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p
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C
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v
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lar
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Yo
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th
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d
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CC B
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li
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C
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r
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s
p
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A
uth
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r
:
Vis
k
a
s
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i P
.
Kala
n
j
ati
Dep
ar
t
m
en
t o
f
A
n
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m
y
a
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d
His
to
lo
g
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Facu
lt
y
o
f
Me
d
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Un
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s
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A
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lan
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Su
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ab
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m
ail:
v
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ac
.
id
1.
I
NT
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O
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C
ar
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io
v
asc
u
lar
d
is
ea
s
e
s
(
C
V
Ds)
b
ec
o
m
e
a
g
lo
b
al
ep
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m
i
c
an
d
h
a
v
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b
ee
n
r
ep
o
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ted
to
b
e
ass
o
ciate
d
to
th
e
o
v
er
w
ei
g
h
t
a
n
d
o
b
esit
y
[
1
-
3
]
.
Mid
d
le
u
p
p
er
ar
m
cir
cu
m
f
er
e
n
ce
(
MU
AC
)
,
w
aist
ci
r
cu
m
f
er
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ce
(
W
C
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an
d
h
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cir
cu
m
f
er
en
ce
(
H
C
)
h
av
e
b
ee
n
d
e
m
o
n
s
tr
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as
t
h
e
ef
f
icien
t
s
cr
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n
i
n
g
p
ar
a
m
eter
s
f
o
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s
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a
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d
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a
n
t
h
e
b
o
d
y
m
a
s
s
in
d
e
x
(
B
MI
)
[
4
-
6
]
.
T
h
ese
p
ar
am
eter
s
h
a
v
e
b
ee
n
p
r
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p
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d
to
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d
co
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p
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c
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c
h
o
lest
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le
m
ia
an
d
h
y
p
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m
ia
[
7
-
9
]
.
O
b
esit
y
an
d
B
MI
z
-
s
co
r
es
w
er
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r
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m
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s
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n
d
r
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m
e,
h
y
p
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u
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m
ia
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n
d
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ch
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m
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g
l
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[
10
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]
.
I
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g
en
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p
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latio
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t
h
e
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r
ev
alen
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m
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l)
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p
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x
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m
a
tel
y
3
7
-
40%
[
1
1
,
1
3
,
1
4
]
.
P
r
ev
io
u
s
s
t
u
d
ies
h
a
v
e
b
ee
n
f
o
c
u
s
ed
o
n
v
ar
io
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s
ag
e
g
r
o
u
p
s
an
d
clin
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b
ac
k
g
r
o
u
n
d
[
4
-
6
]
,
h
o
w
e
v
er
,
to
th
e
b
est
o
f
o
u
r
k
n
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e,
d
ata
f
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t
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m
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l
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y
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m
ale
s
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d
f
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ar
e
s
t
ill
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m
ited
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T
h
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d
ata
ar
e
v
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f
o
r
p
r
ev
en
ti
v
e
m
ed
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n
e
o
f
t
h
e
ca
r
d
io
v
ascu
lar
d
is
ea
s
es
to
d
ev
elo
p
in
th
e
later
li
f
e
[
15
-
17
]
.
Her
e
w
e
in
v
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tig
a
te
t
h
e
as
s
o
ciatio
n
b
et
w
ee
n
MU
AC
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W
C
an
d
HC
to
t
h
e
l
ev
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o
f
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C
a
n
d
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A
as
t
h
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s
e
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t
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m
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tr
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t
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p
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in
d
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l
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lt
h
y
m
ale
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n
d
f
e
m
ale
s
t
u
d
en
ts
(
1
7
-
2
3
y
ea
r
o
ld
)
.
2.
RE
S
E
ARCH
M
E
T
H
O
D
T
h
e
eth
ical
clea
r
an
ce
o
f
th
i
s
s
tu
d
y
w
as
g
r
an
ted
b
y
t
h
e
E
th
ica
l
C
o
m
m
ittee
n
o
.
1
7
9
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C
C
.
F
ODM
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V/2
0
1
9
.
E
ac
h
p
ar
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t
s
ig
n
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h
e
in
f
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ed
co
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e
n
t
a
n
d
co
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e
n
t
f
o
r
in
f
o
r
m
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p
ap
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s
p
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r
t
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th
e
s
tu
d
y
.
T
h
e
p
ar
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an
ts
w
er
e
r
ec
r
u
ited
f
r
o
m
Ked
ir
i
city
,
I
n
d
o
n
e
s
ia
(
7
4
m
ales
a
n
d
7
6
f
e
m
ales,
r
e
s
p
ec
tiv
el
y
)
,
a
g
e
1
7
-
2
3
y
ea
r
o
ld
,
w
it
h
n
o
p
r
ev
io
u
s
h
ea
lt
h
p
r
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b
le
m
s
i.e
.
m
e
tab
o
lic
s
y
n
d
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m
e,
h
y
p
er
ch
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le
s
ter
o
le
m
ia
a
n
d
h
y
p
er
u
r
ice
m
ia.
T
h
e
T
C
(
in
m
g
/
d
L
)
an
d
U
A
(
i
n
m
g
/
d
L
)
w
er
e
an
al
y
s
ed
f
r
o
m
th
e
f
i
n
g
er
p
r
ick
ca
p
illar
y
b
lo
o
d
-
te
s
t
u
s
in
g
a
s
tic
k
m
ac
h
i
n
e
(
E
as
y
T
o
u
ch
GC
Hb
,
T
ai
w
a
n
)
w
ith
o
u
t
p
r
io
r
f
asti
n
g
.
I
n
th
is
s
tu
d
y
,
h
y
p
er
c
h
o
lest
er
o
le
m
ia
w
as
d
ef
i
n
ed
w
h
e
n
th
e
to
tal
ch
o
lest
er
o
l
lev
el
w
as
≥2
0
0
m
g
/
d
L
;
w
h
ils
t
h
y
p
er
u
r
ice
m
ia
w
as
d
ef
i
n
ed
i
f
p
ar
ticip
an
ts
h
a
v
i
n
g
t
h
eir
U
A
co
n
ce
n
tr
atio
n
w
as>
7
.
0
m
g
/d
L
(
4
1
6
.
4
μ
m
o
l/
L
)
a
m
o
n
g
m
ale
s
o
r
>
6
.
0
m
g
/
d
L
(
3
5
6
.
9
μ
m
o
l/
L
)
a
m
o
n
g
f
e
m
ale
s
[
11,
13,
14
]
.
T
h
e
s
e
cu
t
-
o
f
f
v
a
lu
e
s
w
e
r
e
s
e
l
e
ct
e
d
a
s
t
h
ey
a
r
e
g
e
n
e
r
a
l
ly
u
s
e
d
in
c
li
n
ic
a
l
l
a
b
o
r
a
t
o
r
i
es
an
d
h
av
e
b
e
e
n
p
r
o
p
o
s
e
d
i
n
p
r
ev
i
o
u
s
s
tu
d
i
es
i
n
r
e
la
t
i
o
n
t
o
m
e
ta
b
o
l
i
c
s
y
n
d
r
o
m
e
an
d
c
a
r
d
i
o
v
as
cu
la
r
d
i
s
e
a
s
e
o
u
t
c
o
m
es
t
o
d
e
f
in
e
h
y
p
e
r
c
h
o
l
es
t
e
r
o
lem
i
a
an
d
h
y
p
e
r
u
r
i
c
em
i
a
[
11,
18,
19
]
.
A
ll
a
n
t
h
r
o
p
o
m
etr
ic
m
ea
s
u
r
e
m
en
ts
w
er
e
tak
e
n
in
ac
co
r
d
an
c
e
w
it
h
W
o
r
ld
Hea
lth
Or
g
an
iz
atio
n
(
W
HO)
s
tan
d
ar
d
s
b
y
t
w
o
p
r
e
-
tr
ai
n
ed
m
ed
ical
d
o
cto
r
s
(
tech
n
ical
p
er
s
o
n
n
e
ls
tr
ain
ed
i
n
r
esear
c
h
m
eth
o
d
s
)
[
6
,
1
4
,
2
0
]
.
A
ll
a
n
t
h
r
o
p
o
m
etr
ic
m
ea
s
u
r
e
m
en
ts
w
er
e
tak
e
n
t
w
ice
an
d
th
e
av
er
ag
e
w
as
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ec
o
r
d
ed
.
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f
th
e
m
ea
s
u
r
e
m
e
n
t
s
v
ar
ied
b
y
m
o
r
e
t
h
a
n
0
.
2
c
m
,
a
th
ir
d
m
ea
s
u
r
e
m
en
t
w
a
s
co
n
d
u
cted
.
T
h
e
av
er
ag
e
o
f
t
h
e
n
e
ar
est
t
w
o
m
ea
s
u
r
es
w
a
s
r
ec
o
r
d
ed
.
T
h
e
MU
A
C
,
W
C
an
d
HC
w
er
e
m
ea
s
u
r
ed
in
a
s
tan
d
i
n
g
p
o
s
itio
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f
o
llo
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i
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g
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t
an
d
ar
d
p
r
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ce
d
u
r
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u
s
i
n
g
ca
lib
r
ated
in
s
tr
u
m
e
n
t.
MU
AC
w
as
m
ea
s
u
r
ed
w
it
h
a
n
o
n
-
s
tr
etc
h
ab
le
MU
A
C
m
ea
s
u
r
in
g
tap
e
at
a
p
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in
t
eq
u
id
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ta
n
t
b
et
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ee
n
th
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r
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p
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ca
p
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th
e
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lecr
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ce
s
s
o
f
th
e
u
l
n
a.
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aist
cir
cu
m
f
er
e
n
ce
w
as
m
ea
s
u
r
ed
m
id
w
a
y
b
et
w
ee
n
t
h
e
lo
w
er
r
ib
m
ar
g
in
an
d
th
e
iliac
cr
e
s
t i
n
t
h
e
h
o
r
izo
n
tal
p
la
n
e.
Hip
cir
cu
m
f
er
en
ce
w
as
m
ea
s
u
r
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at
th
e
p
o
in
t
y
ield
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n
g
t
h
e
m
ax
i
m
u
m
cir
cu
m
f
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ce
o
v
er
t
h
e
b
u
tto
ck
s
u
s
in
g
a
tap
e
m
ea
s
u
r
e
[
5,
1
5
,
21
]
.
A
ll
d
ata
w
er
e
an
a
l
y
ze
d
u
s
i
n
g
SP
SS
1
7
.
0
(
USA
)
a
n
d
Ma
x
S
tat
L
ite
3
.
0
6
(
Ger
m
a
n
y
)
.
T
h
e
Ko
l
m
o
g
o
r
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v
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S
m
ir
n
o
v
n
o
r
m
alit
y
test
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n
d
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ar
tlett
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o
m
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g
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eit
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test
o
f
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ar
tlett
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er
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ca
lcu
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ted
p
r
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r
to
th
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ep
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t
t
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tes
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r
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n
n
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h
it
n
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y
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to
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al
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th
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d
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f
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ce
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f
ea
ch
v
ar
iab
le
a
m
o
n
g
m
ale
s
an
d
f
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m
ales.
T
h
e
P
ea
r
s
o
n
o
r
Sp
ea
r
m
a
n
co
r
r
elatio
n
tes
ts
w
er
e
ap
p
lied
to
s
ee
k
co
r
r
elati
o
n
s
b
et
w
ee
n
th
e
T
C
to
W
C
,
t
o
HC
an
d
to
MU
AC
in
b
o
th
m
ale
an
d
f
e
m
ale
g
r
o
u
p
s
.
L
i
n
ea
r
r
eg
r
es
s
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n
an
al
y
s
is
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et
w
ee
n
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C
as
th
e
d
ep
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d
en
t
v
ar
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le
a
n
d
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A
,
MU
AC
,
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C
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d
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a
s
i
n
d
ep
en
d
en
t
v
ar
iab
les
w
er
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co
n
d
u
cted
to
s
ee
k
th
e
r
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n
s
h
ip
in
m
ales
a
n
d
in
f
e
m
ales.
L
ev
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l o
f
s
i
g
n
if
ican
ce
w
as c
o
n
s
id
er
ed
w
h
e
n
p
<0
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0
5
.
3.
RE
SU
L
T
S
A
ND
D
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SCU
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N
Of
1
5
0
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u
b
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ts
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7
6
f
e
m
ale
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d
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4
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ale
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t
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ts
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m
p
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e
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t
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d
y
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ac
co
r
d
in
g
l
y
.
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ab
le
1
s
h
o
w
s
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s
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m
m
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th
e
ir
ch
ar
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cs.
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h
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r
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g
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o
f
T
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ales
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a
s
1
0
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g
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L
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w
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ils
t
a
m
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g
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m
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s
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0
3
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3
3
8
m
g
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d
L
.
Sev
e
n
t
y
p
ar
ticip
an
ts
h
ad
a
h
y
p
er
ch
o
l
ester
o
le
m
ia
(
4
6
.
7
%)
an
d
th
e
r
ests
w
er
e
n
o
r
m
a
l.
Six
tee
n
m
ales
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d
1
4
f
e
m
a
le
s
h
ad
h
y
p
er
u
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ice
m
ia
(
3
0
%);
w
h
il
s
t
th
e
r
est
s
w
er
e
n
o
r
m
al.
T
h
e
av
er
ag
e
an
d
s
tan
d
ar
d
d
ev
iatio
n
o
f
T
C
,
W
C
,
HC
an
d
MU
AC
ar
e
d
etailed
in
T
ab
le
1
.
T
h
e
T
C
,
MU
AC
an
d
H
C
w
er
e
h
o
m
o
g
en
eo
u
s
an
d
n
o
r
m
all
y
d
i
s
tr
ib
u
ted
w
h
ils
t t
h
e
U
A
a
n
d
W
C
w
er
e
n
o
t th
u
s
w
e
co
n
d
u
cted
th
e
in
d
ep
en
d
e
n
t t
-
test
f
o
r
th
e
p
ar
a
m
etr
ic
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n
d
Ma
n
n
-
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h
itn
e
y
t
e
s
t
f
o
r
t
h
e
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o
n
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p
ar
a
m
etr
ic
d
ata
as
s
h
o
w
n
in
T
a
b
le
1
.
W
e
o
b
s
er
v
ed
h
ig
h
er
v
al
u
es
i
n
T
C
,
U
A
,
M
UAC,
W
C
a
n
d
H
C
o
f
m
ales
co
m
p
ar
ed
to
t
h
e
f
e
m
ale
s
.
T
h
e
r
e
w
er
e
s
i
g
n
if
ican
t
l
y
d
if
f
er
e
n
ce
s
b
et
w
ee
n
th
e
U
A
,
MU
A
C
a
n
d
W
C
o
f
m
a
les
t
h
an
f
e
m
a
les
(
p
<0
.
0
0
1
,
p
=0
.
0
0
9
,
p
=0
.
0
0
1
,
r
esp
ec
tiv
el
y
)
.
Ho
w
ev
er
n
o
s
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g
n
i
f
ica
n
t
d
i
f
f
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ce
s
w
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f
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u
n
d
b
et
w
ee
n
t
h
e
T
C
a
n
d
H
C
a
m
o
n
g
m
ale
s
a
n
d
f
e
m
ales (
p
=0
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0
5
3
an
d
p
=
0
.
8
6
5
,
r
esp
ec
tiv
el
y
)
.
Am
o
n
g
m
ale
s
,
ass
o
ciat
io
n
b
e
t
w
ee
n
T
C
to
t
h
e
U
A
,
M
U
A
C
,
W
C
an
d
H
C
w
a
s
m
o
d
er
ate
w
it
h
ea
c
h
b
eta
v
alu
e
o
f
0
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3
1
7
,
0
.
3
7
4
,
0
.
3
6
5
an
d
0
.
3
6
7
,
r
esp
ec
tiv
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;
all
o
f
th
e
s
e
h
ad
a
s
ig
n
i
f
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ca
n
t
co
ef
f
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n
t
o
f
co
r
r
elatio
n
(
p
<0
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0
5
)
.
T
h
e
p
r
o
p
o
r
tio
n
o
f
v
ar
ian
ce
in
T
C
t
h
at
ca
n
b
e
ex
p
lai
n
ed
b
y
U
A
w
a
s
1
0
.
1
%;
1
4
%
b
y
th
e
MU
AC
;
1
3
.
4
%
b
y
th
e
W
C
an
d
1
3
.
5
%
b
y
t
h
e
H
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.
On
th
e
o
th
er
h
a
n
d
,
t
h
e
p
r
o
p
o
r
tio
n
o
f
v
ar
ian
ce
i
n
U
A
t
h
a
t
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t.
J
.
P
u
b
lic
Hea
lth
Sci
.
I
SS
N:
2
2
5
2
-
8806
C
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cto
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s
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d
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n
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i P
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la
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ca
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e
ex
p
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b
y
T
C
w
a
s
1
0
.
1
%;
1
6
%
b
y
th
e
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AC
;
1
4
.
2
%
b
y
th
e
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C
a
n
d
1
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3
%
b
y
t
h
e
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as
s
h
o
w
n
in
T
ab
le
2
.
T
h
er
e
w
er
e
p
o
s
iti
v
e
s
i
g
n
if
ican
t
co
r
r
elatio
n
s
b
etw
ee
n
T
C
to
th
e
U
A
,
o
r
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AC
,
o
r
WC
,
o
r
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a
m
o
n
g
m
a
le
s
t
u
d
en
ts
.
T
h
e
s
t
r
o
n
g
est
co
r
r
elatio
n
w
as
s
h
o
wn
b
et
w
ee
n
t
h
e
W
C
an
d
HC
a
m
o
n
g
m
a
les
w
it
h
r
=0
.
9
2
6
(
p
<0
.
0
0
1
)
;
w
h
il
s
t
th
e
w
ea
k
est
co
r
r
elatio
n
w
as
s
h
o
wn
b
et
w
ee
n
th
e
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C
an
d
UA
am
o
n
g
m
a
les
alth
o
u
g
h
th
e
r
w
as
s
til
l
s
h
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e
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h
at
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3
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(
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)
.
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o
n
g
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e
m
ale
s
,
a
s
s
o
ciatio
n
b
et
w
ee
n
T
C
to
t
h
e
UA;
an
d
b
et
w
ee
n
U
A
to
t
h
e
H
C
w
as
h
i
g
h
er
co
m
p
ar
ed
to
th
e
o
th
er
v
ar
iab
le
ass
o
ciat
io
n
s
w
it
h
th
e
b
ea
t
v
al
u
e
o
f
0
.
4
7
1
an
d
0
.
2
3
8
,
r
esp
ec
t
iv
el
y
;
all
o
f
t
h
ese
h
ad
a
s
i
g
n
i
f
ican
t
co
ef
f
ic
ien
t
o
f
co
r
r
elati
o
n
(
p
<0
.
0
5
)
.
T
h
e
p
r
o
p
o
r
tio
n
o
f
v
ar
ian
ce
i
n
T
C
th
at
ca
n
b
e
ex
p
lai
n
ed
b
y
U
A
was
2
2
.
2
%;
w
h
ils
t
o
n
l
y
0
.
2
%
b
y
th
e
MU
AC
;
0
.
2
%
b
y
t
h
e
W
C
a
n
d
0
.
5
%
b
y
th
e
HC
.
O
n
th
e
o
th
er
h
a
n
d
,
t
h
e
p
r
o
p
o
r
tio
n
o
f
v
ar
ia
n
c
e
in
U
A
t
h
at
ca
n
b
e
e
x
p
lain
ed
b
y
T
C
w
as
2
2
.
2
%;
w
h
il
s
t
o
n
l
y
0
.
7
%
b
y
t
h
e
M
U
A
C
;
2
.
7
%
b
y
t
h
e
W
C
an
d
5
.
7
%
b
y
t
h
e
H
C
as
s
h
o
w
n
in
T
ab
le
3
.
T
ab
le
1
.
Dif
f
er
en
ce
s
b
et
w
ee
n
T
C
,
UA
,
MU
A
C
,
W
C
a
n
d
HC
o
f
m
ales to
f
e
m
ales
No
I
n
d
e
p
e
n
d
e
n
t
t
-
t
e
st
(
o
r
M
a
n
n
-
W
h
i
t
n
e
y
t
e
st
)
M
a
l
e
(
µ
±
S
D
)
F
e
mal
e
(
µ
±
S
D
)
p
1
T
o
t
a
l
C
h
o
l
e
st
e
r
o
l
i
n
mg
/
dL
2
0
7
.
3
9
±
4
.
6
9
1
9
3
.
6
8
±
4
0
.
2
8
0
.
0
5
3
2
S
e
r
u
m o
f
U
r
i
c
A
c
i
d
i
n
mg
/
dL
5
.
9
5
±
1
.
7
8
4
.
8
6
±
1
.
4
3
<
0
.
0
0
1
*
3
M
U
A
C
i
n
c
m
2
8
.
3
6
±
4
.
7
7
2
6
.
4
5
±
3
.
9
7
0
.
0
0
9
*
4
W
a
i
st
C
i
r
c
u
mf
e
r
e
n
c
e
i
n
c
m
8
2
.
1
±
1
.
6
7
4
.
5
9
±
1
.
1
0
.
0
0
1
*
5
H
i
p
C
i
r
c
u
mf
e
r
e
n
c
e
i
n
c
m
9
7
.
1
9
±
9
.
8
9
6
.
9
3
±
8
.
7
1
0
.
8
6
5
n
74
76
*
si
g
-
2
t
a
i
l
e
d
T
ab
le
2
.
A
s
s
o
ciatio
n
b
et
w
ee
n
T
C
an
d
UA
to
th
e
MU
AC
,
W
C
an
d
HC
a
m
o
n
g
m
ales
M
A
L
ES
L
i
n
e
a
r
r
e
g
r
e
ssi
o
n
t
e
st
I
n
d
e
p
e
n
d
e
n
t
v
a
r
i
a
b
l
e
No
D
e
p
e
n
d
e
n
t
v
a
r
i
a
b
l
e
TC
UA
M
U
A
C
WC
HC
1
TC
R
2
=
0
.
1
0
1
B
e
t
a
=
0
.
3
1
7
p
=
0
.
0
0
6
*
B=
8
.
1
2
4
R
2
=
0
.
1
4
B
e
t
a
=
0
.
3
7
4
p=
0
.
0
0
*
B=
3
.
5
8
5
R
2
=
0
.
1
3
4
B
e
t
a
=
0
.
3
6
5
p=
0
.
0
0
1
*
B=
1
.
2
0
9
R
2
=
0
.
1
3
5
B
e
t
a
=
0
.
3
6
7
p=
0
.
0
0
1
*
B=
1
.
7
1
3
2
UA
R
2
=
0
.
1
0
1
B
e
t
a
=
0
.
3
1
7
p=
0
.
0
0
6
*
B=
0
.
0
1
2
R
2
=
0
.
1
6
B
e
t
a
=
0
.
4
p
<
0
.
0
0
1
*
B=
0
.
1
4
9
R
2
=
0
.
1
4
2
B
e
t
a
=
0
.
3
7
7
p
=
0
.
0
0
1
*
B=
0
.
0
4
9
R
2
=
0
.
1
8
3
B
e
t
a
=
0
.
4
2
8
p
<
0
.
0
0
1
*
B=
0
.
0
7
8
P
e
a
r
so
n
(
o
r
S
p
e
a
r
man
)
c
o
r
r
e
l
a
t
i
o
n
t
e
s
t
.
*
i
s st
a
t
i
st
i
c
a
l
l
y
si
g
n
i
f
i
c
a
n
t
.
No
V
a
r
i
a
b
l
e
TC
UA
M
U
A
C
WC
HC
1
TC
r=
0
.
3
1
p=
0
.
0
0
7
*
r=
0
.
3
7
4
p=
0
.
0
0
1
*
r=
0
.
3
4
9
p=
0
.
0
0
2
*
r=
0
.
3
6
7
p=
0
.
0
0
1
*
2
UA
r=
0
.
4
5
1
p
<
0
.
0
0
1
*
r=
0
.
4
5
5
p
<
0
.
0
0
1
*
r=
0
.
5
0
8
p
<
0
.
0
0
1
*
3
M
U
A
C
r=
0
.
8
1
8
p
<
0
.
0
0
1
*
r=
0
.
8
1
1
p
<
0
.
0
0
1
*
4
WC
r=
0
.
9
2
6
p
<
0
.
0
0
1
*
5
HC
Am
o
n
g
f
e
m
ales,
t
h
er
e
w
er
e
p
o
s
itiv
e
s
ig
n
i
f
ica
n
t
co
r
r
elatio
n
s
b
et
w
ee
n
T
C
to
UA
(
r
=0
.
4
0
8
,
p
<
0
.
0
0
1
)
;
b
et
w
ee
n
U
A
to
HC
(
r
=0
.
2
4
5
,
p
=0
.
0
3
3
)
;
b
etw
ee
n
MU
A
C
to
W
C
(
r
=0
.
7
8
9
,
p
<0
.
0
0
1
)
;
b
et
w
ee
n
MU
AC
to
HC
(
r
=0
.
7
6
8
,
p
<
0
.
0
0
1
)
an
d
b
et
w
ee
n
H
C
to
W
C
(
r
=0
.
8
4
8
,
p
<0
.
0
0
1
)
.
T
h
e
s
tr
o
n
g
est
co
r
r
elatio
n
w
as
s
h
o
w
n
b
et
w
ee
n
t
h
e
W
C
a
n
d
H
C
a
m
o
n
g
f
e
m
ale
s
w
it
h
r
=0
.
8
4
8
(
p
<0
.
0
0
1
)
;
w
h
il
s
t
t
h
e
w
ea
k
est
co
r
r
elatio
n
w
a
s
s
h
o
w
n
b
et
w
ee
n
t
h
e
T
C
a
n
d
W
C
a
m
o
n
g
f
e
m
ale
s
(
r
=0
.
0
6
5
,
p
=0
.
5
7
8
)
.
R
ev
er
s
ed
co
r
r
elatio
n
w
as
s
h
o
w
n
b
et
w
ee
n
T
C
an
d
MU
A
C
w
i
th
r
=
-
0
.
0
4
1
(
p
=0
.
7
2
7
)
.
I
n
o
u
r
s
tu
d
y
,
1
p
o
in
t
in
cr
ea
s
e
o
n
t
h
e
U
A
co
r
r
esp
o
n
d
ed
to
8
.
1
2
4
p
o
in
ts
in
cr
ea
s
e
o
n
th
e
T
C
;
1
p
o
in
t
in
cr
ea
s
e
o
n
th
e
MU
AC
co
r
r
esp
o
n
d
ed
to
3
.
5
8
5
p
o
in
ts
in
cr
ea
s
e
o
n
th
e
T
C
;
1
p
o
in
t
in
cr
ea
s
e
o
n
t
h
e
W
C
co
r
r
esp
o
n
d
ed
to
1
.
2
0
9
p
o
in
ts
in
cr
ea
s
e
o
n
t
h
e
T
C
;
a
n
d
1
p
o
in
t
i
n
cr
ea
s
e
o
n
th
e
H
C
co
r
r
esp
o
n
d
ed
to
1
.
7
1
3
p
o
in
ts
in
cr
ea
s
e
o
n
t
h
e
T
C
o
f
m
ales.
F
u
r
th
er
m
o
r
e,
a
m
o
n
g
m
ales,
1
p
o
in
t in
cr
ea
s
e
o
n
t
h
e
T
C
co
r
r
esp
o
n
d
ed
t
o
0
.
0
1
2
p
o
in
ts
i
n
cr
ea
s
e
o
n
t
h
e
U
A
;
1
p
o
i
n
t
i
n
cr
ea
s
e
o
n
th
e
M
U
A
C
co
r
r
esp
o
n
d
ed
to
0
.
1
4
9
p
o
in
ts
i
n
cr
ea
s
e
o
n
t
h
e
U
A;
1
p
o
in
t
i
n
cr
ea
s
e
o
n
t
h
e
W
C
co
r
r
esp
o
n
d
ed
to
0
.
0
4
9
p
o
in
ts
i
n
cr
e
ase
o
n
th
e
U
A
;
a
n
d
1
p
o
in
t
in
cr
ea
s
e
o
n
th
e
HC
co
r
r
esp
o
n
d
ed
t
o
0
.
0
7
8
p
o
in
ts
in
cr
ea
s
e
o
n
th
e
U
A
.
On
t
h
e
o
th
er
h
an
d
,
a
m
o
n
g
f
e
m
ales,
1
p
o
in
t
i
n
cr
ea
s
e
o
n
t
h
e
U
A
co
r
r
esp
o
n
d
ed
to
1
3
.
2
3
4
p
o
in
ts
i
n
cr
ea
s
e
o
n
th
e
T
C
;
w
it
h
1
p
o
in
t
in
cr
ea
s
e
o
n
th
e
MU
AC
co
r
r
esp
o
n
d
ed
to
0
.
4
1
3
p
o
in
ts
d
ec
r
ea
s
e
o
n
th
e
T
C
;
1
p
o
in
t
i
n
cr
ea
s
e
o
n
th
e
W
C
co
r
r
esp
o
n
d
ed
to
0
.
1
6
8
p
o
in
ts
i
n
cr
ea
s
e
o
n
th
e
T
C
;
an
d
1
p
o
in
t
in
cr
ea
s
e
o
n
th
e
HC
co
r
r
esp
o
n
d
ed
to
0
.
3
4
3
p
o
i
n
ts
i
n
cr
ea
s
e
o
n
t
h
e
T
C
.
Am
o
n
g
f
e
m
ale
s
,
1
p
o
in
t
in
cr
ea
s
e
o
n
t
h
e
T
C
co
r
r
esp
o
n
d
ed
to
0
.
0
1
7
p
o
in
ts
in
cr
ea
s
e
o
n
th
e
U
A
;
1
p
o
in
t
in
cr
ea
s
e
o
n
t
h
e
MU
A
C
co
r
r
esp
o
n
d
ed
to
0
.
0
3
1
p
o
in
ts
in
cr
ea
s
e
o
n
th
e
U
A
;
1
p
o
in
t
in
cr
ea
s
e
o
n
th
e
W
C
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A
s
s
o
ciatio
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et
w
ee
n
T
C
an
d
UA
to
th
e
MU
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W
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a
m
o
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e
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e
n
d
e
n
t
v
a
r
i
a
b
l
e
TC
UA
M
U
A
C
WC
HC
1
TC
R
2
=
0
.
2
2
2
B
e
t
a
=
0
.
4
7
1
p
<
0
.
0
0
1
*
B
=
1
3
.
2
3
4
R
2
=
0
.
0
0
2
B
e
t
a
=
-
0
.
0
4
1
p=
0
.
7
2
7
B=
-
0
.
4
1
3
R
2
=
0
.
0
0
2
B
e
t
a
=
0
.
0
4
p=
0
.
7
3
2
B=
0
.
1
6
8
R
2
=
0
.
0
0
5
B
e
t
a
=
0
.
0
7
4
p=
0
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P
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a
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(
o
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p
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man
)
c
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*
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s st
a
t
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c
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t
.
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a
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a
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1
TC
r=
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HC
Her
e
w
e
o
b
s
er
v
ed
h
ig
h
er
MU
AC
,
W
C
an
d
HC
a
m
o
n
g
m
ales
co
m
p
ar
ed
to
f
e
m
ales.
T
h
e
an
th
r
o
p
o
m
etr
ic
m
ea
s
u
r
e
s
ar
e
th
e
r
es
u
lt
o
f
b
o
th
g
e
n
etic
a
n
d
en
v
ir
o
n
m
e
n
tal
f
ac
to
r
s
.
T
h
e
i
n
ter
ac
tio
n
b
et
w
ee
n
th
ese
f
ac
to
r
s
co
u
ld
b
e
ex
p
lai
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g
th
e
d
i
f
f
er
en
ce
s
w
it
h
i
n
an
d
b
et
w
ee
n
g
r
o
u
p
s
[
22
-
24
]
.
A
p
il
o
t
s
tu
d
y
co
n
d
u
cted
a
m
o
n
g
s
t
1
0
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p
ar
ticip
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ts
ag
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d
1
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-
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y
ea
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ld
in
Sin
g
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o
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s
h
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th
at
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m
e
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n
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t
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t
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,
w
e
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t
,
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d
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w
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1
7
3
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2
c
m
,
6
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.
5
k
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a
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d
2
3
.
2
k
g
/
m
2
f
o
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m
a
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s
;
w
h
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1
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1
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m
,
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6
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m
a
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s
,
r
e
s
p
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c
t
i
v
e
l
y
.
T
h
ey
r
ep
o
r
ted
th
at
m
a
l
e
s
h
a
d
l
a
r
g
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r
b
o
d
y
d
i
m
e
n
s
i
o
n
s
t
h
a
n
f
e
m
a
l
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s
;
d
i
f
f
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r
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n
c
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b
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e
a
b
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t
0
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7
t
o
1
7
.
4
cm
[
20
]
.
I
n
o
th
er
s
tu
d
y
,
it
w
as
r
ep
o
r
ted
th
at
m
a
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m
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m
as
s
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w
h
ils
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av
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m
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at
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th
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s
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Ma
l
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k
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m
u
late
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s
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e
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k
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ab
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f
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m
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g
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all
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ac
cu
m
u
late
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s
u
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ar
o
u
n
d
th
e
h
ip
s
a
n
d
th
i
g
h
s
[
20
-
24
]
.
P
r
ev
io
u
s
s
tu
d
y
s
h
o
w
ed
th
at
f
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m
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-
s
p
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if
ic
d
if
f
er
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ce
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in
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b
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atter
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h
at
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f
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m
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to
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m
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s
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m
ales.
T
h
ese
p
atter
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s
ar
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in
f
lu
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d
b
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th
e
u
n
iq
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s
an
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p
h
y
s
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f
it
n
es
s
in
b
o
th
s
ex
e
s
[8
,
9
,
1
2
]
.
W
e
f
o
u
n
d
th
e
T
C
an
d
UA
o
f
m
ales
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h
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t
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A
l
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Z
h
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l.
r
ep
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ted
th
at
th
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to
tal
ch
o
le
s
ter
o
l
lev
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s
w
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if
ican
t
l
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n
g
f
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m
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s
th
a
n
th
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m
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r
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p
.
Ho
w
ev
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th
e
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al
s
o
o
b
s
er
v
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th
at
th
e
B
MI
,
W
C
an
d
w
aist
to
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s
ig
n
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d
to
th
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k
f
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s
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g
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m
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les
[
2
5
]
.
Her
e
w
e
also
f
o
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n
d
th
at
h
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h
er
T
C
co
r
r
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s
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n
if
ica
n
tl
y
to
th
e
h
i
g
h
er
MU
AC
,
W
C
an
d
HC
a
m
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m
a
les;
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f
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m
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o
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h
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tl
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r
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d
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n
l
y
to
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g
h
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H
C
.
I
t
w
as
r
ep
o
r
ted
th
at
MU
AC
w
a
s
co
r
r
elate
d
w
e
ll
to
th
e
B
MI
a
n
d
co
u
ld
in
d
icate
th
e
n
u
tr
itio
n
al
s
tat
u
s
a
m
o
n
g
s
t
ad
u
lt
s
.
T
h
e
W
C
a
n
d
H
C
h
av
e
also
b
ee
n
d
em
o
n
s
tr
ated
to
h
av
e
a
g
o
o
d
ass
o
ciatio
n
to
t
h
e
n
u
tr
iti
o
n
al
s
tat
u
s
a
n
d
B
MI
[
3
,
8
,
1
6
]
.
A
lar
g
e
h
ip
cir
cu
m
f
er
e
n
ce
s
ee
m
s
to
co
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v
e
y
s
tr
o
n
g
a
n
d
in
d
ep
en
d
en
t
p
r
o
tectio
n
ag
ai
n
s
t
d
e
v
elo
p
m
en
t
o
f
C
VD
o
r
ea
r
l
y
m
o
r
ta
lit
y
in
w
o
m
e
n
.
Hip
s
ize
d
o
es
n
o
t
s
ee
m
to
b
e
r
elate
d
to
C
VDs
in
m
e
n
.
Ho
w
e
v
er
,
it
c
an
n
o
t
b
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ex
c
lu
d
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en
tire
l
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th
at
w
id
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h
ip
s
m
a
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e
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ag
ain
s
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l
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talit
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.
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t
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t
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o
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.
T
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t
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w
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co
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to
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e
h
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g
h
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r
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s
k
o
f
C
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a
m
o
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g
s
t
ad
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lt
s
.
T
h
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waist
to
h
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r
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s
w
id
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s
t
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ied
in
ter
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r
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to
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m
m
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s
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ce
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in
t
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p
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ab
d
o
m
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(
v
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f
at)
.
I
f
t
h
e
w
ai
s
t
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ir
cu
m
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ce
is
h
i
g
h
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th
a
n
th
e
h
ip
cir
cu
m
f
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n
ce
t
h
e
ap
p
le
s
h
a
p
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b
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y
is
f
o
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m
ed
;
w
h
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s
t
h
e
w
ai
s
t
c
ir
cu
m
f
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en
ce
i
s
lo
w
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th
a
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th
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h
ip
cir
cu
m
f
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n
ce
th
e
n
t
h
is
w
o
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ld
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th
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y
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Ma
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a
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ted
to
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ap
p
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h
ap
ed
b
o
d
y
th
an
f
e
m
ale
s
,
an
d
v
ice
v
er
s
a.
T
h
is
lead
s
to
t
h
e
p
r
o
p
o
s
ed
p
r
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tectiv
e
HC
a
m
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g
f
e
m
ale
s
f
r
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m
t
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e
r
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k
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f
d
ev
elo
p
in
g
m
etab
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lic
s
y
n
d
r
o
m
e
an
d
C
VD
[
8
,
1
6
,
2
1
]
.
Evaluation Warning : The document was created with Spire.PDF for Python.
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81
Fro
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k
f
ac
to
r
f
o
r
i
s
c
h
e
m
ic
h
ea
r
t
d
is
ea
s
e
an
d
s
tr
o
k
e.
Hig
h
ch
o
les
ter
o
l
lev
els
co
u
ld
b
e
o
cc
u
r
r
e
d
d
u
e
to
h
er
ed
it
y
i.e
.
f
a
m
ilia
l
h
y
p
er
ch
o
le
s
ter
o
le
m
ia,
e
x
ce
s
s
i
v
e
w
eig
h
t,
ex
er
ci
s
e
an
d
/
o
r
p
h
y
s
ical
ac
tiv
it
y
,
a
g
e
an
d
s
e
x
,
alco
h
o
l
u
s
e
a
n
d
m
en
tal
s
tr
es
s
ar
e
s
o
m
e
o
f
d
et
er
m
in
a
n
t
s
f
o
r
.
Af
ter
ap
p
r
o
x
im
atel
y
a
g
e
5
0
y
ea
r
o
ld
,
w
o
m
en
o
f
ten
h
av
e
h
ig
h
er
to
tal
ch
o
lest
er
o
l
le
v
el
s
t
h
an
m
en
o
f
th
e
s
a
m
e
a
g
e;
w
h
il
s
t
at
p
r
e
-
m
e
n
o
p
au
s
e
w
o
m
e
n
ten
d
to
h
av
e
lo
w
er
to
t
al
ch
o
lest
er
o
l
le
v
els
t
h
a
n
m
en
o
f
th
e
s
a
m
e
ag
e.
C
h
o
le
s
ter
o
l
is
a
f
at
-
lik
e
s
u
b
s
tan
ce
n
ee
d
ed
to
b
u
ild
v
ar
io
u
s
s
tr
u
ct
u
r
es
in
t
h
e
h
u
m
an
b
o
d
y
as
w
el
l
as
to
p
r
o
d
u
ce
ch
em
ica
ls
an
d
h
o
r
m
o
n
es
th
a
t
ar
e
ess
en
tial
s
f
o
r
th
e
b
o
d
y
’
s
f
u
n
ctio
n
.
Ho
w
e
v
er
,
ex
ce
s
s
am
o
u
n
ts
ca
n
b
e
d
ep
o
s
ited
at
th
e
v
asc
u
lar
w
alls
a
s
th
e
p
laq
u
es
th
u
s
m
i
g
h
t
b
e
d
ec
r
ea
s
in
g
t
h
e
a
m
o
u
n
t o
f
b
lo
o
d
f
lo
w
to
t
h
e
o
r
g
an
s
[
2
2
,
2
4
,
2
6
]
.
Am
o
n
g
m
ales,
w
e
o
b
s
er
v
e
d
s
tr
o
n
g
co
r
r
esp
o
n
d
en
ce
b
et
w
ee
n
ea
ch
o
f
t
h
e
an
t
h
r
o
p
o
m
etr
ic
m
ea
s
u
r
e
m
e
n
t to
t
h
e
U
A
le
v
els
w
h
ils
t si
m
ilar
p
a
tter
n
w
a
s
o
n
l
y
f
o
u
n
d
b
et
w
ee
n
HC
a
n
d
U
A
a
m
o
n
g
f
e
m
ale
s
.
O
n
th
e
o
th
er
h
a
n
d
,
th
e
u
r
ic
ac
id
lev
els
i
n
t
h
e
cu
r
r
en
t
s
t
u
d
y
wer
e
h
ig
h
l
y
co
r
r
esp
o
n
d
ed
to
th
e
lev
el
o
f
t
h
e
to
tal
ch
o
lest
er
o
l
in
b
o
th
g
e
n
d
er
s
.
W
h
er
e
th
er
e
is
a
n
i
m
b
ala
n
ce
b
et
w
ee
n
th
e
b
r
ea
k
d
o
w
n
o
f
p
u
r
in
es
a
n
d
th
e
r
ate
o
f
u
r
ic
ac
id
ex
cr
etio
n
,
h
y
p
er
u
r
icem
ia
i
s
p
r
o
d
u
ce
d
.
T
h
e
u
r
ic
ac
id
in
t
h
e
b
lo
o
d
is
s
atu
r
ate
d
at
ap
p
r
o
x
i
m
atel
y
6
.
4
to
7
m
g
/
d
L
;
w
h
er
e
th
e
u
r
ate
i
s
f
ilter
ed
th
r
o
u
g
h
t
h
e
g
lo
m
er
u
lu
s
w
h
i
ls
t
r
ea
b
s
o
r
b
ed
,
s
ec
r
eted
an
d
th
e
r
ea
b
s
o
r
b
ed
ag
ain
i
n
t
h
e
p
r
o
x
i
m
al
t
u
b
u
le
o
f
t
h
e
k
id
n
e
y
.
T
h
e
i
n
cr
ea
s
ed
i
n
t
h
e
s
er
u
m
u
r
ate
lev
el
w
o
u
ld
in
cr
ea
s
e
t
h
e
u
r
ate
ex
cr
etio
n
[
11,
1
8
,
1
9
]
.
Hy
p
er
u
r
ice
m
ia
h
a
v
e
b
ee
n
as
s
o
ciate
d
to
th
e
i
n
cr
ea
s
ed
t
h
e
m
o
r
talit
y
r
ate
in
th
e
p
atie
n
t
s
o
f
h
y
p
er
ten
s
io
n
a
n
d
s
tr
o
k
e.
I
t
is
r
ep
o
r
ted
th
at
h
y
p
er
u
r
ic
e
m
ia
i
s
h
i
g
h
er
i
n
t
h
e
p
atie
n
ts
s
u
f
f
er
ed
f
r
o
m
t
h
e
m
etab
o
lic
s
y
n
d
r
o
m
e.
T
h
e
u
n
d
er
l
y
in
g
p
ath
o
lo
g
y
m
a
y
i
n
cl
u
d
e
th
e
i
n
cr
ea
s
ed
i
n
f
la
m
m
ato
r
y
p
ath
w
a
y
s
ig
n
aled
b
y
th
e
r
aisi
n
g
o
f
th
e
lev
el
o
f
c
-
r
e
ac
tiv
e
p
r
o
tein
(
C
R
P
)
an
d
t
h
e
I
L
-
1
c
y
to
k
in
e
i
n
t
h
e
o
b
esit
y
w
h
ic
h
i
n
t
u
r
n
w
o
u
ld
alter
th
e
s
tr
u
ctu
r
e
o
f
t
h
e
k
id
n
e
y
th
u
s
g
lo
m
er
u
lar
f
iltra
tio
n
f
u
n
ctio
n
[
11,
1
8
,
1
9
]
.
P
r
ev
io
u
s
s
tu
d
y
r
ep
o
r
ted
th
at
p
er
s
o
n
s
w
it
h
o
b
esit
y
w
o
u
ld
h
a
v
e
h
i
g
h
er
r
is
k
to
d
e
v
elo
p
th
e
m
etab
o
lic
s
y
n
d
r
o
m
e
an
d
C
VD.
I
n
o
b
esit
y
t
h
e
i
n
s
u
li
n
r
esi
s
tan
ce
te
n
d
to
ea
s
il
y
o
cc
u
r
an
d
h
as
b
ee
n
a
s
s
o
ci
ated
to
th
e
r
aised
in
f
la
m
m
a
to
r
y
c
y
to
k
i
n
e
le
v
els
i.e
.
T
NF
-
α
a
n
d
lep
ti
n
le
v
els
w
it
h
lo
w
ad
ip
o
n
ec
tin
lev
e
ls
[
1
0
,
2
2
,
2
4
]
.
T
h
ese
w
o
u
ld
s
u
b
s
eq
u
en
tl
y
f
ac
il
itati
n
g
th
e
d
e
v
elo
p
m
e
n
t
o
f
m
etab
o
lic
s
y
n
d
r
o
m
e
t
h
at
in
cr
ea
s
e
th
e
r
i
s
k
f
o
r
s
u
f
f
er
i
n
g
th
e
d
iab
etes
m
e
llit
u
s
t
y
p
e
2
(
DM
-
2
)
an
d
/
or
ca
r
d
io
v
ascu
l
ar
d
is
ea
s
e
(
C
VD)
[
1
0
,
2
2
,
2
6
]
.
Pre
v
en
ti
v
e
an
d
p
r
o
m
o
ti
v
e
m
ed
icin
e
s
h
o
u
ld
b
e
e
m
p
h
a
s
ized
esp
ec
ial
l
y
a
m
o
n
g
s
t
t
h
e
s
ee
m
in
g
l
y
h
ea
lt
h
y
y
o
u
th
s
to
lo
w
er
i
n
g
t
h
e
in
cid
en
ce
o
f
th
e
s
e
d
is
ea
s
es
in
th
e
later
li
f
e
.
T
h
ese
m
a
y
i
n
cl
u
d
e
to
h
a
v
in
g
h
ea
lt
h
y
d
iet
f
o
r
e
x
a
m
p
le
f
o
o
d
s
r
ic
h
in
p
o
l
y
p
h
e
n
o
ls
i.e
.
b
er
r
ies
an
d
g
r
ee
n
tea
[
2
7
,
2
8
]
.
W
h
ils
t
p
r
ac
ticin
g
d
ail
y
e
x
er
cise
an
d
/
o
r
r
o
u
tin
e
p
h
y
s
ical
ac
tiv
it
y
to
b
alan
ce
th
e
ten
d
e
n
c
y
o
f
s
ed
e
n
tar
y
li
f
e
s
t
y
le
a
f
f
e
cted
b
y
to
o
m
u
c
h
o
f
g
ad
g
et
u
s
e
in
t
h
is
m
o
d
er
n
w
o
r
ld
w
o
u
ld
b
e
b
en
ef
icial
e
v
en
in
t
h
e
m
etab
o
licall
y
h
ea
lt
h
y
o
b
ese
p
er
s
o
n
s
to
d
ec
r
ea
s
e
th
e
ca
r
d
io
v
ascu
lar
d
is
ea
s
e
r
is
k
s
[
29
,
30
].
4.
CO
NCLU
SI
O
N
T
h
e
r
is
k
f
ac
to
r
o
f
C
VD
s
co
u
l
d
b
e
f
o
u
n
d
a
m
o
n
g
s
t
t
h
e
s
ee
m
in
g
l
y
h
ea
l
th
y
y
o
u
n
g
ad
u
lt
s
i
n
o
u
r
s
t
u
d
y
.
A
ll
a
n
t
h
r
o
p
o
m
etr
y
an
d
b
io
ch
e
m
ical
m
ar
k
er
s
s
tu
d
ied
w
er
e
h
i
g
h
er
a
m
o
n
g
m
ale
s
th
a
n
a
m
o
n
g
f
e
m
ale
s
.
T
h
e
t
o
tal
ch
o
lest
er
o
l
an
d
u
r
ic
ac
id
le
v
els
w
er
e
s
i
g
n
i
f
ica
n
tl
y
as
s
o
ciate
d
to
all
an
t
h
r
o
p
o
m
etr
y
s
t
u
d
ied
a
m
on
g
m
ales,
w
h
il
s
t
a
m
o
n
g
f
e
m
ales
s
tr
o
n
g
co
r
r
elatio
n
w
as
o
n
l
y
f
o
u
n
d
b
et
w
ee
n
th
e
h
ip
cir
cu
m
f
er
en
c
e
an
d
th
e
u
r
ic
ac
id
lev
el.
ACK
NO
WL
E
D
G
E
M
E
NT
S
T
h
an
k
y
o
u
to
t
h
e
Fac
u
lt
y
o
f
Me
d
icin
e,
U
n
i
v
er
s
itas
A
ir
la
n
g
g
a,
S
u
r
ab
a
y
a,
I
n
d
o
n
e
s
ia
a
n
d
T
h
e
I
I
K
-
B
W
,
Ked
ir
i,
I
n
d
o
n
esia.
T
h
is
s
t
u
d
y
r
ec
eiv
ed
fu
n
d
in
g
s
f
r
o
m
U
n
iv
er
s
itas
Air
lan
g
g
a
.
REFEREN
CES
[1
]
G
ru
n
d
y
S
M
.
,
“
Us
e
o
f
e
m
e
rg
in
g
l
ip
o
p
ro
tei
n
risk
f
a
c
to
rs
in
a
s
se
ss
m
e
n
t
o
f
c
a
rd
io
v
a
sc
u
lar
risk
,
”
J
AM
A
,
v
o
l.
3
0
7
,
n
o
.
2
3
,
p
p
.
2
5
4
0
-
2
5
4
2
,
2
0
1
2
,
d
o
i:
1
0
.
1
0
0
1
/j
a
m
a
.
2
0
1
2
.
6
8
9
6
.
[2
]
Ca
sa
s
R
.
,
Ca
stro
-
Ba
rq
u
e
r
o
S
.
,
Estru
c
h
R
.
,
S
a
c
a
n
e
ll
a
E.
,
“
Nu
tr
i
ti
o
n
a
n
d
c
a
rd
i
o
v
a
sc
u
lar
h
e
a
lt
h
,
”
In
ter
n
a
ti
o
n
a
l
J
o
u
rn
a
l
o
f
M
o
lec
u
l
a
r S
c
ien
c
e
s
.
,
v
o
l.
19
,
n
o
.
12
,
p
.
3
9
8
8
,
2
0
1
8
.
[3
]
De
sp
re
s
JP
.
,
“
Bo
d
y
f
a
t
d
istri
b
u
ti
o
n
a
n
d
risk
o
f
c
a
rd
io
v
a
sc
u
lar
d
i
se
a
se
,
”
Circ
u
la
ti
o
n
,
v
o
l.
1
2
6
,
n
o
.
1
0
,
p
p
.
1
3
0
1
-
1
3
1
3
.
2
0
1
2
.
[4
]
Ha
t
m
a
RD.
,
“
L
ip
id
p
r
o
f
il
e
s
a
m
o
n
g
d
iv
e
rse
e
th
n
ic
g
ro
u
p
s
i
n
I
n
d
o
n
e
sia
,
”
Acta
M
e
d
ica
In
d
o
n
e
s
i
a
n
a
.
,
v
o
l.
4
3
,
n
o
.
1
,
p
p
.
4
-
1
1
,
2
0
1
1
.
[5
]
Ca
m
e
ro
n
A
J,
Ro
m
a
n
iu
k
H
.
,
Ore
ll
a
n
a
L
.
,
Da
ll
o
n
g
e
v
il
le
J
.
,
Do
b
s
o
n
A
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7
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[1
8
]
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N.
,
“
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u
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[1
9
]
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.
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.
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re
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At
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2
0
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e
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e
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.
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“
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