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ab
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is
ab
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[
1
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.
Mo
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a
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I
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i
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2
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[
2
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.
Desp
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a
f
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r
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tr
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[
3
]
.
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r
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ca
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(
C
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[
4
]
.
I
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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2
2
5
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8806
I
J
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Vo
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5
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No
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1
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1
6
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11
2
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co
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[
5
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Mo
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I
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[
6
]
.
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[
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Kan
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[
8
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lt
h
b
eh
a
v
io
r
s
.
Self
-
e
f
f
icac
y
is
a
n
in
d
iv
id
u
al
’
s
co
n
f
id
en
ce
to
s
u
c
ces
s
f
u
l
l
y
b
eh
a
v
e
i
n
a
ce
r
tain
w
a
y
[
9
]
.
T
h
er
ef
o
r
e,
h
ea
lth
b
eh
av
io
r
s
o
f
MI
p
atien
ts
n
ee
d
to
b
e
p
r
o
m
o
ted
b
y
m
a
n
ip
u
lat
in
g
s
el
f
-
e
f
f
icac
y
u
s
i
n
g
s
e
lf
-
ef
f
icac
y
-
b
a
s
ed
in
ter
v
en
t
io
n
[
1
0
]
.
P
r
ev
io
u
s
r
esear
c
h
s
tu
d
ie
s
h
av
e
tr
ied
to
p
r
o
v
id
e
i
n
ter
v
e
n
tio
n
s
b
as
ed
o
n
t
h
e
s
e
lf
-
e
f
f
icac
y
t
h
eo
r
y
[
1
1
]
-
[
1
3
]
.
I
n
f
ac
t,
p
r
ev
io
u
s
s
t
u
d
ies
co
n
ce
r
n
ed
in
p
ar
ticip
atio
n
i
n
C
R
an
d
h
o
s
p
ital
r
ea
d
m
i
s
s
io
n
s
[
1
2
]
,
s
h
o
w
e
d
in
s
i
g
n
i
f
ican
t
r
es
u
lts
f
o
r
an
y
b
eh
av
io
r
s
s
u
c
h
as
d
iet
an
d
s
m
o
k
i
n
g
ce
s
s
atio
n
[
1
3
]
,
an
d
d
id
n
o
t
in
v
esti
g
ate
clin
ical
o
u
tco
m
es
a
n
d
s
m
o
k
i
n
g
ce
s
s
atio
n
[
1
1
]
.
W
h
er
ea
s
s
m
o
k
i
n
g
w
a
s
a
s
ig
n
i
f
ica
n
t
r
is
k
f
ac
to
r
f
o
r
MI
an
d
d
ea
th
[
1
4
]
.
Desp
ite
th
e
s
t
u
d
y
o
f
Ah
y
an
a
[
1
1
]
s
h
o
w
ed
s
i
g
n
if
ican
t
l
y
p
o
s
itiv
e
e
f
f
ec
ts
,
p
ar
ticip
an
ts
s
t
ill
r
ep
o
r
ted
s
o
m
e
b
ar
r
ier
s
to
w
ar
d
s
d
ietar
y
b
eh
av
io
r
s
a
n
d
m
ed
icatio
n
ad
h
er
en
ce
d
u
e
to
t
h
e
ea
ti
n
g
cu
lt
u
r
e
in
o
n
e
f
a
m
il
y
.
T
h
er
ef
o
r
e,
in
th
is
s
t
u
d
y
,
th
e
r
e
s
ea
r
ch
er
w
ill
co
n
tr
o
l
in
f
l
u
en
ci
n
g
f
ac
to
r
s
an
d
in
v
o
lv
e
f
a
m
il
y
in
th
e
C
R
p
r
o
g
r
a
m
to
en
h
a
n
ce
s
el
f
-
e
f
f
icac
y
a
n
d
h
ea
lth
b
eh
a
v
io
r
s
,
as
w
ell
as
o
v
er
co
m
e
t
h
e
b
ar
r
ier
s
.
Fa
m
il
y
h
a
s
a
p
o
w
er
f
u
l
in
f
lu
e
n
ce
o
n
less
e
n
i
n
g
b
ar
r
ier
s
an
d
e
n
h
an
c
in
g
s
el
f
-
ef
f
ic
ac
y
[
15
]
.
P
r
ev
io
u
s
r
e
s
ea
r
ch
p
r
o
v
ed
th
at
f
a
m
il
y
p
ar
ticip
atio
n
in
e
x
er
cise
to
g
et
h
er
w
it
h
p
atien
ts
w
o
u
ld
in
cr
e
ase
p
atien
t
’
s
co
n
f
id
en
ce
a
n
d
l
ess
e
n
an
x
iet
y
w
h
en
co
m
p
ar
ed
w
it
h
th
o
s
e
w
h
o
s
e
f
a
m
il
y
o
n
l
y
o
b
s
er
v
ed
[
16
]
.
I
n
ad
d
itio
n
to
h
ea
lt
h
b
eh
a
v
io
r
s
,
th
e
A
H
A
r
ec
o
m
m
e
n
d
ed
th
e
c
o
n
tr
o
l a
n
d
m
ai
n
te
n
an
ce
o
f
b
o
d
y
w
ei
g
h
t,
ch
o
lest
er
o
l,
b
lo
o
d
p
r
ess
u
r
e,
a
n
d
b
lo
o
d
g
l
u
co
s
e
le
v
el
s
f
o
r
p
atien
t
s
w
h
o
p
ar
ticip
ate
i
n
C
R
p
r
o
g
r
a
m
[
7
]
,
[
17
]
.
Sav
a
g
e,
Sa
n
d
er
s
o
n
,
B
r
o
w
n
,
B
er
r
a,
an
d
A
d
es
[
1
8
]
r
ep
o
r
te
d
th
at
c
lin
ical
o
u
tco
m
es
w
ill
p
r
o
v
id
e
i
m
p
o
r
tan
t
in
f
o
r
m
atio
n
to
g
u
id
e
th
e
tr
e
at
m
e
n
t.
E
s
s
e
n
tia
ll
y
,
m
ea
s
u
r
i
n
g
cl
in
ica
l
o
u
tco
m
es
i
s
a
c
r
itical
ele
m
e
n
t
f
o
r
o
p
tim
izin
g
tr
ea
t
m
e
n
t
in
a
C
R
p
r
o
g
r
am
a
n
d
m
o
n
ito
r
in
g
t
h
e
r
is
k
f
ac
to
r
s
o
f
a
ca
r
d
iac
ev
e
n
t
[
7
]
.
Fo
r
th
is
r
ea
s
o
n
s
,
th
is
s
t
u
d
y
d
ev
elo
p
ed
an
d
tes
t
ed
th
e
e
f
f
ec
ts
o
f
a
f
a
m
il
y
b
as
ed
s
elf
-
e
f
f
icac
y
p
r
o
g
r
a
m
o
n
h
ea
lth
b
e
h
av
io
r
s
a
n
d
clin
ical
o
u
tco
m
es a
m
o
n
g
MI
p
atien
t
s
.
2.
RE
S
E
ARCH
M
E
T
H
O
D
2
.
1
.
Set
t
ing
a
nd
s
a
m
ple
T
h
e
s
a
m
p
le
o
f
th
i
s
s
t
u
d
y
w
a
s
6
0
p
atien
ts
w
ith
MI
an
d
t
h
e
s
elec
ted
f
a
m
il
y
m
e
m
b
er
s
.
MI
p
atien
ts
w
er
e
r
ec
r
u
ited
f
r
o
m
th
e
C
I
C
U
(
C
ar
d
iac
I
n
ten
s
i
v
e
C
ar
e
U
n
it)
o
r
th
e
HC
C
U
(
Hig
h
C
ar
d
iac
C
ar
e
Un
it)
o
f
Hasan
Sad
i
k
i
n
Ho
s
p
ital,
W
est
J
av
a
P
r
o
v
in
ce
,
I
n
d
o
n
es
ia.
A
f
a
m
il
y
m
e
m
b
er
w
a
s
d
ef
i
n
ed
as
a
b
lo
o
d
r
elativ
e,
s
p
o
u
s
e,
o
r
o
th
er
f
a
m
il
y
m
e
m
b
er
w
h
o
cu
r
r
en
tl
y
liv
ed
w
it
h
th
e
p
atien
t
an
d
n
o
t
i
n
clu
d
ed
f
a
m
il
y
h
elp
er
.
T
h
e
s
a
m
p
le
o
f
MI
p
atie
n
ts
w
as
s
el
ec
ted
u
s
i
n
g
t
h
e
f
o
llo
w
in
g
i
n
cl
u
s
io
n
cr
iter
ia:
1
)
ag
ed
>1
8
y
e
ar
s
o
ld
;
2
)
h
av
e
n
o
co
g
n
iti
v
e
i
m
p
a
ir
m
e
n
t
;
3
)
ag
r
ee
to
p
a
r
ticip
ate
in
th
e
s
tu
d
y
;
4
)
ab
le
to
co
m
m
u
n
icate
i
n
I
n
d
o
n
esia
n
lan
g
u
ag
e
;
5
)
h
av
e
a
f
a
m
il
y
m
e
m
b
er
w
h
o
i
s
ab
le
to
p
ar
ticip
ate
th
r
o
u
g
h
o
u
t
th
e
p
r
o
g
r
a
m
;
6
)
li
v
e
a
t
h
o
m
e
w
ith
f
a
m
i
l
y
af
ter
d
is
ch
ar
g
e
f
r
o
m
t
h
e
h
o
s
p
ital;
7
)
av
ailab
le
f
o
r
a
telep
h
o
n
e
f
o
llo
w
-
u
p
an
d
v
is
it
to
t
h
e
O
P
D
;
9
)
h
av
e
s
tab
le
h
e
m
o
d
y
n
a
m
ic
lev
e
ls
;
an
d
1
0
)
h
a
v
e
n
o
c
h
est
p
ain
o
r
d
y
s
p
n
ea
.
T
h
is
s
t
u
d
y
w
as
co
n
d
u
cted
f
r
o
m
Octo
b
er
,
2
3
2
0
1
4
t
o
Ma
r
ch
,
1
0
2
0
1
5
.
2
.
2
.
Sa
m
pli
ng
pro
ce
du
re
s
C
o
n
v
en
ie
n
ce
s
a
m
p
li
n
g
w
as
u
s
ed
as
t
h
e
s
a
m
p
li
n
g
p
r
o
ce
d
u
r
e
o
f
th
i
s
s
t
u
d
y
.
T
h
e
p
atien
ts
w
h
o
co
n
s
en
ted
to
p
ar
ticip
ate
in
th
e
s
tu
d
y
w
er
e
r
an
d
o
m
ize
d
w
ith
t
h
e
m
o
d
if
ied
s
tr
atif
ied
-
b
lo
ck
m
et
h
o
d
.
R
an
d
o
m
izatio
n
w
a
s
s
tr
ati
f
ied
ac
co
r
d
in
g
to
g
en
d
er
(
t
w
o
le
v
e
ls
:
m
ale,
a
n
d
f
e
m
ale)
an
d
ag
e
(
t
w
o
lev
el
s
:
≤
6
5
y
ea
r
s
o
ld
,
an
d
>
6
5
y
ea
r
s
o
ld
)
.
W
ith
t
h
ese
t
w
o
co
v
ar
ia
tes,
t
h
er
e
w
er
e
f
o
u
r
p
o
s
s
ib
le
s
tr
ata.
T
h
en
,
p
r
o
p
o
r
tio
n
al
allo
ca
tio
n
w
as
co
n
d
u
cted
b
y
c
alcu
lati
n
g
th
e
p
er
ce
n
tag
e
o
f
e
ac
h
s
tr
at
u
m
f
r
o
m
th
e
p
o
p
u
lat
i
o
n
,
an
d
th
e
n
u
m
b
er
o
f
s
a
m
p
le
i
n
ea
c
h
s
tr
at
u
m
was
ca
lcu
lated
b
y
u
s
in
g
t
h
e
to
tal
s
a
m
p
le
o
f
6
0
p
atien
ts
[
19
]
.
T
h
e
n
u
m
b
er
o
f
s
a
m
p
les a
n
d
co
v
ar
iate
b
et
w
ee
n
th
e
co
n
tr
o
l g
r
o
u
p
an
d
t
h
e
ex
p
er
im
e
n
tal
g
r
o
u
p
w
er
e
eq
u
al.
P
atien
ts
w
h
o
a
g
r
ee
d
to
p
ar
ticip
ated
in
th
e
s
t
u
d
y
w
e
r
e
id
en
tifie
d
th
e
c
h
ar
ac
ter
is
tic
s
an
d
allo
ca
ted
i
n
to
o
n
e
s
tr
atu
m
t
h
at
m
et
w
i
th
th
e
ch
ar
ac
ter
is
tic
s
.
T
h
e
s
i
m
p
le
r
an
d
o
m
izatio
n
w
as
th
e
n
co
n
d
u
cted
in
-
g
r
o
u
p
o
f
ea
ch
s
tr
at
u
m
to
d
eter
m
i
n
e
t
h
e
p
ar
ticip
an
t’
s
ass
ig
n
m
en
t in
to
th
e
ex
p
er
i
m
en
tal
g
r
o
u
p
o
r
th
e
c
o
n
tr
o
l g
r
o
u
p
b
y
f
lip
p
in
g
t
h
e
c
o
in
.
W
h
en
th
e
h
ea
d
ap
p
ea
r
ed
,
th
e
p
atien
t
w
a
s
ass
i
g
n
ed
in
to
ex
p
er
i
m
e
n
tal
g
r
o
u
p
,
w
h
ile
tail
ap
p
ea
r
ed
;
th
e
p
atien
t
w
as
as
s
ig
n
ed
in
to
co
n
tr
o
l g
r
o
u
p
.
T
h
e
p
r
o
ce
s
s
w
a
s
co
n
ti
n
u
ed
u
n
ti
l a
ll b
lo
ck
s
w
e
r
e
f
illed
w
ith
t
h
e
s
e
t n
u
m
b
er
o
f
s
a
m
p
les.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
P
HS
I
SS
N:
2252
-
8806
C
a
r
d
ia
c
R
eh
a
b
ilit
a
tio
n
o
n
He
a
lth
B
eh
a
vio
r
s
a
n
d
C
lin
ica
l O
u
tco
mes .
.
.
.
(
Yu
s
s
h
y
K
u
r
n
ia
Herlia
n
i)
3
2
.
3
.
Da
t
a
a
na
ly
s
is
T
h
e
r
esear
ch
er
u
s
ed
d
esc
r
ip
tiv
e
an
d
in
f
er
e
n
tial
s
ta
tis
t
ics
to
an
al
y
ze
t
h
e
d
ata.
Descr
ip
tiv
e
s
tatis
tic
s
w
a
s
u
s
ed
to
an
al
y
ze
a
n
d
d
escr
ib
e
th
e
d
e
m
o
g
r
ap
h
ic
d
ata
an
d
h
ea
lt
h
in
f
o
r
m
a
tio
n
o
f
th
e
p
atien
t
s
.
T
h
e
in
d
ep
en
d
en
t
t
–
test
w
as
u
s
e
d
to
test
th
e
m
ea
n
s
co
r
e
d
i
f
f
er
en
ce
s
b
et
w
ee
n
th
e
ex
p
er
i
m
en
tal
g
r
o
u
p
a
n
d
t
h
e
co
n
tr
o
l
g
r
o
u
p
.
A
cc
o
r
d
in
g
l
y
,
th
e
p
air
ed
t
–
test
w
as
u
s
ed
to
test
th
e
m
ea
n
s
co
r
e
d
if
f
er
en
ce
s
w
it
h
i
n
th
e
ex
p
er
i
m
e
n
tal
g
r
o
u
p
,
b
ef
o
r
e
an
d
af
ter
r
ec
eiv
in
g
t
h
e
p
r
o
g
r
a
m
.
2
.
4
.
Da
t
a
co
llect
io
n t
o
o
l
2
.
4
.
1
.
De
m
o
g
ra
ph
ic
da
t
a
a
nd
hea
lt
h r
ela
t
ed
qu
estio
nn
a
ire
(
DD
H
Q
)
T
h
e
DDHQ
co
n
s
is
ts
o
f
t
w
o
co
m
p
o
n
e
n
t
s
,
n
a
m
e
l
y
t
h
e
p
ati
en
t
’
s
in
f
o
r
m
at
io
n
a
n
d
t
h
e
h
e
alth
r
elate
d
d
ata,
an
d
th
e
f
a
m
i
l
y
’
s
i
n
f
o
r
m
atio
n
an
d
h
ea
lt
h
r
elate
d
d
ata.
T
h
e
p
atien
t’
s
i
n
f
o
r
m
atio
n
a
n
d
h
ea
lth
r
elate
d
d
ata
w
er
e
a
g
e,
g
en
d
er
,
B
MI
,
m
ar
i
tal
s
tat
u
s
,
lev
el
o
f
ed
u
ca
tio
n
,
m
o
n
th
l
y
i
n
co
m
es,
o
cc
u
p
atio
n
,
an
d
n
u
m
b
er
o
f
h
o
s
p
italizatio
n
s
,
t
y
p
es
o
f
MI
,
tr
ea
t
m
e
n
t,
a
n
d
m
ed
icatio
n
.
T
h
e
Fa
m
il
y
’
s
in
f
o
r
m
a
tio
n
a
n
d
h
ea
lt
h
r
elate
d
d
ata
co
m
p
o
s
ed
o
f
a
g
e,
g
e
n
d
er
,
m
ar
ital
s
tat
u
s
,
m
o
n
t
h
l
y
in
co
m
es,
ed
u
ca
tio
n
le
v
el,
o
cc
u
p
atio
n
,
r
e
latio
n
s
h
ip
w
it
h
t
h
e
p
atien
t,
f
a
m
il
y
h
i
s
to
r
y
,
ex
p
er
i
en
ce
in
ta
k
in
g
ca
r
e
o
f
a
p
atien
t
w
it
h
MI
,
an
d
th
e
lev
el
o
f
co
n
f
id
en
ce
f
o
r
tak
i
n
g
ca
r
e
o
f
a
p
atien
t
w
ith
MI
.
2
.
4
.
2
.
M
o
dified
m
y
o
ca
rdia
l inf
a
rc
t
io
n hea
lt
h beha
v
io
rs ques
t
io
nn
a
ire
(
M
o
dified
M
I
H
B
Q
)
T
h
e
Mo
d
if
ied
MI
HB
Q
i
s
a
s
elf
-
r
ep
o
r
ted
h
ea
lt
h
b
e
h
av
io
r
s
q
u
e
s
tio
n
n
air
e
th
at
w
as
d
ev
elo
p
ed
b
y
Ah
y
an
a
[
11
]
b
ased
o
n
t
h
e
Am
er
ican
Hea
r
t
Ass
o
ciatio
n
a
n
d
Am
er
ican
Ass
o
ciat
io
n
o
f
C
ar
d
io
v
asc
u
lar
an
d
P
u
l
m
o
n
ar
y
R
e
h
ab
ilit
atio
n
.
T
h
e
co
m
p
o
n
e
n
ts
o
f
m
o
d
if
ied
MI
HB
Q
co
n
s
is
ted
o
f
f
iv
e
s
u
b
s
ca
le
s
o
f
h
ea
lt
h
b
eh
av
io
r
s
:
1
)
d
ietar
y
m
o
d
i
f
i
ca
tio
n
;
2
)
ex
er
cise;
3
)
m
ed
ic
atio
n
ad
h
er
en
ce
;
4
)
s
tr
es
s
m
an
ag
e
m
e
n
t;
a
n
d
5
)
s
m
o
k
in
g
ce
s
s
atio
n
.
T
h
e
s
co
r
e
w
a
s
r
ated
as
1
=
n
ev
er
,
2
=
s
o
m
eti
m
es,
3
=
o
f
ten
,
an
d
4
=
r
o
u
tin
el
y
.
E
x
ce
p
t
th
e
n
eg
at
iv
e
q
u
est
io
n
s
(
2
,
4
,
5
,
6
,
1
2
,
1
3
,
1
4
,
1
5
,
1
6
,
1
7
,
3
0
,
3
1
,
3
2
,
3
3
)
,
th
e
s
co
r
e
w
as
r
e
v
er
s
ed
.
T
h
e
to
tal
s
co
r
e
r
an
g
e
s
f
r
o
m
3
4
to
1
3
6
.
Hig
h
er
s
co
r
es in
d
icate
m
o
r
e
f
r
eq
u
e
n
t
p
er
f
o
r
m
a
n
ce
o
f
h
ea
lt
h
b
eh
av
i
o
r
s
.
2
.
4
.
3
.
Self
-
E
f
f
ica
cy
in Ca
rdia
c
H
ea
lt
h B
eha
v
io
rs Sca
le
(
SE
CH
B
S)
.
Self
-
e
f
f
icac
y
w
a
s
m
ea
s
u
r
ed
b
y
th
e
Sel
f
-
E
f
f
icac
y
i
n
C
ar
d
iac
Hea
lth
B
eh
av
io
r
s
Scale
(
SEC
HB
S)
.
T
h
e
SECHB
S
w
h
ich
h
as
f
i
v
e
s
u
b
-
s
ca
le
s
w
as
m
o
d
if
ied
b
y
t
h
e
r
esear
ch
er
b
ased
o
n
th
e
s
el
f
-
ef
f
icac
y
t
h
eo
r
y
a
n
d
ca
r
d
iac
r
eh
ab
ilit
atio
n
g
u
id
eli
n
e
estab
lis
h
ed
b
y
t
h
e
Am
er
ican
Hea
r
t
A
s
s
o
ciatio
n
(
A
H
A
)
[
7
]
,
[
20
]
.
T
h
e
p
atien
t’
s
s
elf
-
co
n
f
id
e
n
ce
ca
n
b
e
r
ated
o
n
a
s
ca
le
o
f
0
to
1
0
.
T
h
e
h
i
g
h
e
r
s
co
r
e
r
ef
er
s
to
a
m
o
r
e
co
n
f
id
en
t state
to
p
er
f
o
r
m
v
ar
io
u
s
ca
r
d
iac
h
ea
l
th
b
eh
a
v
io
r
s
.
2
.
4
.
4
.
Clini
ca
l
o
utc
o
m
e
s
pa
ra
m
et
e
rs
T
h
e
clin
ical
o
u
tco
m
es
t
h
at
w
er
e
ass
ess
ed
in
th
i
s
s
t
u
d
y
:
wer
e
b
lo
o
d
p
r
ess
u
r
e
(
B
P
)
,
b
lo
o
d
g
lu
co
s
e,
ch
o
lest
er
o
l,
an
d
B
MI
.
B
P
w
a
s
m
ea
s
u
r
ed
b
y
a
m
er
cu
r
y
s
p
h
y
g
m
o
m
an
o
m
eter
as
r
ec
o
m
m
e
n
d
ed
b
y
t
h
e
A
H
A.
B
MI
w
a
s
ca
lcu
lated
b
y
m
ea
s
u
r
i
n
g
t
h
e
h
e
ig
h
t
a
n
d
th
e
w
e
ig
h
t
o
f
th
e
p
atie
n
t
u
s
i
n
g
a
d
ig
ital
w
ei
g
h
t
s
ca
le
p
r
o
v
id
ed
b
y
t
h
e
h
o
s
p
ital.
B
lo
o
d
g
lu
co
s
e
an
d
c
h
o
lest
er
o
l
w
er
e
m
ea
s
u
r
ed
at
t
h
e
h
o
s
p
ital
lab
o
r
ato
r
y
.
I
n
o
r
d
er
to
g
et
a
n
ac
cu
r
ate
v
al
u
e
o
f
b
lo
o
d
g
lu
co
s
e
an
d
c
h
o
lest
er
o
l
le
v
els,
th
e
p
atien
t
s
w
er
e
i
n
s
tr
u
ct
ed
to
tak
e
n
o
t
h
i
n
g
o
r
ally
e
x
ce
p
t
w
ater
an
d
m
ed
ic
atio
n
f
o
r
1
2
h
o
u
r
s
b
ef
o
r
e
th
e
t
est.
2
.
5
.
I
nte
rv
ent
io
n
T
h
is
f
i
v
e
-
w
ee
k
p
r
o
g
r
a
m
f
o
r
MI
p
atien
ts
w
as
d
ev
elo
p
ed
b
y
th
e
r
e
s
ea
r
ch
er
b
ased
o
n
t
h
e
i
n
teg
r
atio
n
o
f
th
e
s
e
lf
-
e
f
f
icac
y
th
eo
r
y
,
t
h
e
co
n
ce
p
t
o
f
f
a
m
il
y
s
u
p
p
o
r
t
an
d
th
e
Am
er
ica
n
Hea
r
t
As
s
o
ciatio
n
’
s
(
A
H
A
)
r
ec
o
m
m
e
n
d
atio
n
s
o
f
a
C
R
p
r
o
g
r
a
m
.
T
h
e
p
r
o
g
r
a
m
co
m
p
r
i
s
ed
o
f
t
w
o
s
es
s
io
n
s
:
t
h
e
i
n
-
h
o
s
p
it
al
s
ess
io
n
s
a
n
d
t
h
e
f
o
llo
w
-
u
p
s
ess
io
n
s
.
I
n
-
h
o
s
p
ita
l
s
es
s
io
n
s
w
er
e
d
eliv
er
ed
t
w
o
d
a
y
s
an
d
co
n
s
i
s
ted
o
f
a
n
i
n
t
r
o
d
u
cto
r
y
m
ee
t
in
g
w
it
h
f
a
m
il
y
m
e
m
b
er
,
an
d
t
wo
ti
m
es
m
ee
ti
n
g
s
.
T
h
e
ac
tiv
i
t
ies
co
n
s
i
s
ted
o
f
ed
u
ca
t
io
n
al
a
n
d
s
h
ar
i
n
g
s
es
s
io
n
,
v
icar
io
u
s
e
x
p
er
ien
ce
v
id
eo
ab
o
u
t
MI
p
atien
ts
w
h
o
h
av
e
h
ad
s
u
cc
ess
i
n
p
er
f
o
r
m
in
g
h
ea
lt
h
b
eh
av
io
r
s
,
f
ac
ilit
ated
p
atie
n
ts
,
an
d
f
a
m
il
y
to
u
n
d
er
s
ta
n
d
n
o
r
m
al
s
en
s
atio
n
s
an
d
p
o
s
s
ib
le
m
in
o
r
p
h
y
s
ical
d
is
co
m
f
o
r
t
s
,
d
em
o
n
s
tr
ated
b
r
ea
t
h
i
n
g
f
o
r
r
e
lax
atio
n
a
n
d
ex
er
cise.
Fo
llo
w
u
p
s
ess
io
n
w
as
u
n
d
er
ta
k
en
wee
k
l
y
b
y
telep
h
o
n
e
ca
lls
to
d
is
cu
s
s
o
b
s
tacle
s
an
d
s
tr
ateg
ie
s
u
s
ed
to
o
v
er
co
m
e
th
ese
o
b
s
tacle
s
,
f
o
llo
w
ed
b
y
af
f
ir
m
atio
n
o
f
t
h
e
p
atien
t
’
s
e
f
f
o
r
ts
a
n
d
s
u
cc
e
s
s
e
s
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8806
I
J
P
HS
Vo
l.
5
,
No
.
1
, M
ar
ch
2
0
1
6
:
1
–
11
4
3.
RE
SU
L
T
S
3
.
1
.
T
he
de
m
o
g
ra
ph
i
c
a
n
d hea
lt
h r
ela
t
ed
cha
ra
ct
er
is
t
ics o
f
t
he
pa
t
ient
s
T
h
e
d
em
o
g
r
ap
h
ic
a
n
d
h
ea
lt
h
r
elate
d
ch
ar
ac
ter
is
tics
o
f
th
e
p
a
tien
t
s
p
r
esen
ted
in
T
ab
le
1
.
T
ab
le
1
.
T
h
e
Dif
f
er
e
n
ce
s
o
f
P
atien
t
s
De
m
o
g
r
ap
h
ic
C
h
ar
ac
te
r
is
tics
o
f
t
h
e
E
x
p
er
i
m
en
t
al
an
d
th
e
C
o
n
tr
o
l G
r
o
u
p
s
(
N
=
60)
Ch
a
ra
c
teristic
Ex
p
e
rime
n
tal
G
ro
u
p
(n
=
3
0
)
Co
n
tr
o
l
G
ro
u
p
(n
=
3
0
)
S
tatisti
c
v
a
lu
e
s
p
-
v
a
lu
e
n
%
n
%
Ag
e
(
y
e
a
r)
M
e
a
n
=
5
6
.
8
7
S
D =
9
.
6
5
M
e
a
n
=
5
5
.
8
0
S
D =
8
.
9
6
.
4
4
b
.
6
5
9
(M
in
–
M
a
x
)
=
(3
7
-
79)
G
e
n
d
e
r
.
0
9
a
.
7
5
4
M
a
le
24
8
0
.
0
%
23
7
6
.
7
%
F
e
m
a
le
6
2
0
.
0
%
7
2
3
.
3
%
M
a
rit
a
l
sta
tu
s
.
2
4
d
.
0
3
8
*
M
a
rried
27
9
0
.
0
%
30
100%
W
id
o
w
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I
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N
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I
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4.
DIS
CU
SS
I
O
N
4
.
1
.
Self
-
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f
i
ca
cy
in
ca
rdia
c
hea
lt
h beha
v
io
rs
.
Self
-
e
f
f
icac
y
o
f
MI
p
atien
ts
in
t
h
e
e
x
p
er
i
m
e
n
tal
g
r
o
u
p
af
ter
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i
n
g
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n
ter
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tio
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w
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s
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ig
n
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f
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tl
y
b
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th
a
n
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r
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ec
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g
t
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e
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n
ter
v
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n
tio
n
(
T
ab
le
3
)
.
T
h
e
p
o
s
itiv
e
o
u
tco
m
es
o
n
s
el
f
-
ef
f
icac
y
af
ter
t
h
e
p
atien
t
s
h
ad
r
ec
ei
v
ed
th
e
i
n
ter
v
e
n
tio
n
w
er
e
r
elate
d
to
f
o
u
r
s
o
u
r
ce
s
o
f
s
el
f
-
e
f
f
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y
t
h
at
w
er
e
u
s
ed
to
d
ev
elo
p
th
e
p
r
o
g
r
a
m
i
n
cl
u
d
in
g
m
as
ter
y
e
x
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ien
ce
,
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s
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ce
,
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al
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s
u
asio
n
,
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d
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ical
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n
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h
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s
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d
y
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m
a
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x
p
er
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ce
w
as
f
ac
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a
ted
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r
o
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g
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i
n
v
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l
v
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n
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th
e
p
atie
n
ts
i
n
e
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er
cise a
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d
p
r
ac
tice
to
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s
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r
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h
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l
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e
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ates b
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e
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d
a
f
ter
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e.
Ma
s
ter
y
e
x
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m
ize
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h
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tio
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ler
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v
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ilit
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er
f
o
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m
h
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lth
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eh
a
v
io
r
s
[
2
1
]
.
T
h
e
v
icar
io
u
s
e
x
p
er
ien
ce
w
as
p
r
o
v
id
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g
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a
v
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t
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atien
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cc
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ed
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s
t
o
f
th
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atien
t
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n
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h
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s
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d
y
(
g
en
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t
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to
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th
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atie
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itio
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w
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tili
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tio
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n
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s
in
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l
v
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th
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atie
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t’
s
f
a
m
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H
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e
n
,
W
i
n
d
er
,
R
ait,
B
u
s
elli,
a
n
d
A
l
[
2
2
]
also
r
ep
o
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ted
th
at
en
co
u
r
ag
e
m
e
n
t
a
n
d
p
atien
t
ed
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ca
tio
n
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e
f
f
ec
ti
v
e
to
p
r
o
m
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te
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e
lf
-
ef
f
icac
y
o
f
h
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lt
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b
e
h
av
io
r
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ter
a
ca
r
d
iac
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v
e
n
t.
T
h
e
p
h
y
s
i
o
lo
g
ical
an
d
e
m
o
tio
n
al
r
esp
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s
e
s
w
er
e
p
r
o
v
id
ed
w
it
h
i
n
f
o
r
m
atio
n
ab
o
u
t
n
o
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m
a
l
s
en
s
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io
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a
n
d
an
y
p
o
s
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ib
le
p
h
y
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ical
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is
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m
f
o
r
ts
.
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h
e
y
w
er
e
also
tau
g
h
t
th
e
s
tr
ateg
ie
s
to
r
ed
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ce
an
y
f
ee
li
n
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o
f
d
is
co
m
f
o
r
t to
en
co
u
r
a
g
e
a
m
o
r
e
p
o
s
itiv
e
e
m
o
tio
n
al
s
t
ate
.
4
.
2
.
H
ea
lt
h
beha
v
io
rs
T
h
e
h
ea
lth
b
eh
a
v
io
r
s
o
f
t
h
e
e
x
p
er
i
m
e
n
tal
g
r
o
u
p
af
ter
r
ec
ei
v
in
g
t
h
e
i
n
ter
v
e
n
tio
n
w
er
e
s
i
g
n
i
f
ica
n
tl
y
b
etter
th
an
b
e
f
o
r
e
r
ec
eiv
i
n
g
t
h
e
i
n
ter
v
e
n
tio
n
(
T
ab
le
5
)
.
I
n
ad
d
itio
n
,
th
e
h
ea
lt
h
b
eh
a
v
io
r
s
af
ter
r
ec
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in
g
t
h
e
in
ter
v
e
n
tio
n
in
t
h
e
ex
p
er
i
m
en
t
al
g
r
o
u
p
w
er
e
s
i
g
n
i
f
ican
tl
y
b
e
tter
th
an
t
h
at
o
f
t
h
e
co
n
tr
o
l
g
r
o
u
p
(
tab
le
6
)
.
I
t
is
p
o
s
s
ib
le
th
a
t
t
h
e
r
es
u
lt
s
w
er
e
in
f
lu
e
n
ce
d
b
y
f
ea
tu
r
e
s
o
f
t
h
e
p
r
o
g
r
am
t
h
at
i
n
cl
u
d
ed
:
(
1
)
d
ev
elo
p
in
g
b
ased
o
n
s
o
u
r
ce
s
o
f
s
el
f
-
e
f
f
icac
y
;
(
2
)
i
n
v
o
lv
i
n
g
f
a
m
il
y
m
e
m
b
er
s
to
p
r
o
m
o
te
h
ea
lt
h
b
e
h
av
io
r
s
;
(
3
)
in
itiatin
g
d
u
r
in
g
t
h
e
in
p
atien
t
p
h
a
s
e
w
h
e
n
p
atie
n
t
s
p
er
ce
iv
ed
a
h
i
g
h
h
ea
lt
h
r
is
k
af
ter
a
ca
r
d
iac
ev
e
n
t
an
d
ar
e
m
o
r
e
m
o
t
iv
ated
to
lear
n
;
(
4
)
co
n
ti
n
u
in
g
w
i
th
a
p
h
o
n
e
f
o
llo
w
-
u
p
s
es
s
io
n
af
ter
d
is
ch
ar
g
e
to
m
o
n
ito
r
a
n
d
p
r
o
v
id
e
r
ein
f
o
r
ce
m
en
t
o
n
h
ea
lt
h
b
eh
av
io
r
s
.
I
n
th
i
s
s
t
u
d
y
,
t
h
e
i
n
cr
ea
s
i
n
g
s
elf
-
e
f
f
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y
i
n
ca
r
d
iac
h
ea
l
th
b
eh
a
v
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r
s
s
co
r
e
in
MI
p
a
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s
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m
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o
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lt
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t
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p
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it
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g
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el
f
-
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f
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e
m
o
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lik
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ad
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an
ar
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th
o
s
e
w
i
th
lo
w
s
el
f
-
ef
f
icac
y
[
23
]
.
I
n
th
e
s
t
u
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y
o
f
Kan
g
et
al
[
8
]
ca
r
d
iac
s
elf
-
e
f
f
icac
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s
h
o
w
ed
t
h
e
g
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test
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a
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l.
P
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ev
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eg
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p
ar
ticip
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in
ca
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a
b
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atio
n
[
1
1
]
,
[
2
4
]
.
Fa
m
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i
n
v
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v
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m
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t
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p
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m
ed
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ce
to
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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C
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9
in
s
tr
u
m
en
ta
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f
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r
m
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p
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o
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n
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o
m
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atie
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ts
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r
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b
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ier
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R
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tab
le
o
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a
lo
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p
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[
2
5
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.
Dietar
y
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a
v
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w
a
s
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ted
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to
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atel
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5
%
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latio
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co
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s
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h
s
alt
y
f
o
o
d
[
2
6
]
.
T
h
er
ef
o
r
e,
th
e
ea
tin
g
cu
lt
u
r
e
in
a
f
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in
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all
y
ap
p
r
o
p
r
i
ate
d
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y
m
o
d
i
f
icatio
n
s
[
27
]
in
o
r
d
er
to
s
u
p
p
o
r
t
d
ietar
y
b
e
h
av
io
r
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T
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p
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h
a
s
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g
n
i
f
ican
t
ef
f
ec
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o
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e
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s
m
an
a
g
e
m
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th
at
w
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e
as
s
o
ciate
d
w
ith
t
h
e
f
a
m
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in
v
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l
v
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m
en
t
in
p
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id
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p
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P
r
ev
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ted
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m
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tr
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u
tes
t
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p
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er
a
d
h
er
en
ce
to
o
th
er
h
ea
lth
b
eh
a
v
io
r
s
af
ter
MI
[
2
8
]
.
S
m
o
k
i
n
g
ce
s
s
at
io
n
b
eh
av
io
r
in
t
h
e
p
r
esen
t
s
tu
d
y
w
as
s
ig
n
i
f
ica
n
tl
y
ch
a
n
g
ed
.
T
h
e
r
ed
u
ctio
n
i
n
n
u
m
b
er
o
f
s
m
o
k
er
s
i
n
t
h
is
s
tu
d
y
w
a
s
ad
v
an
tag
eo
u
s
i
n
r
ed
u
cin
g
th
e
r
is
k
o
f
MI
[
2
9
]
.
4
.
3
.
Clini
ca
l o
utc
o
m
e
s
.
I
n
th
e
p
r
esen
t
s
tu
d
y
,
t
h
e
ef
f
e
ctiv
e
n
ess
o
f
th
e
p
r
o
g
r
a
m
o
n
b
lo
o
d
p
r
ess
u
r
e
(
B
P)
w
a
s
n
o
t
s
ig
n
i
f
ica
n
t.
P
r
ev
io
u
s
s
t
u
d
i
es
r
ev
ea
led
th
at
B
P
d
id
n
o
t
f
all
s
ig
n
if
ican
tl
y
w
h
en
p
atie
n
ts
ta
k
e
less
t
h
an
8
0
%
o
f
th
e
ir
p
r
escr
ib
ed
m
ed
icatio
n
.
So
m
e
h
o
w
,
i
n
t
h
e
p
r
ese
n
t
s
t
u
d
y
t
h
e
p
atie
n
ts
r
ep
o
r
ted
h
av
i
n
g
s
ig
n
i
f
ica
n
tl
y
b
etter
m
ed
icatio
n
ad
h
er
en
ce
b
eh
a
v
io
r
.
Hen
ce
,
th
e
r
es
u
lt
s
i
n
t
h
e
p
r
esen
t
s
t
u
d
y
r
ev
ea
led
as
t
h
e
i
m
p
ac
t
o
f
n
o
r
m
al
le
v
el
o
f
B
P
in
m
o
s
t
o
f
t
h
e
p
atien
ts
at
b
aselin
e.
I
n
t
h
e
p
r
esen
t
s
t
u
d
y
,
to
tal
c
h
o
lest
er
o
l,
L
DL
,
a
n
d
tr
ig
l
y
ce
r
id
e
o
f
t
h
e
ex
p
er
i
m
e
n
tal
g
r
o
u
p
af
ter
r
ec
eiv
i
n
g
th
e
i
n
ter
v
en
t
io
n
w
er
e
s
ig
n
i
f
ica
n
tl
y
b
etter
th
a
n
b
e
f
o
r
e
r
ec
eiv
i
n
g
th
e
in
ter
v
e
n
tio
n
an
d
b
etter
t
h
a
n
t
h
at
o
f
th
e
co
n
tr
o
l
g
r
o
u
p
.
T
h
e
s
e
f
i
n
d
i
n
g
s
ar
e
co
n
g
r
u
e
n
t
w
i
t
h
t
h
e
r
es
u
lts
o
f
t
h
e
s
tu
d
y
co
n
d
u
cted
b
y
J
ia
n
g
e
t
al
[
2
4
]
w
h
ic
h
r
ep
o
r
ted
to
t
al
ch
o
lest
er
o
l,
L
D
L
,
an
d
tr
i
g
l
y
ce
r
id
es
s
h
o
w
ed
s
ig
n
i
f
ica
n
tl
y
g
r
ea
ter
r
ed
u
ctio
n
in
th
e
e
x
p
er
i
m
e
n
tal
g
r
o
u
p
.
Un
f
o
r
tu
n
atel
y
,
t
h
e
e
f
f
ec
t
o
f
th
e
p
r
o
g
r
a
m
d
id
n
o
t
s
h
o
w
s
ig
n
if
ican
t
r
es
u
lts
o
n
HD
L
.
A
s
i
m
ilar
p
h
en
o
m
e
n
o
n
w
as
al
s
o
o
b
s
er
v
ed
f
r
o
m
th
e
s
t
u
d
y
co
n
d
u
c
ted
b
y
Ka
n
g
et
al
[
8
]
in
th
a
t
H
DL
le
v
els
w
er
e
n
o
t
s
tatis
t
icall
y
s
i
g
n
i
f
ican
t
b
et
wee
n
t
w
o
g
r
o
u
p
s
r
elate
d
to
th
e
lo
w
er
e
f
f
icac
y
o
f
l
ip
id
-
lo
w
er
i
n
g
d
r
u
g
s
i
n
in
f
lu
e
n
ci
n
g
HD
L
.
P
atien
ts
i
n
th
e
p
r
ese
n
t
s
t
u
d
y
w
er
e
ta
k
in
g
lip
id
-
lo
w
er
i
n
g
d
r
u
g
s
a
t
h
o
s
p
i
tal
d
is
c
h
ar
g
e.
T
h
e
r
esu
lt
s
co
u
ld
b
e
i
n
f
lu
e
n
ce
d
b
y
th
e
ef
f
ec
t
o
f
t
y
p
e
s
o
f
lip
id
-
lo
w
er
i
n
g
d
r
u
g
s
in
c
l
u
d
i
n
g
g
e
n
er
i
c
an
d
b
r
an
d
ed
d
r
u
g
s
th
at
w
er
e
n
o
t
co
n
tr
o
lled
.
Ho
w
ev
er
,
th
e
lev
els
o
f
c
h
o
lest
er
o
l
w
er
e
n
o
t
af
f
ec
ted
b
y
th
e
t
y
p
e
s
o
f
lip
id
-
lo
w
er
i
n
g
d
r
u
g
s
if
t
h
e
p
atie
n
ts
n
o
t
ad
h
er
e
to
t
h
e
m
ed
icatio
n
.
A
cc
o
r
d
in
g
l
y
,
th
e
s
i
g
n
i
f
ican
t
c
h
a
n
g
e
s
o
f
m
ed
icatio
n
ad
h
er
en
ce
e
f
f
icac
y
a
n
d
m
ed
ic
atio
n
ad
h
er
e
n
ce
b
eh
a
v
io
r
s
co
r
e
o
f
t
h
e
p
atie
n
ts
i
n
th
e
e
x
p
er
i
m
en
tal
g
r
o
u
p
af
ter
r
ec
eiv
in
g
th
e
i
n
ter
v
e
n
tio
n
also
co
n
tr
ib
u
ted
o
n
th
e
b
etter
lev
el
o
f
ch
o
lest
er
o
l.
Mo
r
eo
v
er
,
th
e
p
r
o
g
r
am
in
v
o
lv
e
d
th
e
f
a
m
il
y
to
s
u
p
p
o
r
t
th
e
p
ati
en
ts
o
n
b
e
h
av
io
r
c
h
an
g
e.
A
d
d
itio
n
all
y
,
in
t
h
is
s
t
u
d
y
,
t
h
e
e
f
f
icac
y
o
f
d
r
u
g
s
o
n
HDL
an
d
t
y
p
e
s
o
f
th
e
lip
id
-
l
o
w
er
in
g
d
r
u
g
s
n
ee
d
to
b
e
in
v
esti
g
ated
m
o
r
e
to
p
r
o
v
e
th
e
tr
u
e
ef
f
ec
t
o
f
t
h
e
p
r
o
g
r
am
o
n
th
e
cli
n
ical
o
u
tco
m
es.
T
h
e
r
esu
lt
s
h
o
w
s
t
h
at
6
3
.
3
%
o
f
th
e
p
atie
n
t
s
h
ad
a
n
o
r
m
a
l
s
c
o
r
e
o
f
B
MI
.
I
n
th
e
p
r
esen
t
s
t
u
d
y
,
B
MI
o
f
th
e
e
x
p
er
i
m
e
n
tal
g
r
o
u
p
a
f
ter
r
ec
eiv
in
g
th
e
in
ter
v
e
n
tio
n
w
a
s
n
o
t
s
i
g
n
if
ican
t
l
y
b
etter
th
a
n
th
e
co
n
tr
o
l
g
r
o
u
p
.
T
h
e
f
in
d
i
n
g
w
a
s
s
i
m
i
lar
w
it
h
t
h
e
r
ep
o
r
t
b
y
J
ian
g
et
al
[
24
].
T
h
e
r
esu
lt
m
i
g
h
t
b
e
r
elate
d
w
i
th
t
h
e
n
o
r
m
al
s
co
r
e
o
f
B
MI
in
m
o
s
t
o
f
p
atien
t
s
at
b
aselin
e,
an
d
also
th
e
ef
f
ec
t
o
f
in
s
ig
n
i
f
ica
n
t
b
etter
r
esu
lts
o
n
d
ietar
y
b
eh
av
io
r
.
P
atien
ts
m
a
y
co
n
tr
o
l
th
e
ir
d
iet
s
u
ch
as
r
e
s
tr
icti
n
g
t
h
eir
f
at
an
d
ch
o
le
s
ter
o
l
i
n
tak
e
w
h
ich
ap
p
ea
r
s
to
h
av
e
a
s
ig
n
i
f
ica
n
t
e
f
f
ec
t
o
n
c
h
o
le
s
ter
o
l
lev
els.
Ho
w
e
v
er
,
t
h
e
p
atie
n
ts
s
h
o
w
ed
a
lac
k
o
f
atte
n
tio
n
i
n
r
estricti
n
g
t
h
eir
ca
r
b
o
h
y
d
r
ate
in
tak
e
o
r
s
o
m
e
ev
en
ate
m
o
r
e.
I
n
th
e
p
r
esen
t
s
tu
d
y
,
f
a
s
ti
n
g
b
lo
o
d
g
lu
co
s
e
o
f
th
e
in
ter
v
en
tio
n
g
r
o
u
p
w
as
s
i
g
n
i
f
ica
n
tl
y
b
ette
r
af
ter
r
ec
eiv
i
n
g
t
h
e
i
n
ter
v
e
n
t
io
n
b
u
t
n
o
t
s
i
g
n
i
f
ican
tl
y
b
ett
er
th
an
th
e
co
n
tr
o
l
g
r
o
u
p
.
I
t
m
a
y
b
e
r
elate
d
to
th
e
ea
tin
g
cu
ltu
r
e
o
f
I
n
d
o
n
es
ian
p
eo
p
le
w
h
er
e
r
ice
is
th
e
d
aily
m
ai
n
f
o
o
d
an
d
r
ice
cr
ea
te
h
ig
h
ca
r
b
o
h
y
d
r
ate
an
d
g
lu
co
s
e.
5.
CO
NCLU
SI
O
NS
T
h
e
f
in
d
i
n
g
s
o
f
t
h
is
s
t
u
d
y
clea
r
l
y
i
n
d
icate
t
h
e
p
o
s
iti
v
e
e
f
f
ec
t
o
f
f
a
m
i
l
y
b
ased
s
el
f
-
ef
f
icac
y
e
n
h
a
n
ci
n
g
ca
r
d
iac
r
eh
ab
ilit
atio
n
p
r
o
g
r
a
m
o
n
s
el
f
-
ef
f
icac
y
,
h
ea
lth
b
e
h
a
v
io
r
s
,
an
d
s
o
m
e
cli
n
ical
o
u
tco
m
es
i
n
MI
p
atie
n
t
s
s
u
c
h
as
f
as
tin
g
b
lo
o
d
g
lu
co
s
e,
to
tal
ch
o
lest
er
o
l,
L
D
L
,
tr
ig
l
y
ce
r
id
e,
an
d
B
MI
ex
ce
p
t
f
o
r
s
y
s
to
lic
an
d
d
iast
o
li
c
b
lo
o
d
p
r
ess
u
r
e,
an
d
HD
L
le
v
els.
T
h
is
s
t
u
d
y
in
d
icate
d
t
h
at
en
co
u
r
ag
in
g
MI
p
atien
t
s
a
n
d
f
a
m
il
y
m
e
m
b
er
s
to
ad
o
p
t
C
R
p
r
o
g
r
a
m
an
d
co
n
ti
n
u
e
i
m
p
le
m
e
n
t
i
n
th
eir
d
ail
y
lif
e
is
b
en
ef
ic
ial
f
o
r
MI
p
at
ien
ts
.
Hea
lt
h
ca
r
e
p
r
o
v
id
er
s
s
h
o
u
ld
co
n
ce
r
n
m
o
r
e
in
p
r
o
m
o
ti
n
g
th
e
C
R
p
r
o
g
r
a
m
s
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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ar
ch
2
0
1
6
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1
–
11
10
ACK
NO
WL
E
D
G
E
M
E
NT
S
T
h
is
s
tu
d
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w
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s
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p
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esear
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f
u
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t
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Dir
ec
to
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at
Gen
er
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h
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E
d
u
ca
tio
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Min
i
s
tr
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o
f
Na
tio
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al
E
d
u
ca
t
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d
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an
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Gr
ad
u
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Sch
o
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k
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it
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h
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d
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R
E
F
E
R
E
NC
E
S
[1
]
T
h
y
g
e
se
n
K
.
,
A
lp
e
rt
JS
.
,
W
h
it
e
HD
.
,
―
Un
iv
e
rsa
l
d
e
f
in
it
io
n
o
f
M
y
o
c
a
rd
ial
In
f
a
rc
ti
o
n
‖,
J
o
u
rn
a
l
o
f
th
e
Ame
ric
a
n
Co
ll
e
g
e
o
f
Ca
r
d
io
l
o
g
y
,
v
o
l.
50
,
2
0
0
7
.
[2
]
M
in
istry
o
f
He
a
lt
h
o
f
th
e
Re
p
u
b
l
ic
o
f
In
d
o
n
e
sia
,
―
P
ro
f
il
k
e
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h
a
tan
In
d
o
n
e
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tah
u
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2
0
1
3
[
In
d
o
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e
si
a
h
e
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lt
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p
ro
f
il
e
in
2
0
1
3
]
‖
,
2
0
1
4
.
Re
tri
e
v
e
d
f
ro
m
:
h
tt
p
:
//
ww
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[3
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Kik
k
e
rt
W
J
.
,
Ho
e
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rs
L
P
.
,
Da
m
m
a
n
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L
iev
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KV
.
,
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ss
e
n
BE
.
,
V
is
M
M
.
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He
n
r
iq
u
e
s
JP
.
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―
Re
c
u
rre
n
t
m
y
o
c
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rd
ial
in
f
a
rc
ti
o
n
a
f
ter
p
rim
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r
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e
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tan
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ry
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terv
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n
m
y
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Ame
ric
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-
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,
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0
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.
[4
]
M
u
rra
y
J
.
,
Cra
ig
s
C
L
.
,
Hill
KM
.
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Ho
n
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y
S
.
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Ho
u
se
A
.
,
―
A
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m
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ti
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iate
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w
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tak
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letio
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f
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rd
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lar
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l
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a
n
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e
‖,
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C
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r
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a
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Diso
rd
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p
p
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1
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0
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2
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.
[5
]
Ra
d
i
B
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A
.
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Ku
sm
a
n
a
D.
,
―
Re
h
a
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il
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tas
i
Ka
rd
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lar
Di
I
n
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o
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[
c
a
rd
iac
re
h
a
b
il
it
a
ti
o
n
in
In
d
o
o
n
e
sia
]
‖,
J
u
r
n
a
l
Ka
rd
i
o
l
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g
i
I
n
d
o
n
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sia
,
v
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l.
30
,
p
p
.
43
-
5
,
2
0
0
9
.
[6
]
M
a
ji
d
A
.
,
―
A
n
a
li
sis
f
a
k
to
r
-
f
a
k
to
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n
g
b
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ra
w
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stif
d
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ru
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h
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g
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n
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ly
sis
o
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f
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s
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iate
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h
o
sp
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g
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k
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0
1
0
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‖
,
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a
ste
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0
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ro
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.
[7
]
Ba
lad
y
GJ
.
,
W
il
li
a
m
s M
A
.
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A
d
e
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P
A
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,
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o
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o
ss
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,
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o
o
d
y
JM.
,
―
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o
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rd
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Co
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‖,
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l.
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p
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.
[8
]
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n
g
Y
.
,
Ya
n
g
I
S
.
,
Ki
m
N.
,
―
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o
rre
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s
o
f
He
a
lt
h
Be
h
a
v
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in
P
a
ti
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n
ts
W
it
h
Co
ro
n
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ry
A
rter
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se
‖,
Asia
n
Nu
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v
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(
1
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p
.
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-
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0
.
[9
]
Ba
n
d
u
ra
A
.
,
―
S
e
lf
-
Eff
i
c
a
c
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T
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‖,
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w
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rk
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H.
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m
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n
,
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9
7
.
[1
0
]
L
a
u
-
Walk
e
r
M
.
,
"
P
re
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g
se
lf
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e
ff
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c
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il
ln
e
ss
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c
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ts:
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p
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rv
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it
ish
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o
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rn
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l
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lt
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[1
1
]
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h
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n
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,
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s
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a
ste
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la Un
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rsity
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2
]
Ca
rro
ll
DL
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n
k
in
S
H
.
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o
p
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r
B
A
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ra
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terv
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re
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o
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rn
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r
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g
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l.
22
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p
.
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3
-
19
,
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0
0
7
.
[1
3
]
S
o
n
g
KJ
.
,
―
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h
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e
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ts
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f
se
lf
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l.
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p
.
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18
,
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0
0
3
.
[1
4
]
Am
e
rica
n
He
a
rt
As
so
c
iatio
n
,
―
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e
tt
in
g
h
e
a
lt
h
y
‖,
2
0
1
4
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p
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5
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u
sz
c
z
y
n
sk
a
A
.
,
S
c
h
w
a
rz
e
r
R.
,
―
M
u
lt
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e
n
sio
n
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l
h
e
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lt
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lo
c
u
s
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f
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o
n
tro
l:
c
o
m
m
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ts
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n
th
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c
t
a
n
d
it
s
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u
re
m
e
n
t
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J
He
a
lt
h
Psy
c
h
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l
,
v
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(5
)
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p
p
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42
,
2
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0
5
.
[1
6
]
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m
p
b
e
ll
T
L
.
,
―
T
h
e
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ff
e
c
ti
v
e
n
e
s
s
o
f
fa
m
il
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in
ter
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l
d
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rd
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rs
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o
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rn
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l
o
f
M
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ri
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o
l.
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p
p
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2
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3
-
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0
0
3
.
[1
7
]
Ha
riad
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A
.
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―
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b
u
n
g
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n
o
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e
sitas
d
e
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n
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b
e
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k
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u
lt
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risk
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p
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[1
8
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a
v
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g
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D
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n
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n
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M
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rra
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d
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A
.
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―
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n
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se
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rc
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rd
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o
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Ca
rd
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l.
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p
.
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0
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1
.
[1
9
]
Ka
n
g
M
.
,
Ra
g
a
n
B
G
.
,
P
a
rk
J.
,
―
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ss
u
e
s
in
o
u
tco
m
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s
re
se
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h
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n
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ra
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t
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o
u
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h
letic T
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n
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ti
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r
a
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s
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v
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p
p
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[2
0
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Ba
n
d
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ra
A
.
,
―
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u
id
e
f
o
r
c
o
n
stru
c
t
in
g
se
lf
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e
f
f
i
c
a
c
y
sc
a
les
‖,
In
D.
P
a
jare
s,
F
.
,
Urd
a
n
,
T
.
(Ed
s.),
―
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e
lf
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e
ff
ic
a
c
y
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e
li
e
fs
o
f
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les
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ts:
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f
o
rm
a
ti
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n
a
g
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u
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g
‖,
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re
e
n
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,
CT
.
,
p
p
.
3
0
7
–
37
,
2
0
0
6
.
[2
1
]
Du
H
.
,
Ev
e
re
tt
B
.
,
Ne
w
to
n
P
.
,
S
a
lam
o
n
so
n
Y
.
,
Da
v
id
so
n
P.
,
―
S
e
lf
-
e
ff
ic
a
c
y
:
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u
se
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u
l
c
o
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c
t
t
o
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te
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in
p
e
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p
le w
i
th
sta
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le c
h
ro
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it
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4
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Jia
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v
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p
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8
8
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5
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L
in
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m
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li
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a
se
su
p
p
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ro
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p
:
a
c
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p
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m
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lt
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E
d
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c
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ti
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Res
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rc
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,
v
o
l.
24
,
p
p
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6
4
6
-
54
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2
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0
9
.
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