Intern
ati
o
n
a
l
Jo
urn
a
l
o
f
P
u
b
lic Hea
l
th Science (IJ
P
HS)
V
o
l.3
,
No
.2
,
Jun
e
2
014
, pp
. 63
~68
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63
Jo
urn
a
l
h
o
me
pa
ge
: h
ttp
://iaesjo
u
r
na
l.com/
o
n
lin
e/ind
e
x.ph
p
/
IJPHS
Prooxidative Role of Hyperinsu
linemia in Metabolic Sydrome
Formation
Nelli Uzbekova
1
,
D
ilo
ro
m Musa
khodja
ev
a
2
1
Andijan
State
Medical Institute Andijan
,
Uzb
e
k
i
stan
2
Immunomorph
olog
y
DPT,
Institute of Imm
unolog
y
,
Academ
y
o
f
Scien
c
e, Uzb
e
k
i
stan
Article Info
A
B
STRAC
T
Article histo
r
y:
Received J
u
n
4, 2013
Rev
i
sed
Jan 20, 201
4
Accepte
d April
26, 2014
The pattern of
h
y
per
i
nsulin
emia was
studied i
n
patien
t
s with
m
e
tabolic
s
y
ndrome. The
levels of basal insu
linemia (BI)
, malondiald
e
h
yde (MDA)
and cat
al
aze (C
A) as
an index of oxidativ
e s
t
res
s
and s
o
m
e
m
e
taboli
c
parameters
have been
studied
in
me
n and
women with metabolic s
y
ndrome.
Basal insulin
emia correlated sign
ifican
tly
with m
a
londialdeh
y
d
e
levels both
in men and women. Close relations
hip was
also found between basal
insulinem
ia
and
waist c
i
rcum
fere
nce.
Keyword:
In
su
lin
em
ia
Malo
nd
iald
eh
y
d
e
Catalaze
Metab
o
lic p
a
rameters
Metab
o
lic synd
ro
m
e
Copyright ©
201
4 Institut
e
o
f
Ad
vanced
Engin
eer
ing and S
c
i
e
nce.
All rights re
se
rve
d
.
Co
rresp
ond
i
ng
Autho
r
:
Dilo
ro
m
Mu
sak
hod
j
a
ev
a,
Im
m
unom
orphology DPT, Ins
titute of
Im
m
u
nol
ogy,
Uzbe
kistan Ac
adem
y of Scie
nce,
74
Ya
hy
o
G
u
l
y
am
ov, Tas
h
ke
nt
1
0
0
0
6
0
,
Uz
beki
st
a
n
.
Em
a
il: d
ily
m@xn
et.u
z,
ranosab
itov
a
@yaho
o
.co
m
1.
INTRODUCTION
C
u
r
r
ent
l
y
, a
m
e
t
a
bol
i
c
sy
ndr
om
e (M
S) i
s
bec
o
m
i
ng t
h
e one
o
f
t
h
e
m
o
st
im
port
a
nt
and
gr
o
w
i
n
g
health issues i
n
Uz
be
kistan.
The prese
n
ce
of MS is ass
o
c
i
ated with increased ris
k
of c
o
ronary artery
disease
and
at
he
rot
h
r
o
m
bosi
s
[1]
.
There a
r
e
very im
portant mechanis
m
s
in
th
e course of
ox
id
ativ
e
stress
(OS) c
o
nnect
ed with t
h
e
pr
ocess
of at
h
e
rot
h
r
o
m
bosi
s
,
especi
al
l
y
i
n
cardi
ovasc
ul
ar
versi
on
o
f
M
S
. T
h
e m
a
jor
com
pone
nt
s o
f
t
h
e OS
are "re
s
pi
rat
o
r
y
bu
rst
"
i
n
pol
ym
orp
h
o
n
u
cl
ear l
e
u
k
o
cy
t
e
s,
l
i
pop
r
o
t
e
i
n
per
oxi
dat
i
o
n
(
L
P
O
)
an
d t
h
e a
n
t
i
oxi
dan
t
enzym
e
s. They lead to e
ndothelial dysfunction,
whic
h triggers a
ca
scade
of
react
ions i
n
vol
v
ed in the
fo
rm
ati
on
of
at
her
o
scl
e
r
o
t
i
c
p
l
aques
[
2
]
.
Act
i
v
at
o
r
s o
f
t
h
ese p
r
ocesses
are va
ri
o
u
s sp
eci
fi
c and
n
o
n
s
peci
fi
c fact
or
s. Am
ong t
h
e
m
, a speci
al
place has a hy
peri
nsulinem
ia (HI) - the m
a
in pathogen
eti
c
m
echanism
f
o
r the MS
developm
ent [2],[3]. In
assessing
its p
a
rticip
atio
n
in
t
h
e OS we
h
a
ve to
rem
e
m
b
er t
h
at th
e co
m
p
lex
relation
s
h
i
p
s
o
f
insu
lin
with
o
t
h
e
r
metab
o
lic facto
r
s are no
t fu
l
l
y d
e
tected
yet. Po
ssib
le
pat
h
op
hy
si
ol
ogi
cal
rel
a
t
i
ons
hi
ps
of i
n
sul
i
n
em
i
a
wi
t
h
gen
d
e
r
di
ffe
re
nces, a
g
e
fact
o
r
an
d t
h
e s
p
ee
d
of
de
vel
o
pi
n
g
of at
her
o
scl
e
rot
i
c
va
scul
a
r
chan
ges m
a
y
pl
ay
an
im
port
a
nt
r
o
l
e
[2]
-
[
4]
.
Lev
e
ls of m
a
l
o
nd
iald
eh
yd
e (MDA), th
e syste
m
o
f
fu
n
c
t
i
o
n
a
lly in
terrel
a
ted
an
tiox
i
d
a
n
t
en
zym
e
s,
includi
ng catal
ase (CA), are
considere
d
as
sensitive inde
x of the
OS, a
n
d accordi
ngly,
of a
n
increa
se
d lipid
p
e
rox
i
d
a
tion
an
d in
cr
eased ath
e
rog
e
n
ecity [1
],
[2
],
[5
].
Th
e
pu
rpo
s
e
o
f
th
is st
u
d
y
was t
o
an
alyze th
e i
n
terrelatio
n
s
h
i
p
s
b
e
t
w
een
b
a
sal i
n
sulin
e
m
ia an
d
param
e
t
e
rs of m
a
l
ondi
al
de
hy
de an
d cat
al
ase, and i
n
fl
ue
nce
of m
e
t
a
bol
i
c
com
pone
nt
s of
m
e
t
a
bol
i
c
sy
nd
rom
e
on these
proce
sses.
Evaluation Warning : The document was created with Spire.PDF for Python.
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e
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64
2.
R
E
SEARC
H M
ETHOD
A
gr
ou
p
of
4
0
m
e
n (m
ean ag
e 5
2
,
4
±
0
,
7 y
ears) a
n
d
35
w
o
m
e
n (m
ean age
49
,5
±
0,
8
y
ears)
wi
t
h
a
di
ag
no
si
s of
M
S
were exa
m
i
n
ed. M
ean l
e
vel
s
of sy
st
ol
i
c
and di
ast
o
l
i
c
bl
oo
d p
r
ess
u
re i
n
bot
h gr
o
ups
were
15
4,
0
5
±
2,
6
2
/
99
,3
4
± 1
,
4
3
a
nd
1
5
0
,
2
1
± 3
,
12 /
88
,2
8
± 2
,
18 m
m
Hg. A
n
t
h
r
o
p
o
m
e
t
r
i
c
param
e
t
e
rs of p
a
t
i
e
nt
s
- a b
o
d
y
m
a
ss
in
d
e
x
(BMI),
waist circu
m
feren
ce (WC ) an
d
m
e
tab
o
lic - to
tal ch
o
l
estero
l (TC), tri
g
lycerid
es
(TG
)
,
l
o
w de
n
s
i
t
y
l
i
popr
ot
ei
ns
(
L
DL
), hi
g
h
-
d
e
n
si
t
y
l
i
pop
rot
e
i
n
(H
DL
) chol
est
e
r
o
l
,
bl
oo
d gl
uc
ose
a
nd basal
i
n
sul
i
n
( B
I)
-
are re
fl
ect
ed i
n
Fi
gu
re
1,
2,
3
.
The
co
nt
r
o
l
gr
o
up c
o
nsi
s
t
e
d
of
1
0
h
eal
t
h
y
m
e
n an
d 1
0
heal
t
h
y
wom
e
n wi
t
h
n
o
rm
al
bl
oo
d
p
r
essur
e
(
1
16
,1
7
±
1,
32
/
7
4
,
3
2
±
1,
27
m
m
Hg).
In
sul
i
n
l
e
vel
s
we
re
det
e
rm
ined
by
ELIS
A
aut
o
m
a
t
e
d m
e
t
hod
usi
n
g ELI
SA
ki
t
s
of «
A
cc
u
b
i
n
d M
i
cro
w
e
l
l
s
»
fi
r
m
(USA) i
n
t
h
e l
a
b
o
rat
o
ry
"Im
m
unoge
n-Test" at the Institute of Im
m
unology
of
Uzbe
kistan
Ac
adem
y of Science (Tashke
n
t). Lipi
d
l
e
vel
s
were m
easure
d
by
t
h
e
bi
oc
hem
i
cal
anal
y
zer ex
pre
s
s «
R
efl
o
t
r
o
n
P
l
us»
(R
oc
he,
Germ
any
)
. LD
L was
calcu
lated
b
y
Friedwald
.
Th
e
co
n
t
en
t of lip
id p
e
rox
i
d
a
tio
n
was assess
ed
b
y
t
h
e l
e
vel
i
n
t
h
e bl
oo
d se
r
u
m
of t
h
e
seco
nda
ry
p
r
o
duct
- M
D
A
det
e
rm
i
n
ed
by
react
i
o
n
w
ith
2-th
i
o
b
a
rb
itu
ric acid.
Catalase activ
ity was
det
e
rm
i
n
ed fr
o
m
t
h
e press
u
re
oxi
dat
i
o
n m
o
ly
bdat
e
wi
t
h
hy
dr
o
g
en
per
o
xi
d
e
. St
at
i
s
t
i
cal
anal
y
s
i
s
of t
h
e r
e
sul
t
s
was c
o
nducted in the
statistical soft
wire
“St
a
tistica”.
Figure
1
Clinical par
a
me
te
rs of
p
a
tie
n
ts
w
i
th met
ab
olic syn
d
ro
m
3.
R
E
SU
LTS AN
D ANA
LY
SIS
In
d
e
term
in
in
g o
f
BI in
m
e
n
with
MS lev
e
ls (22
,
8
± 0,57
m
U
/ L) were h
i
gh
er th
en
con
t
ro
l v
a
lu
es
(1
0,
1
4
±
0
,
3
9
m
U
/
L), an
d i
t
was al
m
o
st
twi
ce hi
ghe
r, c
o
n
f
i
r
m
i
ng a
pr
esence
of
hy
p
e
ri
ns
ul
i
n
em
i
a
.
Wh
e
n
com
p
ari
ng B
I
wom
e
n wi
t
h
M
S
(1
5,
0
5
±
0
,
6
1
m
U
/
m
l
) and i
n
t
h
e c
ont
r
o
l
g
r
o
u
p
(
1
0
,
0
7
±
0,
63 m
U
/
L) l
e
ss
in
crease
of its
lev
e
l. Sign
ifican
t d
i
ffere
nce
i
n
l
e
vel
s
o
f
B
I
base
d o
n
ge
nd
er
just
i
f
i
e
s
nee
d
i
n
t
h
e
fu
rt
he
r
st
udy
of t
h
e i
n
s
u
l
i
n
e
m
i
a
l
i
nkages
wi
t
h
ot
her c
o
m
ponent
s
of
M
S
, t
h
e
para
m
e
t
e
rs of
whi
c
h a g
r
ou
p
of
m
e
n an
d
wom
e
n are
di
f
f
e
rent
(Fi
g
u
r
e
2
)
.
31,56
78,5
74,59
99,8
90,21
23,94
22,92
32,87
0
20
40
60
80
100
120
Men
(controls)
Women
(co
n
trols)
Men
(MS
)
Women
(MS)
BMI
(kg/m
2
)
WC
(sm
)
Evaluation Warning : The document was created with Spire.PDF for Python.
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6
Proo
xida
tive Ro
le o
f
Hyp
e
rinsu
lin
emia
i
n
Meta
bo
lic S
y
nd
ro
me Fo
rma
tion
(Nelli Uzb
e
ko
va
)
65
Fi
gure 2
Gl
uc
ose-i
n
s
u
l
i
n
ch
arac
teri
sti
c
s
o
f
p
a
tien
ts w
i
th
metabolic syndrome
Th
us, i
n
m
e
n c
o
m
p
ared t
o
w
o
m
e
n o
n
t
h
e
ba
ckg
r
ou
n
d
of
si
m
i
l
a
r sy
st
ol
i
c
bl
o
o
d
pres
ure
,
t
h
ere
was
a
si
gni
fi
ca
nt
(
p
<0.
0
0
1
)
hi
ghe
r
l
e
vel
s
o
f
di
as
t
o
l
i
c
bl
o
o
d
p
r
essur
e
(
9
9,
34
± 1
,
4
3
a
n
d
88
,2
8 ±
2
,
1
8
m
m
Hg,
respect
i
v
el
y
)
wi
t
h
g
r
eat
er d
u
rat
i
o
n of hy
p
e
rt
ensi
o
n
(9
,5
5
± 0,
8
4
an
d 3,
25 ± 0,
29
y
ears)
.
At
c
o
m
p
ara
b
l
e
several
m
e
t
a
bol
i
c
(B
M
I
,
bl
oo
d
gl
uc
ose,
hi
g
h
c
h
ol
est
e
rol
)
pa
ram
e
ters
of m
e
n
and
w
o
m
e
n di
ffe
re
d
sig
n
i
fican
tly in
th
e d
e
g
r
ee
o
f
d
e
po
sition
of ab
do
m
i
n
a
l ad
ip
o
s
e tissu
e
(p
<0
.0
01), trig
lycerid
e
s (p
<0
.0
01
) and
LD
L
(p
<0
.0
01)
(Figu
r
e 3)
.
4,52
4,53
5,95
5,66
10,14
10,07
15,05
22,8
0
5
10
15
20
25
Men
(controls)
Women
(controls)
Men
(MS)
Women
(MS)
Glucose
(mmol/
l)
Basal
Insulinem
ia
(m/ml)
Evaluation Warning : The document was created with Spire.PDF for Python.
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e
201
4 :
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3
– 68
66
Figure
3 Lipi
d pr
ofile in
patients
with me
tab
o
lic s
y
ndr
ome
Co
rrelatio
n
analysis BI lev
e
l
s
with p
a
ram
e
ters
o
f
b
ody
wei
g
ht
i
n
m
e
n wi
t
h
m
e
t
a
bol
ic sy
n
d
r
o
m
e
reveale
d
reliable direct correl
a
tion. Re
gressi
on a
n
alysis
of th
e relatio
nship
with
BMI l
e
v
e
ls of in
su
lin
em
ia
showe
d
that the influe
nce
of
ant
h
r
o
pom
etri
c pa
ram
e
t
e
rs o
n
t
h
e
f
unct
i
onal
st
at
e of
t
h
e
β
-cells b
e
co
m
e
s
si
gni
fi
ca
nt
at
a
B
M
I
≥
2
8
kg/
m
2
(
p
= 0,32
,
p =
0
.
0
3
)
.
A
t
th
e sam
e
ti
me in
su
lin
em
i
a
pr
ov
id
ed
sign
if
ican
t
i
n
fl
ue
nce
on
B
M
I l
e
vel
s
i
n
B
I
fr
om
15.
0
m
U
/
m
l
and hi
g
h
er
(
p =
0,
34
, p
= 0
.
0
4
7
)
. R
e
gres
si
o
n
l
a
st
d
e
p
e
nd
ing
show
ed th
at t
h
e
valu
e
o
f
r r
eaches 0.54
at
m
o
d
e
r
a
te GI
(
≥
18
,0 m
U
/
m
l
) i
n
co
nt
rast
t
o
0.
37
i
n
consideri
n
g as
inde
pe
ndent
variables
BMI.
This s
u
ggests
a greater im
port
an
ce
of th
e
GI in
t
h
e
relatio
n
s
h
i
p
w
ith
BMI [2
],
[6
].
Anal
y
s
i
s
o
f
t
h
e rel
a
t
i
ons
hi
p
of B
I
had s
h
o
w
n t
h
at
R
T
at
10
0 cm
and
has a st
abl
e
si
gni
fi
ca
nt
st
im
ul
at
i
ng eff
ect
on i
n
sul
i
ne
m
i
a (
m
axim
u
m
p = 0,54,
p
= 0.0
0
3
)
. At
t
h
e sam
e
t
i
m
e
, hel
p
t
o
i
n
crea
se t
h
e
l
e
vel
s
o
f
B
I
an
d
WC
, st
a
r
t
i
n
g
wi
t
h
13
.5
m
U
/
L (m
axim
um
p =
0,
6
6
,
p =
0
.
00
4
)
.
In
wo
m
e
n
with
MS, on
ly WC was
correlated with the le
vel BI
(
p
= 0
,
40, p
= 0
.
02)
. The r
e
g
r
ession
an
alysis, th
erefore,
d
i
d no
t fi
n
d
its
cred
ib
le d
e
p
e
nd
ing
on th
e sp
ecific
param
e
ter v
a
lu
es of in
su
lin
emia an
d
WC
. I
n
m
e
n, level
s
of M
S
B
I
at
a val
u
e of
13 m
U
/
m
l
, and m
o
re di
rect
l
y
correl
a
t
e
d wi
t
h
TG ( P = 0,
29
, p =
0.
04
6
)
. At
hi
g
h
er B
I
(
≥
1
7
m
U
/
m
l
) si
gni
fi
cant
l
y
negat
i
ve co
rrel
a
t
i
o
n
wi
t
h
H
D
L (
p
= -0,
3
6,
p = 0.
04
9
)
an
d
in
su
lin
em
ia was no
t co
rrelated
with
lip
id para
m
e
ters.
MDA con
cen
t
r
atio
n
s
in m
a
les
ex
ceed
e
d 2-fold
th
en
t
a
r
g
e
t
M
S
(
p
<
0
.
0
1
)
.
I
n
w
o
m
e
n
w
i
t
h
M
S
a
n
d
with
ou
t, th
e lev
e
ls o
f
MDA were no
t d
i
fferen
t (Figu
r
e
4
)
.
Howev
e
r, th
e co
rrelatio
n
of MDA with
in
su
lin
was
si
gni
fi
ca
nt
(
p
<0.
0
1
)
b
o
t
h
i
n
m
e
n (p
=
0,
3
5
)
,
a
n
d
i
n
w
o
m
e
n (
p
=
0
,
5
0
)
.
In
m
e
n, t
h
i
s
associ
at
i
o
n
b
ecam
e
si
gni
fi
ca
nt
i
n
t
h
e G
I
(
≥
16 m
U
/
L), a
n
d i
n
wom
e
n i
t
doe
s not
de
pen
d
o
n
t
h
e s
p
eci
fi
c
val
u
es
of B
I
.
M
DA
lev
e
ls in m
e
n
and
correlated
with
t
h
e
ratio
o
f
WC
and ON
(p =
0
,
43
,
p <0.05
)
in th
e ab
sen
ce
o
f
th
i
s
connection
i
n
wom
e
n.
C
a
t
a
l
a
se l
e
vels i
n
M
S
wors
ened ra
pi
dl
y
,
and i
n
m
e
n i
t
was
m
o
re pr
on
o
unce
d
t
h
a
n
wom
e
n (p
<0
.0
01). Marked
inv
e
rse co
rrelatio
n
with the lev
e
l of SC
in
su
li
n
in
bo
th
men
(p
=
-0,34), an
d in
wo
m
e
n
(p
= -
0,
32
). Al
s
o
i
n
t
h
e GI (
≥
0,
15 m
U
/
L), t
h
i
s
feed
back
becom
e
s
m
o
re im
port
a
nt
. S
C
conce
n
t
r
at
i
o
n was
i
nve
rsel
y
co
rre
l
a
t
e
d wi
t
h
R
T
i
n
bot
h m
e
n (
p
= -
0
,
3
4
)
, a
n
d i
n
wom
e
n (
p
=
-0
,3
2)
.
Th
e BI lev
e
l in
m
e
n
was treated
as GI.
GI
in
wo
m
e
n was
l
e
ss pro
n
o
u
n
c
e
d. T
h
e effect
of g
e
n
d
er
on
t
h
e com
pone
nt
s of M
S
, s
o
l
d
t
h
r
o
u
g
h
t
h
e en
vi
r
onm
ent
a
l
fact
ors p
r
e
v
i
o
usl
y
repo
rt
ed P
o
u
l
sen P. et
al
. (20
0
1
)
4,35
4,1
6,33
6,02
2,47
2,3
2,13
5,35
4,69
0,98
0,89
1,6
1,11
1,15
0,87
0,91
0
1
2
3
4
5
6
7
Men
(controls)
Women(controls)
Men(MS)
Women
(MS)
Cholesterol
(mmol/l)
Triglycerids
(
ммоль
/
л
)
LDL
(mmol/l)
HDL
(mmol/l)
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
PH
S I
S
SN
:
225
2-8
8
0
6
Proo
xida
tive Ro
le o
f
Hyp
e
rinsu
lin
emia
i
n
Meta
bo
lic S
y
nd
ro
me Fo
rma
tion
(Nelli Uzb
e
ko
va
)
67
and
Per
o
va N
.
et
al
. (2
01
1
)
[
2
]
,
[
7
]
.
Lay
e
r
B
I
fl
o
o
r
,
s
o
m
e
aut
h
ors e
x
pl
ai
n di
ffe
rence
s
i
n
l
i
f
est
y
l
e
, i
n
c
l
udi
n
g
eating pattern
s [4]
,
[8]
.
Si
gni
fi
cant
di
f
f
ere
n
ces i
n
l
e
v
e
l
s
of B
I
i
n
m
e
n an
d
wo
m
e
n in
terested
in
th
e MS in
ter
m
s o
f
features
in
su
lin
em
ia co
rrelatio
ns wit
h
o
t
h
e
r co
m
p
on
en
ts of th
e clu
s
ter
[2
],
[4
].
In
ou
r
stud
y,
in
su
lin
co
rr
elated
w
ith
th
e
param
e
t
e
rs by
whi
c
h t
h
ese
gr
o
ups
di
ff
ere
d
- R
T
, T
G
, L
D
L. T
h
e nat
u
r
e
of t
h
e i
d
e
n
t
i
f
i
e
d co
rrel
a
t
i
o
ns al
s
o
depe
n
d
on
ge
n
d
er
.
Th
e m
e
n
in
th
e reg
r
ession
an
alysis id
en
tified
th
e k
e
y ro
le in th
e relatio
n
s
h
i
p
BI with
an
thropo
m
e
tric
param
e
t
e
rs. In
consi
d
eri
ng t
h
e nat
u
re
of t
h
e rel
a
t
i
o
ns
hi
p
of a
b
d
o
m
i
nal obesi
t
y
an
d GI [
1
]
,
[
2
]
,
t
h
e
s
e dat
a
su
ppo
rt th
e
p
r
i
m
acy o
f
its in
men
.
Clo
s
er si
g
n
i
fican
t correlatio
n
s
with
BI
(p= 0
,
6
6
)
com
p
are
d
with BM
I (p
=
0,
34
) i
n
m
e
n and a
rel
a
t
i
ons
h
i
p B
I
wi
t
h
W
C
i
n
wom
e
n ( P
= 0,
40
, p = 0
.
0
2
)
.
It
i
ndi
cat
es
a val
u
e o
f
ab
d
o
m
i
nal
obe
si
t
y
(AO
)
as a cl
i
n
i
cal
m
a
rke
r
o
f
M
S
.
For
w
o
m
e
n i
n
peri
m
e
nopa
us
e B
I
cor
r
el
at
ed o
n
l
y
wi
t
h
W
C
. The
ex
isten
ce
of t
h
ese correlation
s
is con
s
isten
t
with
th
e
c
o
ncl
u
si
on
o
f
D.
C
o
rry
o
n
t
h
e
r
o
l
e
of
vi
sce
r
al
fat
accum
u
lation in wom
e
n as a constant SG at the sa
m
e
ti
me lower values of postpr
andial insulin, which is
p
a
rticu
l
arly i
m
p
o
rtan
t i
n
ligh
t
of th
e po
ssi
ble presence
of M
I
in m
e
n
with
ou
t AD.
It is ass
o
ciated
with
AS typi
cal
M
S
i
ndi
cat
ors
dy
sl
i
p
o
p
r
o
t
e
i
n
em
ia
(DLP):
T
G
, de
creased HDL
[1]
,
[4]
,
[9]
.
It i
s
theref
o
r
e logical ap
p
earan
ce in
m
e
n
co
rrelatio
n
s
with
p
a
ram
e
ters BI DLP in
th
is order: th
e
lev
e
ls of in
su
lin
em
ia 1
2
m
U
/ L or m
o
re is si
g
n
i
fican
t (p
<0.05
)
, its relation
s
h
i
p
with
TG
( P = 0,29
) in
t
h
e BI
17
m
U
/
m
l
or
m
o
re - fee
d
bac
k
with
param
e
ters
HDL
(
P =
-0
,3
4)
.
Gend
er
d
i
fferen
ces
o
f
ch
aract
eristics of lip
id m
e
ta
b
o
lis
m
a
n
d lack of co
rrelatio
n
with
BI fem
a
le MC
m
a
y
be associ
at
ed wi
t
h
di
f
f
e
r
ent
l
e
vel
s
of i
n
sul
i
nem
i
a [2]
.
Ho
we
ver, i
n
heal
t
h
y
y
o
u
n
g
wom
e
n had h
i
ghe
r
rates and
lower HDL - TG co
m
p
ared
to
men
with
sim
ila
r
l
e
vel
s
o
f
B
I
[
6
]
,
[
10]
.
Gen
d
e
r
di
f
f
ere
n
ces
o
f
basal
and
p
o
st
p
r
a
ndi
al
i
n
sul
i
n
em
i
a
and
TG e
x
pl
ai
n cert
a
i
n
di
fferences in t
h
e ac
cum
u
lation of
visceral fat i
n
men
and
wom
e
n [
3
]
[
6]
. St
ro
n
g
est
p
o
ssi
bl
e
ass
o
ci
at
i
on
wi
t
h
ot
her
com
p
o
n
ent
s
o
f
t
h
e
GI
of
M
S
i
n
wom
e
n
ha
ve
whe
n
t
h
ey
ha
v
e
t
y
pe 2
di
a
b
et
es [
4
]
.
The
differe
n
ce
s in t
h
e le
vels
and
correlatio
n lin
k BI
with
an
thropo
m
e
tric
an
d lip
id p
a
rameters reflect
th
e d
i
fferen
t role o
f
in
su
lin
in th
e
m
ech
an
ism
s
o
f
fo
rm
atio
n
of m
e
tab
o
lic
syn
d
ro
m
e
in
men
and
wo
m
e
n
.
Th
is
defi
nes t
h
e di
f
f
ere
n
t
app
r
oac
h
es t
o
t
h
e di
a
g
nosi
s
of G
I
an
d R
& D base
d o
n
ge
nde
r. I
f
m
e
n surr
ogat
e
, but
a
v
a
lid
m
a
rk
er o
f
th
is state i
s
BI, th
en
women
sh
ou
ld
be assessed
in
su
lin
em
ia
in
st
ress tests [2
],[7
]. In
post
m
eno
p
aus
a
l
wom
e
n, re
v
eal
ed a cl
ose
r
rel
a
t
i
ons
hi
p
b
e
tween
th
e lip
id
ch
aracteris
tics and
GI [6
]. At th
e
sam
e
ti
me, th
e
u
n
i
v
e
rsality o
f
th
e co
rrelatio
ns with
BI
FROM p
r
ov
es th
e
valu
e o
f
th
is si
m
p
le
m
easu
r
emen
t in
the dia
g
nosis
of MS.
In a
ssoci
at
i
o
ns
wi
t
h
m
e
t
a
bol
i
c
B
I
c
o
m
pone
nt
s o
f
M
S
i
n
m
e
n an
d
wom
e
n are
i
n
t
e
rest
i
n
g
i
n
t
e
rm
s of
th
eir
relatio
n
s
hip
with
th
e m
e
ch
an
ism
s
o
f
the op
erati
ng sys
t
e
m
. There
is
evide
n
ce
of m
o
r
e
pro
n
o
u
n
ce
d OS i
n
men
[6
],
[9
],
[10
]].
Th
er
e is a
r
e
po
r
t
abo
u
t
the p
r
o
t
ectiv
e
ro
l
e
o
f
estrad
io
l i
n
th
e pro
t
ection
o
f
t
h
e
v
e
ssel
wall in
respon
se t
o
th
e OS [1
0
]
, in
add
itio
n
t
o
trad
itio
n
a
l i
d
eas abou
t its effects
o
n
lip
id
m
e
tab
o
lism
.
Th
ese d
a
ta
are co
nsisten
t
th
at we
id
en
tified
:
h
i
gh
er
lev
e
ls
of MDA
(p <0.0
01) an
d low l
e
v
e
ls
o
f
C
A
in m
e
n MS (p
<0.001) in c
o
ntrast
to healthy
m
e
n and
women. Due to
t
h
e ge
ne
rally accepted
role
of MDA
and s
p
acecra
f
t, as i
n
dicators
of the
oxi
dative st
ress
[2],[8
] is
of intere
st to t
h
em
based
on
gende
r
. Som
e
at
t
e
m
p
t
s
have
been
m
a
de t
o
assess t
h
e
rel
a
t
i
ons
hi
p o
f
oxi
di
zed L
D
L
wi
t
h
t
h
e pa
ram
e
t
e
rs AO
, cl
os
el
y
r
e
l
a
t
e
d
to
th
e
DLP and
IR /
GI [5
],[9
]. In
th
is conn
ectio
n it is inform
at
iv
e in
d
i
cato
r
s
rev
e
aled
th
e
relatio
nsh
i
p
o
f
MDA and the
spacecra
f
t with BI and
W
C
. Whe
n
significa
n
t diffe
re
nces in the levels of
BI, MDA a
nd
CA in
m
e
n and
wom
e
n o
f
t
h
e co
rre
l
a
t
i
on of t
h
e sa
m
e
t
y
pe, whi
c
h m
a
y refl
ect
the val
u
e o
f
p
r
oo
xi
da
nt
i
n
s
u
l
i
n
em
i
a
rega
rdl
e
ss
o
f
g
e
nde
r. T
h
e
pr
o
oxi
dant
rol
e
of
B
I
i
n
m
e
n i
s
becom
i
ng a si
g
n
i
f
i
cant
(
P = 0
,
3
5
,
p <0
.0
5
o
n
l
y
i
n
G
I
cond
itio
n
s
.
In
su
lin
em
ia affect OS op
tion
s
in
two
ways in
m
a
le
p
a
tien
t
s
- d
i
rectly (co
r
relatio
n
with
MDA),
b
a
ck
(correlation
with
SC) and
i
n
d
i
rectly th
rou
g
h
t
h
e ch
aracteristics o
f
a m
o
re p
r
on
oun
ced th
eir AO (B
I
co
rrelatio
n
with
RT and
RT
with
MDA, C
A
).
At th
e sa
m
e
t
i
m
e
, t
h
e pre
s
ence
of c
o
r
r
el
at
i
on rel
a
t
i
o
ns
hi
p
of B
I
wo
m
e
n
in
th
e
ab
sen
ce of
GI
can
argu
e th
e im
p
o
r
tan
ce th
ey ev
en
l
o
w levels o
f
i
n
su
lin
in
th
e
fo
rm
atio
n
o
f
t
h
e
MS-clin
ical mark
er of ab
domin
al o
b
e
sity. Th
ese
d
a
ta
are con
s
isten
t
with
th
e
v
i
ew th
at an
im
p
o
r
tan
t
pat
h
op
hy
si
ol
o
g
i
cal
r
o
l
e
o
f
R
& D
an
d
GM
i
n
t
h
e
i
n
duct
i
on
m
echani
s
m
s
of A
O
[
1
]
,
[
5
]
,
[
8
]
.
4.
CO
NCL
USI
O
N
Thu
s
, th
e assum
p
t
i
o
n
is th
at th
e realizatio
n o
f
g
e
n
d
e
r d
i
fferen
ces in
th
e
in
ten
s
ity o
f
the o
p
e
ratin
g
sy
st
em
happe
n
s
t
h
r
o
u
g
h
h
o
r
m
onal
fact
ors
un
de
r t
h
e i
n
fluence of age a
n
d ins
u
lin
em
ia. Possi
ble
m
ech
anism
s
of i
n
sulinem
ia’s prooxi
dant
role in MS are
m
odulated
by
AO
param
e
ters according to
gende
r. T
h
e
pre
s
ence
of
gen
d
e
r
di
f
f
e
rences
o
f
t
h
e i
n
sul
i
n
act
i
on t
o
t
h
e e
n
d
o
t
h
el
i
u
m
expl
ai
ns cl
ose
r
co
nnect
i
o
n
of
G
I
an
d
cardi
ovasc
ul
ar
di
seases
i
n
m
e
n, u
n
l
i
k
e wom
e
n.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
S
SN
:
2
252
-88
06
I
J
PH
S
Vo
l.
3
,
N
o
.
2
,
Jun
e
201
4 :
6
3
– 68
68
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mone
-
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d
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ob
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in
in
the
seru
m l
i
p
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d an
d l
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”
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.,
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t
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a
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.
BIOGRAP
HI
ES OF
AUTH
ORS
Nelli Uzbekov
a,
MD.
W
o
rks at the Andijan Sta
t
e Me
dica
l Institu
te,
t
h
e
card
i
olog
y d
e
partm
e
nt
, her s
c
ien
tifi
c
ine
t
er
ests
are in fund
amental
and applied immunology
, cur
r
en
tly
she
is working on PhD dissertation top
i
c
devoted
to
non-communicable diseases.
Dilo
ro
m
Mu
sak
hod
j
a
ev
a,
Do
ct
o
r
o
f
B
i
o
l
o
g
i
cal Scien
ce is th
e
Ch
ief of th
e
Im
m
unom
orphology DPT
of the Institute
of
Im
m
unology, Uz
bekistan’s Aca
d
em
y of
Sci
e
nce. H
e
r
sci
e
nt
i
f
i
c
i
n
t
e
rest
s are i
n
t
h
e fu
ndam
e
nt
al
and ap
pl
i
e
d
im
m
unol
ogy
,
im
m
unop
hi
si
ol
ogy
, i
m
m
une
m
echani
s
m
s
of i
n
fl
am
m
a
t
i
on,
de
vel
o
pi
ng t
u
m
o
rs an
d
op
hal
m
i
c
di
seases, e
n
d
o
c
r
i
n
ol
ogy
,
re
pr
o
duct
i
ve a
n
d
pe
di
at
ri
c im
m
unol
o
g
y
as wel
l
.
Pho
n
e
: +99
8
71
2
330
113
(
o
f
)
e-m
a
i
l: d
ily
m@xn
et.u
z
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