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Vo
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9
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2
,
A
p
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201
9
,
p
p
.
1321
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1
3
2
6
I
SS
N:
2088
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8708
,
DOI
:
1
0
.
1
1
5
9
1
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j
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.
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i
2
.
pp
1
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2
1
-
1326
1321
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1.
I
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C
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Kid
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C
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[
1
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C
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k
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r
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w
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a
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h
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C
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[
2
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.
T
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ate
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ates to
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h
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7
3
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7
3
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n
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th
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i
f
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ail
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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N
:
2
0
8
8
-
8708
I
n
t J
E
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&
C
o
m
p
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n
g
,
Vo
l.
9
,
No
.
2
,
A
p
r
il
201
9
:
1
3
2
1
-
1326
1322
p
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i
v
es
th
e
r
es
u
lt
a
n
d
t
h
e
a
n
al
y
s
is
w
h
ic
h
in
cl
u
d
es
p
r
o
p
o
s
ed
m
et
h
o
d
o
lo
g
y
,
e
x
p
er
i
m
e
n
tal
a
n
al
y
s
is
a
n
d
its
f
i
n
d
in
g
s
,
a
n
d
f
i
n
all
y
t
h
e
co
n
cl
u
s
io
n
an
d
f
u
t
u
r
e
o
u
tlo
o
k
in
S
ec
tio
n
4
.
2.
RE
S
E
ARCH
M
E
T
H
O
D
I
n
th
is
s
ec
t
io
n
,
th
e
w
o
r
k
r
elate
d
to
th
e
an
aly
s
is
,
d
iag
n
o
s
i
s
,
an
d
p
r
e
d
ictio
n
o
f
C
h
r
o
n
ic
Kid
n
e
y
D
is
ea
s
e
o
f
p
ast
y
ea
r
s
is
p
r
esen
ted
.
Mic
h
elle
M
[
3
]
f
o
u
n
d
th
e
r
o
le
o
f
v
ar
ian
t
s
o
f
th
e
A
P
OL
I
g
e
n
e
ca
u
s
i
n
g
v
ar
io
u
s
f
o
r
m
s
o
f
k
id
n
e
y
d
is
ea
s
e
p
r
o
g
r
ess
io
n
i
n
A
f
r
ica
n
d
escen
t.
J
ess
ica
[
4
]
p
r
o
p
o
s
ed
m
an
a
g
e
m
e
n
t
s
tr
ate
g
ies
w
h
ic
h
in
cl
u
d
e
in
f
i
n
d
in
g
n
e
w
p
o
ten
t
ial
b
io
m
ar
k
er
s
f
o
r
m
o
n
i
to
r
in
g
th
e
d
iab
etes
m
e
llit
u
s
d
is
ea
s
e
an
d
also
th
e
n
e
w
p
o
ten
tial
t
h
er
ap
ies
f
o
r
s
lo
w
in
g
d
o
w
n
th
e
p
r
o
g
r
es
s
io
n
o
f
t
h
e
d
iab
etes
m
el
lit
u
s
a
n
d
ch
r
o
n
ic
k
i
d
n
e
y
d
is
ea
s
e.
T
h
e
tr
ea
t
m
e
n
t
o
f
C
h
r
o
n
ic
Kid
n
e
y
Dis
ea
s
e
ass
o
ciate
d
w
it
h
d
y
s
li
p
id
em
ia
is
p
r
esen
ted
in
[
5
]
,
w
h
er
e
t
h
e
s
ta
tin
s
h
a
v
e
a
m
o
d
er
ate
ef
f
ec
t
o
n
th
e
C
KD
an
d
ad
d
itio
n
o
f
E
ze
ti
m
ib
e
to
a
s
tatin
m
a
y
p
r
ev
en
t
C
KD.
G
alv
an
[
6
]
p
r
o
p
o
s
ed
th
e
o
v
er
v
ie
w
o
f
t
h
e
r
o
le
o
f
m
ito
ch
o
n
d
r
ial
d
y
s
f
u
n
c
tio
n
i
n
ch
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e
in
t
h
e
d
ev
elo
p
m
e
n
t
o
f
d
iab
etic
n
ep
h
r
o
p
ath
y
a
n
d
t
h
e
an
al
y
s
i
s
f
o
u
n
d
t
h
e
m
ito
c
h
o
n
d
r
ial
tar
g
et
s
w
h
ic
h
i
m
p
r
o
v
e
t
h
e
tr
ea
t
m
e
n
t
o
f
ch
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e.
Mic
h
elle
A
[
7
]
d
is
cu
s
s
t
h
e
f
ac
t
o
r
s
o
f
t
h
e
p
r
o
g
r
e
s
s
io
n
o
f
th
e
r
en
al
d
y
s
f
u
n
ctio
n
.
T
h
e
w
o
r
k
i
n
[
8
]
esti
m
ates
th
e
p
r
ed
ictiv
e
ab
ilit
y
o
f
ca
r
d
io
v
asc
u
lar
d
is
ea
s
e
in
p
atie
n
t
s
w
it
h
c
h
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e.
T
w
o
co
m
m
o
n
r
i
s
k
s
co
r
es
w
er
e
u
s
ed
i
n
ev
a
lu
at
in
g
t
h
e
p
r
ed
ictab
ili
t
y
o
f
t
h
e
ca
r
d
io
v
ascu
lar
e
v
en
t.
T
h
e
r
esu
lt
s
co
n
cl
u
d
e
t
h
at
th
e
p
r
o
b
ab
ilit
y
o
f
a
er
o
s
cler
o
tic
ca
r
d
io
v
asc
u
la
r
ev
e
n
t
s
i
n
p
atien
ts
w
it
h
C
K
D
r
eg
ar
d
less
o
f
r
e
n
al
f
u
n
ctio
n
,
a
lb
u
m
i
n
u
r
ia
an
d
p
r
ev
io
u
s
ca
r
d
io
v
ascu
lar
ev
e
n
ts
.
P
o
n
till
o
et
a
l.
[
9
]
in
v
esti
g
ated
w
h
et
h
er
C
KD2
7
3
,
a
u
r
in
ar
y
b
io
m
ar
k
er
in
p
r
ed
ictin
g
t
h
e
g
lo
m
er
u
lar
f
iltra
tio
n
r
ate.
I
n
th
e
in
v
e
s
ti
g
atio
n
,
th
e
u
r
in
ar
y
b
io
m
ar
k
er
C
K
D2
7
3
p
r
ed
icts
th
e
s
ta
g
e
3
C
KD.
T
h
e
w
o
r
k
i
n
[
1
0
]
p
r
o
p
o
s
ed
a
p
r
e
d
ictio
n
o
f
au
to
n
o
m
ic
n
eu
r
o
p
ath
y
in
c
h
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e
in
s
ta
g
e
5
,
w
h
er
e
t
h
e
w
o
r
k
ca
r
r
ied
o
u
t
in
t
w
o
s
ta
g
es,
th
e
f
ir
s
t
s
tag
e
co
n
tain
ed
a
s
et
o
f
q
u
es
tio
n
n
ai
r
es
an
d
f
o
llo
w
ed
b
y
t
h
e
tes
tin
g
o
f
p
o
s
t
u
r
al
h
y
p
o
te
n
s
io
n
.
T
h
e
r
esu
lt
s
co
n
cl
u
d
ed
th
at
t
h
e
d
is
tr
ib
u
tio
n
o
f
a
u
to
n
o
m
ic
n
e
u
r
o
p
ath
y
w
it
h
t
h
e
q
u
esti
o
n
n
air
e
m
eth
o
d
w
as
h
i
g
h
er
th
an
th
e
p
o
s
t
u
r
al
h
y
p
o
ten
s
io
n
.
Stack
[
1
1
]
p
r
o
p
o
s
ed
th
e
m
ea
s
u
r
e
s
o
f
C
KD
wh
ich
i
m
p
r
o
v
e
s
ca
r
d
io
v
asc
u
lar
d
is
ea
s
e
p
r
ed
ictio
n
,
th
e
m
ea
s
u
r
e
s
co
n
clu
d
ed
th
at
b
o
th
GFR
a
n
d
AC
R
ar
e
th
e
ca
s
u
al
ca
u
s
e
o
f
ca
r
d
io
v
ascu
lar
d
is
ea
s
e.
B
ilan
cio
[
1
2
]
p
r
o
p
o
s
ed
a
p
r
e
d
ictiv
e
m
o
d
el
f
o
r
ca
r
d
i
o
v
ascu
lar
d
is
ea
s
e
in
c
ase
o
f
k
id
n
e
y
tr
a
n
s
p
la
n
ts
,
i
n
t
h
e
an
al
y
s
is
an
d
3
4
v
ar
iab
les
w
er
e
i
n
v
e
s
ti
g
ated
an
d
th
e
co
n
f
id
en
ce
i
n
ter
v
al
an
d
h
az
ar
d
r
atio
w
er
e
ca
lcu
lated
,
th
e
d
iab
etic
n
ep
h
r
o
p
ath
y
p
r
ed
icate
d
9
1
.
2
%
o
f
ca
r
d
io
v
asc
u
lar
d
is
ea
s
e.
T
h
e
p
atter
n
s
,
p
r
ed
ictio
n
an
d
p
r
o
g
r
ess
io
n
o
f
t
h
e
ch
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e
ar
e
p
r
esen
ted
i
n
[
1
3
]
,
p
atter
n
s
s
u
c
h
as
tr
aj
ec
to
r
y
an
d
n
o
n
-
tr
aj
ec
to
r
y
,
p
r
o
g
r
ess
io
n
s
s
u
c
h
a
g
lo
m
er
u
lar
f
il
tr
atio
n
r
ate
lea
d
in
g
to
h
y
p
er
ten
s
io
n
,
a
n
e
m
ia
an
d
m
i
n
er
al
b
o
r
e
d
is
o
r
d
er
s
.
C
h
ien
[
1
4
]
p
r
o
p
o
s
ed
a
p
r
ed
ictiv
e
m
o
d
el
f
o
r
th
e
b
eg
in
n
in
g
o
f
c
h
r
o
n
ic
k
id
n
e
y
d
is
e
ase
w
h
er
e
a
c
lin
icall
y
b
ased
m
o
d
el
is
co
n
s
tr
u
cte
d
b
y
t
h
e
b
io
m
ed
ical
p
ar
a
m
eter
s
s
u
c
h
a
s
r
ec
ei
v
er
o
p
er
atin
g
c
h
ar
ac
ter
is
tic
s
c
u
r
v
e
a
n
d
t
h
e
o
p
ti
m
al
c
u
to
f
f
v
al
u
e.
L
ai
e
t
a
l.
[
1
5
]
ai
m
ed
i
n
c
lar
if
y
in
g
th
e
as
s
o
ciatio
n
b
et
w
ee
n
th
e
i
n
f
ec
tio
u
s
d
is
ea
s
e
a
n
d
C
K
D.
L
o
g
is
t
ic
m
o
d
el
s
w
er
e
u
s
ed
f
o
r
p
r
ev
alen
ce
r
atio
o
f
HC
V
ch
r
o
n
ic
i
n
f
ec
t
io
n
s
f
o
r
C
KD,
th
e
r
esu
lt
s
co
n
cl
u
d
e
th
at
HC
V
v
ir
al
lo
ad
an
d
HC
V
g
en
o
t
y
p
e
2
ar
e
th
e
s
tr
o
n
g
p
r
ed
icto
r
s
o
f
ch
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e.
3.
RE
SU
L
T
S
A
ND
AN
AL
Y
SI
S
W
e
ex
p
er
i
m
e
n
ted
o
u
r
p
r
o
p
o
s
ed
A
B
C
4
.
5
tech
n
iq
u
e
o
n
c
h
r
o
n
ic
k
id
n
e
y
d
is
ea
s
e
d
ataset
co
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cted
f
r
o
m
a
p
r
iv
ate
h
o
s
p
ital
in
T
a
m
il
Nad
u
.
T
h
e
d
ataset
co
n
tain
ed
elev
en
n
u
m
er
ic
a
n
d
f
o
u
r
tee
n
n
o
m
in
a
l
attr
ib
u
tes,
co
n
tain
i
n
g
4
0
0
o
b
s
er
v
atio
n
s
w
ith
t
w
o
class
e
s
’
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d
an
d
n
o
t
ck
d
.
T
h
e
d
etailed
attr
ib
u
te
in
f
o
r
m
atio
n
i
s
p
r
esen
te
d
in
T
ab
le
1
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
E
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&
C
o
m
p
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n
g
I
SS
N:
2088
-
8708
A
n
en
s
emb
le
mu
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-
mo
d
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tech
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iq
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p
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ch
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ey
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(
K
o
ma
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ma
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N
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1323
T
ab
le
1
.
A
ttrib
u
te,
C
la
s
s
,
an
d
Valu
e
o
f
C
KD
D
ata
s
et
S.
No
A
t
t
r
i
b
u
t
e
V
a
l
u
e
t
y
p
e
1
A
g
e
A
g
e
i
n
y
e
a
r
s
2
B
l
o
o
d
P
r
e
ssu
r
e
N
u
me
r
i
c
3
S
p
e
c
i
f
i
c
G
r
a
v
i
t
y
N
o
mi
n
a
l
4
A
l
b
u
mi
n
N
o
mi
n
a
l
5
S
u
g
a
r
N
o
mi
n
a
l
6
R
e
d
b
l
o
o
d
c
e
l
l
s
N
o
mi
n
a
l
7
P
u
s
C
e
l
l
N
o
mi
n
a
l
8
P
u
s
C
e
l
l
C
l
u
mp
s
N
o
mi
n
a
l
9
B
a
c
t
e
r
i
a
N
o
mi
n
a
l
10
B
l
o
o
d
G
l
u
c
o
se
R
a
n
d
o
m
N
u
me
r
i
c
11
B
l
o
o
d
U
r
e
a
N
u
me
r
i
c
12
S
e
r
u
m C
r
e
a
t
i
n
i
n
e
N
u
me
r
i
c
13
S
o
d
i
u
m
N
u
me
r
i
c
14
P
o
t
a
ssi
u
m
N
u
me
r
i
c
15
H
e
mo
g
l
o
b
i
n
N
u
me
r
i
c
16
P
a
c
k
e
d
C
e
l
l
V
o
l
u
me
N
u
me
r
i
c
17
W
h
i
t
e
B
l
o
o
d
C
e
l
l
C
o
u
n
t
N
u
me
r
i
c
18
R
e
d
B
l
o
o
d
C
e
l
l
C
o
u
n
t
N
u
me
r
i
c
19
H
y
p
e
r
t
e
n
si
o
n
N
o
mi
n
a
l
20
D
i
a
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ec
h
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e.
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h
e
w
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w
o
s
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g
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;
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th
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ir
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s
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g
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r
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1
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r
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1
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4
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k
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h
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m
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tep
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in
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f
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ic
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ase
(
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as f
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:
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1
.
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n
th
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f
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.
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ith
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to
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t d
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test
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b
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4
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5
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lled
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s
n
e
w
d
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s
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s
u
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th
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n
ta
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f
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0
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s
t
d
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s
g
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v
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n
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in
p
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s
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th
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w
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lear
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s
f
r
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m
t
h
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4
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5
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t
w
ea
k
ed
in
f
av
o
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f
m
is
cla
s
s
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f
ied
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s
ta
n
ce
s
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eir
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g
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ted
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m
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h
e
f
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al
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u
tco
m
e
r
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r
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t
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b
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o
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ted
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if
ier
f
o
r
C
h
r
o
n
ic
Kid
n
e
y
D
is
ea
s
e.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
0
8
8
-
8708
I
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t J
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&
C
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p
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g
,
Vo
l.
9
,
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201
9
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1326
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L
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ter
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h
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w
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in
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g
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r
e
2
.
P
er
f
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m
a
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ce
m
et
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in
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3
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Fig
u
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4
an
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u
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2
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3
.
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4
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h
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ier
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r
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5
.
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ier
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n
th
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k
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Vec
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ch
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ac
h
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4
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f
ier
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n
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ar
ticle
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Op
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it
h
M
u
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L
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P
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tr
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[
1
6
]
ac
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q
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
E
lec
&
C
o
m
p
E
n
g
I
SS
N:
2088
-
8708
A
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[
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1
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ase
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4.
CO
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t
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n
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4
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DT
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A
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m
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a
C
h
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Kid
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(
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4
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ig
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1
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b
le
lear
n
in
g
al
g
o
r
ith
m
s
o
n
a
C
h
r
o
n
ic
Kid
n
e
y
Dis
ea
s
e
d
ataset
f
o
r
i
m
p
r
o
v
ed
p
er
f
o
r
m
a
n
ce
ca
n
d
o
f
u
r
t
h
er
o
u
tlo
o
k
.
RE
F
E
R
E
NC
E
S
[1
]
O’H
a
re
A
M
.
,
e
t
a
l
,
“
A
g
e
Eff
e
c
ts
Ou
tco
m
e
s
in
Ch
ro
n
ic
Kid
n
e
y
Dis
e
a
se
,
”
J
Am
S
OC
Ne
p
h
ro
l
,
v
o
l.
18
(1
0
)
,
p
p
.
2
7
5
8
-
6
5
.
Oc
t
2
0
0
7
.
[2
]
“
Kid
n
e
y
Dise
a
se
:
I
m
p
ro
v
in
g
G
lo
b
a
l
O
u
tco
m
e
(KD
I
G
O)
CKD
W
o
rk
g
ro
u
p
.
KD
IG
O
2
0
1
2
Cli
n
i
c
a
l
P
ra
c
ti
c
e
a
n
d
G
u
id
e
li
n
e
s
f
o
r
th
e
Ev
a
lu
a
ti
o
n
a
n
d
M
a
n
a
g
e
m
e
n
t
o
f
Ch
ro
n
ic
Ki
d
n
e
y
Dis
e
a
se
,
”
Kid
n
e
y
In
t
S
u
p
p
l.
,
v
o
l.
3
,
p
p
.
1
-
1
5
0
,
2
0
1
3
.
[3
]
M
ich
e
ll
e
M
.
Estrella,
Ru
lan
S
.
P
a
re
k
h
,
“
T
h
e
Ex
p
a
n
d
in
g
Ro
le
o
f
A
P
OL
1
Ris
k
in
Ch
ro
n
ic
Kid
n
e
y
Dis
e
a
se
a
n
d
Ca
rd
io
v
a
sc
u
lar Dise
a
se
,
”
S
e
min
a
rs
in
Ne
p
h
r
o
lo
g
y
,
v
ol
.
3
7
,
i
ss
u
e
6
,
pp.
5
2
0
-
5
2
9
,
2
0
1
7
.
[4
]
Je
ss
ica
K.
Ya
k
u
sh
W
il
li
a
m
s,
“
M
a
n
a
g
e
m
e
n
t
S
trate
g
ie
s
f
o
r
P
a
ti
e
n
ts
w
it
h
Dia
b
e
ti
c
Kid
n
e
y
Dise
a
se
a
n
d
Ch
ro
n
ic
Kid
n
e
y
Dise
a
se
in
Dia
b
e
tes
,
”
Nu
rs
in
g
Cl
in
ics
o
f
No
rt
h
Ame
ric
a
,
v
ol
.
5
2
,
i
ss
u
e
4
,
p
p
.
5
7
5
-
5
8
7
,
2
0
1
7
.
[5
]
Dra
g
a
n
a
L
o
v
re
,
S
u
la
y
S
h
a
h
,
A
a
n
u
S
i
h
o
ta,
Viv
ian
A
.
F
o
n
se
c
a
,
“
M
a
n
a
g
in
g
Dia
b
e
tes
a
n
d
Ca
rd
io
v
a
sc
u
lar
Risk
in
Ch
ro
n
ic Kid
n
e
y
Dise
a
se
P
a
ti
e
n
ts
,
”
En
d
o
c
rin
o
l
o
g
y
a
n
d
M
e
ta
b
o
li
sm
Cli
n
ics
o
f
No
rt
h
Ame
ric
a
,
2
0
1
7
.
[6
]
Da
n
iel
L
.
G
a
l
v
a
n
,
Na
th
a
n
a
e
l
H.
G
re
e
n
,
F
a
rh
a
d
R.
Da
n
e
sh
,
“
T
h
e
H
a
ll
m
a
rk
s o
f
M
it
o
c
h
o
n
d
rial
Dy
s
f
u
n
c
ti
o
n
in
Ch
r
o
n
i
c
Kid
n
e
y
Dise
a
se
,
”
Kid
n
e
y
In
ter
n
a
t
io
n
a
l
,
v
ol
.
9
2
,
i
ss
u
e
5
,
p
p
.
1
0
5
1
-
1
0
5
7
,
2
0
1
7
.
[7
]
M
ic
h
e
ll
e
A
.
Hla
d
u
n
e
w
ich
,
“
Ch
ro
n
ic
Kid
n
e
y
Dise
a
se
,
a
n
d
P
re
g
n
a
n
c
y
,
”
In
S
e
min
a
rs
i
n
Ne
p
h
ro
l
o
g
y
,
v
ol
.
3
7
,
i
ss
u
e
4
,
pp.
3
3
7
-
3
4
6
,
2
0
1
7
.
[8
]
S
a
n
ti
a
g
o
Ce
d
e
ñ
o
M
o
ra
,
M
a
rian
G
o
ico
e
c
h
e
a
,
Esth
e
r
T
o
rre
s,
“
Ca
r
d
io
v
a
sc
u
lar
Risk
P
re
d
ictio
n
i
n
Ch
ro
n
ic
Kid
n
e
y
Dise
a
se
P
a
ti
e
n
ts,
”
Ne
fro
lo
g
í
a
(
En
g
li
sh
Ed
it
io
n
),
v
ol
.
3
7
,
i
ss
u
e
3
,
p
p
.
2
9
3
-
3
0
0
,
2
0
1
7
.
[9
]
Clau
d
ia
P
o
n
ti
ll
o
,
Z
h
e
n
-
Yu
Z
h
a
n
g
,
Jo
o
st
P
.
S
c
h
a
n
stra
,
“
P
re
d
ictio
n
o
f
Ch
ro
n
ic
Ki
d
n
e
y
Dise
a
s
e
S
tag
e
3
b
y
CKD
2
7
3
,
a
Urin
a
ry
P
ro
teo
m
ic Bi
o
m
a
r
k
e
r
,
”
Kid
n
e
y
In
ter
n
a
ti
o
n
a
l
Re
p
o
rts
,
v
ol
.
2
,
i
ss
u
e
6
,
p
p
.
1
0
6
6
-
1
0
7
5
,
2
0
1
7
.
[1
0
]
A
li
A
b
d
u
lm
a
ji
d
d
y
a
b
A
ll
a
w
i,
“
P
re
d
ictio
n
o
f
A
u
to
n
o
m
ic
Ne
u
ro
p
a
th
y
in
Ch
r
o
n
ic
Kid
n
e
y
Dise
a
s
e
(sta
g
e
5
)
Ira
q
i
P
a
ti
e
n
ts
(
Ca
se
-
c
o
n
tro
l
S
t
u
d
y
)
,
”
Dia
b
e
tes
&
M
e
ta
b
o
li
c
S
y
n
d
r
o
me
:
Cli
n
ic
a
l
Res
e
a
rc
h
&
Re
v
iews
,
v
ol
.
1
1
,
pp.
S
9
6
9
-
S
9
7
3
,
2
0
1
7
[1
1
]
A
u
stin
G
S
tac
k
,
“
Co
m
m
o
n
M
e
a
s
u
re
s
o
f
Ch
ro
n
ic
Kid
n
e
y
Dis
e
a
se
Im
p
ro
v
e
V
a
sc
u
lar
Risk
P
re
d
ictio
n
,
”
T
h
e
L
a
n
c
e
t
Dia
b
e
tes
&
En
d
o
c
rin
o
l
o
g
y
,
v
ol
.
5
,
i
ss
u
e
9
,
p
p
.
6
7
5
-
6
7
7
,
2
0
1
7
.
[1
2
]
G
.
Bil
a
n
c
io
,
M
.
Ce
lan
o
,
V.
Co
z
z
a
,
F
.
Zi
n
g
o
n
e
,
G
.
P
a
ll
a
d
in
o
,
M
.
C
ir
il
lo
,
“
Early
P
re
d
icti
o
n
o
f
Ca
rd
io
v
a
sc
u
lar
Dise
a
s
e
in
Kid
n
e
y
T
r
a
n
sp
lan
t
Re
c
ip
ien
ts
,”
T
ra
n
sp
la
n
ta
ti
o
n
Pro
c
e
e
d
i
n
g
s
,
v
ol
.
4
9
,
i
ss
u
e
9
,
p
p
.
2
0
9
2
-
2
0
9
8
,
2
0
1
7
.
[1
3
]
Da
v
id
Co
ll
ister,
T
h
o
m
a
s
F
e
rg
u
so
n
,
P
a
u
l
K
o
m
e
n
d
a
,
Na
v
d
e
e
p
T
a
n
g
ri,
“
T
h
e
P
a
tt
e
rn
s,
Risk
F
a
c
to
rs,
a
n
d
P
re
d
icti
o
n
o
f
P
r
o
g
re
ss
io
n
i
n
C
h
ro
n
ic
Kid
n
e
y
Dise
a
se
:
A
Na
rra
ti
v
e
Re
v
ie
w
,
”
S
e
min
a
rs
i
n
Ne
p
h
ro
l
o
g
y
,
v
ol
.
3
6
,
i
ss
u
e
4
,
pp.
2
7
3
-
2
8
2
,
2
0
1
6
.
[1
4
]
Ku
o
-
L
io
n
g
Ch
ien
,
H
u
n
g
-
Ju
L
in
,
Ba
i
-
Ch
in
L
e
e
,
“
A
P
re
d
ictio
n
M
o
d
e
l
f
o
r
th
e
Risk
o
f
In
c
id
e
n
t
Ch
ro
n
ic
Kid
n
e
y
Dise
a
se
,
”
T
h
e
Ame
ric
a
n
J
o
u
rn
a
l
o
f
M
e
d
icin
e
,
v
ol
.
1
2
3
,
i
ss
u
e
9
,
pp.
8
3
6
-
8
4
6
.
e
2
,
2
0
1
0
.
[1
5
]
T
a
i
-
S
h
u
a
n
L
a
i,
M
e
i
-
Hs
u
a
n
L
e
e
,
Hw
a
i
-
I.
Ya
n
g
,
“
Hig
h
H
e
p
a
ti
ti
s
C
V
iral
L
o
a
d
a
n
d
G
e
n
o
ty
p
e
2
a
re
S
tro
n
g
P
re
d
ict
o
r
s
o
f
Ch
ro
n
ic Ki
d
n
e
y
Dise
a
se
,
”
Kid
n
e
y
In
ter
n
a
ti
o
n
a
l
,
v
ol
.
9
2
,
i
ss
u
e
3
,
p
p
.
7
0
3
-
7
0
9
,
2
0
1
7
.
[1
6
]
Ko
m
a
l
Ku
m
a
r.
N,
V
ig
n
e
s
w
a
ri.
D,
B
A
S
Ro
o
p
a
De
v
i,
“
M
S
O
-
M
L
P
Dia
g
n
o
stic
A
p
p
ro
a
c
h
f
o
r
De
tec
ti
n
g
DENV
S
e
ro
t
y
p
e
s
,
”
In
ter
n
a
ti
o
n
a
l
J
o
u
rn
a
l
o
f
P
u
re
a
n
d
Ap
p
li
e
d
M
a
t
h
e
ma
ti
c
s
,
v
ol
.
1
1
8
(
5
),
pp
.
1
-
6
,
2
0
1
8
.
B
I
O
G
RAP
H
I
E
S
O
F
AUTH
O
RS
K
o
m
a
l
K
u
m
a
r
N
is
c
u
rre
n
tl
y
w
o
rk
in
g
a
s
a
n
A
ss
ist
a
n
t
P
r
o
f
e
ss
o
r
in
th
e
De
p
a
rtm
e
n
t
o
f
In
f
o
r
m
a
ti
o
n
T
e
c
h
n
o
lo
g
y
,
V
e
l
T
e
c
h
Hig
h
T
e
c
h
Dr.
Ra
n
g
a
ra
jan
Dr.
S
a
k
u
n
th
a
la E
n
g
in
e
e
rin
g
Co
ll
e
g
e
,
Ch
e
n
n
a
i
,
T
a
m
il
Na
d
u
,
I
n
d
ia.
His res
e
a
rc
h
i
n
tere
st i
n
c
lu
d
e
s m
a
c
h
in
e
lea
rn
in
g
,
d
a
ta
m
in
in
g
,
a
n
d
c
lo
u
d
c
o
m
p
u
ti
n
g
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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N
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9
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2
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r
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201
9
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1
3
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1326
1326
Dr
.
R.
L
a
k
s
h
m
i
T
u
la
si
i
s cu
rre
n
tl
y
w
o
rk
in
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a
s an
As
so
c
iate
P
ro
f
e
s
so
r
in
th
e
De
p
a
rtme
n
t
o
f
Co
m
p
u
ter
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c
ien
c
e
a
n
d
En
g
in
e
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ri
n
g
,
RV
R
&
JC
Co
ll
e
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o
f
En
g
in
e
e
rin
g
,
G
u
n
tu
r,
A
n
d
h
ra
P
ra
d
e
sh
,
In
d
ia.
He
r
re
se
a
rc
h
in
tere
sts in
c
lu
d
e
I
n
f
o
rm
a
ti
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Re
t
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a
l,
S
e
m
a
n
ti
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w
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b
.
V
ig
n
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sw
a
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u
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k
in
g
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s
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s
sista
n
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P
r
o
f
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o
r
in
th
e
De
p
a
rtm
e
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t
o
f
In
f
o
rm
a
ti
o
n
T
e
c
h
n
o
lo
g
y
,
V
e
l
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e
c
h
M
u
lt
i
T
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c
h
Dr.
Ra
n
g
a
ra
j
a
n
Dr.
S
a
k
u
n
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a
la
En
g
in
e
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rin
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Co
ll
e
g
e
,
Ch
e
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n
a
i,
T
a
m
il
Na
d
u
,
In
d
ia.
He
r
re
se
a
rc
h
in
tere
sts in
c
lu
d
e
Da
ta M
in
i
n
g
,
M
a
c
h
in
e
L
e
a
rn
in
g
.
Evaluation Warning : The document was created with Spire.PDF for Python.