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I
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a
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en
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b
l
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d
co
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p
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n
t
s
[
1
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-
[
3
]
.
H
e
m
a
to
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[
4
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-
[
6
]
.
T
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va
r
i
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us
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gr
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i
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s
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h
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v
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obs
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v
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d t
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r
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f
l
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c
t
c
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t
r
a
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t
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f
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s
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pos
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t
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s
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tiliz
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f
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C
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as
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s
(
WB
Cs
)
,
a
n
d bl
ood pl
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t
e
l
e
t
s
[
7]
-
[9
]
.
M
an
y
m
at
h
e
m
at
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cal
m
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s
h
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v
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o c
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m
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of
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C
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B
C
s
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s
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I
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m
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t
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d
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bl
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b
y
a
di
s
or
de
r
i
n
t
h
e
R
B
C
s
h
a
pe
s
[
10]
-
[
12]
.
T
h
e
r
e
s
u
l
t
i
ng
num
be
r
of
R
B
C
s
,
W
B
C
s
,
a
n
d s
i
c
k
l
e
c
e
l
l
s
a
r
e
t
o be
in
v
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s
te
d
to
i
n
v
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s
ti
g
a
te
d
if
f
e
r
e
n
t
s
o
r
ts
o
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c
a
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d
io
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s
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u
la
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d
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s
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es
.
T
h
r
ee
m
aj
o
r
ab
n
o
r
m
al
i
t
i
es
can
b
e
r
eco
g
n
i
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w
h
e
n
b
l
o
o
d
p
ar
t
i
cl
es
co
u
n
t
i
n
g
i
s
ac
h
i
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v
ed
.
T
h
es
e t
y
p
es
o
f
ab
n
o
r
m
a
l
i
t
y
ar
e s
u
m
m
ar
i
zed
b
el
o
w
:
a)
F
e
w
er
n
u
m
b
er
o
f
R
B
C
s
t
h
an
t
h
e n
o
r
m
a
l
i
s
a cl
ear
cl
u
e o
f
b
l
o
o
d
an
em
i
a [
1
3
]
,
[
14]
.
Evaluation Warning : The document was created with Spire.PDF for Python.
In
t
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&
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[
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6
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8
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H
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ex
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,
ci
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cu
m
s
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ces
a
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d
v
ar
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at
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s
[
1
9
]
.
M
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f
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d
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e b
y
b
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t
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s
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t
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ab
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2
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]
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Evaluation Warning : The document was created with Spire.PDF for Python.
In
t
J
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c
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C
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m
p
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I
SSN
:
2088
-
8708
A
M
A
T
L
A
B
m
ode
l
f
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di
agnos
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ng s
i
c
k
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s
and ot
he
r
bl
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d abn
or
m
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(
M
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m
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d A
l
-
Mo
m
i
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)
5063
F
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gu
r
e
3.
Gr
a
y
-
s
cal
ed
i
m
a
g
e
F
i
gu
r
e
4.
B
i
n
ar
y
b
l
o
o
d
s
m
ear
i
m
ag
e
Fi
g
ur
e
5
.
R
e
m
o
v
i
n
g
cel
l
s
'
n
u
cl
ei
F
i
g
ur
e
6
.
D
et
ach
i
n
g
o
v
er
l
ap
p
e
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ci
r
cl
es
,
cl
ear
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n
g
bor
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r
s
a
n
d r
e
m
ov
i
n
g
t
i
ny
pa
r
t
i
c
l
e
s
4.
RE
S
U
L
T
S
AND D
I
S
CU
S
S
I
O
N
F
i
gu
r
e
s
2
t
h
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5
s
h
o
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t
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s
u
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o
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di
f
f
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e
n
t
de
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on
a
l
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or
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ps
,
i
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i
s
f
ound t
h
a
t
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he
d
et
ect
i
o
n
p
r
o
ces
s
b
eco
m
es
m
o
r
e ef
f
i
ci
e
n
t
i
n
t
h
e g
r
a
y
l
e
v
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h
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e ca
s
e i
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co
l
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R
G
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h
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ca
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e d
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o
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d
w
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n
m
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o
gr
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y s
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.
S
i
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a
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y,
m
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f
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r
t
o
b
l
a
c
k a
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w
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e
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can
s
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b
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ta
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ll
y
i
m
p
r
o
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e t
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e
d
et
ect
i
o
n
p
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o
ces
s
.
O
n
e
o
f
t
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m
aj
o
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p
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s
t
h
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u
ce t
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f
f
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c
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o
f
H
o
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g
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t
r
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o
r
m
ap
p
r
o
ach
t
o
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ci
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l
ar
o
b
j
ect
s
i
s
t
h
e
o
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er
l
ap
p
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r
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.
T
h
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o
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a
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a
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kl
e
d
i
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s
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ppe
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r
c
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e
s
pr
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o a
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C
H
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.
F
i
g
u
r
e 7
s
h
o
w
s
R
B
C
s
an
d
W
B
C
s
as
d
et
ect
ed
w
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t
h
t
h
e p
r
o
p
o
s
ed
al
g
o
r
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t
h
m
w
h
er
e R
B
C
s
ar
e b
o
r
d
er
ed
w
i
t
h
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ed
ed
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d
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B
C
s
ar
e
b
o
r
d
er
ed
w
i
t
h
g
r
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e
s
.
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g
o
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d
accu
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ac
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n
d
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i
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g
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an
d
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h
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s
w
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s
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a
i
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e
d b
y
a
ppl
y
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t
h
e
pr
op
os
e
d m
e
t
h
od.
F
i
g
u
r
e
8 on t
h
e
ot
h
e
r
h
a
n
d de
t
e
c
t
s
s
i
c
k
l
e
c
e
l
l
s
a
n
d i
n
boun
ds
t
h
e
m
w
i
t
h
bl
u
e
c
ol
or
e
dg
e
s
.
T
h
e
pr
opos
e
d a
ppr
oa
c
h
f
or
e
s
t
i
m
a
t
i
ng
t
h
e
hi
g
h
-
to
-
w
id
t
h
a
s
p
e
c
t r
a
tio
w
a
s
i
nve
s
t
e
d
t
o
gi
ve
e
nc
o
ur
a
g
i
n
g
r
e
s
ul
t
s
.
T
he
a
l
go
r
i
t
h
m
t
he
n c
o
unt
s
t
he
nu
m
b
e
r
o
f
r
e
d
,
w
hi
t
e
,
a
nd
s
i
c
kl
e
c
e
l
l
s
t
o
r
ev
eal
an
y
pr
oba
bl
e
bl
ood a
bn
or
m
a
l
i
t
y
.
Fi
g
ur
e
7
.
R
e
d
a
n
d
w
h
ite
b
lo
o
d
c
e
lls
d
e
te
c
tio
n
F
i
g
ur
e
8.
S
ic
k
le
cel
l
s
d
et
ect
i
o
n
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SSN
:
20
88
-
8708
In
t
J
E
l
e
c
&
C
o
m
p
E
n
g
,
V
o
l.
11
, N
o
.
6
,
D
ecem
b
er
2021
:
5
060
-
50
65
5064
5.
CO
NCL
U
S
I
O
N
I
m
ag
e p
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o
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s
i
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t
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n
i
q
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b
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i
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al
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t
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.
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s
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u
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t
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s
te
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te
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m
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eg
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A
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s
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t
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H
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h
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s
t
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e
n
m
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r
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r
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s
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B
C
o
r
R
B
C
.
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i
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l
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l
s
ar
e c
o
n
s
i
d
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ed
a d
i
s
t
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e
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l
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n
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w
a
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lo
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h
a
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1
.
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h
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le
n
g
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d
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a
t
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o,
w
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m
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d i
n t
hi
s
pa
pe
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as
as
p
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r
at
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et
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l
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ar
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at
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g
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n
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m
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y
,
R
B
C
,
W
B
C
,
an
d
s
i
ck
l
e cel
l
s
.
R
EF
ER
EN
C
ES
[
1]
P
. Y
. L
i
u
e
t a
l.
,
“
C
e
l
l
r
e
f
r
a
c
t
i
v
e
i
nde
x
f
or
c
e
l
l
bi
ol
og
y
a
nd di
s
e
a
s
e
di
a
g
nos
i
s
:
pa
s
t
,
pr
e
s
e
nt
a
nd f
ut
ur
e
,
”
L
ab
o
n a
Ch
i
p
, v
ol
.
16
,
n
o.
4,
pp.
63
4
-
64
4,
201
6,
do
i
:
10.
10
39/
c
5l
c
0
14
45j
.
[
2]
M
.
H
ab
aza
e
t a
l.
,
“R
ap
i
d
3
D
r
ef
r
act
i
v
e
-
i
nde
x
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m
a
g
i
ng
o
f
l
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v
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c
e
l
l
s
i
n s
us
pe
ns
i
o
n w
i
t
hout
l
a
be
l
i
ng
us
i
ng
d
ie
le
c
tr
o
p
h
o
r
e
tic
c
e
ll r
o
ta
ti
o
n
,
”
A
d
va
n
ce S
ci
en
ce,
v
ol
.
4,
no.
2
,
20
17
,
A
r
t
.
no.
1
600
20
5,
d
o
i:
10.
10
02/
a
dv
s
.
20
1
60
02
05
.
[
3]
T
. P
. D
e
e
p
a
, N
.
R
e
d
d
y
, K
. S
a
n
t
h
o
s
h
i
,
M
.
P
r
i
y
a
a
n
d
N
. L
a
k
s
h
m
i
, “
S
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p.
6
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26
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.
[
4]
J
.
G
i
en
g
er
,
K
.
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är
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.
N
eu
k
am
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Re
p
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.
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,
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-
5.
[
5]
T
.
R
.
N
or
oha
a
nd R
.
A
.
F
oc
k
,
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P
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nal
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p
p
lie
d
H
e
m
a
to
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ol
.
9,
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o.
3,
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1
0
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018
,
d
oi
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0.
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h_2
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.
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6]
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.
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r
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.
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l
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lin
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La
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ra
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ry
Me
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ol
.
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1
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5
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,
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10
16
/
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.
[
7]
A.
W
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he
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.
D
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upt
a
,
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om
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15.
[
8]
T
.
A
v
s
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v
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R
.
Z
hu
,
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.
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pov
,
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.
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y
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ov
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.
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i
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P
h
ys
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cs
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t
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i
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[
9]
A
.
L
ar
s
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n
,
L
.
C
ar
l
s
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n
,
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.
K
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d
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MC
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, v
ol
.
20,
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1
,
pp
.
20
-
77
,
20
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-
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[
1
0]
C.
Y
.
Ki
t
e
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l.
,
“
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S
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f
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obi
l
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l
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m
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nt
e
r
nat
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o
nal
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our
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om
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t
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6
,
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20
-
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29
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p3
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[
1
1]
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.
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be
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g
u,
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r
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opoe
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t
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n i
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ll
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n
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nt
e
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nat
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on
al
J
o
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al
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h St
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in
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d H
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nc
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s
,
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l
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o
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,
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p.
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-
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20
,
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.
22
25
9/
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1
2]
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.
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h
at
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ee,
A
.
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g
r
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w
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.
A
d
ap
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d
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.
K
.
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ar
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c
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p
p.
1
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1
3]
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.
A
g
a
r
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.
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t
s
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L
a
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or
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ppr
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nat
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o
nal
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ou
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nal
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or
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m
at
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gy
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ol
.
4
2,
no
.
s
1
,
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1
07
-
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2,
2
020,
doi
:
1
0.
1
11
1/
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j
l
h.
13
20
0
.
[
1
4]
M
.
T
et
s
ch
k
e,
P
.
L
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l
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en
t
h
al
,
T
.
P
o
t
t
g
i
es
s
er
,
an
d
T
.
F
i
s
ch
er
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at
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at
i
cal
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o
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C
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oo
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r
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l
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6
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oi
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pr
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15
7.
[
1
5]
U
.
B
u
r
ak
,
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M
ed
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er
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en
c
y
:
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eu
k
o
s
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s
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l
obal
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ur
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l
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e
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d B
l
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o
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l
.
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2,
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p.
25
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9/
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[
1
6]
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.
H.
T
ah
a
e
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l.
,
“
N
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l
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j
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m
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.
[
1
7]
B.
P
. D
.
I
nu
s
a
e
t a
l.
,
“
S
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ck
l
e cel
l
d
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s
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cs
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nat
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o
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our
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al
of
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ng
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l
. 5
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[
1
8]
S
.
B
hi
nde
,
G
.
G
j
pi
a
s
r
,
A
.
A
na
nd,
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C
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ll A
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-
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1
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R
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upr
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v
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1
0,
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6,
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5
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-
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5,
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[
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0]
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.
K
ha
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h
a
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IJ
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,
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.
8,
no.
3,
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.
17
31
-
1
74
0,
20
18
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