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alu
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o
f
p
r
o
p
er
ty
1
4
eq
u
al
to
(
0
)
.
T
ab
le
1
s
u
m
m
ar
izes
th
e
im
p
o
r
tan
t
an
d
m
o
s
t
r
ec
en
t
r
esear
ch
th
at
class
if
ied
th
is
d
is
ea
s
e
b
y
ca
teg
o
r
izin
g
th
e
d
atab
ase
(
Statlo
g
)
th
e
d
ata
s
et
in
th
e
tab
le
s
o
r
ted
b
y
y
ea
r
o
f
p
u
b
licatio
n
.
T
ab
le
1
.
Su
m
m
ar
y
o
f
p
r
ev
io
u
s
r
elev
an
t r
esear
c
h
a
c
c
u
r
a
c
y
M
e
t
h
o
d
s
u
se
d
R
e
se
a
r
c
h
e
r
N
a
me
a
n
d
Y
e
a
r
o
f
P
u
b
l
i
c
a
t
i
o
n
8
6
%
N
a
v
i
e
b
a
y
e
s a
n
d
l
a
p
l
si
n
g
smo
t
h
i
n
g
[
V
i
n
c
y
C
h
e
r
i
a
n
2
0
1
7
]
8
3
.
5
1
6
5
%
B
a
y
e
s Ne
t
[
B
h
a
r
t
i
D
a
n
se
n
a
2
0
1
7
]
7
5
.
8
8
8
9
%
C
h
a
o
t
i
c
P
a
r
t
i
c
l
e
S
w
a
r
m O
p
t
i
mi
z
a
t
i
o
n
Z
a
h
r
a
A
ssar 2
0
1
5
]
[
z
a
d
e
h
8
7
.
5
%
S
u
p
p
o
r
t
V
e
c
t
o
r
M
a
c
h
i
n
e
[
E
b
e
n
e
z
e
r
O
.
O
l
a
n
i
y
i
2
0
1
5
]
8
9
%
G
A
a
n
d
K
N
N
w
i
t
h
w
e
i
g
h
t
s
[
A
sh
a
G
.
K
a
r
e
g
o
w
d
a
2
0
1
4
]
8
5
.
5
9
%
F
e
a
t
u
r
e
S
e
l
e
c
t
i
o
n
b
a
se
d
L
e
a
st
S
q
u
a
r
e
Tw
i
n
S
u
p
p
o
r
t
V
e
c
t
o
r
M
a
c
h
i
n
e
[
D
i
v
y
a
T
o
mar 2
0
1
4
]
8
5
.
9
%
H
y
b
r
i
d
N
a
ï
v
e
B
a
y
e
s C
l
a
ssi
f
i
e
r
a
n
d
K
N
N
[
El
ma
Z
.
F
e
r
d
o
u
sy
2
0
1
3
]
6
2
.
2
2
%
K
me
a
n
s
[
S
h
a
d
i
I
.
A
b
u
d
a
l
f
a
2
0
1
3
]
7
5
.
1
5
%
G
A
t
o
r
e
d
u
c
e
f
e
a
t
u
r
e
a
n
d
d
e
t
e
r
mi
n
e
c
e
n
t
e
r
s fo
r
K
-
me
a
n
s
[
A
sh
a
G
.
K
a
r
e
g
o
w
d
a
2
0
1
2
]
8
4
.
4
4
%
K
N
N
[
M
u
h
a
m
ma
d
A
r
i
f
2
0
1
2
]
8
6
.
6
6
6
7
%
F
u
z
z
y
Emp
h
a
t
i
c
C
o
n
s
t
r
a
i
n
t
s Su
p
p
o
r
t
V
e
c
t
o
r
M
a
c
h
i
n
e
[
M
o
st
a
f
a
S
a
b
z
e
k
a
r
2
0
1
0
]
2.
P
RO
P
O
SE
D
M
E
T
H
O
D
Au
to
m
a
ted
clas
s
if
icatio
n
f
o
r
d
is
ea
s
es
is
o
n
e
o
f
t
h
e
m
o
s
t i
m
p
o
r
tan
t a
p
p
licatio
n
s
th
a
t
u
s
e
co
m
p
u
ter
s
to
s
er
v
e
p
eo
p
le
in
h
ea
lt
h
in
s
tit
u
ti
o
n
s
.
T
h
is
s
t
u
d
y
d
ea
ls
w
it
h
u
s
i
n
g
k
-
m
ea
n
s
m
eth
o
d
i
n
t
h
e
cla
s
s
i
f
icatio
n
o
f
h
ea
r
t
attac
k
a
n
d
t
h
e
n
p
r
o
p
o
s
es
a
m
e
th
o
d
to
i
m
p
r
o
v
e
t
h
e
p
er
f
o
r
m
a
n
ce
o
f
t
h
is
m
e
th
o
d
b
y
u
s
i
n
g
th
e
g
e
n
etic
al
g
o
r
it
h
m
f
o
r
r
ed
u
cin
g
p
r
o
p
er
ties
an
d
d
e
lete
th
e
i
n
s
i
g
n
if
ican
t p
r
o
p
er
ti
es
.
2
.
1
.
Cla
s
s
if
y
Da
t
a
ba
s
e
u
s
ing
(
K
-
M
e
a
ns
)
I
n
itiall
y
i
t
w
a
s
s
elec
ted
as
a
m
et
h
o
d
to
class
if
y
t
h
e
s
elec
t
ed
d
atab
ase
ac
co
r
d
in
g
to
th
e
f
o
llo
w
i
n
g
s
tep
s
:
A
l
g
o
r
i
t
h
m
(
k
-
m
e
a
n
s
(
t
o
c
l
a
ssi
f
y
h
e
a
r
t
a
t
t
a
c
k
In
p
u
t
:
g
l
o
b
a
l
d
a
t
a
b
a
se
(
S
t
a
t
l
o
g
(
.
Ou
t
p
u
t
:
a
c
c
u
r
a
c
y
o
f
c
l
a
ssi
f
i
c
a
t
i
o
n
.
S
t
e
p
s
:
1.
D
e
t
e
r
mi
n
e
t
h
e
n
u
m
b
e
r
o
f
c
l
u
st
e
r
s a
n
d
b
e
2
.
2.
C
h
o
o
se
t
w
o
r
o
w
s
o
f
t
h
e
2
7
0
r
o
w
s
t
o
b
e
t
h
e
p
r
i
mary
c
e
n
t
e
r
s
f
o
r
t
h
e
t
w
o
c
l
u
st
e
r
s,
a
n
d
t
h
i
s
i
s
d
o
n
e
r
a
n
d
o
ml
y
p
r
o
v
i
d
e
d
t
h
a
t
o
n
e
o
f
t
h
e
c
a
se
s i
s
c
l
a
ss
i
f
i
e
d
(
0
)
w
h
i
l
e
t
h
e
o
t
h
e
r
i
s
c
l
a
ssi
f
i
e
d
a
s
(
1
).
3.
Ea
c
h
c
a
se
i
s
a
l
l
o
c
a
t
e
d
t
o
t
h
e
a
p
p
r
o
p
r
i
a
t
e
c
l
u
st
e
r
b
y
c
a
l
c
u
l
a
t
i
n
g
t
h
e
Eu
c
l
i
d
e
a
n
d
i
st
a
n
c
e
b
e
t
w
e
e
n
t
h
e
c
a
se
a
n
d
t
h
e
c
e
n
t
e
r
s.
4.
U
p
d
a
t
e
t
h
e
c
o
u
n
t
e
r
r
e
sp
o
n
si
b
l
e
f
o
r
t
h
e
c
a
l
c
u
l
a
t
i
o
n
o
f
t
h
e
n
u
m
b
e
r
o
f
c
a
se
s
c
o
r
r
e
c
t
l
y
c
l
a
ssi
f
i
e
d
(
z
)
i
f
t
h
e
k
-
me
a
n
s
st
a
t
u
s
c
l
a
ssi
f
i
c
a
t
i
o
n
i
s
i
d
e
n
t
i
c
a
l
t
o
t
h
e
o
r
i
g
i
n
a
l
c
a
t
e
g
o
r
y
i
n
t
h
e
d
a
t
a
b
a
se
.
5.
U
p
d
a
t
e
c
e
n
t
e
r
s b
y
c
a
l
c
u
l
a
t
i
n
g
t
h
e
a
v
e
r
a
g
e
v
a
l
u
e
s o
f
e
a
c
h
c
l
u
s
t
e
r
.
6.
R
e
p
e
a
t
s
t
e
p
s 3
-
5
i
f
t
h
e
st
o
p
c
o
n
d
i
t
i
o
n
i
s n
o
t
sa
t
i
sf
y
,
i
t
s
a
t
i
sf
y
w
h
e
n
t
h
e
r
e
i
s n
o
c
h
a
n
g
e
o
n
t
h
e
c
e
n
t
e
r
s a
n
d
t
h
i
s me
a
n
s t
h
a
t
t
h
e
c
a
se
s h
a
v
e
st
a
b
i
l
i
z
e
d
i
n
t
h
e
c
l
u
st
e
r
s a
s
a
f
i
n
a
l
f
o
r
m.
7.
C
a
l
c
u
l
a
t
e
t
h
e
f
i
n
a
l
r
a
t
i
o
f
o
r
t
h
e
c
l
a
ssi
f
i
c
a
t
i
o
n
b
y
t
h
e
f
o
l
l
o
w
i
n
g
e
q
u
a
t
i
o
n
:
R
a
t
e
=
(
N
u
mb
e
r
o
f
c
a
se
s c
l
a
ssi
f
i
e
d
c
o
r
r
e
c
t
l
y
/
2
7
0
)
×
1
0
0
%
(
1
)
2
.
2
.
I
m
pro
v
ed
P
er
f
o
r
m
a
nce
o
f
K
-
M
ea
ns
by
t
he
G
enet
ic
Alg
o
rit
h
m
T
h
e
class
if
icat
io
n
s
y
s
te
m
d
ep
en
d
s
o
n
p
r
o
p
er
ties
h
av
e
a
s
ig
n
if
ica
n
t
i
m
p
ac
t
o
n
t
h
e
ac
cu
r
ac
y
o
f
s
y
s
te
m
esp
ec
iall
y
s
o
m
e
o
f
t
h
ese
p
r
o
p
er
ties
ar
e
n
o
t
n
ec
ess
ar
y
a
n
d
m
a
y
ca
u
s
e
th
e
s
y
s
te
m
to
f
all
d
o
w
n
s
o
it
is
b
est
to
d
elete
th
e
m
.
B
ec
a
u
s
e
is
co
m
p
lex
a
n
d
it
is
d
if
f
ic
u
lt
to
d
eter
m
i
n
e
t
h
ese
p
r
o
p
er
ties
th
at
n
e
g
ati
v
el
y
a
f
f
ec
t
o
n
t
h
e
p
er
f
o
r
m
a
n
ce
o
f
t
h
e
s
y
s
te
m
,
t
h
i
s
tas
k
w
as a
s
s
ig
n
ed
to
th
e
g
en
etic
alg
o
r
ith
m
.
T
h
e
g
en
etic
alg
o
r
it
h
m
s
u
g
g
e
s
ts
t
h
e
b
es
t
p
r
o
p
er
t
ies
th
at
k
-
m
ea
n
s
ca
n
r
el
y
o
n
it
i
n
t
h
e
p
r
o
c
ess
o
f
class
i
f
icatio
n
b
y
u
s
in
g
g
en
e
tic
p
r
o
ce
s
s
es
to
cr
ea
te
g
e
n
er
atio
n
s
o
f
c
h
r
o
m
o
s
o
m
e
s
.
T
h
e
p
r
o
p
o
s
ed
p
r
o
p
e
r
ties
ar
e
d
er
iv
ed
f
r
o
m
th
e
ch
r
o
m
o
s
o
m
e
w
h
ic
h
is
e
v
al
u
ated
b
y
r
u
n
n
i
n
g
t
h
e
k
-
m
ea
n
s
an
d
ca
lcu
la
tin
g
th
e
ac
c
u
r
ac
y
o
f
t
h
e
s
y
s
te
m
.
Af
ter
p
r
o
d
u
cin
g
s
ev
er
al
g
en
er
atio
n
s
th
e
al
g
o
r
ith
m
e
n
d
s
w
it
h
ch
o
o
s
i
n
g
th
e
c
h
r
o
m
o
s
o
m
e
w
h
ic
h
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
0
8
8
-
8708
I
n
t J
E
lec
&
C
o
m
p
E
n
g
,
Vo
l.
8
,
No
.
2
,
A
p
r
il
201
8
:
12
56
–
12
61
1258
p
r
o
v
id
es
th
e
p
r
o
p
er
ties
ca
p
a
b
le
o
f
r
aisi
n
g
th
e
ac
cu
r
ac
y
o
f
th
e
s
y
s
te
m
to
th
e
h
ig
h
es
t
p
o
s
s
ib
le
lev
el.
Deta
ils
o
f
th
e
p
r
o
p
o
s
ed
m
et
h
o
d
ar
e
illu
s
t
r
ated
in
th
e
f
o
llo
w
i
n
g
s
tep
s
:
Ste
p o
ne:
“
co
n
s
tr
u
ct
in
g
a
g
e
n
etic
f
o
u
n
d
atio
n
”
T
h
is
p
h
ase
in
c
lu
d
es t
h
r
ee
s
u
b
s
tep
s
:
1
)
"
S
p
ec
if
y
g
e
n
etic
al
g
o
r
ith
m
co
ef
f
icie
n
t
s
"
T
h
e
d
atab
ase
is
s
to
r
ed
in
a
n
e
x
ce
l
f
ile.
T
h
e
f
i
le
i
s
co
n
v
er
ted
i
n
to
a
t
w
o
-
d
i
m
e
n
s
io
n
al
m
atr
i
x
co
n
tain
i
n
g
2
7
0
r
o
w
s
an
d
1
4
co
lu
m
n
s
to
p
r
ev
en
t
a
n
y
er
r
o
r
s
o
r
ch
an
g
ed
m
a
y
b
e
h
ap
p
en
ed
o
n
th
e
s
e
v
al
u
es
a
n
d
f
o
r
ea
s
e
o
f
u
s
e.
I
n
th
is
s
tep
s
p
e
ci
f
y
s
o
m
e
o
f
th
e
p
ar
a
m
eter
s
th
at
th
e
g
e
n
etic
al
g
o
r
ith
m
ar
e
n
e
ed
an
d
as f
o
llo
w
s
:
1.
L
e
n
g
t
h
o
f
c
h
r
o
m
o
s
o
m
e=
n
u
m
b
er
o
f
f
ea
t
u
r
es
i
n
d
atab
ase
=1
3
(
w
h
er
e
ea
c
h
g
en
e
f
r
o
m
ch
r
o
m
o
s
o
m
e
is
ass
i
g
n
ed
to
ea
ch
p
r
o
p
er
ty
in
t
h
e
d
atab
ase
a
n
d
f
ea
t
u
r
e
N
O.
1
4
is
e
x
cl
u
d
ed
b
ec
au
s
e
it
i
s
a
n
i
d
ea
l
o
u
tp
u
t
t
h
at
is
u
s
ed
to
co
m
p
ar
e
w
it
h
th
e
s
y
s
te
m
o
u
tp
u
t
s
)
.
2.
Nu
m
b
er
o
f
c
h
r
o
m
o
s
o
m
e
in
t
h
e
g
en
er
atio
n
=
5
0
.
3.
Nu
m
b
er
o
f
g
e
n
er
atio
n
s
t
h
at
ar
e
cr
ea
ted
=
6
0
.
4.
P
r
o
b
ab
ilit
y
o
f
cr
o
s
s
o
v
er
=
0
.
8
.
5.
P
r
o
b
ab
ilit
y
o
f
m
u
tatio
n
=
0
.
2
.
I
t
is
w
o
r
t
h
m
en
tio
n
i
n
g
t
h
at
all
th
e
ab
o
v
e
p
ar
a
m
e
ter
s
lea
v
e
t
h
eir
v
al
u
e
to
t
h
e
d
esi
g
n
er
o
f
t
h
e
alg
o
r
ith
m
t
h
r
o
u
g
h
e
x
p
er
i
m
e
n
t
ex
ce
p
t
ch
r
o
m
o
s
o
m
e
le
n
g
th
it
is
co
n
s
tan
t
b
ec
a
u
s
e
i
t
d
ep
en
d
s
o
n
t
h
e
n
u
m
b
er
o
f
p
r
o
p
e
r
ties
in
th
e
d
atab
ase.
2
)
"
G
en
er
ate
p
r
im
ar
y
s
o
ciet
y
"
T
h
e
in
itial
s
o
ciet
y
is
g
e
n
er
ate
d
r
an
d
o
m
l
y
ac
co
r
d
in
g
to
th
e
p
ar
a
m
eter
s
s
p
ec
i
f
ied
in
t
h
e
p
r
ev
io
u
s
s
tep
.
T
h
e
o
u
tp
u
t
o
f
t
h
is
s
tep
is
a
g
e
n
er
atio
n
co
n
ta
in
i
n
g
5
0
ch
r
o
m
o
s
o
m
es.
T
h
e
g
e
n
es
o
f
th
e
c
h
r
o
m
o
s
o
m
e
ar
e
g
iv
e
n
b
in
ar
y
v
al
u
es
(
0
,
1
)
.
I
f
t
h
e
v
al
u
e
o
f
th
e
g
e
n
e
i
s
0
t
h
e
f
ea
tu
r
e
w
il
l
b
e
n
e
g
lecte
d
a
n
d
co
n
s
id
er
ed
an
u
n
n
ec
es
s
ar
y
f
ea
t
u
r
e
to
b
e
d
is
p
o
s
ed
o
f
.
I
f
th
e
v
al
u
e
o
f
th
e
g
e
n
e
is
(
1
)
th
is
f
ea
t
u
r
e
is
i
m
p
o
r
tan
t
an
d
is
t
ak
en
i
n
to
ac
co
u
n
t
as
o
n
e
o
f
th
e
f
ea
tu
r
es
w
h
ic
h
k
-
m
ea
n
s
i
s
b
ased
in
th
e
clas
s
i
f
i
ca
tio
n
.
Fo
r
e
x
a
m
p
le
as
s
u
m
e
t
h
e
g
en
e
tic
al
g
o
r
ith
m
g
en
er
ated
t
h
e
n
e
x
t c
h
r
o
m
o
s
o
m
e:
1
0
0
0
0
0
0
1
1
1
0
0
1
T
h
is
ch
r
o
m
o
s
o
m
e
e
x
p
lai
n
s
i
n
th
e
f
o
llo
w
i
n
g
w
a
y
:
a.
Neg
lecte
d
f
ea
tu
r
es
n
u
m
b
er
s
(
n
o
t n
ec
ess
ar
y
)
: 2
,
3
,
7
,
8
,
9
,
1
0
,
1
1
,
1
2
b.
I
m
p
o
r
tan
t p
r
o
p
er
ty
n
u
m
b
er
s
(
p
r
o
p
o
s
ed
)
: 1
,
4
,
5
,
6
,
1
3
3
)
"
E
v
alu
ated
ch
r
o
m
o
s
o
m
e
an
d
ca
lcu
late
f
it
n
e
s
s
"
I
n
o
r
d
er
to
m
ea
s
u
r
e
t
h
e
q
u
al
it
y
o
f
t
h
e
f
ea
t
u
r
es
p
r
o
p
o
s
ed
b
y
t
h
e
g
e
n
etic
al
g
o
r
ith
m
t
h
e
k
-
m
ea
n
s
alg
o
r
ith
m
d
escr
ib
ed
in
p
ar
a
g
r
ap
h
(
3
-
1
)
is
ap
p
lied
a
s
i
f
t
h
e
d
atab
ase
co
n
tain
ed
o
n
l
y
t
h
e
f
ea
tu
r
es
p
r
o
p
o
s
ed
b
y
th
e
g
e
n
etic
a
lg
o
r
it
h
m
a
n
d
t
h
e
o
th
er
(
n
o
n
-
i
m
p
o
r
ta
n
t)
f
ea
t
u
r
es
w
o
u
ld
b
e
d
is
r
e
g
ar
d
ed
an
o
t
h
er
s
ta
te
m
e
n
t
:
f
o
r
ea
ch
ch
r
o
m
o
s
o
m
e
i
n
th
e
g
e
n
er
atio
n
a
k
-
m
ea
n
s
f
u
n
ctio
n
i
s
ca
l
led
f
o
r
its
ev
al
u
atio
n
th
u
s
t
h
e
f
itn
es
s
v
a
lu
e
o
f
th
e
ch
r
o
m
o
s
o
m
e
i
s
t
h
e
ac
cu
r
ac
y
o
f
th
e
cla
s
s
i
f
icat
io
n
ca
lc
u
lated
b
y
k
-
m
ea
n
s
w
h
ic
h
is
i
llu
s
tr
ate
d
b
y
E
q
u
atio
n
(1
(
.
Ste
p t
w
o
: “
Gr
ea
t
g
en
er
atio
n
t
h
r
o
u
g
h
o
p
er
atio
n
s
g
en
et
ic”
T
h
e
g
en
etic
a
lg
o
r
it
h
m
d
o
es
n
o
t
s
to
p
at
t
h
e
p
r
i
m
ar
y
g
en
er
atio
n
b
u
t
co
n
tin
u
e
s
to
g
e
n
er
ate
o
th
er
g
en
er
atio
n
s
b
y
s
i
m
u
lati
n
g
th
e
h
u
m
a
n
w
a
y
o
f
g
en
er
ati
n
g
b
ac
k
w
ar
d
g
en
er
atio
n
s
to
s
u
s
tain
l
if
e.
T
h
e
p
r
o
ce
s
s
o
f
cr
ea
tin
g
a
f
a
m
il
y
i
n
h
u
m
a
n
s
o
cieties
b
eg
i
n
s
w
it
h
th
e
ch
o
i
ce
o
f
t
w
o
in
d
i
v
id
u
a
ls
.
T
h
is
c
h
o
ice
is
o
f
te
n
m
ad
e
r
an
d
o
m
l
y
a
n
d
t
h
en
c
h
ild
r
en
ar
e
b
o
r
n
af
ter
m
ar
r
iag
e.
I
n
t
h
es
e
ch
ild
r
en
t
h
er
e
m
a
y
b
e
g
e
n
et
ic
m
u
tatio
n
s
to
ad
d
d
iv
er
s
it
y
i
n
s
o
ciet
y
.
T
h
is
i
s
ex
ac
tl
y
w
h
at
t
h
e
g
en
e
tic
a
lg
o
r
ith
m
d
o
es
d
u
r
i
n
g
th
e
g
en
er
atio
n
o
f
o
t
h
er
g
en
er
atio
n
s
:
s
elec
tio
n
,
cr
o
s
s
o
v
er
,
s
tu
d
y
o
f
t
h
e
p
r
o
b
ab
ilit
y
o
f
a
m
u
tatio
n
.
T
h
e
m
et
h
o
d
s
u
s
ed
to
ca
r
r
y
o
u
t
g
en
et
ic
p
r
o
ce
s
s
es in
t
h
i
s
r
esea
r
ch
ar
e
:
a.
E
x
ec
u
te
s
elec
tio
n
p
r
o
ce
s
s
b
y
u
s
in
g
b
in
ar
y
s
et
m
et
h
o
d
.
b.
Select
u
n
i
f
o
r
m
m
at
i
n
g
m
et
h
o
d
to
p
er
f
o
r
m
cr
o
s
s
o
v
er
.
c.
T
h
e
m
u
tatio
n
is
i
m
p
le
m
en
ted
i
n
(
2
m
)
.
As
w
it
h
i
n
d
i
v
id
u
al
o
f
t
h
e
p
r
i
m
ar
y
s
o
ciet
y
t
h
e
s
a
m
e
m
et
h
o
d
is
u
s
ed
to
e
v
alu
ate
t
h
e
ch
r
o
m
o
s
o
m
e
s
o
f
n
e
w
g
en
er
atio
n
s
b
y
ca
lcu
lati
n
g
th
e
ac
c
u
r
ac
y
o
f
t
h
e
clas
s
if
icatio
n
b
y
ca
ll
in
g
t
h
e
cla
s
s
if
ier
(
k
-
m
ea
n
s
)
as
d
escr
ib
ed
in
s
tep
2
.
T
h
e
g
en
eti
c
alg
o
r
ith
m
co
n
ti
n
u
es
to
g
e
n
er
ate
co
m
m
u
n
i
ties
u
n
til
t
h
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n
u
m
b
er
o
f
g
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r
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g
en
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ated
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p
p
in
g
co
n
d
itio
n
ad
o
p
ted
in
th
i
s
r
esear
ch
.
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u
g
h
t
h
e
f
o
llo
w
i
n
g
p
o
in
ts
:
a.
Dis
p
la
y
t
h
e
ac
c
u
r
ac
y
o
f
t
h
e
s
y
s
te
m
s
(
k
-
m
ea
n
s
)
a
n
d
i
m
p
r
o
v
ed
m
e
th
o
d
w
h
ic
h
ar
e
ca
lcu
lat
ed
b
y
ap
p
ly
i
n
g
E
q
u
atio
n
(
1
)
.
b.
Dis
p
la
y
t
h
e
n
u
m
b
er
o
f
v
alid
c
ases
(
n
o
t p
atien
t)
th
at
w
er
e
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s
s
i
f
ied
b
y
b
o
th
s
y
s
te
m
s
co
r
r
ec
tl
y
.
c.
C
alcu
late
th
e
n
u
m
b
er
o
f
i
n
f
ec
t
ed
ca
s
es
(
p
atien
t)
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at
b
o
th
s
y
s
te
m
s
ca
n
co
r
r
ec
tl
y
clas
s
i
f
icati
o
n
.
d.
T
h
e
f
in
al
v
alu
e
s
o
f
cl
u
s
ter
ce
n
ter
s
.
e.
T
h
e
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y
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te
m
ca
lc
u
late
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o
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e
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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mea
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ith
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1261
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V
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Bh
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Da
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.
Evaluation Warning : The document was created with Spire.PDF for Python.