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d
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ited
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m
o
v
i
n
g
o
n
l
y
th
e
ca
r
io
u
s
lesi
o
n
[
1
]
.
So
o
n
,
i
t
is
ex
p
ec
ted
f
o
r
r
esto
r
ativ
e
m
ater
ials
to
u
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g
o
co
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h
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ite
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ater
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tit
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te
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m
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m
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ill
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s
f
o
r
r
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r
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n
o
f
ca
v
itie
s
in
p
r
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m
ar
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teet
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[
2
]
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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6
I
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t.
J
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P
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Hea
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Sci.,
Vo
l.
1
0
,
No
.
2
,
J
u
n
e
20
21
:
241
–
248
242
T
h
e
co
m
m
i
s
s
io
n
o
f
Am
er
ic
an
A
ca
d
e
m
y
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f
P
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Den
tis
tr
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(
AA
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D
)
ac
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p
ts
a
g
u
id
e
f
o
r
r
esto
r
ativ
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d
en
ti
s
tr
y
i
n
1
9
9
1
[
3
]
.
T
h
e
last
f
u
ll
r
ev
i
s
io
n
o
f
t
h
is
co
n
s
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n
s
u
s
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s
in
2
0
1
4
.
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h
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e
h
a
v
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n
3
5
m
eta
-
an
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s
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w
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1
9
9
5
an
d
2
0
1
3
,
s
u
p
p
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tin
g
th
is
g
u
i
d
e,
w
h
ic
h
in
c
lu
d
e
s
y
s
te
m
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ch
ec
k
-
u
p
s
an
d
6
2
co
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tr
o
lled
clin
ical
test
s
.
T
h
e
ass
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s
m
en
t
o
f
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ch
o
f
t
h
e
to
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ased
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n
e
w
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it
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s
to
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class
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f
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.
R
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m
m
en
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h
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b
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ad
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g
ev
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ased
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t
h
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p
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t
ial
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tr
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s
tu
d
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s
,
m
eta
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a
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s
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n
d
s
y
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te
m
a
tic
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ev
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w
s
)
;
e
v
id
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n
ce
o
f
cli
n
ical
s
t
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ies;
e
x
p
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t
o
p
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s
(
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s
p
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tiv
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s
tu
d
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s
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ca
s
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r
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ts
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in
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d
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s
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d
o
p
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o
f
cli
n
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ex
a
m
i
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er
s
)
[
4
]
.
I
t
h
as
b
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t
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at
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ar
tial
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ca
v
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o
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s
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llo
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m
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t
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f
a
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ai
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o
f
th
e
p
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lp
in
p
er
m
an
e
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t te
et
h
[
5
]
.
Glass
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io
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o
m
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ce
m
e
n
ts
h
a
v
e
b
ee
n
u
s
ed
in
d
en
tal
m
ed
ici
n
e
as
a
r
esto
r
ativ
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m
ater
ial
s
in
ce
t
h
e
b
eg
in
n
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f
1
9
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T
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n
t
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g
la
s
s
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er
ce
m
e
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t
s
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s
to
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s
,
alo
n
g
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h
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e
m
o
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ied
w
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h
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s
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la
s
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o
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er
s
.
T
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ater
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s
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o
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m
en
t
in
t
h
e
w
o
r
k
p
r
o
ce
s
s
,
r
ed
u
ce
d
ti
m
e,
n
ee
d
ed
f
o
r
m
i
x
t
u
r
e,
i
n
cr
ea
s
ed
d
u
r
ab
i
lit
y
a
n
d
i
m
p
r
o
v
ed
s
u
s
tai
n
ab
ilit
y
.
A
ll
g
lass
-
io
n
o
m
er
s
h
a
v
e
q
u
alitie
s
th
at
m
a
k
e
th
e
m
f
a
v
o
r
ab
le
to
u
s
e
in
p
r
im
ar
y
teet
h
,
in
cl
u
d
in
g
th
e
ch
e
m
ical
b
o
n
d
to
w
ar
d
s
th
e
en
a
m
el
an
d
d
en
ti
n
;
te
m
p
er
a
tu
r
e
ex
te
n
s
io
n
,
s
u
c
h
as
th
at
o
f
d
en
tal
s
tr
u
ctu
r
e
s
;
b
io
co
m
p
atib
ilit
y
; r
elea
s
i
n
g
o
f
f
l
u
o
r
id
e
an
d
d
ec
r
ea
s
ed
s
en
s
iti
v
it
y
to
w
ar
d
s
m
o
is
t
u
r
e,
co
m
p
ar
ed
w
it
h
r
esin
s
.
T
h
e
f
lu
o
r
id
e
r
elea
s
ed
f
r
o
m
t
h
e
g
las
s
-
io
n
o
m
er
ce
m
e
n
t
s
i
s
i
n
ter
ce
p
ted
f
r
o
m
t
h
e
ar
ea
o
f
th
e
ad
j
ac
en
t
en
a
m
e
l
a
n
d
d
en
ti
n
,
w
h
ic
h
lead
s
to
b
etter
r
es
ilie
n
ce
o
f
t
h
e
tee
th
to
w
ar
d
s
ac
id
ic
e
x
p
o
s
itio
n
[
3
]
.
On
l
y
o
n
e
o
f
th
e
s
tu
d
ie
s
s
h
o
w
s
t
h
at
t
h
e
r
elea
s
e
o
f
f
l
u
o
r
id
e
ca
n
o
cc
u
r
f
o
r
o
n
e
y
ea
r
m
i
n
i
m
u
m
.
T
h
e
r
e
is
co
n
cl
u
s
i
v
e
e
v
id
en
ce
,
t
h
at
th
e
m
o
d
i
f
ied
w
ith
r
es
in
g
las
s
-
io
n
o
m
er
s
ar
e
ef
f
icie
n
t
i
n
th
e
r
esto
r
atio
n
o
f
clas
s
I
ca
v
ities
.
T
h
is
ex
p
er
t
o
p
in
io
n
is
s
u
s
tai
n
ed
f
o
r
class
I
I
ca
v
i
tie
s
an
d
th
eir
r
esto
r
atio
n
s
in
p
r
i
m
ar
y
tee
th
[
6
]
,
[
7
]
.
C
o
m
p
o
m
er
s
ar
e
p
o
l
y
ac
id
-
m
o
d
if
ied
co
m
p
o
s
ites
b
ased
o
n
r
esin
,
a
n
d
th
e
y
m
a
k
e
th
e
ir
ap
p
ea
r
an
ce
in
d
en
tis
tr
y
i
n
th
e
9
0
s
.
T
h
e
m
ate
r
ial
co
n
s
is
ts
o
f
7
2
%
s
tr
o
n
ti
u
m
f
l
u
o
r
s
ilicate
g
las
s
a
n
d
th
e
s
iz
e
o
f
th
e
p
ar
ticle
s
is
2
.
5
m
icr
o
m
eter
s
[
8
]
.
Mo
s
t
o
f
th
e
s
t
u
d
ies
s
h
o
w
th
at
co
m
p
o
m
er
s
h
a
v
e
a
ten
d
en
c
y
o
f
i
m
p
r
o
v
ed
p
h
y
s
ical
q
u
alities
co
m
p
ar
ed
to
g
las
s
-
io
n
o
m
er
s
(
a
n
d
r
esi
n
-
m
o
d
if
ied
g
lass
-
io
n
o
m
er
s
)
f
o
r
r
esto
r
ati
o
n
s
o
f
p
r
i
m
ar
y
teet
h
.
T
h
er
e
h
as
n
o
t
b
ee
n
an
estab
li
s
h
ed
d
if
f
er
en
ce
i
n
t
h
e
ca
r
io
s
ta
ti
c
ef
f
ec
t
o
f
t
h
e
co
m
p
o
m
er
s
co
m
p
ar
ed
to
th
e
o
th
er
o
b
tu
r
atio
n
m
a
te
r
ials
[
9
]
-
[
1
1
]
.
C
o
m
p
o
m
er
s
m
a
y
b
e
a
ch
o
ice
in
s
tead
o
f
o
th
er
r
esto
r
ati
v
e
m
ater
ials
f
o
r
p
r
i
m
ar
y
d
en
titi
o
n
f
o
r
class
I
an
d
I
I
ca
v
itie
s
[
1
2
]
,
[
1
3
]
.
C
lass
I
I
I
ca
v
ities
o
r
ap
r
o
x
i
m
al
r
esto
r
atio
n
s
o
f
p
r
im
ar
y
i
n
ciso
r
s
ar
e
o
f
ten
p
r
ep
ar
e
d
w
it
h
a
lab
ial
o
r
lin
g
u
al
ac
ce
s
s
,
to
in
clu
d
e
a
b
ig
g
er
s
u
r
f
ac
e
f
o
r
b
etter
ad
h
esio
n
an
d
i
m
p
r
o
v
i
n
g
t
h
e
lo
n
g
e
v
it
y
o
f
th
e
r
esto
r
atio
n
s
[
1
4
]
.
C
av
ities
a
n
d
f
ill
in
g
s
i
n
t
h
e
ce
r
v
i
x
r
eg
io
n
f
r
o
m
c
lass
V
o
f
p
r
im
ar
y
in
c
is
o
r
s
ar
e
s
i
m
ilar
to
th
e
o
n
es i
n
p
er
m
a
n
en
t d
e
n
titi
o
n
[
3
]
.
I
f
th
e
p
atien
t
s
ar
e
i
n
an
estab
li
s
h
ed
h
i
g
h
ca
r
ies
r
is
k
,
r
esto
r
ati
o
n
s
ca
n
b
e
p
er
f
o
r
m
ed
b
y
u
s
i
n
g
a
cr
o
w
n
[
1
5
]
-
[
1
8
]
.
A
r
etr
o
s
p
ec
ti
v
e
s
tu
d
y
s
h
o
w
s
th
a
t
8
0
%
o
f
t
h
e
tee
th
ar
e
co
m
p
letel
y
p
r
eser
v
ed
u
p
u
n
til
t
h
r
ee
y
ea
r
s
af
ter
th
e
p
lace
m
e
n
t
o
f
p
r
ef
o
r
m
ed
cr
o
w
n
s
an
d
2
0
%
w
er
e
p
ar
tiall
y
p
r
es
er
v
ed
,
n
o
t
a
s
in
g
l
e
p
r
im
ar
y
to
o
t
h
w
a
s
m
is
s
i
n
g
[
1
9
]
.
Oth
er
r
etr
o
s
p
ec
t
iv
e
s
tu
d
y
w
i
th
d
u
r
atio
n
24
-
7
4
m
o
n
t
h
s
h
a
s
8
0
%
s
u
cc
ess
r
ate
i
n
r
esto
r
atio
n
s
w
i
th
p
r
ef
o
r
m
ed
cr
o
w
n
s
[
2
0
]
.
C
o
m
p
o
s
ite
is
t
h
e
r
esto
r
ativ
e
m
ater
ial
o
f
ch
o
ice
[
3
]
,
[
2
1
]
.
B
is
p
h
e
n
o
l
A
(
Me
th
y
l
m
eth
ac
r
y
l
ate)
an
d
its
co
n
tain
er
s
ar
e
r
es
in
co
m
p
o
n
e
n
ts
,
in
c
lu
d
ed
i
n
s
ea
la
n
ts
an
d
co
m
p
o
s
i
tes.
T
h
er
e
i
s
s
u
b
s
tan
t
ial
ev
id
en
ce
f
r
o
m
a
m
eta
-
an
a
l
y
s
is
o
f
5
9
clin
ical
s
t
u
d
ies
o
f
co
m
p
o
s
ite
f
illi
n
g
s
i
n
class
I
a
n
d
I
I
,
w
h
ich
s
h
o
w
9
0
%
s
u
cc
ess
r
ate
a
f
ter
1
0
y
ea
r
s
w
i
th
e
x
p
er
i
m
e
n
tal
c
o
n
d
itio
n
s
[
2
2
]
.
P
ast
co
n
tr
o
lled
s
tu
d
ies,
co
m
p
ar
i
n
g
co
m
p
o
s
i
te
r
esto
r
atio
n
s
w
it
h
a
m
al
g
a
m
also
s
h
o
w
s
u
cc
es
s
.
T
h
ese
s
tu
d
ie
s
s
h
o
w
t
h
at
a
r
ea
s
o
n
f
o
r
th
e
lac
k
o
f
s
u
cc
ess
in
th
ese
r
e
s
to
r
atio
n
s
i
s
th
e
r
ec
id
i
v
e
ca
r
ies
[
2
3
]
-
[
2
6
]
.
T
h
er
e
is
co
n
v
in
c
in
g
e
v
id
en
ce
th
at
co
m
p
o
s
ite
f
ill
in
g
s
f
o
r
cla
s
s
I
i
n
p
r
i
m
ar
y
teet
h
ar
e
s
u
cc
es
s
f
u
l
[
2
7
]
,
[
2
8
]
.
On
ly
o
n
e
s
tu
d
y
s
h
o
w
ed
s
u
cc
e
s
s
i
n
r
esto
r
atio
n
s
o
f
clas
s
I
I
,
f
ille
d
w
it
h
co
m
p
o
s
ite.
I
n
p
r
im
ar
y
teeth
r
esto
r
atio
n
s
it
is
i
m
p
o
r
tan
t
to
tak
e
in
to
ac
co
u
n
t
th
at
th
e
to
o
th
i
s
g
o
in
g
to
ex
f
o
liate
in
an
in
ter
v
al
o
f
t
w
o
y
ea
r
s
[
2
9
]
.
I
n
p
e
r
m
a
n
e
n
t
m
o
lar
s
co
m
p
o
s
ite
s
ar
e
r
ec
o
m
m
en
d
ed
[
3
0
]
.
C
o
n
ce
r
n
i
n
g
t
h
e
d
if
f
er
en
t
t
y
p
e
s
o
f
co
m
p
o
s
i
tes
(
h
y
b
r
id
,
n
a
n
o
,
m
ac
r
o
an
d
m
icr
o
p
ar
ticles)
th
er
e
ar
e
r
esu
lts
,
s
h
o
w
in
g
th
e
s
i
m
ilar
itie
s
in
t
h
eir
clin
ical
e
f
f
icie
n
c
y
.
T
h
e
r
ec
o
m
m
e
n
d
atio
n
s
o
f
th
e
c
o
m
m
i
s
s
io
n
o
f
AA
P
D
f
o
r
co
m
p
o
s
i
te
m
ater
ial
s
ar
e
as
f
o
l
lo
w
s
:
Fo
r
p
r
im
ar
y
m
o
lar
s
th
er
e
ar
e
co
n
t
r
o
lled
s
tu
d
ies,
w
h
ic
h
in
cl
u
d
e
co
m
p
o
s
i
te
r
esi
n
s
s
u
cc
es
s
f
u
ll
y
w
h
e
n
t
h
e
y
ar
e
u
s
ed
in
class
I
r
esto
r
atio
n
s
.
Fo
r
class
I
I
lesi
o
n
s
o
f
p
r
i
m
ar
y
tee
th
th
er
e
is
o
n
e
co
n
tr
o
lled
s
tu
d
y
s
h
o
w
i
n
g
s
u
cc
e
s
s
i
n
r
esto
r
atio
n
s
w
it
h
co
m
p
o
s
ites
f
o
r
t
w
o
y
ea
r
s
.
I
n
p
er
m
a
n
e
n
t
m
o
lar
s
th
er
e
ar
e
m
e
ta
-
a
n
al
y
s
e
s
,
s
h
o
w
i
n
g
t
h
at
co
m
p
o
s
i
te
m
ater
ials
ca
n
b
e
s
u
cc
es
s
f
u
ll
y
u
s
ed
f
o
r
cla
s
s
I
a
n
d
I
I
r
esto
r
atio
n
s
.
T
h
e
co
n
cl
u
s
io
n
s
o
f
t
h
e
m
e
ta
-
an
al
y
s
es
s
h
o
w
t
h
at
t
h
e
ad
h
e
s
i
v
e
m
ater
ials
to
w
ar
d
s
th
e
en
a
m
el
an
d
d
en
t
in
d
ec
r
ea
s
e
th
e
m
ar
g
in
a
l
d
is
co
lo
r
atio
n
an
d
v
is
u
all
y
“
d
ef
i
n
e”
t
h
e
b
o
r
d
er
s
o
f
th
e
d
if
f
er
e
n
t c
o
m
p
o
s
ite
m
ater
ials
.
Sealan
t
s
f
o
r
d
ee
p
f
is
s
u
r
es.
F
i
s
s
u
r
e
ca
r
ies
o
f
t
h
e
o
cc
l
u
s
al
s
u
r
f
ac
e
i
s
8
0
%
to
9
0
%
o
f
all
ca
r
ies
in
p
er
m
a
n
e
n
t
teeth
an
d
4
4
%
in
p
r
i
m
ar
y
m
o
lar
s
[
2
8
]
.
Sealan
ts
a
r
e
d
escr
ib
ed
as
a
m
ater
ial,
p
lace
d
in
d
ee
p
f
is
s
u
r
es
an
d
p
its
in
ca
r
ie
s
p
r
ed
is
p
o
s
ed
teeth
.
T
h
e
y
ar
e
co
n
n
ec
ted
m
icr
o
m
ec
h
a
n
icall
y
(
w
ith
m
ic
r
o
r
eten
tio
n
s
a
f
ter
etch
i
n
g
)
w
h
i
ch
ai
m
s
to
p
r
ev
en
t
th
e
ac
ce
s
s
o
f
ca
r
io
g
en
ic
b
ac
ter
ia
an
d
th
eir
f
o
o
d
s
o
u
r
ce
,
t
h
u
s
d
ec
r
ea
s
in
g
th
e
r
is
k
o
f
ca
r
ie
s
d
e
v
elo
p
m
e
n
t
[
3
0
]
.
T
h
e
ev
id
en
ce
o
f
th
eir
ef
f
ic
ien
c
y
i
s
ac
h
ie
v
ed
af
ter
a
s
u
r
v
e
y
o
f
C
o
ch
r
an
e.
T
h
e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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.
P
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lic
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lth
Sci.
I
SS
N:
2
2
5
2
-
8806
R
ela
tive
s
h
a
r
e,
fr
eq
u
en
cy
a
n
d
co
r
r
ela
tio
n
o
f res
to
r
a
tio
n
s
in
b
o
th
d
e
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ta
l d
e
n
titi
o
n
s
…
(
Do
b
r
in
ka
Da
mya
n
o
v
a
)
243
s
ea
lan
t
s
p
lace
d
in
th
e
c
lin
ic
o
n
t
h
e
o
cc
lu
s
al
f
is
s
u
r
e
o
f
t
h
e
p
er
m
an
e
n
t
m
o
lar
teet
h
i
n
ch
i
ld
r
en
an
d
ad
o
lesce
n
t
s
lead
to
a
r
ed
u
ctio
n
o
f
ca
r
ies
u
p
to
4
8
y
ea
r
s
[
3
1
]
.
A
cc
o
r
d
in
g
to
th
e
m
eta
-
a
n
al
y
s
i
s
o
f
2
4
s
t
u
d
ies
t
h
e
e
f
f
icie
n
c
y
o
f
t
h
e
a
u
to
p
o
l
y
m
er
is
ed
s
ea
la
n
ts
lead
s
to
a
p
r
ev
e
n
tio
n
o
f
ca
r
ies
u
p
to
7
1
%.
Stu
d
ie
s
f
o
r
th
e
ir
r
ep
ea
ted
p
lace
m
en
t
s
h
o
w
a
s
u
cc
es
s
r
at
e
o
f
8
0
%
to
9
0
%
f
o
r
1
0
o
r
m
o
r
e
y
ea
r
s
[
3
2
]
,
[
3
3
]
.
Fo
r
th
e
u
s
e
o
f
s
ea
lan
ts
f
o
r
t
h
e
p
r
ev
en
tio
n
o
f
d
e
n
tal
ca
r
ie
s
i
n
f
is
s
u
r
e
s
o
f
p
r
i
m
ar
y
teet
h
,
w
e
h
av
e
n
o
t
f
o
u
n
d
m
o
r
e
p
u
b
li
s
h
e
d
ar
ticles
to
s
u
p
p
o
r
t
th
ese
s
u
c
ce
s
s
e
s
[
3
4
]
.
On
e
s
t
u
d
y
s
h
o
w
s
7
6
.
5
%
s
u
cc
ess
in
s
ea
lan
ts
o
n
p
r
i
m
ar
y
teet
h
f
o
r
t
w
o
y
ea
r
s
a
n
d
eig
h
t
m
o
n
t
h
s
f
o
llo
w
u
p
[
3
5
]
.
2.
RE
S
E
ARCH
M
E
T
H
O
D
T
h
e
r
esear
ch
ai
m
ed
to
a
n
al
y
s
i
s
o
f
t
h
e
r
elativ
e
s
h
ar
e,
f
r
eq
u
en
c
y
an
d
co
r
r
elatio
n
o
f
r
es
to
r
atio
n
s
i
n
b
o
t
h
d
en
tal
d
en
titi
o
n
s
i
n
ch
i
ld
h
o
o
d
.
2
.
1
.
Clini
ca
l
m
et
ho
ds
a
nd
d
esig
n o
f
t
he
re
s
ea
rc
h
T
h
e
s
u
b
j
ec
t
o
f
o
b
s
er
v
atio
n
w
e
r
e
ch
ild
r
en
(
n
=6
0
2
)
w
it
h
p
r
i
m
ar
y
,
m
i
x
ed
o
r
p
er
m
a
n
en
t
d
e
n
ti
tio
n
,
w
h
o
h
ad
tr
ea
t
m
e
n
t
w
it
h
r
esto
r
ati
v
e
f
ill
in
g
s
in
a
to
tal
o
f
6
0
2
p
atien
ts
.
T
h
e
m
i
n
i
m
al
a
g
e
o
f
th
e
ch
ild
r
en
i
s
eq
u
a
l
to
th
r
ee
an
d
th
e
m
a
x
i
m
u
m
a
g
e
is
1
8
y
ea
r
s
.
T
h
e
p
atien
ts
li
v
e
i
n
Var
n
a,
B
u
lg
ar
ia
a
n
d
ar
e
ch
o
s
e
n
at
r
an
d
o
m
,
b
ased
o
n
h
i
g
h
ca
r
ies
r
i
s
k
an
d
ac
t
iv
e
ca
r
ies
lesi
o
n
s
,
d
eter
m
i
n
ed
b
y
ca
r
ies
r
is
k
a
s
s
e
s
s
m
e
n
t.
T
h
e
c
h
ild
r
en
h
av
e
a
d
eter
m
in
ed
h
i
g
h
ca
r
ies
r
is
k
D
M
FT
(
t)
>
1
.
T
h
e
m
ater
ials
w
e
ap
p
lied
a
r
e
th
e
f
o
llo
w
i
n
g
:
r
esin
-
m
o
d
if
ied
g
la
s
s
-
io
n
o
m
er
ce
m
e
n
t
(
R
i
v
a
L
i
g
h
t
C
u
r
e
Gla
s
s
I
o
n
o
m
er
C
e
m
e
n
t,
co
m
p
o
m
er
s
D
y
r
ac
t
R
(
D
eT
r
ey
G
m
b
H
Ger
m
a
n
y
)
,
lig
h
t
c
u
r
in
g
n
a
n
o
-
h
y
b
r
id
co
m
p
o
s
ite
f
o
r
f
il
lin
g
s
[
3
6
]
.
I
n
o
r
d
er
to
ac
h
iev
e
tec
h
n
iq
u
e
s
an
d
r
esu
lt
s
f
o
r
p
r
ev
en
ti
v
e
tr
ea
t
m
e
n
t
an
d
p
r
ev
e
n
tio
n
,
w
e
p
lace
d
s
ea
lan
ts
o
n
t
h
e
n
o
n
-
ca
r
io
u
s
p
it
an
d
f
is
s
u
r
es
[
3
7
]
.
C
r
iter
ia
f
o
r
in
cl
u
d
in
g
th
e
c
h
ild
r
en
:
cli
n
icall
y
h
ea
lt
h
y
,
w
it
h
o
u
t
s
y
s
te
m
ic
d
is
ea
s
e
s
,
w
it
h
o
u
t
p
ath
o
lo
g
y
o
f
th
e
o
r
al
m
u
co
s
a.
P
lace
a
n
d
p
er
io
d
o
f
co
n
d
u
ct
.
T
h
e
s
tu
d
y
w
a
s
co
n
d
u
cted
in
t
h
e
Fac
u
lt
y
o
f
d
en
tal
m
ed
ici
n
e,
Me
d
ical
u
n
iv
er
s
it
y
o
f
Var
n
a,
in
t
h
e
ti
m
e
p
er
io
d
2
0
1
6
-
2
0
1
8
.
T
h
is
s
t
u
d
y
is
r
etr
o
s
p
ec
ti
v
e,
b
ased
o
n
m
ed
ical
d
ata
o
f
th
e
p
ar
ticip
an
ts
a
n
d
it
r
esear
ch
es
t
h
e
f
r
eq
u
en
c
y
,
r
el
ativ
e
s
h
ar
e
a
n
d
co
r
r
el
atio
n
o
f
r
esto
r
atio
n
s
o
f
ir
r
ev
er
s
ib
le
a
n
d
ca
v
itated
ca
r
ie
s
lesi
o
n
s
w
ith
o
r
w
it
h
o
u
t
p
u
lp
i
n
f
la
m
m
at
io
n
,
d
iag
n
o
s
ed
as
d
3
,
d
4
lesi
o
n
s
o
f
p
r
i
m
ar
y
an
d
p
er
m
an
e
n
t
teet
h
.
T
h
e
ex
a
m
in
er
s
ar
e
s
p
ec
iali
s
ts
i
n
p
e
d
iatr
ic
d
en
tis
tr
y
.
T
h
e
p
atien
t
s
ar
e
d
iv
id
ed
in
to
1
6
g
r
o
u
p
s
ac
c
o
r
d
in
g
to
ag
e
li
m
it.
I
n
o
r
d
er
f
o
r
th
e
r
esear
ch
to
b
e
p
r
ec
is
e
f
o
r
ev
er
y
p
atie
n
t
a
ca
r
ies
in
d
e
x
DM
F(T
+t)
h
a
s
b
ee
n
d
eter
m
in
ed
.
C
ar
io
u
s
(
d
)
,
ex
tr
ac
ted
d
u
e
to
ca
r
ies
(
m
)
an
d
f
illed
(
f
)
teet
h
ar
e
r
eg
is
ter
ed
.
W
h
en
d
ef
i
n
i
n
g
th
e
ca
r
ie
s
in
d
e
x
,
n
o
n
-
ca
v
itated
lesi
o
n
s
d
1
b
ar
e
also
in
cl
u
d
ed
.
Or
al
s
tatu
s
is
d
o
cu
m
e
n
ted
u
s
in
g
an
ep
id
e
m
io
l
o
g
ical
d
en
tal
h
ea
l
th
ass
es
s
m
en
t
ca
r
d
.
A
ll
p
atie
n
ts
h
av
e
r
ec
eiv
ed
a
d
ec
lar
atio
n
o
f
co
n
s
e
n
t
f
o
r
ch
ec
k
u
p
an
d
tr
ea
t
m
e
n
t,
s
ig
n
ed
b
y
th
eir
p
ar
en
ts
.
T
h
e
ep
id
em
io
lo
g
ical
ch
ar
t
i
n
clu
d
es
a
p
ass
p
o
r
t
s
ec
tio
n
,
d
en
tal
s
tat
u
s
,
r
eg
i
s
tr
atio
n
o
f
th
e
lev
e
l
o
f
o
r
al
h
y
g
ien
e,
e
v
al
u
atio
n
o
f
t
h
e
r
is
k
o
f
ca
r
ie
s
an
d
a
n
al
y
s
i
s
o
f
th
e
d
ia
g
n
o
s
ticall
y
es
tab
lis
h
ed
ca
r
ies
les
io
n
s
.
Un
it
s
o
f
o
b
s
er
v
atio
n
ar
e
p
r
im
ar
y
a
n
d
p
er
m
a
n
e
n
t
teeth
,
w
it
h
o
r
w
ith
o
u
t
ca
r
ies
lesi
o
n
s
,
ac
tiv
e
ca
r
ies
lesi
o
n
s
d
iag
n
o
s
ed
a
s
d
1
b
.
Me
an
s
o
f
o
b
s
er
v
atio
n
ar
e
ca
r
io
u
s
,
f
ill
ed
o
r
m
is
s
i
n
g
to
o
th
d
u
e
to
ca
r
ies.
E
x
a
m
i
n
ed
in
d
icato
r
s
ar
e
DM
FT
,
DM
F
(
T
+t)
.
D
m
f
co
n
s
i
s
ts
o
f
d
+
m
+
f
.
T
h
e
s
t
u
d
y
ca
lc
u
late
s
ac
co
r
d
in
g
to
to
o
t
h
.
T
h
e
v
alu
e
o
f
th
e
i
n
d
ex
i
s
ca
lcu
late
d
f
o
r
/d
1
,
d
2
/ a
n
d
/d
3
,
d
4
/.
2
.
2
.
Sta
t
is
t
ica
l
m
et
ho
d
s
a
nd
a
na
l
y
s
is
Descr
ip
tio
n
a
n
al
y
s
is
-
t
h
e
q
u
an
tit
y
d
i
s
tr
ib
u
tio
n
o
f
t
h
e
e
x
a
m
i
n
ed
f
ea
t
u
r
es,
d
i
v
id
ed
in
to
g
r
o
u
p
s
,
th
e
av
er
ag
e
an
d
s
ta
n
d
ar
d
d
ev
iatio
n
,
9
5
%
in
ter
v
al
o
f
ch
a
n
g
e
in
th
e
av
er
ag
e
v
al
u
e
ar
e
d
escr
ib
es
in
ch
ar
ts
.
Dis
p
er
s
io
n
a
n
al
y
s
i
s
(
A
NO
V
A
)
-
T
h
e
p
u
r
p
o
s
e
o
f
th
i
s
a
n
a
l
y
s
i
s
i
s
to
es
tab
lis
h
t
h
e
p
r
es
en
ce
o
r
ab
s
en
ce
o
f
in
f
lu
e
n
ce
o
f
t
w
o
o
r
m
o
r
e
f
ac
to
r
s
o
n
t
h
e
a
v
er
ag
e
n
u
m
b
er
v
alu
e
o
f
th
e
ex
a
m
i
n
ed
i
n
d
ica
to
r
s
.
T
h
e
li
m
i
t
w
a
s
ch
o
s
en
as
p
=0
.
0
5
.
T
h
is
i
s
a
ch
a
n
ce
to
cr
ea
te
an
er
r
o
r
o
f
f
ir
s
t
d
e
g
r
ee
,
to
d
is
m
i
s
s
t
h
e
ze
r
o
h
y
p
o
th
e
s
is
.
R
eg
r
es
s
io
n
a
n
al
y
s
i
s
o
f
P
ea
r
s
o
n
–
it
ai
m
s
to
ac
h
iev
e
a
p
r
ec
is
e
s
tatis
t
ical
m
o
d
el,
d
escr
ib
in
g
th
e
d
ep
en
d
en
c
y
o
f
th
e
v
al
u
es
o
f
co
u
n
t,
f
r
eq
u
e
n
c
y
a
n
d
t
y
p
e
o
f
t
h
e
d
if
f
er
e
n
t
r
esto
r
atio
n
i
n
c
h
ild
ag
e
d
ep
en
d
in
g
o
n
d
if
f
er
en
t
v
ar
iab
les
s
u
ch
a
s
ag
e
a
n
d
ca
r
ies
r
is
k
o
f
th
e
c
h
ild
r
en
,
f
r
eq
u
e
n
c
y
o
f
ca
r
ies
an
d
ca
r
ies
i
n
d
ex
o
f
ev
al
u
atio
n
o
f
th
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I
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2
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J
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20
21
:
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248
244
3.
RE
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4.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t.
J
.
P
u
b
lic
Hea
lth
Sci.
I
SS
N:
2
2
5
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-
8806
R
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245
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0
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3
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.
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9
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.
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i
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T
ab
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.
R
elatio
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s
h
i
p
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et
w
ee
n
f
illi
n
g
w
it
h
co
m
p
o
m
er
s
a
n
d
th
e
ca
r
ies in
d
e
x
DM
F (
T
+
t)
o
f
th
e
s
tu
d
ied
p
atien
ts
M
o
d
e
l
U
n
st
a
n
d
a
r
d
i
z
e
d
c
o
e
f
f
i
c
i
e
n
t
s
S
t
a
n
d
a
r
d
i
z
e
d
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f
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t
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g
.
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0
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o
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6
7
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0
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8
7
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t
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(
p
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.
3
.
1
.
Dis
cus
s
io
n
R
esto
r
ati
v
e
tr
ea
t
m
en
t
o
f
d
en
t
al
ca
r
ies
d
o
es
n
o
t
s
to
p
th
e
d
ev
elo
p
m
e
n
t
o
f
t
h
e
ca
r
io
u
s
p
r
o
ce
s
s
.
T
h
i
s
co
n
clu
s
io
n
h
as
lo
n
g
b
ee
n
k
n
o
w
n
in
m
o
d
er
n
p
ed
iatr
ic
d
en
ti
s
tr
y
.
P
ar
t
o
f
th
e
ca
r
ies
lesi
o
n
s
d
o
es
n
o
t
p
r
o
g
r
ess
an
d
th
er
e
is
n
o
n
ee
d
f
o
r
th
eir
r
esto
r
atio
n
.
T
h
e
n
e
w
m
a
n
a
g
e
m
en
t
o
f
d
en
tal
m
ed
ici
n
e
an
d
d
en
tal
ca
r
ies
in
cl
u
d
e
s
a
ca
r
ies
r
is
k
a
s
s
e
s
s
m
e
n
t
an
d
u
n
d
er
s
tan
d
i
n
g
th
e
p
at
h
o
lo
g
y
o
f
th
e
ca
r
ies
p
r
o
ce
s
s
.
S
u
itab
le
p
r
ev
en
ti
v
e
m
et
h
o
d
s
an
d
an
in
d
iv
id
u
al
co
n
tr
o
l
o
f
th
e
p
r
o
g
r
ess
io
n
o
f
th
e
ca
r
i
es
ar
e
n
ec
ess
ar
y
,
co
m
p
leted
w
it
h
in
v
asi
v
e
an
d
r
esto
r
ativ
e
th
er
ap
y
o
n
l
y
w
h
e
n
n
ee
d
ed
[
3
8
]
.
T
h
e
in
f
o
r
m
atio
n
f
o
r
th
e
d
iag
n
o
s
tic
s
o
f
ca
r
ies
in
p
r
i
m
ar
y
t
ee
th
is
s
ca
r
ce
[
3
9
]
an
d
in
th
is
d
en
titi
o
n
th
er
e
ar
e
d
if
f
er
en
t
cr
iter
ia
d
ep
en
d
in
g
o
n
th
e
t
h
in
la
y
er
s
o
f
en
a
m
el
an
d
d
en
ti
n
an
d
t
h
e
w
id
er
in
ter
d
en
tal
co
n
tacts
[
4
0
]
.
T
h
e
in
d
icatio
n
s
f
o
r
r
esto
r
ativ
e/
o
b
s
tr
u
cti
v
e
/
th
er
ap
y
ar
e
s
ca
r
ce
l
y
s
tu
d
ied
an
d
th
e
d
ec
is
io
n
s
d
ep
en
d
o
n
t
h
e
as
s
e
s
s
m
e
n
t
o
f
th
e
cli
n
icia
n
[
4
1
]
.
I
n
m
o
d
er
n
d
en
tal
c
lin
ics
t
h
er
e
i
s
s
till
a
n
ee
d
f
o
r
m
a
k
i
n
g
a
d
ec
is
io
n
w
h
e
n
to
r
esto
r
e
a
ca
r
ies
lesi
o
n
,
t
h
e
cli
n
ical
cr
it
er
ia
f
o
r
v
is
u
al
d
is
co
v
er
y
o
f
en
a
m
e
l
ca
v
ita
tio
n
,
o
b
s
er
v
atio
n
o
f
t
h
e
en
a
m
el
a
n
d
x
-
r
a
y
o
f
t
h
e
lesi
o
n
s
[
4
2
]
-
[
44
]
.
T
h
e
s
u
cc
es
s
a
n
d
p
r
o
s
f
r
o
m
th
e
r
esto
r
ativ
e
tr
ea
t
m
e
n
t
i
n
cl
u
d
e:
o
b
s
tr
u
cti
n
g
th
e
ca
v
i
t
y
o
f
t
h
e
ca
v
itate
d
lesi
o
n
s
af
ter
th
e
p
r
ep
ar
atio
n
o
r
d
ef
ec
ts
i
n
t
h
e
en
a
m
el.
I
t
is
n
ec
e
s
s
ar
y
to
s
to
p
t
h
e
p
r
o
g
r
ess
io
n
o
f
th
e
d
em
in
er
aliza
t
io
n
o
f
ar
ea
s
o
f
th
e
en
a
m
el,
w
h
ic
h
a
r
e
ca
r
ies
n
o
n
-
r
esi
s
ta
n
t,
r
esto
r
e
th
e
to
o
th
s
tr
u
ct
u
r
e’
s
en
tire
t
y
an
d
p
r
ev
en
t
t
h
e
s
p
r
ea
d
in
g
o
f
th
e
i
n
f
ec
t
io
n
to
w
ar
d
s
th
e
p
u
l
p
,
as
w
ell
a
s
p
r
ev
en
t
t
h
e
m
i
g
r
atio
n
o
f
teet
h
as
a
r
esu
lt o
f
to
o
t
h
s
tr
u
c
tu
r
e
lo
s
s
.
T
h
e
p
o
ten
tial
r
is
k
s
o
f
r
esto
r
ativ
e
m
et
h
o
d
in
cl
u
d
e
a
d
ec
r
ea
s
e
in
th
e
f
u
n
ctio
n
lo
n
g
e
v
it
y
o
f
th
e
teeth
b
y
m
ak
in
g
t
h
e
m
m
o
r
e
s
u
s
p
icio
u
s
to
f
r
ac
t
u
r
es,
r
ec
id
iv
e
le
s
io
n
s
,
u
n
s
u
cc
es
s
f
u
l
r
esto
r
atio
n
o
r
m
a
k
in
g
a
co
lli
s
io
n
w
it
h
t
h
e
p
u
lp
w
h
ile
d
r
illi
n
g
,
[
45
]
-
[
4
7
]
.
P
r
im
ar
y
teet
h
ca
n
b
e
m
o
r
e
p
r
o
n
e
to
u
n
s
u
cc
es
s
f
u
l
r
esto
r
at
io
n
.
W
h
en
o
b
s
tr
u
ctin
g
p
r
i
m
ar
y
teet
h
,
th
e
clin
icia
n
n
ee
d
s
to
d
eter
m
i
n
e
t
h
e
r
e
m
ai
n
i
n
g
ti
m
e
th
at
th
e
to
o
th
is
g
o
in
g
to
s
p
e
n
d
in
th
e
o
r
al
ca
v
it
y
,
b
ef
o
r
e
it e
x
f
o
liates.
On
e
o
f
t
h
e
m
ai
n
g
o
als
o
f
th
e
r
esto
r
ativ
e
tr
ea
t
m
e
n
t
i
s
l
i
m
iti
n
g
t
h
e
d
e
m
in
er
aliza
t
io
n
f
r
o
m
th
e
ca
r
ie
s
,
p
r
o
tectin
g
a
n
d
p
r
ev
en
ti
n
g
th
e
to
o
th
s
tr
u
ct
u
r
es
a
n
d
m
a
in
tai
n
in
g
t
h
e
v
italit
y
o
f
th
e
p
u
lp
,
w
h
e
n
p
o
s
s
ib
le.
T
h
e
Am
er
ica
n
A
ca
d
e
m
y
o
f
P
ed
iatr
ic
Den
tis
tr
y
(
AA
P
D
)
d
eter
m
i
n
es
t
h
at
th
e
ai
m
o
f
tr
ea
ti
n
g
ca
r
io
u
s
teet
h
is
to
p
r
ev
en
tio
n
th
e
v
ita
lit
y
o
f
t
h
e
p
u
lp
,
esp
ec
iall
y
f
o
r
p
er
m
a
n
en
t
teet
h
w
it
h
u
n
d
er
d
ev
elo
p
ed
r
o
o
ts
.
Т
h
er
e
ar
e
m
ater
ials
a
n
d
m
et
h
o
d
s
f
o
r
r
esto
r
atio
n
o
f
p
er
m
an
e
n
t
teet
h
i
n
P
ed
iatr
ic
Den
tis
tr
y
[
4
8
]
.
T
h
e
f
ac
t
s
f
r
o
m
t
w
o
r
an
d
o
m
co
n
tr
o
l
s
t
u
d
ies
s
h
o
w
th
at
n
o
p
r
ep
ar
atio
n
ca
n
s
to
p
t
h
e
d
ev
elo
p
m
e
n
t
o
f
th
e
to
o
th
c
ar
ies
f
o
r
as
lo
n
g
a
s
p
r
ev
en
ti
n
g
t
h
e
to
o
th
a
n
d
ca
v
it
y
b
y
s
ea
li
n
g
w
it
h
a
d
ef
i
n
iti
v
e
r
esto
r
atio
n
[
4
9
]
,
[
5
0
]
.
4.
CO
NCLU
SI
O
N
T
h
e
av
er
ag
e
f
r
eq
u
en
c
y
o
f
ca
r
ies
lesi
o
n
s
s
h
o
w
s
t
h
eir
h
i
g
h
d
i
s
tr
ib
u
t
io
n
a
m
o
n
g
th
e
ex
a
m
i
n
e
d
p
atien
ts
.
T
h
e
co
r
r
elatio
n
an
al
y
s
is
d
eter
m
i
n
ed
t
h
at
w
i
th
i
n
cr
ea
s
i
n
g
a
g
e
o
f
t
h
e
p
atie
n
t
s
t
h
e
n
u
m
b
e
r
an
d
f
r
eq
u
e
n
c
y
o
f
co
m
p
o
s
i
te
r
esto
r
atio
n
s
an
d
s
e
alan
ts
i
n
th
e
co
n
tr
o
l
g
r
o
u
p
s
in
cr
ea
s
ed
.
T
h
e
d
ir
ec
t
r
atio
an
d
a
v
er
ag
e
d
ep
en
d
en
c
y
s
h
o
w
s
th
at
b
y
i
n
cr
ea
s
i
n
g
th
e
DM
F
(
T
+t)
in
d
ex
o
f
t
h
e
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x
a
m
in
ed
p
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t
s
,
th
er
e
i
s
a
n
in
cr
e
ase
in
t
h
e
n
u
m
b
er
o
f
p
r
ev
en
ti
v
e
f
illi
n
g
s
w
i
t
h
co
m
p
o
s
ites
a
n
d
s
ea
la
n
ts
.
I
n
all
te
s
t
s
an
d
a
n
al
y
s
es
th
er
e
i
s
a
s
tati
s
ticall
y
s
i
g
n
i
f
ican
t
d
if
f
er
e
n
ce
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t.
J
.
P
u
b
lic
Hea
lth
Sci.
I
SS
N:
2
2
5
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tive
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eq
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a
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(
Do
b
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in
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Da
mya
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)
247
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NO
WL
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NT
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is
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RE
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NC
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[1
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Da
m
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rin
k
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Ra
d
o
sv
e
ta
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–
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riso
v
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,
“
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r
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ti
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stu
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f
d
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tal
c
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in
3
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ti
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k
J.M
,
a
n
d
Bro
n
k
h
o
rst
E.
M
,
e
t
a
l.
,
“
M
in
im
a
ll
y
in
v
a
siv
e
in
terv
e
n
ti
o
n
f
o
r
p
rim
a
r
y
c
a
rie
s
les
io
n
s: are
d
e
n
ti
sts im
p
lem
e
n
ti
n
g
th
is
c
o
n
c
e
p
t?
,”
Ca
rie
s R
e
se
a
rc
h
.
v
o
l.
5
3
,
n
o
.
5
,
p
p
.
2
0
4
-
2
1
6
,
2
0
1
9
.
[3
]
T
h
e
R
e
fe
r
e
n
c
e
M
a
n
u
a
l
of
P
e
d
i
a
t
r
i
c
D
e
n
t
i
st
r
y
,
“
P
e
d
i
a
t
r
i
c
r
e
s
to
r
a
t
i
v
e
d
e
n
ti
s
t
r
y
,
”
p
p
.
340
-
3
5
2
.
,
2
0
1
9
.
[
On
l
in
e
]
.
Av
a
i
l
a
b
l
e
:
ww
w
.
a
a
p
d
.
o
rg
/res
e
a
rc
h
/o
ra
l
-
h
e
a
lt
h
-
p
o
li
c
ies
--
re
c
o
m
m
e
n
d
a
ti
o
n
s/p
e
d
iatric
-
re
sto
ra
ti
v
e
-
d
e
n
t
i
str
y
/
[4
]
W
e
y
a
n
t
RJ
e
t
a
l
.
,
“
T
o
p
ica
l
f
lu
o
rid
e
f
o
r
c
a
ries
p
re
v
e
n
ti
o
n
:
Ex
e
c
u
ti
v
e
su
m
m
a
r
y
o
f
th
e
u
p
d
a
ted
re
c
o
m
m
e
n
d
a
ti
o
n
s
a
nd
su
p
p
o
rti
n
g
sy
st
e
m
a
ti
c
re
v
ie
w
,
”
J
o
u
rn
a
l
Am
e
ric
a
n
De
n
t
al
Asso
c
ia
ti
o
n
,
v
o
l.
1
4
4
,
n
o
.
1
1
,
p
p
.
1
2
7
9
-
9
1
.
2
0
1
3
.
[5
]
M
o
jt
a
b
a
,
D
o
rri
e
t
a
l.
,
“
A
trau
m
a
t
ic
re
sto
ra
ti
v
e
trea
t
m
e
n
t
v
e
r
su
s
c
o
n
v
e
n
ti
o
n
a
l
re
sto
ra
ti
v
e
trea
tm
e
n
t
f
o
r
m
a
n
a
g
in
g
d
e
n
tal
c
a
ries
,
”
Co
c
h
ra
n
e
D
a
ta
b
a
se
of
S
y
ste
ma
ti
c
Rev
iews
,
v
o
l.
1
2
,
n
o
.
1
,
p
p
.
1
-
6
8
,
2
0
1
7
.
doi
:
1
0
.
1
0
0
2
/1
4
6
5
1
8
5
8
.
CD0
0
8
0
7
2
.
p
u
b
2
.
[6
]
F
re
n
c
k
e
n
,
Jo
E
,
Ho
lm
g
re
n
,
a
n
d
Ch
r.
J
,
“
Ca
ries
m
a
n
a
g
e
m
e
n
t
th
ro
u
g
h
th
e
A
trau
m
a
ti
c
Re
sto
ra
ti
v
e
Trea
t
m
e
n
t
(
A
R
T
)
a
p
p
ro
a
c
h
a
n
d
g
las
s
-
io
n
o
m
e
rs:
u
p
d
a
te
2
0
1
3
,
”
Bra
z
il
i
a
n
Or
a
l
R
es
e
a
rc
h
,
v
o
l.
28
,
n
o
.
1
S
ã
o
P
a
u
lo
,
2
0
1
4
,
d
o
i:
h
tt
p
s:/
/d
o
i.
o
rg
/1
0
.
1
5
9
0
/S
1
8
0
6
-
8
3
2
4
2
0
1
3
0
0
0
6
0
0
0
0
1
.
[7
]
Ra
g
g
io
DP
.
,
He
ss
e
D,
L
e
n
z
i
T
L
,
G
u
g
li
e
l
m
i
C
A
B,
a
n
d
Bra
g
a
M
M
.
,
“
Is
a
trau
m
a
ti
c
r
e
sto
ra
ti
v
e
trea
t
m
e
n
t
a
n
o
p
t
io
n
f
o
r
re
sto
rin
g
o
c
c
lu
so
-
p
r
o
x
im
a
l
c
a
ries
les
io
n
s
in
p
rim
a
r
y
tee
th
?
A
s
y
ste
m
a
ti
c
r
e
v
ie
w
a
n
d
m
e
ta
-
a
n
a
l
y
sis,”
In
t
e
rn
a
t
io
n
a
l
J
o
u
rn
a
l
Pa
e
d
i
a
tr
ic
De
n
t
a
l,
v
o
l.
2
3
,
n
o
.
6
,
p
p
.
4
3
5
-
4
3
,
2
0
1
3
.
[8
]
P
a
rk
,
E
.
Yo
,
a
n
d
K
a
n
g
,
S
.
,
“
C
u
r
r
e
n
t
a
s
p
e
c
t
s
a
n
d
p
r
o
sp
e
c
t
s
o
f
g
l
a
s
s
i
o
n
o
m
e
r
c
e
m
e
n
t
s
fo
r
c
l
in
ic
a
l
d
e
n
t
i
st
r
y
,
”
Y
e
u
n
g
n
a
m
U
n
i
v
e
r
s
it
y
J
o
u
rn
a
l
o
f
M
e
d
i
c
in
e
,
v
o
l.
3
7
,
n
o
.
3
,
p
p
.
169
-
1
7
8
,
2
0
2
0
,
d
o
i:
h
t
tp
s
:/
/d
o
i
.
o
r
g
/1
0
.
1
2
7
0
1
/
y
u
j
m
.
2
0
2
0
.
0
0
3
7
4
.
[9
]
V
ib
e
k
e
,
Qv
is
t
e
t
a
l.
,
“
F
lu
o
rid
e
s
l
e
a
c
h
in
g
f
ro
m
re
sto
ra
ti
v
e
m
a
teria
l
s
a
n
d
t
h
e
e
f
fe
c
t
o
n
a
d
jac
e
n
t
tee
th
,
”
In
t
e
rn
a
ti
o
n
a
l
De
n
t
al
J
o
u
rn
a
l
,
v
o
l
.
6
0
,
n
o
.
3,
p
p
.
1
5
6
-
1
6
0
,
2
0
1
0
.
[1
0
]
Da
o
u
M
H.,
A
tt
in
T
,
G
ö
h
rin
g
TN.
,
“
Cli
n
ica
l
su
c
c
e
ss
o
f
c
o
m
p
o
m
e
r
a
n
d
a
m
a
l
g
a
m
re
sto
ra
ti
o
n
s
in
p
rim
a
r
y
m
o
lars
:
F
o
ll
o
w
u
p
i
n
3
6
m
o
n
th
s,”
S
c
h
we
i
z M
o
n
a
tssc
h
r Z
a
h
n
me
d
,
v
o
l.
1
1
9
,
n
o
.
1
1
,
p
p
.
1
0
8
2
-
8
,
2
0
0
9
.
[1
1
]
W
e
lb
u
ry
RR.,
S
h
a
w
A
J,
M
u
rra
y
JJ
,
G
o
r
d
o
n
P
H
,
M
c
Ca
b
e
JF
.
,
“
Cl
in
ica
l
e
v
a
lu
a
ti
o
n
o
f
p
a
ired
c
o
m
p
o
m
e
r
a
n
d
g
las
s
io
n
o
m
e
r
re
sto
ra
ti
o
n
s
in
p
r
im
a
r
y
m
o
lars
:
F
in
a
l
re
su
lt
s
a
f
ter
4
2
m
o
n
th
s
,
”
Br
it
ish
De
n
t
al
J
o
u
r
n
a
l
,
v
o
l
.
1
8
9
,
n
o
.
2
,
p
p
.
93
-
7
,
2
0
0
0
.
[1
2
]
Da
m
y
a
n
o
v
a
D
.
M.
,
“
S
e
v
e
re
Earl
y
Ch
il
d
h
o
o
d
C
a
ries
-
A
Cli
n
ica
l
Ca
se
Re
p
o
rt,
”
Arc
h
ive
s
o
f
De
n
t
istry
a
n
d
Or
a
l
He
a
lt
h
,
v
o
l.
2
,
n
o
.
1
,
p
p
.
12
-
1
8
,
2
0
1
9
.
[1
3
]
P
ires
,
C.
W
e
t
a
l.
,
“
Is
th
e
re
a
b
e
s
t
c
o
n
v
e
n
ti
o
n
a
l
m
a
teria
l
f
o
r
r
e
st
o
rin
g
p
o
ste
ri
o
r
p
rim
a
r
y
tee
th
?
A
n
e
tw
o
rk
m
e
ta
-
a
n
a
ly
sis
,
”
Bra
z
il
ia
n
Or
a
l
Res
e
a
rc
h
,
v
o
l.
32
S
ã
o
P
a
u
l
o
2
0
1
8
,
d
o
i
:
1
0
.
1
5
9
0
/
1
8
0
7
-
3
1
0
7
b
o
r
-
2
0
1
8
.
v
o
l3
2
.
0
0
1
0
.
[1
4
]
P
a
ry
a
b
,
M
e
t
a
l
.
,
“
F
ra
c
tu
re
stre
n
g
th
of
se
v
e
re
l
y
d
a
m
a
g
e
d
p
rim
a
r
y
a
n
terio
r
tee
th
a
f
ter
re
sto
ra
ti
o
n
w
it
h
c
o
m
p
o
site
re
sin
a
n
d
re
sin
-
m
o
d
if
ied
g
las
s
io
n
o
m
e
r
c
e
m
e
n
t
,
”
J
o
u
rn
a
l
Isl
a
m
ic
De
n
t
al
Asso
c
i
a
ti
o
n
Ir
a
n
,
v
o
l.
2
8
,
n
o
.
2,
p
p
.
57
-
63
,
2
0
1
6
,
d
o
i
:
1
0
.
3
0
6
9
9
/j
i
d
a
i.
2
9
.
2
.
5
7
.
[1
5
]
Dim
it
ro
v
a
D,
A
n
d
re
e
v
a
R,
a
n
d
Dim
o
v
a
-
G
a
b
ro
v
sk
a
M
.
,
“
A
p
p
li
c
a
ti
o
n
o
f
a
e
sth
e
ti
c
c
ro
w
n
s
in
c
h
il
d
re
n
p
a
ti
e
n
ts
,
”
Va
rn
a
M
e
d
ica
l
F
o
ru
m
,
v
o
l.
7
,
p
p
.
1
7
3
-
1
7
7
,
2
0
1
8
.
[1
6
]
Dim
it
ro
v
a
,
D
,
“
S
tu
d
y
o
f
p
a
ti
e
n
t
sa
ti
sf
a
c
ti
o
n
w
it
h
p
ro
sth
e
ti
c
trea
t
m
e
n
t,
”
J
o
u
rn
a
l
of
M
e
d
ic
a
l
a
n
d
De
n
t
a
l
Pra
c
ti
c
e
,
v
o
l.
5
,
n
o
.
3
,
p
p
.
9
1
4
-
9
1
9
,
2
0
1
8
,
d
o
i:
1
0
.
1
8
0
4
4
/M
e
d
in
f
o
r
m
.
2
0
1
8
5
3
.
9
1
4
.
[1
7
]
Dim
o
v
a
,
M
,
“
R
e
g
istratio
n
o
f
c
e
n
tri
c
o
c
c
lu
sio
n
in
p
a
ti
e
n
ts
w
it
h
b
ru
x
is
m
a
n
d
b
ru
x
o
m
a
n
ia
th
ro
u
g
h
a
rt
icu
latin
g
p
a
p
e
r
a
n
d
t
h
e
sy
st
e
m
t
-
sc
a
n
-
c
o
m
p
a
ra
ti
v
e
a
n
a
l
y
sis
,
”
J
o
u
rn
a
l
o
f
IM
AB
-
An
n
u
a
l
Pro
c
e
e
d
in
g
(
S
c
ien
ti
fi
c
P
a
p
e
rs
)
,
v
o
l.
2
0
,
n
o
.
1
,
p
p
.
5
2
0
-
5
2
6
,
2
0
1
4
,
d
o
i
:
1
0
.
5
2
7
2
/j
im
a
b
.
2
0
1
4
2
0
1
.
5
2
0
.
[1
8
]
Do
n
ly
K
.
J
,
“
Re
st
o
ra
ti
v
e
d
e
n
ti
str
y
f
o
r
c
h
il
d
re
n
,
”
De
n
t
al
Cli
n
ics
No
rth
Am
e
ric
a
,
v
o
l.
5
7
,
n
o
.
1
,
p
p
.
75
-
8
2
,
2
0
1
3
,
d
o
i
:
1
0
.
1
0
1
6
/
j.
c
d
e
n
.
2
0
1
2
.
0
9
.
0
0
1
.
[1
9
]
W
a
li
a
,
T
e
t
a
l.
,
“
A
ra
n
d
o
m
ise
d
c
o
n
tro
ll
e
d
tri
a
l
o
f
th
re
e
a
e
sth
e
ti
c
f
u
ll
-
c
o
ro
n
a
l
re
sto
ra
ti
o
n
s
in
p
r
i
m
a
r
y
m
a
x
il
lar
y
tee
th
,
”
Eu
ro
p
e
a
n
J
o
u
rn
a
l
o
f
Pa
e
d
ia
tric De
n
ti
stry
,
v
o
l
.
1
5
,
n
o
.
2
,
p
p
.
1
1
3
-
8
,
2
0
1
4
.
[2
0
]
A
la
k
i
,
S
.
M
e
t
a
l.
,
“
Co
m
p
a
rin
g
z
irco
n
ia
to
a
n
teri
o
r
strip
c
ro
w
n
s
in
p
rim
a
r
y
a
n
terio
r
tee
th
in
c
h
il
d
r
e
n
:
a
ra
n
d
o
m
ize
d
c
li
n
ica
l
tri
a
l,
”
BM
C
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[2
2
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“
Cli
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[2
3
]
Ch
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“
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[2
4
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20
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[2
5
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“
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[2
6
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.
[2
7
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Bü
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“
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In
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.
[2
8
]
V
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n
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sh
,
K
.
C
,
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r,
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n
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a
s
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y
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d
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,
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.
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.
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“
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ter
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tric
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l.
1
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p
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1
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1
1
.
[2
9
]
Da
m
y
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n
o
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a
,
D
,
“
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h
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n
o
w
led
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o
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rn
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lt
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)
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9
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0
]
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h
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-
S
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lo
ra
n
ta
,
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t
a
l.
,
“
P
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n
d
f
issu
re
se
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lan
ts
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r
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re
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n
g
d
e
n
tal
d
e
c
a
y
in
p
e
rm
a
n
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n
t
tee
th
,”
Co
c
h
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Da
ta
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S
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ma
ti
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Rev
iews
,
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l.
7
,
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o
.
7
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p
.
1
-
1
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0
1
7
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o
i:
1
0
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0
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4
6
5
1
8
5
8
.
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0
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p
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b
5
.
[3
1
]
F
re
n
c
k
e
n
,
Jo
.
E
,
“
A
trau
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a
ti
c
re
st
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ra
ti
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m
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n
t
a
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d
m
in
im
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l
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terv
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stry
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Brit
ish
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n
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J
o
u
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,
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l
.
2
2
3
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o
.
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p
.
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[3
2
]
Al
-
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n
i
,
Ha
ss
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n
F
a
lee
h
F
a
rh
a
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,
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t
a
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“
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n
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Ev
a
lu
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ti
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n
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Br
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Od
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tri
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e
Cl
ín
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In
te
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ra
d
a
,
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l.
20
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2
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2
0
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:
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[3
3
]
Yo
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ig
e
,
Ya
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,
Yu
ich
i,
a
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d
Kim
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ra
,
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lan
t
,”
In
ter
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ti
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s
in
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ia
tric
De
n
ti
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Acc
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J
o
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,
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0
2
0
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4
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0
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0
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8
7
.
[3
4
]
S
a
n
ti
a
g
o
,
J.,
Da
v
id
,
E
,
“
T
h
e
u
se
o
f
tw
o
m
e
d
ia
o
f
in
stru
c
ti
o
n
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n
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io
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g
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:
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q
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si
-
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x
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ri
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tal
stu
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y
,”
In
ter
n
a
ti
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J
o
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rn
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f
A
d
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En
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d
S
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ien
c
e
(
IJ
AE
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S
),
v
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l.
5
,
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o
.
2
,
p
p
.
1
1
1
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1
1
5
,
2
0
1
9
.
[3
5
]
T
u
rto
n
,
B
e
t
a
l.
“
Ep
id
e
m
io
lo
g
ica
l
su
rv
e
y
o
f
e
a
rl
y
c
h
il
d
h
o
o
d
c
a
ries
in
Ca
m
b
o
d
ia
”
.
BM
C
Or
a
l
He
a
l
th
,
v
o
l.
19
,
n
o
.
107
,
p
p
.
1
-
7
,
2
0
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9
,
d
o
i:
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tt
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s:/
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rg
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9
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0
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0
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.
[3
6
]
T
ra
c
y
,
S
h
a
ro
n
e
t
a
l.
,
“
T
o
p
ica
l
f
lu
o
rid
e
f
o
r
c
a
ries
p
re
v
e
n
ti
o
n
:
Ex
e
c
u
ti
v
e
su
m
m
a
r
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th
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u
p
d
a
ted
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o
m
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ti
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n
s an
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s
u
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o
u
rn
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l
of
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e
Ame
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n
De
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Asso
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ti
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n
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9
3
9
)
,
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l.
1
4
4
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o
.
1
1
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1
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.
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rc
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2
0
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3
.
0
0
5
7
.
[3
7
]
Da
m
y
a
n
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v
a
Do
b
ri
n
k
a
,
El
it
sa
,
S
a
b
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,
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a
riy
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,
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d
M
it
e
v
a
-
H
risto
v
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,
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T
re
a
t
m
e
n
t
a
f
ter
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e
ss
o
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a
rl
y
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h
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d
h
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d
c
a
ries
-
c
li
n
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c
a
se
re
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rt
,”
Qu
e
st
J
o
u
rn
a
ls
J
o
u
rn
a
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o
f
M
e
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ica
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De
n
t
a
l
S
c
ien
c
e
Res
e
a
rc
h
,
v
o
l.
4
,
n
o
.
5
,
p
p
.
7
9
-
8
2
,
2
0
1
7
.
[3
8
]
Am
e
rica
n
A
c
a
d
e
m
y
o
f
P
e
d
iatric
De
n
ti
stry
,
“
P
e
d
iatric
re
sto
ra
ti
v
e
d
e
n
ti
stry
.
T
h
e
R
e
f
e
re
n
c
e
M
a
n
u
a
l
o
f
P
e
d
iatric
De
n
ti
stry
.
Ch
ica
g
o
,
Ill
:
Am
e
ric
a
n
A
c
a
d
e
m
y
o
f
P
e
d
iatric
De
n
t
istry
,
p
p
.
371
-
83
,
2
0
2
0
.
[
On
li
n
e
]
.
A
v
a
il
a
b
le:
h
tt
p
s:/
/www
.
a
a
p
d
.
o
rg
/g
lo
b
a
las
se
ts/m
e
d
ia/p
o
li
c
ies
_
g
u
i
d
e
li
n
e
s/b
p
_
r
e
sto
ra
ti
v
e
d
e
n
t.
p
d
f
?
v
=
n
e
w
[3
9
]
Cu
m
m
in
s,
D
,
“
T
h
e
d
e
v
e
lo
p
m
e
n
t
a
n
d
v
a
li
d
a
ti
o
n
o
f
a
n
e
w
te
c
h
n
o
lo
g
y
,
b
a
se
d
u
p
o
n
1
.
5
%
a
rg
in
in
e
,
a
n
in
so
l
u
b
l
e
c
a
lc
i
u
m
c
o
m
p
o
u
n
d
a
n
d
f
lu
o
r
id
e
,
f
o
r
e
v
e
r
y
d
a
y
u
se
in
th
e
p
re
v
e
n
t
io
n
a
n
d
trea
tm
e
n
t
o
f
d
e
n
tal
c
a
ries
.
”
J
o
u
rn
a
l
o
f
d
e
n
ti
stry
,
v
o
l.
4
1
,
n
o
.
S
2
,
p
p
.
s1
–
s
1
1
,
2
0
1
3
,
d
o
i:
h
tt
p
s://
d
o
i
.
o
rg
/1
0
.
1
0
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6
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.
j
d
e
n
t.
2
0
1
0
.
0
4
.
0
0
2
[4
0
]
Ne
lso
n
SJ
, “
W
h
e
e
ler’s
d
e
n
tal
a
n
a
t
o
m
y
,
p
h
y
sio
lo
g
y
,
a
n
d
o
c
c
lu
sio
n
,”
9
th
e
d
.
P
h
il
a
d
e
l
p
h
ia,
P
a
.
:
W
B
S
a
u
n
d
e
rs
;
2
0
1
0
.
[4
1
]
G
h
o
n
e
im
A
e
t
a
l.
,
“
W
h
a
t
in
f
lu
e
n
c
e
s
th
e
c
li
n
ica
l
d
e
c
isio
n
-
m
a
k
in
g
o
f
d
e
n
ti
sts?
A
c
ro
ss
-
s
e
c
ti
o
n
a
l
st
u
d
y
,
”
PL
o
S
ONE
,
v
o
l.
1
5
,
n
o
.
6
,
p
p
.
1
-
1
1
,
2
0
2
0
,
d
o
i
:
h
tt
p
s://
d
o
i.
o
rg
/1
0
.
1
3
7
1
/j
o
u
r
n
a
l.
p
o
n
e
.
0
2
3
3
6
5
2
[4
2
]
Am
e
rica
n
Ac
a
d
e
m
y
o
f
P
e
d
iatric
De
n
ti
str
y
,
“
G
u
id
e
li
n
e
o
n
c
a
ries
risk
a
ss
e
ss
m
e
n
t
a
n
d
m
a
n
a
g
e
m
e
n
t
f
o
r
in
f
a
n
ts,
c
h
il
d
re
n
,
a
n
d
a
d
o
les
c
e
n
ts,
”
Ped
ia
t
r
ic
De
n
t
istry
,
v
o
l.
3
8
,
n
o
.
6
,
(sp
e
c
ial
issu
e
),
p
p
.
1
4
2
-
1
4
9
,
2
0
1
4
.
[4
3
]
Is
m
a
il
A
.
I
e
t
a
l.
,
“
T
h
e
in
tern
a
ti
o
n
a
l
c
a
ries
d
e
tec
ti
o
n
a
n
d
a
ss
e
ss
m
e
n
t
sy
ste
m
(ICD
A
S
):
A
n
in
teg
ra
ted
sy
ste
m
f
o
r
m
e
a
su
rin
g
d
e
n
tal
c
a
ries
,
”
Co
mm
u
n
it
y
De
n
t
istry
Or
a
l
Ep
i
d
e
mio
l
o
g
y
,
v
o
l
.
3
5
,
n
o
.
3
,
p
p
.
1
7
0
-
8,
2
0
0
7
,
d
o
i
:
1
0
.
1
1
1
1
/
j.
1
6
0
0
-
0
5
2
8
.
2
0
0
7
.
0
0
3
4
7
.
x
.
[4
4
]
Be
a
u
c
h
a
m
p
J
e
t
a
l.
,
“
Ev
id
e
n
c
e
-
b
a
se
d
c
li
n
ica
l
re
c
o
m
m
e
n
d
a
ti
o
n
s
f
o
r
t
h
e
u
se
o
f
p
it
-
a
n
d
-
f
issu
re
se
a
lan
ts:
A
re
p
o
rt
o
f
th
e
Am
e
rica
n
d
e
n
tal
a
ss
o
c
iatio
n
c
o
u
n
c
il
o
n
sc
ien
ti
f
ic
a
ffa
irs
,
”
J
o
u
rn
a
l
Am
e
ric
a
n
De
n
t
al
Asso
c
ia
ti
o
n
,
v
o
l.
1
3
9
,
n
o
.
3
,
p
p
.
2
5
7
-
6
8
,
2
0
0
8
,
d
o
i:
1
0
.
1
4
2
1
9
/j
a
d
a
.
a
rc
h
iv
e
.
2
0
0
8
.
0
1
5
5
.
[4
5
]
Ja
m
a
li
,
Z
e
t
a
l.
,
“
Do
e
s
th
e
len
g
th
o
f
d
e
n
tal
trea
tme
n
t
in
f
lu
e
n
c
e
c
h
il
d
re
n
’s
b
e
h
a
v
io
u
r
d
u
rin
g
a
n
d
a
f
te
r
trea
t
m
e
n
t?
A
s
y
ste
m
a
ti
c
re
v
i
e
w
a
n
d
c
rit
ica
l
a
p
p
ra
isa
l,
”
De
n
t
al
Res
e
a
rc
h
De
n
t
al
Cli
n
ics
De
n
t
al
Pro
s
p
e
c
ts
,
v
o
l.
1
2
,
n
o
.
1
,
p
p
.
6
8
-
7
6
,
2
0
1
8
,
d
o
i:
1
0
.
1
5
1
7
1
/
jo
d
d
d
.
2
0
1
8
.
0
1
1
[4
6
]
S
a
leh
a
,
S
h
a
h
e
t
a
l.
,
“
P
a
e
d
iatr
ic
d
e
n
ti
stry
-
n
o
v
e
l
e
v
o
lv
e
m
e
n
t,
”
An
n
a
ls
o
f
M
e
d
ici
n
e
a
n
d
S
u
rg
e
ry
,
v
o
l.
2
5
,
p
p
.
21
-
29
,
2
0
1
8
,
d
o
i:
h
tt
p
s://
d
o
i.
o
rg
/1
0
.
1
1
7
7
/0
0
2
2
0
3
4
5
1
5
5
7
1
1
8
4
[4
7
]
In
n
e
s,
N.
P
e
t
a
l.
,
”
T
h
e
F
iCT
ION
d
e
n
tal
tri
a
l
p
ro
t
o
c
o
l
–
f
il
li
n
g
c
h
il
d
re
n
’s
tee
th
:
i
n
d
ica
ted
o
r
n
o
t?
,
”
BM
C
Or
a
l
He
a
lth
,
v
o
l.
13
,
n
o
.
2
5
,
p
p
.
1
-
1
3
,
2
0
1
3
,
d
o
i:
h
tt
p
s:/
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o
i.
o
rg
/1
0
.
1
1
8
6
/1
4
7
2
-
6
8
3
1
-
13
-
2
[4
8
]
P
e
e
v
,
S
t
,
S
a
b
e
v
a
,
El
,
“
Bo
n
e
b
lo
c
k
a
u
g
m
e
n
tatio
n
-
a
lo
n
g
-
term
f
o
ll
o
w
-
u
p
,
”
S
c
rip
ta
S
c
ie
n
ti
fi
c
a
M
e
d
i
c
in
a
e
De
n
ta
li
s
,
v
o
l.
4
,
No
.
2
,
p
p
.
2
9
-
3
5
,
2
0
1
8
.
[4
9
]
In
n
e
s
N
P
.
,
Ev
a
n
s
DJ
,
a
n
d
St
irr
u
p
s
DR.,
“
S
e
a
li
n
g
c
a
ries
in
p
ri
-
m
a
r
y
m
o
lars
:
R
a
n
d
o
m
ize
d
c
o
n
tro
l
tri
a
l,
5
-
y
e
a
r
re
su
lt
s,”
J
o
u
rn
a
l
De
n
t
al
Res
e
a
rc
h
,
v
o
l.
9
0
,
No
.
1
2
,
p
p
.
1
4
0
5
-
1
0
,
2
0
1
1
,
d
o
i:
1
0
.
1
1
7
7
/
0
0
2
2
0
3
4
5
1
1
4
2
2
0
6
4
.
[5
0
]
S
c
h
w
e
n
d
ick
e
F
e
t
a
l
.
,
“
T
re
a
ti
n
g
p
it
-
a
n
d
-
f
issu
re
c
a
ries
:
A
s
y
ste
m
a
ti
c
re
v
ie
w
a
n
d
n
e
tw
o
rk
m
e
ta
-
a
n
a
l
y
sis
,”
J
o
u
rn
a
l
o
f
De
n
ta
l
Res
e
a
rc
h
,
v
o
l.
9
4
,
n
o
.
4
,
p
p
.
5
2
2
-
33
,
2
0
1
5
,
h
tt
p
s://
d
o
i.
o
rg
/1
0
.
1
1
7
7
/0
0
2
2
0
3
4
5
1
5
5
7
1
1
8
4
.
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