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ased
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ased
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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2
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8
8
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8708
I
J
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C
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Vo
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6
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No
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6
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Dec
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b
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2
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1
6
:
3
1
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3
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111
3104
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er
en
ce
is
e
x
p
lai
n
ed
.
I
n
Se
ctio
n
4
,
t
h
e
p
r
o
p
o
s
ed
ca
s
ca
d
e
s
tati
s
tical
f
u
zz
y
i
n
f
er
en
ce
s
y
s
te
m
w
it
h
tr
ib
al
in
f
o
r
m
atio
n
i
n
f
er
e
n
ce
i
s
d
is
c
u
s
s
ed
.
Sectio
n
5
d
is
cu
s
s
e
s
t
h
e
ex
p
er
i
m
e
n
tal
r
esu
lts
o
f
t
h
e
p
r
o
p
o
s
ed
m
et
h
o
d
.
C
o
n
cl
u
s
io
n
is
d
escr
ib
ed
in
Sec
tio
n
6
.
2.
F
U
Z
Z
Y
ST
R
SI
M
I
L
AR
I
T
Y
DN
A
P
r
o
f
ile
is
a
s
et
o
f
n
u
m
b
er
s
w
h
ic
h
r
e
f
lects
a
p
er
s
o
n
’
s
DN
A
m
ak
e
u
p
,
in
co
n
tr
ast
to
f
u
ll
g
en
o
m
e
s
eq
u
en
c
in
g
.
T
h
er
e
ar
e
m
a
n
y
m
eth
o
d
s
to
d
o
th
is
w
o
r
k
[
2
]
,
b
u
t
ST
R
(
Sh
o
r
t
T
an
d
em
R
ep
ea
ts
)
an
al
y
s
i
s
i
s
p
r
ef
er
r
ed
[
3
]
as
u
s
ed
b
y
t
h
e
U
n
ited
Ki
n
g
d
o
m
a
n
d
Un
i
ted
St
ates.
ST
R
an
al
y
s
is
co
u
n
ts
t
h
e
r
ep
etitio
n
co
u
n
t
o
f
p
atter
n
s
o
f
t
w
o
o
r
m
o
r
e
n
u
c
le
o
tid
es
w
h
ich
ar
e
r
ep
ea
ted
an
d
th
e
r
ep
ea
ted
s
eq
u
e
n
ce
s
ar
e
d
ir
ec
tl
y
ad
j
ac
en
t
to
ea
ch
o
th
er
.
T
h
e
id
ea
is
to
ca
p
t
u
r
e
th
e
ST
R
v
alu
e
o
f
a
f
e
w
lo
ca
ti
o
n
s
in
a
p
er
s
o
n
’
s
g
e
n
etic
m
ak
e
u
p
ca
lled
lo
cu
s
,
as
illu
s
tr
ated
in
Fi
g
u
r
e
1
(
Or
ig
i
n
al
p
ictu
r
e
f
r
o
m
Natio
n
al
I
n
s
tit
u
te
o
f
Sta
n
d
ar
d
s
an
d
T
e
ch
n
o
lo
g
y
(
NI
ST
)
)
.
P
r
ev
io
u
s
r
esear
ch
h
as
b
ee
n
u
n
d
er
tak
en
to
h
ar
n
e
s
s
t
h
e
f
lex
ib
i
lit
y
o
f
Fu
zz
y
Set
to
th
e
D
N
A
(
Deo
x
y
r
ib
o
n
u
cl
eic
A
cid
)
P
r
o
f
ile
m
atc
h
i
n
g
’
s
p
r
o
b
le
m
.
M.
R
.
W
id
y
an
to
et
al.
[
4
]
p
r
o
p
o
s
ed
a
m
et
h
o
d
to
as
s
ig
n
f
u
zz
y
s
i
m
ilar
it
y
m
ea
s
u
r
e
[
1
0
]
b
etw
ee
n
t
w
o
all
ele
m
ar
k
er
s
,
i
n
co
n
tr
ast
to
cr
is
p
0
o
r
1
s
im
ilar
it
y
m
ea
s
u
r
e
u
s
ed
in
co
n
v
e
n
tio
n
al
ST
R
b
ased
DNA
p
r
o
f
ile
m
atc
h
in
g
al
g
o
r
it
h
m
[
1
1
]
.
T
h
e
n
ee
d
to
h
av
e
a
f
u
zz
y
s
i
m
ilar
it
y
m
ea
s
u
r
e
is
tr
i
g
g
er
ed
b
y
th
e
f
ac
t
th
at
ST
R
p
r
o
f
iles
o
f
t
en
s
h
o
w
ed
r
ea
l
-
v
al
u
ed
n
u
m
b
er
s
as
a
n
al
lele
m
ar
k
er
v
al
u
e
in
s
tead
o
f
n
at
u
r
al
n
u
m
b
er
s
.
T
h
is
i
s
s
u
p
p
o
s
ed
l
y
th
e
e
f
f
ec
t
o
f
n
o
is
e
in
th
e
p
r
o
ce
s
s
o
f
an
al
y
zi
n
g
t
h
e
ST
R
p
r
o
f
ile.
Usi
n
g
f
u
zz
y
s
i
m
ilar
it
y
m
ea
s
u
r
e,
t
w
o
al
leles
w
i
th
s
m
all
d
i
f
f
er
e
n
ce
w
il
l sti
l
l g
et
a
s
i
m
ilar
it
y
s
co
r
e
i
n
s
tead
o
f
a
cr
is
p
0
,
w
h
ic
h
d
is
ca
r
d
th
e
p
o
s
s
ib
ilit
y
o
f
th
e
t
w
o
alle
les
h
av
in
g
s
i
m
ilar
it
y
v
alu
e
alt
h
o
u
g
h
o
n
l
y
d
if
f
er
s
l
i
g
h
t
l
y
,
w
h
ic
h
co
u
ld
o
cc
u
r
b
ec
au
s
e
o
f
t
h
e
n
o
is
e
d
u
r
in
g
DN
A
d
ata
ac
q
u
is
i
tio
n
.
Fi
g
u
r
e
1
.
T
h
e
L
o
cu
s
in
C
h
r
o
m
o
s
o
m
al
P
o
s
itio
n
s
I
n
DN
A
p
r
o
f
ile
m
a
tch
i
n
g
p
r
o
b
le
m
,
f
o
r
(
)
am
o
u
n
t o
f
in
d
i
v
id
u
a
l
s
,
th
e
d
ataset
i
s
d
escr
ib
ed
as
*
+
,
(
1
)
w
h
er
e
is
a
v
ec
to
r
o
f
DN
A
p
r
o
f
ile
e
v
id
en
ce
a
n
d
is
a
v
ec
to
r
o
f
DN
A
p
r
o
f
i
le
r
ef
er
e
n
ce
.
T
h
e
v
ec
to
r
an
d
ar
e
th
e
(
)
d
im
e
n
s
io
n
al
v
ec
to
r
co
n
s
is
tin
g
o
f
th
e
v
al
u
e
o
f
1
5
lo
ci
w
i
th
o
u
t a
m
elo
g
e
n
i
n
as
h
as
b
ee
n
u
s
e
d
b
y
Fed
er
al
B
u
r
ea
u
o
f
I
n
v
esti
g
atio
n
(
FB
I
)
[
3
]
.
Valu
e
o
f
e
v
er
y
D
N
A
lo
ci
is
r
ep
r
esen
ted
b
y
f
u
zz
y
n
u
m
b
er
(
as
s
h
o
w
n
b
y
Fi
g
u
r
e
2
)
w
h
er
e
th
e
f
u
zz
in
e
s
s
v
al
u
e
is
s
et
to
b
e
0
.
4
th
r
o
u
g
h
e
x
p
er
i
m
e
n
ts
[
4
]
an
d
th
e
ce
n
ter
o
f
t
h
e
f
u
zz
i
n
es
s
is
th
e
v
al
u
e
o
f
th
e
co
r
r
esp
o
n
d
in
g
lo
ci.
T
h
e
s
im
il
ar
it
y
v
al
u
e
[
1
0
]
b
e
t
w
ee
n
an
a
llele
o
f
DNA
p
r
o
f
ile
ev
id
en
c
e
an
d
DNA
p
r
o
f
ile
r
ef
er
en
ce
is
g
i
v
en
b
y
)
.
(
)
(
)
/
.
(
)
/
)
,
-
,
(
2
)
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
E
C
E
I
SS
N:
2
0
8
8
-
8708
A
N
o
ve
l H
u
ma
n
S
TR
S
imila
r
ity
Meth
o
d
Usi
n
g
C
a
s
c
a
d
e
S
ta
ti
s
tica
l F
u
z
z
y
R
u
les
.
.
.
.
(
M.
R
a
h
ma
t W
id
ya
n
to
)
3105
w
h
er
e
is
th
e
v
al
u
e
o
f
th
e
j
-
th
lo
ci
o
f
th
e
DN
A
p
r
o
f
ile
e
v
id
e
n
ce
an
d
is
t
h
e
v
alu
e
o
f
t
h
e
j
-
th
lo
ci
o
f
th
e
DN
A
p
r
o
f
ile
r
ef
er
e
n
ce
.
Fu
r
t
h
er
b
y
b
r
ea
k
i
n
g
d
o
w
n
th
e
f
o
r
m
u
latio
n
t
h
r
o
u
g
h
d
o
in
g
s
i
m
p
le
m
u
ltip
licat
io
n
o
p
er
atio
n
s
,
it is
o
b
tain
ed
)
(
)
.
(3)
An
d
b
y
d
iv
id
i
n
g
a
n
d
m
u
ltip
l
y
i
n
g
t
h
e
co
ef
f
icie
n
t
s
,
f
i
n
all
y
th
e
s
i
m
p
le
li
n
ea
r
f
o
r
m
is
b
eg
o
tte
n
)
.
(4)
T
h
e
s
i
m
ilar
it
y
b
et
w
ee
n
t
w
o
DN
A
alleles
is
t
h
u
s
ca
lc
u
late
d
as
th
e
a
v
er
ag
e
o
f
t
h
e
s
i
m
il
ar
it
y
o
f
t
h
e
en
tire
lo
cu
s
,
w
h
ic
h
in
t
u
r
n
is
a
r
ith
m
etic
m
ea
n
,
w
h
ich
i
s
ex
p
r
ess
ed
as
)
(
5
)
w
h
er
e
is
th
e
v
alu
e
o
f
s
i
m
i
lar
it
y
b
et
w
ee
n
DN
A
p
r
o
f
ile
e
v
id
en
ce
an
d
DN
A
p
r
o
f
ile
r
e
f
e
r
en
ce
o
f
t
h
e
i
-
th
in
d
iv
id
u
al.
T
h
e
n
ex
t
s
tep
to
o
b
tain
th
e
ST
R
s
i
m
ilar
it
y
v
alu
e
is
to
ca
lcu
late
t
h
e
s
i
m
ilar
it
y
b
et
w
ee
n
an
d
(
)
w
h
ic
h
i
s
t
h
e
f
a
m
il
y
r
e
f
er
en
ce
v
al
u
e
o
f
t
h
e
i
-
t
h
i
n
d
iv
id
u
al
t
h
r
o
u
g
h
Ma
m
d
a
n
i
FIS
[
9
]
w
h
ic
h
co
n
s
is
t
o
f
9
r
u
les as
f
o
llo
w
.
1.
I
f
is
lo
w
a
n
d
is
lo
w
th
e
n
ST
R
Si
m
ilar
i
t
y
i
s
lo
w
,
2.
I
f
is
lo
w
a
n
d
is
med
iu
m
th
en
ST
R
Si
m
ilar
it
y
is
lo
w
,
3.
I
f
lo
w
is
a
n
d
h
ig
h
is
th
en
ST
R
Si
m
ilar
it
y
is
med
iu
m
,
4.
I
f
med
iu
m
is
an
d
is
lo
w
t
h
en
ST
R
Si
m
ilar
it
y
is
med
iu
m
,
5.
I
f
is
med
iu
m
an
d
is
h
ig
h
th
en
ST
R
Si
m
ilar
it
y
is
med
iu
m
,
6.
I
f
is
med
iu
m
an
d
is
h
ig
h
th
en
ST
R
Si
m
ilar
it
y
is
med
iu
m
,
7.
I
f
is
med
iu
m
an
d
is
lo
w
t
h
en
ST
R
Si
m
ilar
it
y
is
med
iu
m
,
8.
If
is
h
ig
h
an
d
is
med
iu
m
th
en
ST
R
Si
m
ilar
it
y
is
med
iu
m
,
9.
If
is
h
ig
h
an
d
is
h
ig
h
th
en
ST
R
Si
m
ilar
it
y
is
h
ig
h
.
Fig
u
r
e
2
.
Fu
zz
y
S
i
m
ilar
it
y
b
et
w
ee
n
T
w
o
L
o
c
u
s
Fo
r
th
e
a
n
tece
d
en
t
t
h
e
f
u
zz
y
m
e
m
b
er
s
h
ip
f
u
n
c
tio
n
f
o
r
lo
w
,
med
iu
m
,
an
d
h
ig
h
ar
e
g
i
v
e
n
b
y
F
ig
u
r
e
3
.
T
h
e
lo
w
m
e
m
b
er
s
h
ip
f
u
n
ct
io
n
v
alu
e
i
s
1
w
h
en
is
0
u
n
til
0
.
1
8
,
an
d
b
ec
o
m
e
0
w
h
e
n
is
0
.
3
.
T
h
e
med
iu
m
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
h
a
s
its
p
ea
k
at
is
0
.
3
5
an
d
h
av
in
g
ze
r
o
v
alu
e
at
is
0
.
2
an
d
0
.
5
.
T
h
e
h
ig
h
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
h
as z
er
o
v
alu
e
at
is
0
.
4
an
d
1
at
is
0
.
5
u
n
ti
l 1
.
Fo
r
th
e
co
n
s
eq
u
e
n
t
th
e
f
u
zz
y
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
f
o
r
lo
w
,
med
iu
m
,
h
ig
h
ar
e
g
iv
en
b
y
Fig
u
r
e
4
.
T
h
e
lo
w
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
v
al
u
e
is
1
w
h
e
n
s
i
m
ilar
it
y
is
0
,
a
n
d
b
ec
o
m
e
s
0
w
h
e
n
s
i
m
ilar
it
y
is
0
.
4
.
T
h
e
med
iu
m
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
h
as
it
s
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ea
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at
s
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ilar
it
y
i
s
0
.
5
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d
h
as
ze
r
o
v
alu
e
w
h
e
n
s
i
m
ilar
it
y
is
0
.
3
an
d
0
.
8
.
T
h
e
h
ig
h
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
h
as
ze
r
o
v
alu
e
at
s
i
m
ilar
it
y
is
0
.
8
an
d
1
at
s
i
m
ilar
it
y
i
s
1
.
μ
)
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
0
8
8
-
8708
I
J
E
C
E
Vo
l.
6
,
No
.
6
,
Dec
em
b
er
2
0
1
6
:
3
1
0
3
–
3
111
3106
Fig
u
r
e
3
.
Fu
zz
y
Me
m
b
er
s
h
ip
Fu
n
ctio
n
f
o
r
A
n
tece
d
en
t
Fig
u
r
e
4
.
Fu
zz
y
Me
m
b
er
s
h
ip
Fu
n
ctio
n
f
o
r
C
o
n
s
eq
u
en
t
3.
T
H
E
S
T
A
T
I
S
T
I
CS O
F
T
RI
B
AL
I
NF
E
R
E
NC
E
I
n
f
o
r
e
n
s
ic
s
cie
n
ce
,
it
h
as
b
ee
n
t
h
e
s
tan
d
ar
d
to
p
r
o
f
ile
DN
A
s
a
m
p
le
s
w
i
th
th
e
S
h
o
r
t
T
an
d
e
m
R
ep
ea
t
(
ST
R
)
ch
ar
ac
ter
is
tic
o
f
ce
r
tai
n
lo
ci
[
1
1
-
1
2
]
.
T
h
e
Fed
er
al
B
u
r
ea
u
I
n
v
esti
g
atio
n
(
FB
I
)
h
a
s
ch
o
s
e
n
1
5
m
ar
k
er
s
(
ca
lled
lo
cu
s
)
an
d
a
m
elo
g
e
n
i
n
b
ased
o
n
ST
R
an
al
y
s
is
to
b
e
th
e
s
tan
d
ar
d
f
o
r
h
u
m
a
n
id
en
ti
f
icatio
n
.
T
h
e
s
tan
d
ar
d
is
ca
lled
C
O
DI
S
(
C
o
m
b
i
n
ed
DN
A
I
n
d
ex
S
y
s
te
m
)
[
3
]
,
en
ab
les
a
u
n
i
f
o
r
m
r
ep
r
esen
tat
io
n
o
f
D
N
A
p
r
o
f
ile
an
d
ex
c
h
a
n
g
e
D
N
A
b
et
w
ee
n
co
u
n
tr
ies.
T
h
e
1
5
lo
cu
s
ar
e
C
SF
F1
P
O,
FG
A
,
T
H0
1
,
T
P
OX,
VW
A
,
D2
1
S1
1
,
D3
S1
3
5
8
,
D5
S8
1
8
,
D7
S
8
2
0
,
D8
S1
1
7
9
,
D1
3
S3
1
7
,
D1
6
S5
3
9
,
D1
8
S5
1
,
D1
9
S
4
3
3
,
D2
S1
3
3
8
,
p
lu
s
a
m
elo
g
e
n
i
n
.
I
n
t
h
e
f
r
eq
u
e
n
t
c
ase
w
h
er
e
n
o
id
en
t
ical
ST
R
m
atc
h
is
f
o
u
n
d
,
a
n
y
in
te
llig
e
n
ce
w
h
ich
co
u
ld
b
e
in
f
er
r
ed
f
r
o
m
th
e
s
a
m
p
le
i
s
v
er
y
p
r
ec
io
u
s
in
aid
in
g
th
e
i
n
v
esti
g
a
tio
n
,
e
s
p
ec
iall
y
i
n
r
ed
u
c
in
g
t
h
e
n
u
m
b
er
o
f
in
ter
v
ie
w
s
an
d
s
u
s
p
ec
ts
.
I
n
f
o
r
m
atio
n
r
eg
ar
d
i
n
g
t
h
e
p
r
o
b
ab
le
eth
n
icit
y
an
d
tr
ib
al
in
f
o
r
m
ati
o
n
o
f
an
o
th
er
w
is
e
to
tall
y
u
n
k
n
o
w
n
o
f
f
en
d
er
m
a
y
h
elp
in
v
es
tig
ato
r
s
to
lo
o
k
f
o
r
tar
g
ets
an
d
s
etti
n
g
p
r
io
r
ities
f
o
r
m
as
s
s
cr
ee
n
i
n
g
o
r
in
ter
v
ie
w
s
[
3
]
.
On
e
o
f
t
h
e
in
f
o
r
m
atio
n
th
a
t
co
u
ld
b
e
i
n
f
e
r
r
ed
is
th
e
tr
ib
al
i
n
f
o
r
m
atio
n
o
f
th
e
p
er
s
o
n
f
r
o
m
w
h
ic
h
th
e
DN
A
s
a
m
p
le
is
p
r
o
f
iled
.
T
h
er
e
h
av
e
b
ee
n
a
lo
t
o
f
s
tu
d
ie
s
co
n
ce
r
n
i
n
g
th
e
v
a
r
iatio
n
o
f
th
e
ST
R
p
r
o
f
ile
p
r
o
p
o
r
tio
n
b
et
w
ee
n
tr
ib
al
p
o
p
u
latio
n
s
[
1
3
-
1
4
]
.
I
n
o
n
e
s
t
u
d
y
,
Gil
l
et
al.
[
1
5
]
h
av
e
d
escr
ib
ed
d
is
tr
ib
u
tio
n
s
f
o
r
t
h
r
ee
tr
ib
al
g
r
o
u
p
s
e
m
p
lo
y
i
n
g
f
o
u
r
d
if
f
er
e
n
t
s
i
n
g
le
lo
cu
s
p
r
o
b
es.
T
h
e
c
o
n
f
ir
m
atio
n
th
at
th
e
tech
n
iq
u
e
i
n
[
1
5
]
ca
n
p
r
o
v
id
e
q
u
ali
f
ied
in
d
icat
io
n
s
,
b
u
t
n
o
t
tr
ib
al
ca
teg
o
r
ical
co
n
c
lu
s
io
n
s
ar
e
g
i
v
e
n
,
it
h
as
b
ee
n
d
escr
ib
ed
b
y
E
v
ett
et
al.
[
6
]
.
I
n
co
n
tr
ast,
i
n
t
h
i
s
p
ap
er
,
th
e
n
o
v
el
m
e
th
o
d
to
i
n
f
er
tr
ib
al
in
f
o
r
m
at
io
n
o
f
a
p
er
s
o
n
is
p
r
o
p
o
s
ed
.
4.
T
H
E
P
RO
P
O
SE
D
T
R
I
B
AL
I
NF
E
R
E
NC
E
T
h
e
d
ev
elo
p
m
e
n
t
o
f
t
h
e
F
u
zz
y
I
n
f
er
en
ce
S
y
s
te
m
(
FI
S)
f
o
r
th
e
DN
A
p
r
o
f
ile
m
atc
h
i
n
g
w
a
s
f
o
cu
s
ed
o
n
h
o
w
to
in
f
er
s
tatis
ticall
y
u
s
ef
u
l
i
n
f
o
r
m
atio
n
f
r
o
m
t
h
e
DN
A
p
r
o
f
i
les.
T
h
e
id
ea
o
f
t
h
e
p
r
o
p
o
s
ed
m
eth
o
d
i
s
to
in
co
r
p
o
r
ate
th
e
s
tatis
tica
l
p
r
o
p
er
ty
o
f
P
r
o
b
ab
ilit
y
Den
s
it
y
Fu
n
ctio
n
o
f
th
e
d
is
tr
ib
u
tio
n
o
f
allele
m
ar
k
er
s
o
f
ce
r
tain
tr
ib
al
in
f
o
r
m
atio
n
a
n
d
in
co
r
p
o
r
ate
th
e
ca
lcu
latio
n
u
s
in
g
T
ak
ag
i
-
S
u
g
e
n
o
FIS
[
8
]
.
Fig
u
r
e
5
s
h
o
w
s
th
e
o
v
er
v
ie
w
o
f
h
o
w
th
e
a
lg
o
r
it
h
m
i
s
ca
r
r
ied
o
u
t.
Star
t
s
tep
is
to
co
m
p
ar
e
t
h
e
DN
A
p
r
o
f
ile
ev
id
en
ce
w
i
th
DN
A
p
r
o
f
ile
r
ef
er
en
ce
f
r
o
m
D
N
A
d
atab
ase.
I
f
al
l r
ef
er
e
n
ce
s
h
a
v
e
n
o
t b
ee
n
ch
e
c
k
ed
,
p
ick
th
e
n
e
x
t r
e
f
er
en
ce
p
r
o
f
i
le.
I
f
all
lo
ci
h
av
e
n
o
t
b
ee
n
co
m
p
ar
ed
th
en
co
m
p
ar
e
t
h
e
n
e
x
t
lo
ci
u
s
i
n
g
th
e
p
r
o
p
o
s
ed
FIS.
I
f
all
lo
cu
s
h
av
e
b
ee
n
co
m
p
ar
ed
,
th
e
n
ch
ec
k
w
h
et
h
e
r
all
r
ef
er
en
ce
s
h
a
v
e
b
ee
n
ch
e
ck
ed
o
r
n
o
t.
I
f
all
r
ef
er
en
ce
s
h
av
e
b
ee
n
c
h
ec
k
ed
th
en
ca
lc
u
late
t
h
e
a
v
er
ag
e
tr
ib
al
s
i
m
ilar
it
y
.
Af
ter
t
h
at,
ca
lcu
l
ate
th
e
ag
g
r
eg
a
te
tr
ib
al
s
i
m
ilar
it
y
v
a
lu
e.
T
h
e
p
r
o
p
o
s
ed
FIS
ca
n
b
e
co
n
f
i
g
u
r
ed
to
u
s
e
as
m
a
n
y
p
r
o
f
il
es
as
in
te
n
d
ed
,
an
d
t
h
er
e
f
o
r
e
g
iv
in
g
t
h
e
in
v
e
s
ti
g
ato
r
th
e
f
le
x
ib
ilit
y
i
n
t
esti
n
g
d
i
f
f
er
e
n
t
tr
ib
al
g
r
o
u
p
s
.
T
h
e
f
o
llo
w
i
n
g
ex
p
lai
n
s
in
d
et
ail
th
e
w
al
k
t
h
r
o
u
g
h
o
f
th
e
f
r
a
m
e
w
o
r
k
th
a
t
is
e
m
b
o
d
ied
in
th
e
p
r
o
p
o
s
ed
FIS,
w
h
ic
h
u
s
es
t
h
e
allele
m
ar
k
er
’
s
d
is
tr
ib
u
tio
n
a
s
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
.
An
d
th
en
ad
j
u
s
t
th
e
s
etti
n
g
s
o
f
t
h
e
T
ak
ag
i
-
Su
g
e
n
o
FIS
an
d
p
er
f
o
r
m
s
o
m
e
ca
lc
u
latio
n
s
to
o
b
tain
th
e
v
al
u
e
t
h
at
r
ef
lec
t
s
th
e
tr
ib
al
i
n
f
o
r
m
atio
n
s
i
m
ila
r
it
y
b
et
w
ee
n
t
w
o
ST
R
-
B
ased
DN
A
p
r
o
f
iles
.
T
h
e
h
y
p
o
t
h
esi
s
in
e
m
b
ed
d
in
g
t
h
e
t
r
ib
al
in
f
o
r
m
atio
n
i
n
f
er
en
ce
i
n
th
e
p
r
o
p
o
s
ed
FIS
is
to
s
o
m
e
h
o
w
i
n
co
r
p
o
r
ate
th
e
s
tatis
t
ical
p
r
o
p
er
ty
o
f
th
e
tr
ib
al
ch
ar
ac
ter
is
tic
s
o
th
at
t
h
e
tr
i
b
al
in
f
o
r
m
atio
n
i
s
n
o
t
lo
s
t
in
th
e
ST
R
s
i
m
ilar
it
y
ca
lcu
latio
n
.
I
t
h
a
s
b
ee
n
n
o
ted
th
at
alt
h
o
u
g
h
M.
R
.
W
id
y
a
n
to
et
al
[
4
]
w
er
e
ad
eq
u
ate
i
n
ass
i
g
n
in
g
a
f
u
zz
y
s
i
m
ilar
it
y
m
ea
s
u
r
e
b
et
w
ee
n
t
w
o
a
lleles,
t
h
e
s
tati
s
tical
in
f
o
r
m
atio
n
r
eg
ar
d
in
g
t
h
e
t
w
o
p
r
o
f
ile
’
s
tr
ib
al
in
f
o
r
m
atio
n
is
lo
s
t.
T
h
is
lo
s
t
i
n
f
o
r
m
atio
n
i
s
w
h
at
t
h
e
s
y
s
te
m
is
tr
y
i
n
g
to
r
eg
ain
.
I
n
itial
s
tatis
tical
a
n
al
y
s
i
s
o
f
th
e
DN
A
p
r
o
f
ile
s
s
h
o
w
ed
an
in
ter
esti
n
g
p
atter
n
.
I
t
s
ee
m
s
th
at
t
h
e
allele
m
ar
k
er
s
’
p
r
o
b
ab
ilit
y
d
is
tr
ib
u
ti
o
n
s
w
it
h
i
n
a
tr
ib
al
g
r
o
u
p
f
o
r
m
a
Gau
s
s
ia
n
d
is
tr
ib
u
tio
n
w
it
h
d
i
f
f
er
en
t
s
ta
n
d
ar
d
d
ev
iatio
n
s
b
et
w
ee
n
tr
ib
al
g
r
o
u
p
s
.
l
o
w
m
e
d
i
u
m
h
i
g
h
l
o
w
m
e
d
i
u
m
h
i
g
h
h
i
g
h
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
E
C
E
I
SS
N:
2
0
8
8
-
8708
A
N
o
ve
l H
u
ma
n
S
TR
S
imila
r
ity
Meth
o
d
Usi
n
g
C
a
s
c
a
d
e
S
ta
ti
s
tica
l F
u
z
z
y
R
u
les
.
.
.
.
(
M.
R
a
h
ma
t W
id
ya
n
to
)
3107
Fig
u
r
e
6
d
ep
icts
t
h
e
p
lo
t
o
f
t
h
e
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ar
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J
av
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ig
u
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e
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h
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Ov
er
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ie
w
o
f
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T
r
ib
al
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n
f
o
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m
atio
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n
f
er
e
n
ce
Fig
u
r
e
6
.
T
h
e
Gau
s
s
ia
n
d
is
tr
i
b
u
tio
n
o
f
A
l
lele
Ma
r
k
er
Val
u
e
A
lt
h
o
u
g
h
it
h
a
s
b
ee
n
s
aid
th
at
ea
ch
tr
ib
al
g
r
o
u
p
h
as
th
eir
u
n
iq
u
e
allele
d
is
tr
ib
u
tio
n
,
th
er
e
is
a
ca
v
ea
t
th
at
t
h
e
d
i
f
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er
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ce
i
n
th
eir
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i
s
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r
ib
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s
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er
y
t
ig
h
t
a
n
d
h
ar
d
ly
d
is
cr
i
m
i
n
ati
v
e.
T
ak
in
g
t
h
i
s
s
tatis
tical
p
r
o
p
er
ty
,
th
e
lo
g
ical
h
y
p
o
th
e
s
is
i
s
to
e
m
b
ed
t
h
i
s
Ga
u
s
s
ian
P
r
o
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ab
ilit
y
De
n
s
it
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Fu
n
ctio
n
(
P
DF)
as
th
e
m
e
m
b
er
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h
ip
f
u
n
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n
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th
e
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r
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o
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ed
FIS
th
at
is
b
u
ilt
.
T
h
is
w
a
y
,
th
e
Gau
s
s
ia
n
f
u
n
ctio
n
ac
ts
s
i
m
ila
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to
a
m
e
m
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er
s
h
i
p
f
u
n
ctio
n
t
h
at
as
s
ig
n
a
v
alu
e
t
o
an
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lele
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ar
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er
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to
w
h
ich
tr
ib
al
g
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p
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t
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elo
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g
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to
.
T
h
e
Gau
s
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ia
n
P
DF
is
d
escr
ib
ed
as
(
)
.
/
(
6
)
W
h
er
e
in
t
h
e
li
g
h
t
o
f
th
e
s
tat
is
tical
i
n
f
o
r
m
atio
n
,
,
is
th
e
m
ea
n
o
f
t
h
e
d
is
tr
ib
u
tio
n
(
th
e
p
ea
k
o
f
t
h
e
cu
r
v
e)
,
an
d
is
t
h
e
s
tan
d
ar
d
d
ev
iatio
n
o
f
t
h
e
d
is
t
r
ib
u
tio
n
.
Fi
g
u
r
e
6
s
h
o
w
s
h
o
w
th
e
Ga
u
s
s
i
a
n
m
e
m
b
er
s
h
ip
f
u
n
ctio
n
g
e
n
er
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ted
f
r
o
m
t
h
e
av
er
a
g
e
an
d
s
tan
d
ar
d
d
ev
iatio
n
o
f
th
e
d
at
a
f
it
s
th
e
m
ar
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er
d
is
tr
ib
u
tio
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o
f
t
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alle
le
m
ar
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er
(
m
ar
k
ed
b
y
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h
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s
p
ik
y
li
n
e
f
l
u
ctu
a
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n
s
)
,
th
u
s
m
o
d
eli
n
g
th
e
p
r
o
b
ab
ilit
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d
en
s
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6
8
10
12
14
16
18
20
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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I
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ip
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a
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ar
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lar
tr
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p
.
Fi
g
u
r
e
7
s
h
o
w
s
t
h
e
d
is
cr
ete
d
is
tr
ib
u
tio
n
o
f
s
tatis
t
i
ca
l
tr
ib
al
d
ata:
r
a
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ata
an
d
Fi
g
u
r
e
8
s
h
o
w
s
t
h
e
ad
j
u
s
ted
d
is
c
r
ete
d
is
tr
ib
u
tio
n
o
f
s
tatis
t
ical
tr
ib
al
d
ata:
af
ter
n
at
u
r
al
ad
j
u
s
t
m
e
n
t
.
Fig
u
r
e
7
.
T
h
e
Dis
cr
ete
Dis
tr
ib
u
tio
n
o
f
Stati
s
tical
T
r
i
b
al
Data
:
R
a
w
Dat
a
Fig
u
r
e
8
.
T
h
e
A
d
j
u
s
ted
Dis
cr
ete
Dis
tr
ib
u
tio
n
o
f
Statis
t
ical
T
r
ib
al
Data
: A
f
ter
Natu
r
al
A
d
j
u
s
t
m
en
t
T
h
e
p
r
o
p
o
s
ed
m
et
h
o
d
co
n
s
is
t
s
o
f
t
w
o
ca
s
ca
d
e
F
u
zz
y
I
n
f
er
en
ce
S
y
s
te
m
s
(
FIS)
.
T
h
e
f
ir
s
t
w
h
ich
i
s
b
ased
o
n
T
ak
ag
i
-
S
u
g
e
n
o
FI
S
[
8
]
is
to
ca
lcu
late
t
h
e
tr
ib
al
s
i
m
ilar
it
y
,
a
n
d
t
h
e
s
ec
o
n
d
th
a
t
is
b
ased
o
n
Ma
m
d
a
n
i
FIS
[
9
]
is
to
ca
lcu
late
th
e
ST
R
s
i
m
ilar
it
y
.
T
h
e
T
ak
ag
i
-
Su
g
e
n
o
FIS
tak
e
s
t
w
o
in
p
u
ts
a
n
d
t
w
o
o
u
tp
u
ts
,
w
i
t
h
t
h
e
f
ir
s
t
o
u
tp
u
t
b
ein
g
t
h
e
i
n
p
u
t
f
o
r
th
e
s
ec
o
n
d
FIS
a
n
d
t
h
e
s
ec
o
n
d
o
u
tp
u
t
i
s
t
h
e
tr
ib
al
s
i
m
i
lar
it
y
th
at
i
n
d
icate
s
h
o
w
clo
s
e
th
e
co
n
tr
o
l
p
r
o
f
ile
an
d
th
e
q
u
er
y
p
r
o
f
ile
eth
n
icall
y
.
T
h
is
is
in
co
n
tr
ast
to
p
r
ev
io
u
s
ex
i
s
ti
n
g
DN
A
m
atc
h
in
g
a
lg
o
r
it
h
m
s
w
h
ic
h
o
n
l
y
p
r
o
d
u
ce
o
n
e
ST
R
s
i
m
ilar
it
y
s
co
r
e
[
4
]
.
T
h
e
tr
ib
al
s
i
m
il
ar
it
y
s
co
r
e
i
s
o
n
l
y
u
s
e
f
u
l
w
h
e
n
t
h
e
ev
id
en
ce
p
r
o
f
ile
is
co
m
p
ar
ed
to
a
g
r
o
u
p
o
f
r
ef
er
en
ce
p
r
o
f
iles
w
h
o
s
e
eth
n
icit
y
is
k
n
o
w
n
b
ef
o
r
eh
an
d
.
Fi
g
u
r
e
9
s
h
o
w
s
t
h
e
ar
r
an
g
e
m
e
n
t o
f
t
h
e
FIS.
Fig
u
r
e
9
.
T
h
e
C
o
n
f
i
g
u
r
atio
n
o
f
th
e
T
ak
ag
i
-
Su
g
e
n
o
FIS
5.
E
XP
E
RM
E
NT
AL
R
E
SU
L
T
S
T
o
ex
am
i
n
e
t
h
e
d
is
cr
i
m
i
n
ati
n
g
ab
ilit
y
o
f
t
h
e
p
r
o
p
o
s
ed
f
u
zz
y
i
n
f
er
e
n
ce
s
y
s
te
m
(
FI
S),
a
p
r
o
to
ty
p
e
i
s
i
m
p
le
m
en
ted
a
n
d
an
ex
p
er
i
m
e
n
t
u
s
i
n
g
a
r
ea
l
d
ataset
co
n
tai
n
in
g
7
2
7
p
r
o
f
iles
f
r
o
m
t
h
e
p
eo
p
le
o
f
I
n
d
o
n
esia
is
co
n
d
u
cted
.
T
h
e
p
r
o
p
o
s
ed
ca
s
ca
d
e
Fu
zz
y
I
n
f
er
e
n
ce
S
y
s
te
m
(
FIS)
is
i
m
p
le
m
e
n
ted
in
M
icr
o
s
o
f
t
.
NE
T
p
latf
o
r
m
u
s
i
n
g
C
#
as
th
e
p
r
o
g
r
a
m
m
i
n
g
la
n
g
u
a
g
e
a
n
d
u
s
i
n
g
Vi
s
u
al
St
u
d
io
2
0
1
5
I
DE
.
T
h
e
d
atab
ase
is
s
to
r
ed
in
a
M
y
SQ
L
DB
MS
s
to
r
in
g
7
2
7
p
r
o
f
ile
d
ata.
T
h
e
Fu
zz
y
L
o
g
ic
L
ib
r
ar
y
i
s
b
ased
o
n
Fu
zz
y
L
o
g
ic
L
ib
r
ar
y
(
h
ttp
://
f
u
zz
y
n
et.
s
o
u
r
ce
f
o
r
g
e.
n
et/)
,
m
o
d
if
ied
to
s
o
m
e
e
x
ten
t
to
s
u
p
p
o
r
t
th
e
f
ea
t
u
r
es
u
s
ed
in
t
h
e
FIS
d
esig
n
w
h
ic
h
is
p
r
ev
io
u
s
l
y
u
n
a
v
ailab
le
in
t
h
e
d
e
f
au
lt
p
ac
k
a
g
e.
T
h
e
d
atab
ase
is
ac
ce
s
s
ed
an
d
m
ap
p
ed
u
s
in
g
t
h
e
O
R
M
Vici
C
o
o
ls
to
r
ag
e
(
h
t
tp
://v
icip
r
o
j
ec
t.c
o
m
/
).
5
.
1
.
ST
R
Si
m
ila
rit
y
E
x
peri
m
e
nt
Desig
n
T
h
e
f
ir
s
t
ex
p
er
i
m
e
n
t
is
to
ex
a
m
i
n
e
th
e
ST
R
Si
m
ilar
it
y
p
er
f
o
r
m
an
ce
b
y
co
m
p
ar
i
n
g
th
e
p
r
o
p
o
s
ed
C
ascad
e
FIS,
th
e
p
r
ev
io
u
s
F
u
zz
y
S
h
o
r
t
T
an
d
em
R
ep
ea
t
(
ST
R
)
Si
m
ilar
it
y
[
4
]
,
an
d
th
e
co
n
v
en
tio
n
al
ST
R
m
atc
h
[
1
1
]
.
T
h
e
d
ata
is
7
2
7
o
f
I
n
d
o
n
esia
ST
R
B
ased
D
N
A
p
r
o
f
iles
.
T
h
e
e
x
p
er
i
m
e
n
t
is
d
e
s
i
g
n
to
ca
lc
u
late
th
e
s
i
m
ilar
it
y
b
et
w
ee
n
ea
ch
ST
R
p
r
o
f
ile
w
it
h
h
is
o
r
h
er
f
a
m
i
l
y
ST
R
p
r
o
f
ile
i.e
.
f
ath
er
o
r
m
o
th
er
o
r
s
ib
lin
g
av
ailab
le
i
n
t
h
e
d
atab
ase.
I
f
th
e
ST
R
s
i
m
i
lar
it
y
is
g
r
ea
ter
th
a
n
0
.
5
th
en
th
e
f
a
m
il
y
r
el
atio
n
s
h
ip
is
co
r
r
ec
t
o
th
er
w
is
e
f
alse.
T
h
e
T
ab
le
1
b
elo
w
s
h
o
w
s
t
h
e
co
r
r
ec
tn
es
s
p
er
ce
n
tag
e
o
f
t
h
e
t
h
r
ee
m
eth
o
d
s
co
m
p
ar
ed
.
T
h
e
S
T
R
S
i
mi
l
a
r
i
t
y
T
r
i
b
a
l
S
i
mi
l
a
r
i
t
y
I
n
p
u
t
t
o
M
a
m
d
a
n
i
F
I
S
Evaluation Warning : The document was created with Spire.PDF for Python.
I
J
E
C
E
I
SS
N:
2
0
8
8
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8708
A
N
o
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l H
u
ma
n
S
TR
S
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ity
Meth
o
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Usi
n
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a
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a
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tica
l F
u
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R
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tab
le
s
h
o
w
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th
a
t
th
e
p
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s
ed
m
e
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ac
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v
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th
e
ac
c
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f
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%,
m
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th
e
p
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u
s
Fu
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y
ST
R
Si
m
i
lar
it
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m
eth
o
d
[
4
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also
ac
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t
h
e
ac
c
u
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ac
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o
f
1
0
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%.
I
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T
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[
1
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ly
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R
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ile.
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t
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C
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Fu
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Mo
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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N
:
2
0
8
8
-
8708
I
J
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C
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Vo
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6
,
No
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6
,
Dec
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b
er
2
0
1
6
:
3
1
0
3
–
3
111
3110
d
is
cr
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m
i
n
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o
f
t
h
e
p
r
o
f
iles
.
Ho
w
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v
er
w
h
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n
ad
j
u
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ted
,
th
e
r
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lt
s
s
h
o
w
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u
p
a
s
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g
n
i
f
ica
n
t
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m
p
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en
t.
T
h
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m
o
s
t i
m
p
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tan
t t
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,
t
h
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r
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h
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t
h
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p
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p
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m
et
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d
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ap
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g
T
ak
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u
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FIS
w
it
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d
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t r
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5.
CO
NCLU
SI
O
NS
A
n
o
v
el
h
u
m
an
ST
R
(
Sh
o
r
t
T
an
d
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m
R
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t)
s
i
m
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et
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s
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n
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s
ca
d
e
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ta
tis
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tr
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f
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in
f
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ce
is
p
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.
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e
p
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p
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m
et
h
o
d
co
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(
FI
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T
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FIS
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s
to
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[1
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H.
Kitak
a
m
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t
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l.
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―
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m
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to
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n
d
A
su
k
a
:
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A
Da
tab
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se
M
a
n
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g
.
e
m
e
n
t
S
y
ste
m
,
‖
Pro
c
.
o
f
2
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th
An
n
u
a
l
Ha
w
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ii
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t
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Co
n
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o
n
S
y
ste
m S
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e
s
,
2
0
0
5
.
[2
]
R
.
C.
M
ich
a
e
li
s,
e
t
a
l.
,
―
A
L
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ig
a
to
r‖
s
G
u
id
e
to
DN
A
:
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ro
m
th
e
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a
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o
ra
to
ry
to
th
e
Co
u
r
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o
m
,
‖
El
se
v
ier
A
c
a
d
e
m
ic
P
re
ss
,
2
0
0
8
.
[3
]
C.
M
.
Ru
it
b
e
rg
,
e
t
a
l.
,
―
S
T
RBa
se
:
A
S
h
o
rt
T
a
n
d
e
m
Re
p
e
a
t
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A
Da
tab
a
s
e
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th
e
Hu
m
a
n
Id
e
n
ti
ty
Tes
ti
n
g
Co
m
m
u
n
it
y
,
‖
Nu
c
leid
a
n
d
Acid
R
e
se
a
rc
h
,
v
ol
/i
ss
u
e
:
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(
1
)
,
2
0
0
1
.
[4
]
M
.
R.
W
id
y
a
n
to
,
e
t
a
l.
,
―
V
a
rio
u
s
d
e
f
u
z
z
i
f
ica
ti
o
n
m
e
th
o
d
s
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A
si
m
il
a
rit
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a
tch
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g
su
in
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f
u
z
z
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in
fe
re
n
c
e
s
y
ste
m
,
‖
J
o
u
rn
a
l
o
f
Ad
v
a
n
c
e
d
C
o
mp
u
ta
ti
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tell
ig
e
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e
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n
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rm
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ti
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s
,
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ol
/i
ss
u
e
:
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(
3
)
,
2
0
1
0
.
[5
]
A
.
L
.
L
o
w
e
,
e
t
a
l.
,
―
In
f
e
rrin
g
e
th
n
ic
o
rig
in
b
y
m
e
a
n
s
o
f
a
n
S
T
R
p
ro
f
il
e
,
‖
Fo
re
n
sic
S
c
ien
c
e
In
ter
n
a
ti
o
n
a
l
,
v
ol
/i
ss
u
e
:
119
(
1
)
,
2
0
0
1
.
[6
]
I.
W
.
Ev
e
tt
,
e
t
a
l.
,
―
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n
in
v
e
stig
a
ti
o
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o
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sib
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it
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e
th
n
ic
o
r
ig
in
f
ro
m
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A
p
ro
f
il
e
s
,
‖
J
.
Fo
re
n
sic
S
c
i
,
v
ol
/i
ss
u
e
:
32
(
4
)
,
1
9
9
2
.
[7
]
Z.
L
iu
a
n
d
H.
X
.
L
i,
―
A
p
ro
b
a
b
i
li
stic
f
u
z
z
y
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s
y
ste
m
f
o
r
m
o
d
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li
n
g
a
n
d
c
o
n
tr
o
l
,
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IEE
E
T
ra
n
s
Fu
zz
y
S
y
ste
ms
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v
ol
/i
ss
u
e
:
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(
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)
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p
p
.
8
4
8
-
8
5
9
,
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0
0
5
.
[8
]
M
.
S
u
g
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o
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―
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n
d
u
strial
a
p
p
li
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a
ti
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s o
f
f
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z
z
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o
n
tro
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se
v
ier S
c
ien
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e
P
u
b
.
Co
.
,
1
9
8
5
.
[9
]
E.
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M
a
m
d
a
n
i,
―
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p
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ti
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le
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m
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o
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o
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In
stit
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ti
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c
trica
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En
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/i
ss
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e
:
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(
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.
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0
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slim
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a
n
,
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u
z
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il
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rit
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M
e
a
su
re
,
‖
S
p
rin
g
e
r,
2
0
0
6
.
[1
1
]
J.
M
.
B
u
tl
e
r,
―
S
T
RBa
se
a
n
d
I
n
f
o
rm
a
ti
o
n
Re
so
u
rc
e
s
o
n
F
o
re
n
sic
DN
A
,
‖
Na
ti
o
n
a
l
In
stit
u
te
o
f
S
tan
d
a
rd
s
&
T
e
c
h
n
o
lo
g
y
–
U.S
.
De
p
t
o
f
Co
m
m
e
rc
e
,
2
0
1
2
.
[1
2
]
T
.
M
.
Cla
y
to
n
,
e
t
a
l.
,
―
A
n
a
ly
sis
a
n
d
in
ter
p
re
tatio
n
o
f
m
i
x
e
d
stra
i
n
s
u
sin
g
DN
A
S
T
R
p
ro
f
il
in
g
,
‖
Fo
re
n
sic
S
c
ien
c
e
In
ter
n
a
t
io
n
a
l
,
v
ol
/i
ss
u
e
:
91
(
1
)
,
1
9
9
8
.
[1
3
]
J.
M
.
B
u
tl
e
r,
―
F
o
re
n
sic
DN
A
Ty
p
in
g
:
Bio
l
o
g
y
a
n
d
T
e
c
h
n
o
lo
g
y
Be
h
in
d
S
T
R
M
a
rk
e
rs
,
‖
A
c
a
d
e
m
i
c
P
re
ss
,
2
0
0
1
.
[1
4
]
X
.
F
o
se
ll
a
a
,
e
t
a
l.
,
―
A
ss
ig
n
in
g
in
d
iv
id
u
a
ls
t
o
e
t
h
n
ic
g
ro
u
p
s
b
a
se
d
o
n
1
3
S
T
R
lo
c
i
,
‖
Pr
o
c
.
o
f
I
n
ter
n
a
ti
o
n
a
l
C
o
n
g
re
ss
S
e
rie
s
,
p
p
.
1
2
6
1
,
2
0
0
4
.
[1
5
]
M
.
G
ra
y
d
o
n
,
e
t
a
l.
,
―
In
f
e
rrin
g
e
t
h
n
icity
u
sin
g
1
5
a
u
to
so
m
a
l
S
T
R
l
o
c
i
—
Co
m
p
a
riso
n
s
a
m
o
n
g
p
o
p
u
latio
n
s
o
f
si
m
il
a
r
a
n
d
d
isti
n
c
tl
y
d
if
fe
re
n
t
p
h
y
sic
a
l
traits
,
‖
Fo
re
n
sic
S
c
ien
c
e
In
ter
n
a
ti
o
n
a
l:
Ge
n
e
ti
c
s
,
v
o
l.
3
,
pp.
2
5
1
–
2
5
4
,
2
0
0
9
.
B
I
O
G
RAP
H
I
E
S
O
F
AUTH
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RS
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