
b
ased
o
n
th
e
r
ea
ctio
n
an
d
t
h
e
d
i
f
f
er
e
n
t
w
o
r
k
b
et
w
ee
n
th
e
t
w
o
t
y
p
e
s
o
f
d
r
u
g
s
.
C
o
n
v
e
n
tio
n
al
tr
ea
t
m
e
n
ts
s
u
c
h
as
s
u
r
g
er
y
,
w
as
m
o
r
e
e
f
f
ec
tiv
e
w
h
en
u
s
i
n
g
in
an
e
m
er
g
en
c
y
,
c
h
r
o
n
ic
ill
n
es
s
,
o
r
s
u
r
g
er
y
ca
s
es,
b
ec
au
s
e
it
h
ad
r
elativ
el
y
f
a
s
ter
ef
f
ec
t.
I
f
i
n
t
h
ese
co
n
d
itio
n
s
p
atien
ts
w
an
ted
to
u
s
e
h
er
b
al
m
ed
icin
e,
co
u
ld
s
till
b
e
g
iv
e
n
b
u
t
m
u
s
t
b
e
co
m
b
i
n
ed
w
ith
co
n
v
e
n
tio
n
al
m
ed
ici
n
e.
Her
b
al
m
ed
icin
e
co
u
ld
b
e
u
s
ed
w
it
h
o
u
r
with
o
u
t
c
o
n
v
e
n
tio
n
a
l
m
ed
icin
e
co
m
b
i
n
i
n
g
,
i
f
t
h
e
p
a
tien
t
s
ti
ll
i
n
n
o
r
m
a
l
o
r
s
tab
il
c
o
n
d
itio
n
.
I
f
it
u
s
ed
w
i
th
co
m
b
i
n
atio
n
,
th
e
n
s
h
o
u
ld
b
e
ti
m
e
in
ter
v
al
w
h
en
co
n
s
u
m
in
g
,
to
ac
h
iev
e
m
a
x
i
m
u
m
e
f
f
e
ctiv
e
n
ess
[
29
]
.
T
h
e
r
esu
lt
o
f
th
is
s
tu
d
y
w
as
p
h
en
o
m
en
o
n
th
a
t
o
b
tain
ed
in
t
h
e
f
ie
ld
.
T
h
is
p
h
en
o
m
e
n
o
n
n
e
ed
s
to
g
et
th
e
atte
n
tio
n
f
r
o
m
h
ea
lt
h
p
r
o
f
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io
n
al
s
s
o
th
a
t
p
r
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p
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m
an
a
g
e
m
e
n
t
o
f
DM
ca
n
b
e
tak
e
n
b
y
DM
p
atien
t
s
w
h
o
u
s
e
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e
eith
er
u
s
ed
w
i
th
o
r
w
it
h
o
u
t c
o
m
b
in
i
n
g
it.
3
.
6
.
F
a
m
ily
s
up
po
rt
t
o
w
a
rds
co
m
p
le
m
e
nta
ry
m
ed
ici
ne
u
s
a
g
e
Fa
m
il
y
s
u
p
p
o
r
t
is
th
e
attit
u
d
e,
ac
tio
n
s
a
n
d
ac
ce
p
ta
n
ce
o
f
th
e
f
a
m
il
y
to
w
ar
d
s
m
e
m
b
er
s
.
Fa
m
il
y
s
u
p
p
o
r
t
is
d
ef
in
ed
as
v
er
b
al
a
n
d
n
o
n
v
er
b
al
i
n
f
o
r
m
atio
n
,
ad
v
ice,
r
ea
l
s
u
p
p
o
r
t
o
r
attitu
d
e
g
iv
en
b
y
p
eo
p
le
w
h
o
ar
e
f
a
m
iliar
w
it
h
th
e
s
u
b
j
ec
t
in
th
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v
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m
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o
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m
o
f
p
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ce
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d
m
at
te
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at
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p
r
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v
id
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e
m
o
tio
n
al
b
en
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f
it
s
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d
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f
f
ec
t
o
n
th
e
b
eh
a
v
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f
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p
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t.
I
n
th
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s
e,
p
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p
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w
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f
ee
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et
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a
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leasan
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e
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m
/
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er
.
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m
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u
p
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r
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is
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ef
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ed
as
a
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f
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cial
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p
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t,
is
a
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m
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u
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as b
ee
n
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in
to
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en
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ar
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m
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n
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io
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m
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u
p
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en
co
u
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e
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en
t
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i
m
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n
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i
m
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n
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io
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o
f
f
ac
ilit
at
iv
e
a
n
d
p
ar
ticip
ativ
e
d
im
en
s
io
n
s
[
3
1
]
.
T
h
is
s
tu
d
y
s
h
o
w
ed
th
a
t
f
a
m
il
y
s
u
p
p
o
r
t
p
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ts
to
u
s
e
h
er
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al
m
ed
icin
e.
Fa
m
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p
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o
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t
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t
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s
e
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m
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e,
r
e
m
i
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c
h
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le
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ti
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e
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r
in
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o
u
t
h
er
b
al
m
ed
icin
e,
d
eliv
er
to
h
ea
lt
h
ca
r
e
f
ac
ilit
ies
o
r
to
b
u
y
m
ed
ici
n
e,
an
d
h
elp
to
p
r
ep
ar
e
h
er
b
al
p
r
ep
ar
atio
n
s
(
s
te
w
)
.
E
x
p
r
ess
io
n
s
o
f
f
a
m
il
y
s
u
p
p
o
r
t
c
an
b
e
s
e
en
f
r
o
m
t
h
e
s
tate
m
e
n
t
o
f
th
e
p
ar
ticip
an
t
s
as f
o
llo
w
s
:
1.
Fa
m
il
y
g
a
v
e
p
er
m
is
s
io
n
to
u
s
e
h
er
b
al
m
ed
icin
e:
“
I
a
s
ke
d
to
my
h
u
s
b
a
n
d
a
n
d
h
e
s
a
id
o
ka
y
”
,
“
My
h
u
s
b
a
n
d
g
a
ve
h
is
p
ermis
s
io
n
”
.
2.
R
e
m
in
d
s
c
h
ed
u
le
/ ti
m
e
to
ta
k
e
m
ed
icin
e:
“
r
emin
d
me
w
h
en
ev
er I
s
h
o
u
ld
ta
ke
me
d
icin
e
”
.
3.
P
r
o
v
id
e
in
f
o
r
m
atio
n
o
n
h
er
b
al
m
ed
icin
e:
“
g
ivin
g
in
fo
r
ma
tio
n
o
n
h
erb
a
l
",
“
I
a
m
a
ls
o
g
i
ve
n
a
b
r
o
ch
u
r
e
a
b
o
u
t
h
erb
a
l m
ed
icin
e
b
y
my
h
u
s
b
a
n
d
“
.
4.
Deliv
er
to
t
h
e
h
ea
l
th
f
ac
il
it
y
o
r
b
u
y
m
ed
ici
n
e:
“
S
o
metime
s
my
h
u
s
b
a
n
d
d
r
ive
me
to
co
n
tr
o
l
in
h
o
s
p
ita
l
”
,
"
of
ten
w
h
en
I
d
o
h
e
a
lth
ch
ec
ki
n
g
,
my
h
u
s
b
a
n
d
d
r
ive
a
n
d
a
cc
o
mp
a
n
y
me
"
,
“
I
a
m
r
emin
d
ed
to
co
n
tr
o
l
.”
5.
Help
to
p
r
ep
ar
e
h
er
b
al
p
r
ep
ar
atio
n
s
(
s
te
w
)
:
“
h
e
h
a
s
ev
en
p
r
ep
a
r
ed
it
s
o
I
ju
s
t
n
ee
d
to
d
r
in
k
it
”
,
“
my
h
u
s
b
a
n
d
g
et
me
b
a
ylea
f o
n
th
e
tr
ee
in
fr
o
n
t o
f o
u
r
h
o
u
s
e
”
.
I
t
w
as
g
e
n
er
all
y
b
elie
v
ed
th
a
t
s
o
cial
s
u
p
p
o
r
t
is
cr
u
cial
to
en
co
u
r
ag
e
s
o
m
eo
n
e
to
h
av
e
p
o
s
itiv
el
y
h
ea
lt
h
b
eh
av
io
u
r
an
d
co
n
d
u
c
t
ef
f
ec
tiv
e
tr
ea
t
m
e
n
t
in
ac
u
te
an
d
ch
r
o
n
ic
d
is
ea
s
e
s
[
3
2
]
.
DM
T
2
is
a
ch
r
o
n
ic
d
is
ea
s
e
t
h
at
r
eq
u
ir
es
w
h
o
le
l
if
e
m
a
n
ag
e
m
e
n
t
s
o
t
h
at
p
ati
e
n
ts
w
ill
s
ee
k
tr
ea
t
m
e
n
t
h
e
t
h
in
k
s
ca
n
s
o
lv
e
h
i
s
co
m
p
lai
n
t
s
.
T
h
er
e
ar
e
ti
m
es
w
h
e
n
p
atie
n
t
i
s
e
x
p
er
ien
ci
n
g
b
o
r
ed
o
m
an
d
s
e
n
s
e
o
f
f
ail
u
r
e
in
ca
r
r
y
i
n
g
o
u
t
th
e
tr
ea
t
m
e
n
t
th
at
ca
u
s
es
p
atie
n
ts
to
s
to
p
th
eir
tr
ea
tm
e
n
t
an
d
s
ea
r
ch
o
r
ch
o
o
s
e
an
o
th
er
tr
ea
tm
e
n
t.
Fa
m
il
y
s
u
p
p
o
r
t
g
iv
e
s
ef
f
ec
t
to
t
h
e
p
atien
t
to
d
eter
m
i
n
e
w
h
ic
h
tr
ea
t
m
en
t
o
p
tio
n
w
ill
b
e
tak
e
n
an
d
th
e
i
m
p
l
e
m
en
tatio
n
o
f
s
el
f
-
ca
r
e.
Fa
m
il
y
s
u
p
p
o
r
t
is
n
ee
d
ed
f
o
r
p
eo
p
le
w
it
h
p
o
s
iti
v
e
att
itu
d
es
to
w
ar
d
C
A
M
a
n
d
th
o
s
e
w
it
h
h
i
g
h
f
a
m
il
y
s
u
p
p
o
r
t a
r
e
m
o
r
e
lik
e
l
y
to
u
s
e
C
A
M
an
d
m
o
r
e
i
n
v
o
l
v
ed
in
s
e
lf
-
ca
r
e
b
eh
av
io
u
r
s
[
2
6
]
.
4.
CO
NCLU
SI
O
N
Stu
d
y
o
n
C
o
m
p
le
m
e
n
tar
y
Me
d
icin
e
Selec
ted
B
eh
av
io
u
r
B
y
DM
P
atien
t
s
i
n
I
n
d
o
n
esia
n
T
r
ad
itio
n
al
Me
d
icin
e
P
o
ly
c
lin
ic,
R
eg
io
n
al
P
u
b
lic
Ho
s
p
ital
Dr
.
So
eto
m
o
Su
r
ab
a
y
a,
h
ad
id
en
tifie
d
s
ix
t
h
e
m
e
s
,
f
i
v
e
t
h
e
m
es
th
at
co
r
r
esp
o
n
d
w
i
th
t
h
e
p
u
r
p
o
s
e
o
f
s
tu
d
y
a
n
d
o
n
e
n
e
w
t
h
e
m
e
th
r
o
u
g
h
an
al
y
s
is
p
r
o
ce
s
s
.
T
h
e
th
e
m
e
w
as
p
s
y
ch
o
lo
g
ical
r
esp
o
n
s
e
af
ter
d
iag
n
o
s
ed
DM
,
o
p
in
io
n
s
ab
o
u
t
th
e
d
is
ea
s
e,
co
m
p
le
m
en
tar
y
m
ed
ici
n
e
u
s
a
g
e
p
atter
n
s
,
th
e
r
ea
s
o
n
f
o
r
u
s
in
g
co
m
p
le
m
e
n
tar
y
m
ed
i
ci
n
e,
r
esp
o
n
s
es
to
th
e
co
m
p
le
m
e
n
tar
y
m
ed
icin
e
a
n
d
f
a
m
il
y
s
u
p
p
o
r
t f
o
r
th
e
u
s
e
o
f
co
m
p
le
m
en
tar
y
m
ed
icin
e
i
n
t
h
e
n
e
w
t
h
e
m
e.
DM
p
atien
t
s
te
n
d
to
u
s
e
m
o
r
e
th
an
o
n
e
tr
ea
t
m
e
n
t a
s
an
ef
f
o
r
t
to
s
o
lv
e
t
h
eir
h
ea
lt
h
p
r
o
b
le
m
s
.
Selecte
d
co
m
p
le
m
e
n
tar
y
m
ed
ici
n
e
w
as
h
er
b
al
m
ed
ici
n
e
w
h
er
e
i
t
u
s
ed
m
o
r
e
t
h
an
o
n
e.
T
h
is
p
atte
r
n
in
d
icate
d
h
ea
ler
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
P
HS
I
SS
N:
2252
-
8806
R
esp
o
n
s
es o
f D
ia
b
etes Mellitu
s
P
a
tien
ts
W
h
o
Used
C
o
mp
leme
n
ta
r
y
Med
icin
e
(
A
n
ita
Jo
elia
n
tin
a
)
373
s
h
o
p
p
in
g
i
n
D
M
p
atie
n
ts
.
Stat
e
m
en
t
p
ar
ticip
an
t
d
escr
ib
ed
as
a
t
h
e
m
e
i
n
t
h
is
s
t
u
d
y
n
ee
d
to
g
et
atte
n
tio
n
f
r
o
m
f
a
m
il
y
,
h
ea
lt
h
ca
r
e
p
r
o
f
ess
io
n
a
ls
,
an
d
g
o
v
er
n
m
e
n
ts
to
m
a
n
ag
e
DM
p
r
o
p
er
ly
.
T
h
e
h
i
g
h
i
n
ter
est
o
f
DM
p
atie
n
t
s
to
u
s
e
co
m
p
le
m
en
tar
y
m
ed
ici
n
e
n
ee
d
s
to
b
e
ac
co
m
o
d
ated
,
s
o
th
e
p
atien
ts
’
tr
ea
t
m
en
t a
l
w
a
y
s
m
o
n
ito
r
ed
.
ACK
NO
WL
E
D
G
E
M
E
NT
S
T
h
e
au
th
o
r
s
w
o
u
ld
lik
e
to
th
a
n
k
all
p
ar
ticip
an
t
s
f
o
r
th
eir
in
f
o
r
m
at
io
n
an
d
ex
p
er
ien
ce
s
th
at
h
av
e
b
ee
n
s
h
ar
ed
w
it
h
u
s
.
RE
F
E
R
E
NC
E
S
[1
]
Am
e
rica
n
Dia
b
e
tes
A
ss
o
c
iatio
n
,
“
Dia
g
n
o
sis a
n
d
Clas
sif
ica
ti
o
n
o
f
D
iab
e
tes
M
e
ll
it
u
s
,
”
Di
a
b
e
tes
Ca
re
,
v
o
l.
3
6
,
2
0
1
3
.
[2
]
In
d
o
n
e
sia
n
S
o
c
iety
o
f
En
d
o
c
ri
n
o
l
o
g
y
,
“
Co
n
se
n
su
s
Co
n
tro
l
a
n
d
P
re
v
e
n
ti
o
n
o
f
Dia
b
e
tes
M
e
ll
it
u
s
ty
p
e
2
in
In
d
o
n
e
sia
,
”
2
0
1
1
.
[3
]
W
.
S
a
ra
h
,
e
t
a
l.
,
”
G
lo
b
a
l
p
re
v
a
len
c
e
o
f
d
iab
e
tes
,
”
Dia
b
e
tes
Ca
re
,
v
o
l
/i
ss
u
e
:
27
(
5
)
,
p
p
.
1
0
4
7
-
1
0
5
3
,
2
0
0
4
.
[4
]
Ag
e
n
c
y
f
o
r
He
a
lt
h
S
tu
d
y
a
n
d
De
v
e
lo
p
m
e
n
t
M
in
istry
o
f
He
a
lt
h
,
“
Ba
sic
He
a
lt
h
Re
se
a
rc
h
in
2
0
1
3
”
,
2
0
1
3
.
[5
]
A
.
J
.
Em
il
y
,
“
Co
m
p
le
m
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
Us
e
a
m
o
n
g
Co
ll
e
g
e
S
tu
d
e
n
ts:
Ro
les
o
f
A
tt
it
u
d
e
a
n
d
He
a
lt
h
Be
li
e
f
M
o
d
e
l
,
”
T
h
e
G
r
a
d
u
a
te
S
c
h
o
o
l
U
n
iv
e
rsity
o
f
W
isc
o
n
sin
-
S
to
u
t,
Gr
a
d
u
a
te
De
g
re
e
/
M
a
jo
r
,
M
S
A
p
p
li
e
d
P
sy
c
h
o
lo
g
y
,
2
0
1
2
.
[6
]
Na
ti
o
n
a
l
Ce
n
ter
o
f
Co
m
p
le
m
e
n
ta
ry
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
(NC
CA
M
),
Na
ti
o
n
a
l
In
stit
u
te
o
f
He
a
lt
h
,
“
Ex
p
lo
r
in
g
th
e
S
c
ien
c
e
o
f
Co
m
p
le
m
e
n
tary
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
,
T
h
ird
S
trate
g
ic
P
lan
2
0
1
1
–
2
0
1
5
,
”
2
0
1
1
.
h
tt
p
s:/
/n
c
c
a
m
.
n
ih
.
g
o
v
/h
e
a
lt
h
/i
n
te
g
ra
ti
v
e
-
h
e
a
lt
h
.
[7
]
S
.
H.
S
a
y
d
a
h
a
n
d
M
.
S
.
Eb
e
rh
a
r
d
t,
“
Us
e
o
f
Co
m
p
le
m
e
n
tar
y
a
n
d
Altern
a
ti
v
e
M
e
d
icin
e
a
m
o
n
g
A
d
u
lt
s
w
it
h
Ch
ro
n
i
c
Dise
a
se
s: Un
it
e
d
S
tate
s 2
0
0
2
,
”
J
Al
ter
n
Co
m
p
lem
e
n
t
M
e
d
,
v
o
l
/
issu
e
:
12
(
8
)
,
pp.
8
0
5
-
8
1
2
,
2
0
0
6
.
[8
]
B
.
G
u
rjee
t
S
.
a
n
d
Y
.
G
lo
ria
,
“
Co
m
p
le
m
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
T
h
e
ra
p
ies
f
o
r
Dia
b
e
tes
:
A
Cli
n
ica
l
Re
v
ie
w
,
”
Cli
n
ica
l
Dia
b
e
tes
,
v
o
l
/i
ss
u
e
:
28
(
4
)
,
p
p
.
1
4
7
-
1
5
5
,
2
0
1
0
.
[9
]
A
.
Kle
in
m
a
n
,
“
P
a
ti
e
n
s
a
n
d
h
e
a
lers
in
t
h
e
c
o
n
tex
o
f
c
u
lt
u
re
,
”
Un
iv
e
rsity
o
f
Ca
li
f
o
rn
ia
P
re
ss
,
Ba
rk
e
ley
L
o
s
A
n
g
e
les
L
o
n
d
o
n
,
1
9
8
0
.
[1
0
]
A
.
Kro
e
g
e
r,
“
A
n
th
ro
p
o
lo
g
ica
l
a
nd
S
o
c
io
-
M
e
d
ica
l
He
a
lt
h
Ca
re
Re
se
a
rc
h
i
n
De
v
e
lo
p
in
g
C
o
u
n
tri
e
s
,
”
S
o
c
.
S
c
i
M
e
d
,
v
o
l
/i
ss
u
e
:
17
(
3
)
,
p
p
.
1
4
7
-
1
6
1
,
1
9
8
3
.
[1
1
]
T
.
T
o
m
iso
n
,
“
He
a
lt
h
-
se
e
k
in
g
b
e
h
a
v
io
u
r
a
n
d
stra
teg
ic
h
e
a
lt
h
c
a
re
p
lan
n
i
n
g
in
S
ierra
L
e
o
n
e
,
”
In
ter
n
a
ti
o
n
a
l
De
v
e
lo
p
me
n
t
,
W
o
rk
in
g
p
a
p
e
r
S
e
rie
s
,
v
o
l
.
13
,
p
p
.
1
3
9
,
2
0
1
3
.
IS
S
N 1
4
7
0
-
2
3
2
0
.
[1
2
]
A
.
R.
Be
ll
,
e
t
a
l.
,
“
Co
m
p
lem
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
Us
e
a
m
o
n
g
A
d
u
lt
s
w
it
h
Dia
b
e
tes
i
n
T
h
e
Un
it
e
d
S
tate
s
,
”
Al
ter
n
a
ti
v
e
T
h
e
ra
p
ies
,
v
o
l
/i
ss
u
e
:
12
(
5
)
,
p
p
.
1
6
-
2
2
,
2
0
0
6
.
[1
3
]
V
.
C
.
L
e
o
n
e
l
,
e
t
a
l
.
,
“
Et
h
n
ic
d
i
ff
e
r
e
n
c
e
s
in
c
o
m
p
le
m
e
n
tar
y
a
n
d
a
lt
e
rn
a
ti
v
e
m
e
d
icin
e
u
se
a
m
o
n
g
p
a
ti
e
n
ts
w
it
h
d
iab
e
tes
,
”
Co
mp
lem
e
n
t
a
ry
T
h
e
ra
p
ies
in
M
e
d
ici
n
e
,
v
o
l
/i
ss
u
e
:
18
(
6
)
,
p
p
.
2
4
1
-
2
4
8
,
2
0
1
0
.
[1
4
]
Ha
ss
a
n
S.,
e
t
a
l.
,
“
Re
a
so
n
s,
P
e
rc
e
iv
e
d
Eff
ic
a
c
y
a
n
d
F
a
c
to
rs
A
ss
o
c
iate
d
w
it
h
Co
m
p
le
m
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
Me
d
icin
e
a
m
o
n
g
M
a
la
y
sia
n
P
a
ti
e
n
s w
it
h
Dia
b
e
tes
M
e
ll
it
u
s
,
”
Br.
J
.
Dia
b
e
tes
Va
sc
.
Dis
,
v
o
l.
1
1
,
p
p
.
92
-
9
8
,
2
0
1
1
.
[1
5
]
Ch
in
g
S
.
M
.
,
e
t
a
l.
,
“
Co
m
p
lem
e
n
tar
y
a
lt
e
rn
a
ti
v
e
m
e
d
icin
e
u
se
a
m
o
n
g
p
a
ti
e
n
ts
w
it
h
ty
p
e
2
d
iab
e
tes
m
e
ll
it
u
s
in
th
e
p
rim
a
r
y
c
a
re
se
tt
in
g
:
a
c
ro
ss
-
se
c
ti
o
n
a
l
stu
d
y
in
M
a
la
y
sia
,
”
B
M
C
C
o
mp
lem
e
n
ta
ry
&
Al
ter
n
a
ti
v
e
M
e
d
icin
e
,
v
o
l.
13
,
pp.
1
4
8
,
2
0
1
3
.
[1
6
]
K.
J.
Iss
e
lb
a
c
h
e
r,
“
Ha
rriso
n
'
s p
ri
n
c
ip
les
o
f
in
tern
a
l
m
e
d
icin
e
,”
A
.
H A
sd
ie,
Terj.
,
Ja
k
a
rta
,
E
G
C,
v
o
l
.
5
,
2
0
0
0
.
[1
7
]
D.
D.
Ig
n
a
tav
iciu
s
a
n
d
M
.
L
.
W
o
rk
m
a
n
,
“
M
e
d
ica
l
S
u
rg
ica
l
Nu
rsin
g
:
Crit
ica
l
t
h
in
k
i
n
g
f
o
r
c
o
ll
a
b
o
ra
ti
v
e
c
a
re
,
”
P
h
il
a
d
e
l
p
h
ia
,
El
se
v
ier
S
a
u
n
d
e
rs,
2
0
0
6
.
[1
8
]
P
.
A
.
P
o
tt
e
r
a
n
d
P
.
A
n
n
e
G
.
,
“
F
u
n
d
a
m
e
n
tals o
f
Nu
rsin
g
,
”
7
th
e
d
it
io
n
.
Ca
n
a
d
a
,
El
se
v
ier M
o
sb
y
,
2
0
0
9
.
[1
9
]
J.
S
.
Do
rm
a
n
,
e
t
a
l.
,
“
He
a
lt
h
Be
li
e
f
s
a
m
o
n
g
In
d
iv
id
u
a
ls
a
t
In
c
re
a
se
d
F
a
m
il
ial
Ris
k
f
o
r
Ty
p
e
2
Dia
b
e
tes
:
I
m
p
li
c
a
ti
o
n
s
f
o
r
P
re
v
e
n
ti
o
n
,
”
Di
a
b
e
tes
Res
Cli
n
Pra
c
t
,
v
o
l
/i
ss
u
e
:
96
(
2
)
,
p
p
.
1
5
6
–
1
6
2
,
2
0
1
2
.
[2
0
]
F
u
n
n
e
l
M
.
M
.,
e
t
a
l.
,
“
Na
ti
o
n
a
l
S
tan
d
a
rd
s
f
o
r
Dia
b
e
tes
S
e
l
f
-
M
a
n
a
g
e
m
e
n
t
Ed
u
c
a
ti
o
n
,
”
Dia
b
e
tes
Ca
re
,
v
o
l/
is
su
e
:
3
4
(
1
)
,
p
p
.
S
8
9
-
S
9
6
,
2
0
1
1
.
[2
1
]
M
e
d
a
g
a
m
a
A
.
B
.,
e
t
a
l.
,
“
Us
e
o
f
Co
m
p
le
m
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
s
(CA
M
s)
Am
o
n
g
Ty
p
e
2
Dia
b
e
tes
P
a
ti
e
n
s
in
S
ri
L
a
n
k
a
:
a
Cro
ss
se
c
ti
o
n
a
l
S
u
rv
e
y
,
”
BM
C
Co
mp
lem
e
n
ta
ry
&
Al
ter
n
a
ti
v
e
M
e
d
icin
e
,
v
o
l.
14
,
p
p
.
3
7
4
,
2
0
1
4
.
[2
2
]
Ha
sh
e
m
p
u
r
M
.
H.
,
e
t
a
l.
,
“
Co
m
p
le
m
e
n
tar
y
a
n
d
a
lt
e
rn
a
ti
v
e
m
e
d
icin
e
u
se
in
Ira
n
ian
p
a
ti
e
n
ts
w
it
h
d
iab
e
tes
m
e
ll
it
u
s
,
”
J
o
u
rn
a
l
In
teg
r M
e
d
,
v
o
l
/
issu
e
:
13
(
5
),
p
p
.
3
1
9
-
3
2
5
,
2
0
1
5
.
[2
3
]
F
a
n
P
.
E
.
M.
,
e
t
a
l.
,
“
P
a
tt
e
rn
s
o
f
Co
m
p
lem
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
Us
e
Am
o
n
g
a
G
ro
u
p
o
f
P
a
ti
e
n
ts
w
it
h
Ty
p
e
2
Dia
b
e
tes
Re
c
e
iv
in
g
Ou
tp
a
ti
e
n
t
Ca
re
in
S
in
g
a
p
o
re
,
”
In
ter
n
a
ti
o
n
a
l
J
o
u
rn
a
l
o
f
Nu
rs
i
n
g
Pr
a
c
ti
c
e
,
v
o
l
/i
ss
u
e
:
19
(
3)
,
pp.
44
-
5
5
,
2
0
1
3
.
[2
4
]
A
.
S
ta
y
e
h
M
.
S.
,
e
t
a
l.
,
“
Co
m
p
lem
e
n
tar
y
a
n
d
a
lt
e
rn
a
ti
v
e
m
e
d
ic
in
e
u
se
a
m
o
n
g
st
P
a
les
ti
n
ian
d
ia
b
e
ti
c
p
a
ti
e
n
ts
,
”
Co
mp
lem
e
n
ta
ry
T
h
e
ra
p
ies
in
Cl
in
ica
l
Pra
c
ti
c
e
,
v
o
l
.
1
8
,
p
p
.
16
-
2
1
,
2
0
1
2
.
[2
5
]
Ch
a
n
g
H
.
A.
,
e
t
a
l
.,
“
Us
e
o
f
Co
m
p
le
m
e
n
tar
y
a
n
d
A
lt
e
rn
a
ti
v
e
M
e
d
icin
e
a
m
o
n
g
P
e
o
p
le
w
it
h
Ty
p
e
2
Dia
b
e
tes
in
T
a
i
w
a
n
:
A
Cro
ss
-
S
e
c
ti
o
n
a
l
S
u
rv
e
y
,
”
Evid
e
n
c
e
-
Ba
se
d
Co
mp
lem
e
n
ta
ry
a
n
d
Al
ter
n
a
ti
v
e
M
e
d
icin
e
,
v
ol
.
2
0
1
1
,
2
0
1
1
.
A
rti
c
le ID
9
8
3
7
9
2
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8
p
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1
0
.
1
1
5
5
/2
0
1
1
/
9
8
3
7
9
2
.
[2
6
]
Ca
n
a
wa
y
R.
,
e
t
a
l.
,
“
P
e
rc
e
p
ti
o
n
s
o
f
Be
n
e
f
it
o
f
Co
m
p
le
m
e
n
tar
y
T
h
e
ra
p
y
Us
e
a
m
o
n
g
P
e
o
p
le
w
it
h
Dia
b
e
tes
a
n
d
Ca
rd
io
v
a
sc
u
lar Dise
a
se
,
”
Fo
rs
c
h
Ko
mp
lem
e
n
tme
d
,
vol
/i
ss
u
e
:
21
(
1
)
,
p
p
.
25
-
3
3
,
2
0
1
4
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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2
5
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-
8806
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Vo
l.
5
,
No
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4
,
Dec
em
b
er
20
1
6
:
367
–
3
7
4
374
[2
7
]
M
it
a
S
.
,
e
t
a
l
.
,
“
Re
a
so
n
s
o
f
u
sin
g
c
o
m
p
le
m
e
n
tar
y
a
n
d
a
lt
e
rn
a
ti
v
e
m
e
d
icin
e
(C
A
M
)
a
m
o
n
g
e
ld
e
rly
M
a
lay
sia
n
o
f
Ku
a
la
L
u
m
p
u
r
a
n
d
S
e
lan
g
o
r
sta
t
e
s:
A
n
e
x
p
lo
ra
to
ry
stu
d
y
,
”
J
o
u
rn
a
l
o
f
Y
o
u
n
g
P
h
a
rm
a
c
ists
,
v
o
l
/i
ss
u
e
:
5
(
2
)
,
p
p
.
50
-
5
3
,
2
0
1
3
.
[2
8
]
A
h
m
a
d
F
.
A
.
,
“A
n
a
l
y
sis
Us
in
g
He
rb
a
l
T
re
a
t
m
e
n
t
F
o
r
Dia
b
e
tes
M
e
ll
it
u
s
P
a
ti
e
n
ts
in
Cli
n
ica
l
He
rb
a
l
S
a
in
ti
f
ica
ti
o
n
Ho
rtu
s
M
e
d
ik
u
s
T
a
wa
n
g
m
a
n
g
u
,
”
T
h
e
sis
,
S
c
h
o
o
l
o
f
P
u
b
li
c
He
a
lt
h
,
Un
iv
e
rsit
y
o
f
In
d
o
n
e
sia
i
n
2
0
1
2
.
[2
9
]
H
.
T
a
n
d
i,
“
T
h
e
Bo
o
k
o
f
M
e
d
ici
n
a
l
P
lan
ts
Ef
f
ica
c
io
u
s,
”
Oc
to
p
u
s
P
u
b
li
sh
i
n
g
Ho
u
se
,
Y
o
g
y
a
k
a
rta,
2
0
1
5
.
[3
0
]
Kristin
a
L
.
a
n
d
S
u
h
a
rm
iati
,
“
Ra
t
io
n
a
li
z
a
ti
o
n
A
n
a
ly
sis
o
f
In
g
re
d
ie
n
ts
Re
m
e
d
y
Dia
b
e
tes
M
e
ll
it
u
s
in
L
a
b
o
ra
to
ry
o
f
Re
se
a
rc
h
a
n
d
De
v
e
lo
p
m
e
n
t
o
f
T
ra
d
it
io
n
a
l
M
e
d
icin
e
T
re
a
tme
n
t
S
e
rv
ice
s
,
”
Bu
ll
e
ti
n
o
f
He
a
lt
h
S
y
ste
m
Re
s
e
a
rc
h
(
Bu
letin
Pen
e
li
ti
a
n
S
istem
Ke
se
h
a
ta
n
)
,
v
o
l
/i
ss
u
e
:
9
(
2
)
,
p
p
.
1
0
7
-
1
1
2
,
2
0
0
6
.
[3
1
]
J.
He
n
sa
rli
n
g
,
“
De
v
e
lo
p
m
e
n
t
a
n
d
P
sy
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