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8806
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ticu
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p
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lev
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[
1
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m
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Am
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[
6
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No
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th
e
ad
d
itio
n
al
s
id
e
-
ef
f
ec
t
ev
en
t
h
o
u
g
h
t
h
e
m
aj
o
r
ity
o
f
s
y
m
p
to
m
s
ar
e
m
o
d
er
ate
s
u
c
h
as
d
izz
y
,
h
ea
d
ac
h
e,
an
d
r
ash
,
tin
y
r
ed
s
p
o
ts
o
n
th
e
s
k
i
n
.
I
n
t
h
e
o
ld
ag
e,
t
h
e
s
id
e
ef
f
ec
t
is
m
o
r
e
s
er
io
u
s
;
it
in
cl
u
d
e
s
ar
r
h
y
t
h
m
ia
o
r
k
id
n
e
y
d
y
s
f
u
n
ctio
n
[
2
]
.
Kap
lan
s
tr
ess
e
s
t
h
at
n
o
n
d
r
u
g
t
h
er
ap
ies
m
a
y
p
r
o
v
id
e
en
o
u
g
h
an
ti
-
h
y
p
er
ten
s
i
v
e
e
f
f
ec
t
to
lo
w
er
b
lo
o
d
p
r
ess
u
r
e
to
a
s
af
e
lev
el
w
it
h
o
u
t
th
e
n
ee
d
f
o
r
an
tih
y
p
er
te
n
s
i
v
e
d
r
u
g
s
.
No
n
d
r
u
g
t
h
er
ap
ies
co
n
s
i
s
t
o
f
d
ietar
y
m
o
d
if
icat
io
n
(
s
o
d
iu
m
,
ca
lciu
m
,
p
o
tass
i
u
m
,
ch
o
les
ter
o
l)
,
w
e
ig
h
t
r
ed
u
cti
o
n
,
li
f
e
-
s
t
y
le
h
ab
it
c
h
a
n
g
e
s
(
s
m
o
k
in
g
,
alco
h
o
l,
p
h
y
s
ical
ac
ti
v
it
y
)
,
an
d
b
eh
a
v
io
r
m
o
d
if
icatio
n
(
e.
g
.
b
io
f
ee
d
b
ac
k
,
p
r
o
g
r
ess
iv
e
r
ela
x
at
io
n
,
co
g
n
iti
v
e
r
e
-
s
tr
u
ct
u
r
in
g
a
n
d
an
g
er
m
o
d
u
lat
io
n
)
[
6
]
.
A
r
o
m
a
th
er
ap
y
ca
n
h
elp
as
ad
j
u
n
ctiv
e
r
elax
i
n
g
th
er
ap
y
,
a
n
d
s
o
m
e
es
s
e
n
tial
o
ils
ar
e
th
o
u
g
h
t
to
h
e
lp
r
ed
u
ce
b
o
r
d
e
r
lin
e
h
y
p
er
te
n
s
io
n
[
2
]
.
So
m
e
e
s
s
e
n
tial
o
ils
h
a
v
e
a
f
f
in
ities
w
it
h
ce
r
tai
n
o
r
g
a
n
s
o
r
s
y
s
te
m
s
,
an
d
w
il
l
h
a
v
e
a
s
p
ec
ial
ef
f
ec
t
o
n
t
h
at
o
r
g
an
o
r
s
y
s
te
m
w
h
e
n
at
t
h
e
p
o
in
t
in
it
s
cir
cu
lat
in
g
j
o
u
r
n
e
y
.
W
h
ate
v
er
p
ar
t
o
f
th
e
e
s
s
e
n
tial
o
il
i
s
le
f
t
a
f
ter
its
t
h
er
ap
eu
tic
w
o
r
k
i
n
t
h
e
b
o
d
y
h
a
s
b
ee
n
d
o
n
e,
w
i
ll
b
e
ex
cr
e
ted
b
y
o
n
e
p
ath
o
r
an
o
th
er
.
I
t
m
a
y
b
e
p
as
s
ed
o
u
t
o
f
th
e
b
o
d
y
i
n
u
r
in
e
o
r
f
ae
ce
s
,
ex
cr
eted
th
r
o
u
g
h
t
h
e
s
k
i
n
as
s
w
ea
t
o
r
r
etu
r
n
ed
to
th
e
lu
n
g
s
to
b
e
ex
h
aled
w
ith
t
h
e
b
r
ea
th
[
3
]
.
So
m
e
t
y
p
es
o
f
ar
o
m
at
h
er
ap
y
w
h
ic
h
ca
n
b
e
u
s
ed
to
d
ec
r
ea
s
e
h
y
p
er
ten
s
io
n
ar
e
s
ag
e,
r
o
s
em
ar
y
,
an
d
lav
en
d
er
[
2
]
.
T
is
s
er
an
d
(
1
9
8
8
)
,
L
av
a
n
d
u
la
a
u
g
u
s
ti
f
o
lia
(
t
r
u
e
L
a
v
e
n
d
er
)
,
th
o
u
g
h
t
to
r
ed
u
ce
th
e
e
f
f
ec
t
o
f
ex
ter
n
al
e
m
o
t
io
n
al
s
ti
m
u
li
b
y
in
cr
ea
s
in
g
g
a
m
m
a
-
a
m
i
n
o
b
u
ty
r
ic
ac
id
(
GA
B
A
)
,
w
h
ic
h
in
t
u
r
n
i
n
h
ib
it
s
n
e
u
r
o
n
s
in
t
h
e
a
m
y
g
d
ale,
p
r
o
d
u
cin
g
a
s
ed
ativ
e
e
f
f
ec
t si
m
i
lar
to
th
at
o
f
d
iaze
p
a
m
.
I
t is o
n
e
o
f
th
e
m
o
s
t
w
id
el
y
u
s
ed
a
n
d
r
esear
ch
ed
ess
e
n
tial
o
il
s
an
d
i
ts
r
ec
o
g
n
ized
a
s
a
r
elax
a
n
t
[
7
]
.
W
est
w
o
o
d
(
1
9
9
1
)
s
tates
lav
e
n
d
er
h
elp
s
b
alan
c
e
th
e
m
in
d
a
n
d
e
m
o
tio
n
s
.
O
n
th
e
o
th
er
h
an
d
,
it
s
ti
m
u
late
s
ap
n
o
eic
r
ef
le
x
b
y
clo
s
in
g
lar
y
n
x
a
n
d
ca
u
s
e
s
p
ar
as
y
m
p
at
h
etic
g
en
er
al
r
esp
o
n
s
e
b
y
t
h
e
d
ec
r
ea
s
e
eith
er
i
n
b
lo
o
d
p
r
ess
u
r
e
o
r
in
h
ea
r
tb
ea
t
[2
-
3]
,
[
7
]
.
L
a
v
en
d
er
ar
o
m
at
h
er
ap
y
ca
n
b
e
u
s
ed
b
y
i
n
h
a
latio
n
m
et
h
o
d
o
r
s
m
ea
r
it
o
n
s
k
i
n
w
h
ile
m
a
s
s
a
g
in
g
it.
Ho
w
e
v
er
,
in
h
alatio
n
is
th
e
s
i
m
p
lest
,
t
h
e
f
aste
s
t,
a
n
d
also
t
h
e
o
ld
est
m
et
h
o
d
[
2
]
.
T
h
e
ab
s
o
r
p
tio
n
o
f
es
s
en
t
ial
o
ils
in
to
th
e
b
lo
o
d
s
tr
ea
m
v
ia
th
e
r
esp
ir
ato
r
y
s
y
s
te
m
is
s
lo
w
er
an
d
m
o
r
e
d
if
f
u
s
iv
e
t
h
an
an
y
o
th
er
f
o
r
m
o
f
ap
p
licatio
n
,
an
d
es
s
en
tial
o
il
s
w
ill
n
o
t
b
u
ild
u
p
h
ig
h
lev
el
s
o
f
co
n
ce
n
tr
atio
n
(
as
lo
n
g
a
s
s
en
s
ib
le
p
r
o
p
o
r
tio
n
ar
e
u
s
ed
)
,
d
u
e
to
th
e
f
ac
t
th
at
t
h
e
o
ils
ar
e
co
n
s
tan
tl
y
b
ei
n
g
r
e
m
o
v
ed
f
r
o
m
t
h
e
b
lo
o
d
s
tr
ea
m
b
y
o
n
e
o
r
m
o
r
e
ex
it
p
ath
w
a
y
s
[
3
]
.
T
h
e
p
r
o
ce
s
s
o
f
h
o
w
lav
e
n
d
e
r
ar
o
m
a
th
er
ap
y
ca
n
h
elp
d
ec
r
ea
s
e
b
lo
o
d
p
r
ess
u
r
e
i
s
a
s
f
o
llo
w
s
:
t
h
e
p
ar
ticles
o
f
ess
e
n
tial
o
il
w
h
ic
h
ar
e
ea
s
il
y
e
v
ap
o
r
ated
u
n
d
er
g
o
es
ev
ap
o
r
atio
n
w
h
e
n
it
is
co
n
tacte
d
w
it
h
air
.
A
r
o
m
a
p
ar
ticles
o
f
ess
e
n
tial
o
il
is
d
is
s
o
lv
ed
in
m
u
co
s
a
th
r
o
u
g
h
t
h
e
i
n
s
id
e
n
a
s
al
c
av
i
t
y
w
h
ich
h
as
g
o
tte
n
s
ti
m
u
la
tio
n
f
r
o
m
t
h
e
r
ec
ep
to
r
.
T
h
e
tied
ar
o
m
atic
m
o
lecu
les
ar
e
r
em
o
v
ed
th
r
o
u
g
h
cilia
wh
ich
ar
e
p
r
o
tr
u
d
ed
f
r
o
m
o
lf
ac
to
r
i
u
s
r
ec
ep
to
r
.
T
h
is
o
lf
ac
to
r
y
ce
ll
r
ec
ep
to
r
h
as
lo
n
g
n
er
v
e
tis
s
u
e
w
h
ich
i
s
ca
lled
ax
o
n
an
d
an
ar
o
m
a
elec
tr
ic
c
h
e
m
is
t
r
y
m
ess
a
g
e
w
h
ic
h
is
tr
an
s
m
itted
alo
n
g
t
h
e
a
x
o
n
o
f
r
ec
ep
to
r
ce
ll
m
er
g
es
w
it
h
o
lf
ac
to
r
iu
s
n
er
v
e.
Ol
f
ac
to
r
i
u
s
n
er
v
e
tis
s
u
e
p
ass
e
s
t
h
r
o
u
g
h
a
p
late
w
h
er
e
et
h
m
o
id
b
o
n
e
i
s
s
to
r
ed
in
n
a
s
al
r
o
o
f
an
d
th
en
r
ea
ch
e
s
o
lf
ac
to
r
iu
s
b
u
lb
u
s
w
h
er
e
an
ar
o
m
a
s
ig
n
al
i
s
ch
e
m
icall
y
c
h
an
g
ed
b
ef
o
r
e
it
is
s
en
t
o
u
t
to
th
e
b
r
ain
.
As
s
o
o
n
as
t
h
e
m
es
s
ag
e
r
ea
ch
es
o
lf
ac
to
r
i
u
s
b
u
lb
u
s
,
i
m
p
u
l
s
e
o
f
o
l
f
ac
to
r
iu
s
ce
ll
p
ass
es
i
n
to
o
lf
ac
to
r
y
ca
n
al
a
n
d
d
ir
ec
tl
y
to
ce
r
eb
r
al
co
r
tex
w
h
er
e
th
e
ar
o
m
a
is
p
er
ce
iv
ed
.
T
em
p
o
r
al
lo
b
u
s
f
r
o
m
th
e
b
r
ain
co
n
ta
in
s
pr
im
ar
y
o
l
f
ac
to
r
iu
s
ar
ea
an
d
is
d
ir
ec
tly
co
n
n
ec
ted
w
it
h
li
m
b
i
c
ar
ea
/s
y
s
te
m
[2
-
3
]
.
L
i
m
b
ic
s
y
s
te
m
is
a
co
m
p
lete
r
in
g
o
f
b
r
ain
s
tr
u
ct
u
r
e
in
ce
r
eb
r
al
co
r
tex
.
T
h
e
m
ai
n
s
tr
u
ctu
r
es
i
n
li
m
b
ic
s
y
s
te
m
ar
e
a
m
y
g
d
ala,
s
ep
tu
m
,
h
ip
p
o
ca
m
p
u
s
,
a
n
ter
io
r
th
ala
m
u
s
,
an
d
h
y
p
o
t
h
ala
m
u
s
.
T
h
ese
s
tr
u
ct
u
r
es
ar
e
co
n
n
ec
ted
w
it
h
a
n
u
m
b
er
o
f
in
tr
icate
p
at
h
w
a
y
s
.
Am
y
g
d
ala
an
d
h
ip
p
o
ca
m
p
u
s
ar
e
t
h
e
m
ai
n
r
eg
io
i
n
p
r
o
ce
s
s
i
n
g
t
h
e
ar
o
m
a.
Am
y
g
d
ala
p
la
y
s
an
i
m
p
o
r
tan
t
r
o
le
in
p
r
o
ce
s
s
in
g
ar
o
m
a
an
d
f
o
r
m
s
e
m
o
ti
o
n
al
m
e
m
o
r
y
;
in
t
h
is
ca
s
e,
a
m
y
g
d
ala
ar
r
an
g
e
s
e
m
o
tio
n
al
r
esp
o
n
s
e.
L
i
m
b
ic
s
y
s
te
m
i
n
ter
ac
ts
w
it
h
ce
r
eb
r
al
co
r
tex
an
d
g
i
v
es
th
e
co
n
tr
ib
u
t
io
n
b
y
t
h
e
r
elatio
n
b
et
w
ee
n
th
in
k
i
n
g
a
n
d
s
e
n
s
i
n
g
,
an
d
h
as
d
ir
ec
t
co
n
n
ec
tio
n
w
it
h
p
ar
ts
o
f
th
e
b
r
ai
n
w
h
ic
h
co
n
tr
o
l
h
ea
r
tb
ea
t,
b
lo
o
d
p
r
ess
u
r
e,
r
esp
ir
atio
n
,
le
v
el
o
f
s
tr
ess
,
a
n
d
h
o
r
m
o
n
al
c
o
n
ten
t
[7
].
E
v
en
th
o
u
g
h
es
s
en
tial
o
il
in
h
alatio
n
is
g
en
er
all
y
r
elate
d
to
o
lf
ac
to
r
iu
s
,
s
ev
er
al
m
o
lec
u
les
f
r
o
m
i
n
h
aled
p
ar
ticles
w
ill
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[
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[
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B
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h
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j
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tiv
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th
e
r
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as
to
an
al
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ath
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atie
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ts
at
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UP
T P
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n
a
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s
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l La
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t U
s
ia
,
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i
.
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h
e
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y
p
o
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esi
s
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f
t
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w
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t
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l
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in
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t
s
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e
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ch
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s
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i
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lt
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d
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ev
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lo
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m
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n
t
p
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g
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m
,
an
d
f
o
r
r
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ch
er
as
a
s
u
p
p
o
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t
in
ap
p
ly
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g
s
cie
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ce
an
d
e
x
p
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ce
in
t
h
is
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h
to
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ed
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s
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2.
RE
S
E
ARCH
M
E
T
H
O
D
T
h
e
r
esear
ch
u
s
ed
q
u
an
t
itati
v
e
m
et
h
o
d
w
ith
q
u
asi
ex
p
er
i
m
en
t a
n
d
s
u
b
j
ec
t e
q
u
al
d
esig
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Su
b
j
ec
t e
q
u
al
d
esig
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is
a
s
er
ial
d
es
ig
n
i
n
wh
ich
a
ll
s
a
m
p
les
u
n
d
er
g
o
ac
ti
v
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s
an
d
t
w
o
p
er
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d
s
in
d
if
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er
en
t
ti
m
e.
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h
e
f
ir
s
t
p
er
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d
is
in
ter
v
e
n
tio
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p
er
io
d
in
w
h
ic
h
th
e
s
a
m
p
les
ar
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g
i
v
en
th
e
in
ter
v
e
n
tio
n
w
it
h
i
n
t
wo
w
ee
k
s
(
1
4
d
ay
s
)
.
T
h
en
,
it
is
alter
n
ated
b
y
t
h
e
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P
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as
h
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d
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th
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tr
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m
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g
t
h
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m
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b
j
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t
w
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t
w
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k
s
(
1
4
d
ay
s
)
.
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h
e
r
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ch
w
as
co
n
d
u
cted
at
th
e
UP
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P
ela
ya
n
a
n
S
o
s
ia
l
L
a
n
ju
t
Usi
a
,
B
in
j
ai.
T
h
e
s
elec
tio
n
o
f
th
e
r
esear
ch
l
o
ca
tio
n
w
a
s
b
ased
o
n
t
h
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co
n
s
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th
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l
d
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ly
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p
le
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in
t
h
e
s
a
m
e
lo
ca
tio
n
s
o
th
a
t
it
m
ad
e
t
h
is
r
e
s
ea
r
ch
ea
s
ier
.
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h
e
r
esear
ch
w
a
s
co
n
d
u
cted
f
r
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m
Ma
y
u
n
til
J
u
n
e,
2
0
1
5
.
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h
e
p
o
p
u
latio
n
w
as
al
l
4
0
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er
ly
p
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p
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t
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a
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n
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ai,
b
ased
o
n
th
e
p
r
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m
in
ar
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s
u
r
v
e
y
.
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s
a
m
p
les
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tak
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n
b
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u
s
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g
f
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s
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eth
o
d
o
f
g
a
th
er
i
n
g
t
h
e
d
ata
w
a
s
as
f
o
llo
w
s
:
1
)
D
u
r
in
g
t
h
e
p
r
o
ce
s
s
o
f
g
ath
er
i
n
g
t
h
e
d
ata,
th
e
r
es
ea
r
ch
er
s
ex
p
lai
n
ed
th
e
b
en
e
f
it
o
f
t
h
e
r
esear
ch
a
n
d
th
e
p
r
o
ce
d
u
r
e
o
f
th
e
r
esear
ch
to
th
e
r
esp
o
n
d
en
ts
-
to
-
b
e
to
f
o
llo
w
th
e
r
esear
c
h
p
r
o
ce
d
u
r
e
an
d
w
er
e
w
illi
n
g
to
p
ar
ticip
ate
b
y
s
i
g
n
in
g
t
h
e
I
n
f
o
r
m
ed
C
o
n
s
e
n
t.
2
)
T
h
ey
ag
r
ee
d
to
f
o
llo
w
th
e
r
esear
ch
p
r
o
ce
d
u
r
e
an
d
f
u
lf
il
led
th
e
cr
iter
ia,
f
illed
o
u
t
th
eir
b
io
-
d
ata
w
h
ich
i
n
cl
u
d
ed
th
eir
ag
e
a
n
d
s
e
x
w
h
ic
h
h
ad
b
ee
n
p
r
ep
ar
e
d
b
y
th
e
r
esear
ch
er
s
.
3
)
I
n
t
h
e
f
ir
s
t
p
er
io
d
,
r
esp
o
n
d
en
ts
w
er
e
g
iv
e
n
p
r
e
-
test
w
it
h
s
p
h
y
g
m
o
m
an
o
m
eter
o
f
No
v
a
b
r
an
d
an
d
s
teth
o
s
c
o
p
e
o
f
L
it
m
a
n
n
b
r
an
d
in
o
r
d
er
to
m
ea
s
u
r
e
th
eir
b
lo
o
d
p
r
ess
u
r
e
w
h
ic
h
w
o
u
ld
b
e
w
r
itten
i
n
t
h
e
o
b
s
er
v
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n
s
h
ee
t
s
,
an
d
th
e
y
w
er
e
g
i
v
en
l
av
en
d
er
o
il
b
y
u
s
in
g
in
h
a
latio
n
.
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y
t
h
e
ti
m
e
t
h
e
b
lo
o
d
p
r
ess
u
r
e
w
as
m
ea
s
u
r
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,
th
e
r
esp
o
n
d
en
ts
w
er
e
ask
ed
to
s
it
d
o
w
n
co
m
f
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tab
l
y
,
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t
h
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w
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p
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m
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tab
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m
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m
an
o
m
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ter
s
ca
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ter
w
a
s
p
u
t
p
ar
allel
w
it
h
t
h
e
r
ese
ar
ch
er
s
’
e
y
e
s
.
Af
ter
th
eir
b
lo
o
d
p
r
ess
u
r
e
w
a
s
m
ea
s
u
r
ed
,
th
e
r
esp
o
n
d
en
t
s
w
er
e
g
iv
e
n
5
d
r
o
p
s
o
f
lav
e
n
d
er
o
il.
B
ef
o
r
e
th
at,
th
e
y
w
er
e
to
ld
to
ex
er
cise
f
o
r
tak
in
g
d
ee
p
b
r
ea
th
(
in
h
ali
n
g
)
in
t
h
e
co
u
n
t o
f
5
,
h
o
ld
in
g
t
h
eir
b
r
ea
th
i
n
t
h
e
co
u
n
t
o
f
5
,
a
n
d
ex
h
ali
n
g
in
t
h
e
co
u
n
t o
f
5
.
Af
ter
t
h
e
y
d
id
w
h
at
h
ad
b
ee
n
ask
ed
,
t
h
e
y
w
er
e
g
i
v
en
la
v
en
d
er
o
il
in
a
p
iece
o
f
co
tto
n
wh
ich
w
as
g
iv
e
n
c
lo
s
e
to
t
h
eir
n
o
s
es
(
ar
o
u
n
d
3
c
m
)
an
d
as
k
ed
to
ta
k
e
t
h
eir
b
r
ea
t
h
in
1
0
m
i
n
u
te
s
.
P
o
s
t
-
test
w
as
th
en
ca
r
r
ied
o
u
t
b
y
m
ea
s
u
r
i
n
g
t
h
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b
lo
o
d
p
r
ess
u
r
e,
u
s
i
n
g
s
p
h
y
g
m
o
m
a
n
o
m
e
ter
,
R
i
esta
No
v
a
b
r
a
n
d
,
an
d
s
tet
h
o
s
c
o
p
e
L
it
m
an
n
b
r
an
d
;
t
h
e
r
es
u
lt
w
a
s
w
r
itte
n
o
n
th
e
o
b
s
er
v
atio
n
s
h
ee
t.
T
h
i
s
ac
ti
v
i
t
y
to
o
k
t
w
o
w
ee
k
s
(
1
4
d
a
y
s
)
.
4
)
.
W
ash
in
g
o
u
t
P
er
io
d
(
W
OP
)
is
th
e
p
er
io
d
o
f
eli
m
i
n
ati
n
g
t
h
e
e
f
f
ec
t
o
f
th
e
p
r
ev
io
u
s
in
ter
v
e
n
tio
n
.
I
t
w
a
s
d
o
n
e
i
n
3
d
a
y
s
;
i
n
t
h
i
s
p
e
r
io
d
th
er
e
w
a
s
n
o
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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P
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N:
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m
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p
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5
)
I
n
th
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s
ec
o
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d
p
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,
th
e
r
esp
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d
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p
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er
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n
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e
ets
w
ith
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u
t
g
i
v
i
n
g
lav
e
n
d
er
o
il
to
b
e
in
h
aled
.
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h
e
in
ter
v
a
l
o
f
m
ea
s
u
r
i
n
g
b
lo
o
d
p
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ess
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r
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et
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s
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a
n
d
p
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test
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as
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m
i
n
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s
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h
is
ac
tiv
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t
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k
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k
s
(
1
4
d
ay
s
)
.
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h
e
asp
ec
t o
f
m
ea
s
u
r
i
n
g
b
lo
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d
p
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u
r
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u
s
ed
r
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ca
le.
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h
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iast
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d
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ter
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tio
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w
h
ic
h
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as
s
aid
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at
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w
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s
s
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if
ica
n
t
w
h
en
p
<
0
.
0
5
3.
RE
SU
L
T
S
T
h
e
r
esear
ch
w
as
co
n
ce
r
n
ed
w
it
h
“
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h
e
I
n
f
lu
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n
ce
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f
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A
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in
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ld
er
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y
P
e
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p
le
w
it
h
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y
p
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ten
s
io
n
a
t
t
h
e
UP
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ela
ya
n
a
n
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o
s
ia
l
La
n
ju
t
Usi
a
,
B
in
j
ai.
”
I
t
w
a
s
co
n
d
u
cted
f
r
o
m
Ma
y
1
8
u
n
til
J
u
n
e
1
7
,
2
0
1
5
.
I
n
t
er
v
en
tio
n
w
it
h
lav
e
n
d
er
ar
o
m
at
h
er
ap
y
f
o
r
th
e
r
esp
o
n
d
en
ts
w
as
g
iv
e
n
in
t
h
e
r
esear
ch
co
n
d
u
cted
f
r
o
m
Ma
y
1
8
u
n
til
Ma
y
3
1
,
2
0
1
5
.
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ash
in
g
o
u
t
P
er
io
d
w
a
s
f
r
o
m
J
u
n
e
1
u
n
til
J
u
n
e
3
,
2
0
1
5
,
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d
th
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n
i
n
ter
v
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t
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th
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t
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ar
o
m
ath
er
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d
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ts
w
a
s
d
o
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e
f
r
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m
J
u
n
e
4
u
n
til
J
u
n
e
1
7
,
2
0
1
5
.
A
t
t
h
e
b
eg
i
n
n
i
n
g
,
th
e
s
a
m
p
les
w
er
e
ex
p
ec
ted
to
b
e
4
0
r
esp
o
n
d
en
ts
,
b
u
t
o
n
l
y
3
2
o
f
th
e
m
w
er
e
w
illi
n
g
t
o
b
e
in
v
o
lv
ed
in
t
h
e
r
esear
ch
.
3
.
1
.
Respo
nd
e
nts’
cha
ra
ct
er
is
t
ics
R
esp
o
n
d
en
ts
’
c
h
ar
ac
ter
is
tic
s
i
n
t
h
is
r
esear
ch
in
c
l
u
d
ed
ag
e
a
n
d
s
e
x
(
s
ee
T
ab
le
1
)
.
T
a
b
le
1
s
h
o
w
s
th
e
d
is
tr
ib
u
tio
n
o
f
t
h
e
r
e
s
p
o
n
d
en
t
s
’
c
h
ar
ac
ter
is
tics
.
T
h
is
tab
le
d
escr
ib
es
th
at
th
e
p
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ce
n
ta
g
e
ag
e
o
f
6
0
–
7
0
w
as
s
i
m
ilar
to
>
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d
m
o
s
t o
f
t
h
e
m
w
er
e
f
e
m
ale
s
(
5
3
.
1
%).
T
ab
le
1
.
Dis
tr
ib
u
tio
n
o
f
R
e
s
p
o
n
d
en
t
s
’
C
h
ar
ac
ter
i
s
tics
V
a
r
i
a
b
l
e
F
r
e
q
u
e
n
c
y
T
o
t
a
l
(
%)
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g
e
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–
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>
7
0
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16
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0
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5
0
%
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e
x
M
a
l
e
F
e
mal
e
15
17
4
6
.
9
%
5
3
.
1
%
3
.
2
.
M
e
a
s
uring
blo
o
d pre
s
s
ure
w
it
h la
v
ender
a
ro
m
a
t
hera
py
inte
rv
ent
io
n
Me
asu
r
e
m
en
t
to
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k
1
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d
ay
s
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n
p
r
e
an
d
p
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t
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ter
v
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n
tio
n
w
it
h
la
v
en
d
er
ar
o
m
at
h
er
ap
y
g
iv
e
n
to
t
h
e
r
esp
o
n
d
en
ts
.
T
ab
le
2
in
d
icate
s
t
h
at
t
h
e
m
ea
n
v
alu
e
o
f
r
e
s
p
o
n
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ts
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s
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s
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b
lo
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d
p
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u
r
e
i
n
p
r
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la
v
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d
er
ar
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m
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n
ter
v
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t
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n
w
a
s
1
6
5
.
5
9
2
m
m
H
g
w
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th
th
e
m
i
n
i
m
u
m
v
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f
1
4
1
.
6
m
m
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g
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m
a
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m
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v
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f
2
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g
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as
9
0
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1
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m
Hg
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Hg
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m
ax
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m
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m
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f
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2
.
8
m
m
H
g
.
B
ased
o
n
T
ab
le
2
,
it
co
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ld
also
b
e
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n
t
h
at
th
e
r
esp
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n
d
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[
7
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,
[
1
3
]
.
T
h
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s
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p
p
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ted
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J
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[
1
4
]
.
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Fro
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lo
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p
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T
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th
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p
in
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aid
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at
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h
y
p
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n
d
p
alp
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[
2
]
,
[
1
5
]
.
L
av
en
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er
is
a
s
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ativ
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o
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g
iv
i
n
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to
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th
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ch
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t
,
an
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s
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[
3
]
.
T
h
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r
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a
s
also
s
u
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Sa
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[
8
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.
B
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1
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ter
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e
in
d
ec
r
e
asin
g
b
lo
o
d
p
r
ess
u
r
e
b
ec
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s
e
th
e
g
r
o
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p
t
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at
w
as
g
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v
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n
d
er
ar
o
m
ath
er
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y
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ter
v
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ad
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o
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i
g
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f
ica
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t
d
ec
r
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ase
t
h
an
th
at
w
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i
ch
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id
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o
t
g
et
a
n
y
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en
d
er
ar
o
m
at
h
er
ap
y
i
n
ter
v
en
tio
n
.
T
h
is
w
a
s
s
u
p
p
o
r
ted
b
y
th
e
r
esear
c
h
co
n
d
u
c
ted
b
y
C
h
o
et
al
(
2
0
1
3
)
o
n
ef
f
ec
ts
a
lav
e
n
d
er
,
r
o
m
a
n
ch
a
m
o
m
i
le,
an
d
n
er
o
li
o
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len
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r
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m
at
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h
e
an
x
iet
y
,
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ital
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ig
n
s
,
a
n
d
s
leep
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u
alit
y
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f
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er
cu
ta
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s
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r
o
n
ar
y
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ter
v
e
n
tio
n
p
atie
n
ts
i
n
in
ten
s
iv
e
ca
r
e
un
its
.
I
t
w
a
s
in
d
icate
d
b
y
t
-
test
p
=
0
,
0
1
1
,
w
h
ic
h
s
h
o
w
ed
t
h
at
a
lav
e
n
d
er
,
r
o
m
a
n
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h
a
m
o
m
ile,
a
n
d
n
er
o
li
o
il
b
le
n
d
ar
o
m
a
th
er
ap
y
co
u
ld
d
ec
r
ea
s
e
b
lo
o
d
p
r
ess
u
r
e
p
atien
ts
co
r
o
n
ar
y
ar
ter
y
d
is
ea
s
e
s
in
an
in
te
n
s
iv
e
ca
r
e
[
1
7
]
.
I
n
th
e
g
r
o
u
p
w
h
ic
h
w
a
s
n
o
t
g
i
v
en
i
n
ter
v
en
t
io
n
t
h
e
d
ec
r
ea
s
e
in
th
e
d
i
s
p
ar
it
y
o
f
s
y
s
to
lic
b
lo
o
d
p
r
ess
u
r
e
in
p
r
e
a
n
d
p
o
s
t
n
o
n
-
i
n
ter
v
e
n
t
io
n
al
s
o
o
cc
u
r
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ed
ev
e
n
t
h
o
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g
h
it
w
as
n
o
t
as
h
ig
h
a
s
t
h
e
d
ec
r
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s
e
in
s
y
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to
lic
b
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o
d
p
r
es
s
u
r
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o
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th
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ter
v
e
n
tio
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g
r
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u
p
.
T
h
is
w
a
s
p
o
s
s
ib
le
b
ec
au
s
e
o
f
t
h
e
o
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er
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ac
to
r
s
s
u
c
h
a
s
d
ieti
n
g
,
p
h
y
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ical
ac
ti
v
it
y
,
a
v
o
id
in
g
s
tr
ess
,
a
n
d
m
ed
ici
n
e
s
.
T
h
er
e
ar
e
t
w
o
m
et
h
o
d
s
in
h
y
p
er
t
en
s
io
n
m
ed
icatio
n
:
p
h
ar
m
ac
o
lo
g
ical
m
ed
icatio
n
an
d
n
o
n
-
p
h
ar
m
ac
o
lo
g
ical
m
ed
icatio
n
[
6
]
.
P
h
ar
m
ac
o
lo
g
ical
m
ed
icatio
n
f
o
r
h
y
p
er
te
n
s
io
n
i
s
u
s
u
all
y
co
m
b
in
ed
w
it
h
s
o
m
e
m
ed
icin
e
s
s
u
ch
a
th
iazid
e
d
iu
r
etic,
an
a
n
g
io
ten
s
i
n
co
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er
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g
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in
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lci
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ch
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eta
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et
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m
in
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i
n
s
u
li
n
,
a
s
tati
n
a
n
d
asp
ir
in
)
[
4
]
.
No
n
-
p
h
ar
m
ac
o
lo
g
ical
m
ed
icatio
n
co
n
s
i
s
t
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i
etar
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o
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i
f
icatio
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s
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alciu
m
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p
o
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m
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ch
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w
e
ig
h
t
r
ed
u
ct
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lif
e
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s
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h
ab
it
c
h
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g
es
(
s
m
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alco
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l,
p
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ical
ac
ti
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)
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an
d
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o
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f
icat
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e.
g
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io
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ee
d
b
ac
k
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p
r
o
g
r
ess
iv
e
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ela
x
atio
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,
co
g
n
iti
v
e
r
e
-
s
tr
u
ct
u
r
in
g
an
d
a
n
g
e
r
m
o
d
u
la
tio
n
)
[
6
]
.
P
in
to
(
2
0
0
7
)
p
o
in
ted
o
u
t
th
at
b
lo
o
d
p
r
ess
u
r
e
m
a
n
a
g
e
m
en
t
f
o
r
eld
er
ly
p
eo
p
le
in
cl
u
d
ed
m
e
d
icin
es,
c
h
an
g
i
n
g
in
lif
es
t
y
le
w
h
ic
h
co
n
s
is
ted
o
f
d
e
cr
ea
s
in
g
s
alt
i
n
ta
k
e,
an
d
co
n
d
u
cti
n
g
p
h
y
s
ical
ex
er
ci
s
e
p
r
o
g
r
a
m
[
1
8
]
.
T
h
e
a
m
o
u
n
t
o
f
d
ec
r
ea
s
e
i
n
s
y
s
to
lic
b
lo
o
d
p
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ess
u
r
e
i
n
th
e
g
r
o
u
p
w
h
ic
h
w
as
g
i
v
e
n
la
v
e
n
d
er
ar
o
m
at
h
er
ap
y
in
ter
v
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n
tio
n
w
a
s
d
if
f
er
e
n
t
f
r
o
m
th
e
a
m
o
u
n
t
o
f
d
ec
r
ea
s
e
in
s
y
s
to
lic
b
lo
o
d
p
r
ess
u
r
e
i
n
t
h
e
g
r
o
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p
w
h
ic
h
w
as
n
o
t
g
i
v
e
n
lav
e
n
d
er
ar
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m
at
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ap
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i
n
ter
v
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tio
n
(
7
.
0
6
4
1
m
m
H
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)
.
T
h
is
w
as
s
u
p
p
o
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ted
b
y
s
y
s
te
m
at
ic
r
ev
ie
w
b
y
Dic
k
i
n
s
o
n
et
al
.
,
2
0
0
6
o
n
lif
est
y
le
i
n
ter
v
e
n
tio
n
s
to
d
ec
r
ea
s
e
r
aised
b
lo
o
d
p
r
e
s
s
u
r
e
:
a
s
y
s
te
m
atic
r
ev
ie
w
o
f
r
an
d
o
m
ized
co
n
tr
o
lled
tr
ials
w
h
ic
h
p
o
in
ted
o
u
t t
h
a
t in
cr
ea
s
ed
d
iet,
ae
r
o
b
ic
ex
er
cises
,
a
n
d
r
estricti
n
g
alco
h
o
l,
s
alt,
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d
f
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s
h
o
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ld
d
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s
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lo
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p
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r
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f
r
o
m
5
.
0
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m
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g
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to
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m
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Hg
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Hg
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95%
:
0
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2
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.
3
)
w
it
h
t
h
e
s
i
m
ilar
it
y
to
th
e
d
ec
r
ea
s
e
in
d
iast
o
lic
b
lo
o
d
p
r
ess
u
r
e
[
1
9
]
.
Ho
w
e
v
er
,
w
h
en
t
h
e
m
ea
n
d
is
p
ar
ity
v
al
u
e
o
f
r
esp
o
n
d
en
ts
’
d
iast
o
lic
b
lo
o
d
p
r
ess
u
r
e
in
p
r
e
an
d
p
o
s
t
in
t
er
v
e
n
tio
n
is
co
m
p
ar
ed
w
it
h
th
e
m
ea
n
d
i
s
p
ar
it
y
v
al
u
e
o
f
r
esp
o
n
d
en
ts
’
d
iast
o
lic
b
lo
o
d
p
r
ess
u
r
e
i
n
p
r
e
an
d
p
o
s
t
n
o
n
-
in
ter
v
e
n
tio
n
,
i
t
w
as
f
o
u
n
d
th
at
th
e
y
w
er
e
n
o
t
s
i
m
ilar
.
T
h
e
m
ea
n
d
is
p
ar
it
y
v
a
lu
e
o
f
r
esp
o
n
d
e
n
ts
’
d
iast
o
lic
b
lo
o
d
p
r
ess
u
r
e
i
n
p
r
e
an
d
p
o
s
t
i
n
ter
v
en
tio
n
d
ec
r
e
ased
w
h
ile
in
p
r
e
an
d
p
o
s
t
n
o
n
-
i
n
ter
v
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n
tio
n
it
in
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s
ed
w
h
ich
co
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ld
b
e
p
r
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v
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b
y
it
s
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s
p
ar
it
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e
v
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th
o
u
g
h
it
w
as
s
till
in
th
e
c
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o
r
y
o
f
n
o
r
m
all
y
h
ig
h
i
n
d
iast
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lic
b
lo
o
d
p
r
ess
u
r
e.
T
h
is
w
as
p
r
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b
ab
ly
b
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s
e
s
o
m
e
o
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r
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lated
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.
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s
o
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s
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n
is
d
e
f
in
ed
as
s
y
s
to
lic
b
lo
o
d
p
r
ess
u
r
e
w
h
ic
h
w
as
≥
140
m
m
H
g
an
d
d
iast
o
lic
b
lo
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d
p
r
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s
s
u
r
e
w
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h
w
a
s
<
9
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m
m
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g
.
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h
is
t
y
p
e
o
f
h
y
p
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te
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s
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n
is
h
y
p
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te
n
s
io
n
w
h
ic
h
o
f
ten
o
cc
u
r
s
in
eld
er
l
y
p
e
o
p
le
an
d
its
p
r
ev
ale
n
ce
in
cr
ea
s
es,
a
lo
n
g
w
i
th
t
h
e
i
n
cr
ea
s
e
in
a
g
e
i
n
w
h
ich
t
w
o
o
f
t
h
e
th
r
ee
p
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s
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n
s
w
h
o
ar
e
m
o
r
e
t
h
an
6
0
y
ea
r
s
o
ld
an
d
t
h
r
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f
th
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f
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r
p
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s
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n
w
h
o
ar
e
m
o
r
e
th
a
n
7
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y
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r
s
o
ld
s
u
f
f
er
ed
f
r
o
m
i
s
o
lated
s
y
s
to
lic
b
lo
o
d
p
r
ess
u
r
e.
T
h
e
ch
a
n
g
e
i
n
li
f
est
y
le
i
s
a
n
in
itial
e
f
f
o
r
t
to
o
v
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co
m
e
a
n
d
d
o
m
ed
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n
i
n
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r
d
er
to
m
ai
n
tai
n
b
lo
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d
p
r
ess
u
r
e
b
elo
w
1
4
0
/9
0
m
m
H
g
[
2
0
]
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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P
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2252
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8806
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)
p
o
in
ted
o
u
t
th
at
a
r
o
m
at
h
er
ap
y
co
u
ld
b
e
g
iv
e
n
i
n
ter
m
itte
n
tl
y
an
d
,
i
f
n
ec
es
s
ar
y
,
o
n
ce
a
d
a
y
[
2
1
]
.
C
o
n
tr
o
lli
n
g
b
lo
o
d
p
r
ess
u
r
e
n
e
ed
s
p
atien
t
’
s
s
tr
o
n
g
w
i
lli
n
g
n
e
s
s
b
u
t
w
it
h
g
en
er
al
ap
p
r
o
ac
h
,
ea
s
y
to
b
e
u
s
ed
,
a
n
d
ec
o
n
o
m
ical.
L
a
v
en
d
er
ar
o
m
at
h
er
ap
y
ca
n
b
e
co
n
s
id
er
ed
as
o
n
e
o
f
t
h
e
n
u
r
s
in
g
in
ter
v
e
n
tio
n
s
at
t
h
e
UP
T
P
ela
ya
n
a
n
S
o
s
ia
l
La
n
ju
t
Usi
a
,
B
in
j
ai,
w
h
ic
h
ca
n
b
e
u
s
ed
to
d
ec
r
ea
s
e
h
y
p
er
ten
s
i
o
n
p
atien
ts
’
b
lo
o
d
p
r
ess
u
r
e
as a
s
u
p
p
le
m
e
n
tar
y
al
ter
n
ati
v
e
th
er
ap
y
b
esid
es t
h
e
u
s
u
al
m
ed
icatio
n
.
T
h
er
e
w
er
e
s
o
m
e
li
m
itatio
n
s
i
n
t
h
is
r
e
s
ea
r
ch
.
T
h
er
e
w
er
e
r
elate
d
to
m
i
n
i
m
izi
n
g
co
n
f
o
u
n
d
in
g
f
ac
to
r
s
w
h
ic
h
w
o
u
ld
in
f
l
u
en
ce
r
esp
o
n
d
en
ts
in
d
ec
r
ea
s
i
n
g
b
lo
o
d
p
r
es
s
u
r
e
in
w
h
ich
s
o
m
e
o
f
th
e
r
es
p
o
n
d
en
ts
to
o
k
an
ti
-
h
y
p
er
te
n
s
io
n
m
ed
icin
e
s
d
u
r
i
n
g
t
h
e
p
r
o
ce
s
s
o
f
t
h
e
r
esear
ch
,
t
h
e
d
if
f
er
e
n
ce
i
n
s
a
lt
a
n
d
an
i
m
al
f
at
in
tak
e
in
f
o
o
d
b
ec
au
s
e
r
esp
o
n
d
en
ts
p
r
o
b
ab
ly
co
u
ld
g
et
f
o
o
d
w
ith
h
i
g
h
s
al
t
an
d
an
i
m
a
l
f
at
in
tak
e
f
r
o
m
th
e
o
u
ts
id
e
o
f
th
e
UPT
,
r
eg
u
lar
an
d
d
if
f
er
e
n
t
e
x
er
cises
o
f
th
e
r
esp
o
n
d
en
ts
,
an
d
ea
ch
r
esp
o
n
d
en
t
h
ad
h
is
o
w
n
w
a
y
to
av
o
id
s
tr
ess
.
B
esid
es
th
at,
t
h
e
li
m
i
t
atio
n
s
o
f
th
is
r
esear
ch
w
er
e
also
r
elate
d
to
th
e
r
esear
ch
d
esig
n
in
w
h
ich
t
h
e
r
esear
ch
u
s
ed
q
u
as
i
ex
p
er
i
m
e
n
tal
d
esi
g
n
f
o
r
th
e
s
a
m
e
s
u
b
j
ec
ts
,
b
u
t
r
an
d
o
m
tec
h
n
iq
u
e
o
n
th
e
s
u
b
j
ec
ts
o
r
r
esp
o
n
d
en
ts
h
ad
n
o
t d
o
n
e
y
et.
5.
CO
NCLU
SI
O
N
T
h
e
r
esu
lt
o
f
th
e
r
e
s
ea
r
ch
,
u
s
in
g
p
air
ed
t
-
tes
t,
s
h
o
w
ed
t
h
at
p
r
o
b
ab
ilit
y
v
alu
e
o
f
t
h
e
m
ea
n
d
is
p
ar
it
y
v
alu
e
o
f
s
y
s
to
lic
b
lo
o
d
p
r
ess
u
r
e
i
n
p
r
e
(
in
t
h
e
f
ir
s
t
m
ea
s
u
r
e
m
e
n
t)
a
n
d
p
o
s
t
(
t
h
e
f
o
llo
w
i
n
g
1
0
m
in
u
te
s
)
n
o
n
-
la
v
en
d
er
ar
o
m
at
h
er
ap
y
i
n
ter
v
e
n
tio
n
w
a
s
α
(
0
.
0
0
0
)
<
0
.
0
5
.
T
h
is
i
n
d
icate
d
th
at
t
h
er
e
w
as
th
e
m
ea
n
d
is
p
ar
it
y
v
al
u
e
o
f
s
y
s
to
lic
b
l
o
o
d
p
r
ess
u
r
e
in
p
r
e
(
in
th
e
f
ir
s
t
m
ea
s
u
r
e
m
e
n
t)
a
n
d
p
o
s
t
(
th
e
f
o
llo
w
in
g
1
0
m
i
n
u
te
s
)
n
o
n
-
la
v
en
d
er
ar
o
m
at
h
er
ap
y
i
n
ter
v
en
tio
n
.
T
h
e
r
es
u
l
t o
f
th
e
r
esear
ch
also
s
h
o
w
ed
t
h
at
b
y
u
s
i
n
g
p
air
ed
t
-
tes
t,
th
e
p
r
o
b
ab
ilit
y
v
al
u
e
o
f
th
e
m
ea
n
d
i
s
p
ar
it
y
o
f
d
iast
o
lic
b
lo
o
d
p
r
ess
u
r
e
i
n
p
r
e
(
in
th
e
f
ir
s
t
m
ea
s
u
r
e
m
e
n
t)
an
d
p
o
s
t
(
t
h
e
f
o
llo
w
in
g
1
0
m
i
n
u
te
s
)
n
o
n
-
la
v
en
d
er
ar
o
m
a
th
er
a
p
y
i
n
ter
v
en
t
io
n
w
as
α
(
0
.
0
0
0
)
<
0
.
0
5
.
T
h
is
in
d
icate
d
th
at
t
h
er
e
w
as
t
h
e
m
ea
n
d
is
p
ar
it
y
v
al
u
e
o
f
d
iast
o
li
c
b
lo
o
d
p
r
ess
u
r
e
in
p
r
e
(
in
t
h
e
f
ir
s
t
m
ea
s
u
r
e
m
en
t)
an
d
p
o
s
t
(
t
h
e
f
o
llo
w
i
n
g
1
0
m
i
n
u
te
s
)
n
o
n
-
la
v
en
d
er
ar
o
m
a
th
er
ap
y
in
ter
v
en
tio
n
.
B
ased
o
n
t
h
e
r
esear
c
h
er
s
’
o
b
s
er
v
atio
n
d
u
r
in
g
t
h
e
s
t
u
d
y
in
g
,
t
h
e
f
ac
to
r
s
o
f
d
ieti
n
g
v
ar
iatio
n
,
p
h
y
s
ica
l
ac
ti
v
itie
s
,
av
o
id
in
g
d
i
f
f
er
e
n
t
s
tr
ess
e
s
,
an
d
s
o
m
e
r
esp
o
n
d
en
t
s
u
s
ed
a
n
ti
-
h
y
p
er
ten
s
io
n
m
ed
i
cin
es
h
ad
ca
u
s
ed
th
e
d
ec
r
ea
s
e
in
b
lo
o
d
p
r
ess
u
r
e
in
n
o
n
-
i
n
ter
v
e
n
tio
n
g
r
o
u
p
.
Fro
m
t
h
i
s
r
es
u
lt,
i
t
w
a
s
f
o
u
n
d
th
a
t
b
esid
es
la
v
e
n
d
er
ar
o
m
ath
er
a
p
y
,
th
er
e
w
er
e
als
o
s
o
m
e
o
t
h
er
alter
n
ati
v
es
to
d
ec
r
ea
s
e
b
lo
o
d
p
r
ess
u
r
e.
T
h
e
o
t
h
e
r
alter
n
ati
v
es
w
h
ic
h
ca
n
o
f
ten
b
e
d
o
n
e
b
y
e
ld
er
l
y
p
eo
p
le
is
th
e
c
h
an
g
e
in
li
f
est
y
le
li
k
e
r
ed
u
ci
n
g
s
alt
a
n
d
a
n
i
m
al
f
a
t
i
n
ta
k
e
i
n
f
o
o
d
,
r
eg
u
lar
e
x
er
cises
,
av
o
id
i
n
g
s
tr
ess
,
a
n
d
tak
i
n
g
m
ed
ici
n
es.
Ho
w
e
v
er
,
it
h
as to
b
e
s
t
u
d
ied
s
p
ec
if
icall
y
to
f
in
d
o
u
t it
s
ef
f
e
ctiv
e
n
ess
.
ACK
NO
WL
E
D
G
E
M
E
NT
S
W
e
th
an
k
P
o
ltek
k
e
s
i
n
s
tit
u
ti
o
n
w
h
o
g
a
v
e
f
i
n
an
cia
l
s
u
p
p
o
r
t
f
o
r
th
is
s
t
u
d
y
a
n
d
w
e
al
s
o
th
an
k
t
h
e
n
u
r
s
es
w
h
o
w
er
e
ac
ti
v
e
to
h
el
p
th
e
r
esear
ch
er
s
to
p
r
o
v
id
e
h
y
p
er
te
n
s
io
n
p
atie
n
ts
a
t
t
h
e
UP
T
P
ela
ya
n
a
n
S
o
s
ia
l
La
n
ju
t
Usi
a
,
B
in
j
ai.
T
h
is
r
esear
ch
w
a
s
s
u
p
p
o
r
ted
b
y
Hea
lt
h
P
o
ly
tec
h
n
ic
Mi
n
is
tr
y
o
f
He
alth
,
Me
d
an
,
No
r
th
Su
m
ater
a,
I
n
d
o
n
e
s
ia
,
I
n
d
o
n
esi
a.
Ou
r
s
p
ec
ial
g
r
atit
u
d
e
is
f
o
r
Dr
.
d
r
.
A
r
li
n
d
a
Sar
i
W
.
,
M.
Kes
.
f
r
o
m
t
h
e
Me
d
ica
l
Sch
o
o
l,
Un
i
v
er
s
it
y
o
f
S
u
m
ater
a
Utar
a,
I
n
d
o
n
esia,
w
h
o
h
a
s
b
ee
n
th
e
r
e
v
ie
w
er
o
f
t
h
is
r
esear
ch
.
RE
F
E
R
E
NC
E
S
[1
]
W
o
rld
He
a
lt
h
Org
a
n
iza
ti
o
n
,
“
G
lo
b
a
l
S
tatu
s
Re
p
o
rt
On
n
o
n
-
c
o
m
m
u
n
ica
b
le
d
ise
a
se
s,
”
G
e
n
e
v
a
,
S
w
it
z
e
rlan
d
,
p
p
.
x
v
,
67
,
2
0
1
4
.
[2
]
Bu
c
k
le
J.
,
“
Cli
n
ic
a
l
Aro
m
a
th
e
ra
p
y
.
Esse
n
ti
a
l
Oil
i
n
P
ra
c
ti
c
e
,
”
S
e
c
o
n
d
E
d
it
i
o
n
,
P
h
il
a
d
e
l
p
h
ia
,
El
se
v
ier
S
c
ien
c
e
,
p
p
.
29
-
32,
2
4
7
-
2
5
0
,
2
0
0
3
.
[3
]
M
c
G
u
in
n
e
ss
H.
,
“
A
ro
m
a
th
e
ra
p
y
.
T
h
e
ra
p
y
Ba
sic
s,
”
S
e
c
o
n
d
E
d
it
i
o
n
,
L
o
n
d
o
n
,
H
o
d
d
e
r
A
rn
o
ld
,
p
p
.
1
2
3
,
2
0
0
7
.
[4
]
W
o
lrd
He
a
lt
h
Org
a
n
iza
ti
o
n
,
“
A
g
lo
b
a
l
b
rief
o
f
HY
P
ERT
ENS
ION
.
S
il
e
n
t
k
il
ler,
g
lo
b
a
l
p
u
b
li
c
h
e
a
lt
h
c
risis,
”
G
e
n
e
v
a
,
S
w
it
z
e
rlan
d
,
p
p
.
9
,
2
0
1
3
.
[5
]
Am
e
rica
n
He
a
rt
A
ss
o
c
iatio
n
,
“
Hig
h
Blo
o
d
P
re
ss
u
re
.
S
tatisti
c
a
l
F
a
c
t
S
h
e
e
t,
”
a
c
c
e
ss
e
s o
n
Oc
to
b
e
r
2
2
,
2
0
1
4
.
[6
]
B
e
a
re
P
.
G
.
a
n
d
M
y
e
rs
J
.
L
.
,
“
P
r
in
c
ip
les
a
n
d
P
ra
c
ti
c
e
o
f
A
d
u
lt
He
a
lt
h
Nu
rsin
g
,
”
S
t
.
L
o
u
is
,
C
V
.
M
o
sb
y
Co
m
p
a
n
y
,
v
ol
.
1,
p
p
.
7
1
3
,
1
9
9
0
.
[7
]
S
n
y
d
e
r
M
.
a
n
d
L
in
d
q
u
ist
R
.
,
“
Co
m
p
le
m
e
n
tar
y
o
f
A
lt
e
rn
a
ti
v
e
T
h
e
ra
p
ies
in
Nu
rsin
g
,
”
six
th
e
d
it
io
n
,
Ne
w
Yo
rk
,
S
p
rin
g
e
r
P
u
b
l
ish
i
n
g
Co
m
p
a
n
y
,
p
p
.
4
0
4
-
4
0
9
.
[8
]
S
a
y
o
rw
a
n
W
.
,
e
t
a
l.
,
“
T
h
e
Eff
e
c
ts
o
f
L
a
v
e
n
d
e
r
Oil
In
h
a
lati
o
n
o
n
Em
o
ti
o
n
a
l
S
tate
s,
A
u
to
n
o
m
ic
Ne
rv
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y
ste
m
,
a
n
d
Bra
in
El
e
c
tri
c
a
l
A
c
ti
v
it
y
,
”
J
M
e
d
Asso
c
T
h
a
i
,
v
o
l/
issu
e
:
9
5
(4
)
,
p
p
.
5
9
8
-
6
0
5
,
2
0
1
2
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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:
2
2
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[9
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Ju
M
.
S
.
,
e
t
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l
.
,
“
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ro
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lee
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id
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,
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Evid
e
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[1
0
]
Ke
a
rn
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y
P
.
M
.
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e
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a
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,
“
G
lo
b
a
l
Bu
rd
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A
n
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ly
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1
]
P
i
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o
E.
,
“
Blo
o
d
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re
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d
A
g
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Po
st
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ra
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),
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[1
2
]
T
in
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.
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t
a
l.
,
“
Co
m
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tar
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1
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2
.
[1
3
]
F
rism
a
n
W
.
H
.
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e
t
a
l.
,
“
Co
m
p
lem
e
n
tar
y
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d
In
teg
ra
ti
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T
h
e
ra
p
ies
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r
Ca
rd
io
v
a
sc
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lar
Dise
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e
,
”
S
t
L
o
u
is
,
M
o
sb
y
In
c
.
[1
4
]
J
.
X
ia
L
.
,
e
t
a
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.
,
“
In
h
a
latio
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Ef
fe
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ss
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ts,
”
A
n
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M
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ica
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h
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rm
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o
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rn
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l
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1
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5
]
Ba
tt
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li
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.
,
“
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p
lete
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id
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ro
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,
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h
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tern
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ti
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Ce
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ro
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e
,
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u
stra
li
a
,
2
0
0
3
.
[1
6
]
M
.
H.
Hu
r
a
n
d
I.
Ba
e
,
“
T
h
e
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ff
e
c
ts
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a
ro
m
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ra
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ti
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B
P
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P
R,
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m
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o
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so
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rm
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ten
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e
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lt
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fter
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ise
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d
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rit
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m
e
ti
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su
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trac
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r,
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In
ter
n
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t
io
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C
o
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fer
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o
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N
u
rs
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g
&
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rg
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n
c
y
M
e
d
icin
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,
L
a
s
Veg
a
s
,
Om
ics
Gr
o
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C
o
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s
,
2
0
1
3
.
[1
7
]
C
h
o
M
.
Y
.
,
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t
a
l.
,
“
Eff
e
c
ts
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f
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ro
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A
n
x
iet
y
,
V
it
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l
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ig
n
s,
a
n
d
S
lee
p
Qu
a
li
ty
o
f
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e
rc
u
tan
e
o
u
s
Co
ro
n
a
ry
In
terv
e
n
ti
o
n
P
a
ti
e
n
ts
in
In
ten
siv
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Ca
re
Un
it
s,
”
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d
-
Ba
se
d
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le
m
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d
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lt
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ti
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e
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icin
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K
o
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a
,
2
0
1
3
.
[1
8
]
P
i
n
t
o
E.
,
“
Blo
o
d
P
re
ss
u
re
a
nd
A
g
e
in
g
,”
Po
stg
r
a
d
u
a
te M
e
d
ica
l
J
o
u
rn
a
l
,
v
o
l/
issu
e
:
8
3
(
9
7
6
),
p
p
.
1
0
9
-
114
,
2
0
0
7.
[1
9
]
H.
O.
Dic
k
in
so
n
,
e
t
a
l
.
,
“
L
if
e
st
y
le
in
terv
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n
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o
n
s
to
re
d
u
c
e
ra
ise
d
b
l
o
o
d
p
re
s
su
re
:
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sy
ste
m
a
ti
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r
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v
ie
w
o
f
ra
n
d
o
m
ize
d
c
o
n
tro
ll
e
d
tri
a
ls
,”
J
o
u
rn
a
l
o
f
Hy
p
e
rte
n
sio
n
,
L
ip
p
in
c
o
t
t
W
il
li
a
m
s
&
W
il
k
in
s
In
c
,
v
o
l/
issu
e
:
2
4
(2
),
p
p
.
2
1
5
–
2
3
3
,
2
0
0
6
.
[2
0
]
J.
Ba
si
le,
“
Hy
p
e
rten
sio
n
in
th
e
El
d
e
rly
:
A
Re
v
ie
w
o
f
th
e
Im
p
o
rtan
c
e
o
f
S
y
sto
li
c
Blo
o
d
P
re
ss
u
re
El
e
v
a
ti
o
n
,
”
Ra
lp
h
H.Jo
h
n
s
o
n
V
A
M
e
d
ica
l
Ce
n
ter,
M
e
d
ica
l
Un
iv
e
rsity
o
f
S
o
u
th
Ca
ro
li
n
a
,
Ch
a
rles
t
o
n
,
2
0
0
2
.
[2
1
]
Ba
sc
h
E
.
,
e
t
a
l.
,
“
M
o
n
o
g
ra
p
h
f
ro
m
Na
tu
ra
l
S
tan
d
a
rd
.
L
a
v
e
n
d
e
r
(Lav
a
n
d
u
la
a
n
g
u
stif
o
li
a
M
il
ler),
”
J
o
u
rn
a
l
o
f
He
rb
a
l
Ph
a
rm
a
c
o
th
e
ra
p
y
Na
t
u
ra
l
S
t
a
n
d
a
rd
,
v
o
l/
issu
e
:
4
(
2
),
p
p
.
6
1
-
72
,
2
0
0
3
.
Evaluation Warning : The document was created with Spire.PDF for Python.