Indonesian J our nal of Electrical Engineering and Computer Science V ol. 36, No. 2, No v ember 2024, pp. 846 ∼ 853 ISSN: 2502-4752, DOI: 10.11591/ijeecs.v36.i2.pp846-853 ❒ 846 De v elopment of explainable machine intelligence models f or heart sound abnormality detection J ee v akala Si v a Ramakrishna 1 , Sonagiri China V enkateswarlu 2 , K ommu Na v een K umar 3 , P arikipandla Shr eya 2 1 Department of Computer Science and Engineering (Articial Intelligence and Machine Learning), Institute of Aeronautical Engineering, Hyderabad, India 2 Department of Electronics and Communication Engineering, Institute of Aeronautical Engineering, Hyderabad, India 3 Department of Electrical and Computer Engineering, Marri Laxman Reddy Institute of T echnology and Management, Hyderabad, India Article Inf o Article history: Recei v ed Mar 8, 2024 Re vised Jul 10, 2024 Accepted Jul 14, 2024 K eyw ords: Explainable learning models Heart abnormalities Heart sound detection LIME SHAP ABSTRA CT De v eloping e xplainable machine intelligence (XAI) model s for heart sound ab- normality detection is a crucial area of research aimed at impro ving the inter - pretability and transparenc y of machine learning algorithms in medical diagnos- tics. In this study , we propose a frame w ork for b uilding XAI models that can ef fecti v ely detect abnormalities in heart sounds while pro viding interpretable e xplanations for their predi ctions. W e le v erage techniques suc h as SHaple y ad- diti v e e xPlanations (SHAP) and local interpreta ble model-agnostic e xplanations (LIME) to generate e xplanations for model predictions, enabling clinicians to understand the rationale behind the algorithm’ s decis ions. Our approach in- v olv es preprocessing heart sound data, training machine learning models, and inte grating XAI techniques to enhance the interpretability of the models. W e e v aluate the performance of our XAI models using standard metrics and demon- strate their ef fecti v eness in accurately detecting heart sound abnormalities while pro viding insightful e xplanations for their predictions. This research contrib utes to the adv ancement of XAI in medical applications, particularly in the domain of cardiac diagnostics, where interpretability is crucial for clinical decision- making. This is an open access article under the CC BY -SA license . Corresponding A uthor: Jee v akala Si v a Ramakrishna Department of Computer Science and Engineering (Articial Intelligence and Machine Learning) Institute of Aeronautical Engineering Hyderabad, India Email: j.si v aramakrishna@iare.ac.in 1. INTR ODUCTION The human heart produces characteristic sounds, kno wn as heart sounds, that result from the closure of heart v alv es and the mo v ement of blood within the heart chambers. These sounds are crucial indicators of cardiac health and can pro vide v aluable diagnostic inform ation about the condition of the heart. Heart sounds are typically cate gorized into tw o main t y pe s: S1 (the rst heart sound) and S2 (the second hear t sound). S1 is produced by the closure of the mit ral and tricuspid v alv es at the be ginning of systole, while S2 is produced by the closure of the aortic and pul monary v alv es at the be gi nning of diastole. The purpose of detecting heart sound abnormalities lies in the early identication of cardiac pathologies, such as v alvular disorders, murmurs, and other structural abnormalities. The heart sound detetion mechanism requires an accurate and reliable detection algorithms, the interpretat ion of comple x heart sound patterns, and the inte gration of these algorithms into J ournal homepage: http://ijeecs.iaescor e .com Evaluation Warning : The document was created with Spire.PDF for Python.
Indonesian J Elec Eng & Comp Sci ISSN: 2502-4752 ❒ 847 clinical practice. The use of machine learning (ML) algorithms in medical diagnostics has sho wn promising results in detecting v arious health conditions [1]-[3]. The comple xity of ML algorithms often mak es it dif cult for clinicians to trust and understand the decisions made by these models, which can hinder their adoption in real w orld healthcare settings [4]. In the conte xt of cardiac diagnostics, the interpretation of heart sounds plays a crucial role in identifying abnormalities and making informed clinical decisions. T raditional methods of heart sound analysis are often subjecti v e and rely hea vily on the e xpertise of clinicians. ML-based approaches ha v e the potential to automate and impro v e the accurac y of the de v eloped models [5] b ut their lack of interpretability limits their practical utility in clinical settings. Se v eral studies [6], [7] ha v e e xplored the application of ML algorithms, such as neural netw orks and decision trees, in heart sound analysis for detecting abnormalities. The studies ha v e demonstrated promising re- sults in terms of accurac y , the y often f all short in pro viding transparent e xplanations for their predictions. This limitation has led to gro wing interest in the de v elopment of e xplainable machine intelligence (XAI) models that can not only achie v e high accurac y b ut also pro vide interpretable e xplanations for their decisions. In this w ork, we propose a no v el approach to address the interpretability challenge in ML-based heart sound abnor - mality detection. Our approach in v olv es le v eraging state-of-the-art XAI techniques, such as SHaple y additi v e e xPlanations (SHAP) and local interpretable model agnostic e xplanations (LIME) [8] to generate e xplanations for the predictions of our ML models. The con v er gence of engineering and medical e xpertise has rapidly adv anced the health care domain. In t his conte xt, we re vie w the progression of heart sound classication and disease diagnosis. The combination of deep con v olutional neural netw orks and mel-frequenc y cepstral coef cients (MFCC) emplo yed to classify normal and abnormal phonocardiograph y signals. The model has achie v ed a competiti v e score b ut did not address the generalizability of their approach to dif ferent subjects [9]. The automatic recognition of heart rate v ariations from phonocardiograms (PCG) using transfer learning with MFCC features has achie v ed high ac- curac y . Ho we v er the limited a v ailability of PCG recordings raises concerns about the generalizability of their method [10]. The heart sound classication using impro v ed MFCC features and CRNN, pro vides an impro v e- ment in classication accurac y . Ho we v er , the model suf fers with computational comple xity , need for further in v estig ation into generalizability and other e xperiment conditions [ 1 1] . The reliance on traditional classiers may limit their ability to capture comple x patterns, and the e v aluation based on the datasets [12]. The recurrent neural netw ork (RNN) based frame w o r k pro vides promising results. Ho we v er , the computational comple xity of RNNs and their performance dependence on dataset used for the analysis [13], [14]. The se gmented and unse gmented PCG signals ha v e been e xplored for heart s oun d classication [15]. The heartbeat sound clas- sication using normal, murmur , and e xtra-systole heartbeat sounds, achie v es competiti v e performance [16]. The deep learning and ensembl e learning techniques for phonocardiogram classication, achie v es competiti v e performance [17]. The classication of normal and abnormal heart sounds using an ensemble approach along with handcrafted features may limit its ability to capture comple x patterns [18]. Heart sound classication using deep learning based CNNs produce an impro v ed classication accu- rac y [19]-[21]. The learnable lter banks is another approach for heart sound detection [22]. The interpretable machine learning techniques applied on medical image pro vides better e xplanati ons for the analysis [23], [24]. In this we ha v e inte grated the XAI techniques into the de v elopment of ML model s for heart sound analysis. The proposed model has the potential to enhance the trust and adoption of ML technologies in cardiac diagnostics. 2. PR OPOSED METHOD The proposed methodology for heart sound abnormality detection using e xplainable machine learning (XML) models is sho wn in Figure 1. The method comprises a series of well-dened steps aimed at de v eloping a rob ust and interpretable model. The methodology can be summarized as follo wing steps: - Step 1: Data collection: the data collection process in v olv es g athering heart sound recordings for normal and abnormal conditions. These recordings are typically obtained from medical databases [25]. - Step 2: Data preprocessing: preprocessing be gins with a thorough inspection of the collected data to identify and remo v e an y outliers, artif acts, or c orrupted recordings that could adv ersely af fect model training. Noise reduction techniques, such as ltering or denoising algorithms, are applied to impro v e the quality of the recordings. - Step 3: Feature e xtraction: feature e xtraction in v olv es transforming ra w heart sound recordings int o a set of rele v ant features that can be used as a fetures while b uilding the model. The features include spectral De velopment of e xplainable mac hine intellig ence models ... (J ee vakala Siva Ramakrishna) Evaluation Warning : The document was created with Spire.PDF for Python.
848 ❒ ISSN: 2502-4752 characteristics and statistical measures that capture the underlying patterns in the heart sounds. - Step 4: Dataset split ting: the dataset is split into training, v alidation, and testing sets using a stratied approach to ensure that each set contains a proportional representation of normal and abnormal heart sounds. - Step 5: Feature scaling: feat ure scaling is applied to normalize the e xtracted features to a consistent range, pre v enting certain features from dominating the model training process due to their lar ger magnitudes. - Step 6: Model training: multiple XML algorithms such as random forest, gradient boosting (GBoost), AdaBoost, K-nearest neighbors (KNN), and logistic re gression (LR) are trained using the preprocessed and scaled features. The training process in v olv es optimizing each algorithm’ s parameters through techniques lik e grid search or randomized search to nd the best-performing conguration. - Step 7: LIME e xplanation: LIME are applied to pro vide local e xplanations for indi vidual predictions made by the XML model. LIME generates interpretable e xplanations by perturbing the input features around a specic instance and observing the changes in the model’ s predictions. - Step 8: SHAP e xplanation: SHAP is used to pro vide global e xplanations for the XML model’ s predictions, highlighting the contrib utions of each feature to the o v erall predictions. SHAP v alues quantify the impact of each feature on the model’ s output and help understand the model’ s decision-making process at a global le v el. - Step 9: V isualization: the results of LIME and SHAP e xplanations are visualized using v arious techniques such as bar plots, and summary plots. V isualization aids in presenting the e xplanations in an intuiti v e and understandable manner , f acilitating their interpretation by domain e xperts and stak eholders. Figure 1. Proposed block diagram for heart sound classication 3. RESUL TS AND DISCUSSION The obtained results demonstrate that emplo ying LIME and SHAP signicantly enhances the inter - pretability of machine learning models used for detecting heart sound abnormalities. These techniques of fer v aluable insights into the decision-making processes of the models by pinpointing the k e y f actors inuencing their classications. Through visualizing the impact of dif ferent v ariables, we ha v e achie v ed a deeper under - standing of the models’ beha vior , thereby enhancing transparenc y and interpretability 3.1. LIME explanations Across the man y classiers used in our analysis, LIME consistently identied the most important v ariables for heart sound cate gorization. LIME is crucial in our analysis because it consistently identies the mos t important v ariables for heart sound cate gorization across v arious classiers. F or e xample, in the random forest classier , LIME e xplanations demonstrated ho w k e y spectral and statistical properties, such as spectral centroid, spectral bandwidth, and zero-crossing rate, were critical in discriminating between normal and pathological heart sounds. 3.1.1. Random f or est classier Figure 2 illustrat es LIME visualization using a random forest classier , emphasizing features such as consistent spectral patterns and statistical properties that play a crucial role in the classication process. These Indonesian J Elec Eng & Comp Sci, V ol. 36, No. 2, No v ember 2024: 846–853 Evaluation Warning : The document was created with Spire.PDF for Python.
Indonesian J Elec Eng & Comp Sci ISSN: 2502-4752 ❒ 849 include the re gularity in spectral centroid and the lo w v ariability in zero-crossing rate. Figure 3 illustrates ho w LIME visual ization re v eals that irre gularities in spectral patterns and statistical features, such as high v ariation in spectral centroid and pronounced changes in zero-crossing rate, are crucial f actors inuencing the classication. Figure 2. LIME visualization where the person has normal heartbeat using random forest Figure 3. LIME visualization where the person has abnormal heartbeat using random forest 3.1.2. GBoost classier Figure 4 illustrates the LIME visualization with a GBoost classier , elucidating ho w distinct spectr al and statistical features contrib ute to a consistent and predictable pattern. This includes stable v alues in spectral centroid and smooth transitions in zero-crossing rate. Figure 5 illustrates ho w LIME visualization with a GBoost classier can unco v er irre gularities in spectral and statistical features, such as abrupt shifts in spectral centroid and signicant v ariability in zero-crossing rate, which play a crucial role in distinguishing abnormal heart sounds. Figure 4. LIME visualization where the person has normal heartbeat using GBoost classier Figure 5. LIME visualization where the person has normal heartbeat using GBoost classier De velopment of e xplainable mac hine intellig ence models ... (J ee vakala Siva Ramakrishna) Evaluation Warning : The document was created with Spire.PDF for Python.
850 ❒ ISSN: 2502-4752 3.1.3. XGB classier Figure 6 illustrates ho w LIME visualization with an e xtreme gradient boosting (XGBoost) cl assier might sho w ho w certain consistent spectral patterns and statistical features, lik e stable spectral centroid and minimal zero-crossing rate, contrib ute to the classication. Figure 7 illustrates ho w LIME visualization for abnormal heart sounds with an XGBoost classier could re v eal ho w irre gularities in spectral patterns and statistical features, such as uctuations in spectral centroid and high zero-crossing rate, play a crucial role in the classication. T able 1 sho ws the accuracies of the classiers using LIME, with the XGB and GBoost achie ving the highest accurac y for heart sound classication, follo wed by the random forest and decision tree. KNN also sho wed respectable accuracies b ut were slightly lo wer compared to the XGB and GBoost classiers. Figure 6. LIME visualization where the person has normal heartbeat using XGB classier Figure 7. LIME visualization where the person has abnormal heartbeat using XGB classier T able 1. Classication accurac y of v arious classiers for normal and abnormal heart sound detection Classier Accurac y (%) Random forest 88.2 GBoost 89.2 XGB 91.8 KNN 70 Decision tree 88.2 3.2. SHAP explanations In our analysis, SHAP consistently identied k e y v ariables for heart sound cate gorization across v ar - ious classiers. F or e xample, in the GBoost classier , SHAP highlighted the importance of features such as spectral rol lof f, RMS ener gy , and tempo in distinguishing normal from pathological heart sounds. These in- sights pro vided a clear understanding of feature contrib utions, enhancing model interpretability . In addition, SHAP analysis re v ealed the consistent impact of t hese features across dif ferent classiers, reinforcing their signicance in heart sound cate gorization and pro viding v aluable insights for model renement and clinical decision-making. 3.2.1. Random f or est In SHAP the features are rank ed based on their importance in the model’ s predictions. F or normal heart sounds, features with higher SHAP v alues, such as spect ral centroid and spectral bandwidth, indicate a strong inuence on the classication, highlighting their importance in distinguishing normal heart sounds. In a SHAP force plot for a random forest classier , the plot sho ws ho w indi vidual feature v alues contrib ute Indonesian J Elec Eng & Comp Sci, V ol. 36, No. 2, No v ember 2024: 846–853 Evaluation Warning : The document was created with Spire.PDF for Python.
Indonesian J Elec Eng & Comp Sci ISSN: 2502-4752 ❒ 851 to the model’ s prediction for a specic instance. F or normal heart sounds, features lik e spectr al centroid and spectral bandwidth with positi v e SHAP v alues indicate their contrib ution to classifying the sound as normal, pro viding a detai led understanding of the model’ s decision process. An e xplanation of SHAP for the random forest classier can be seen in Figure 8. Figure 8. SHAP e xplanations for random forest classier 3.2.2. Gradient boosting In the summary plot as sho wn in Figure 9, SHAP v alues are displayed horizontally , representing the impact of each feature on the model’ s output. Features are sorted by importance, with color indicating the v alue of the feature (red for high, blue for lo w). This plot pro vides a clear o v ervie w of which features are most inu- ential in the model’ s decision-making process. In a force plot, SHAP e xplanations for indi vidual predictions are visualized. F or e xample, for normal heart sounds, the force plot might sho w ho w certain spectral and statistical features lead to a classication of normal, pro viding a detailed breakdo wn of the contrib ution of each feature to the nal predicti on. In comparison with [15] the proposed technique pro vides an alternate perspec ti v e on heart sound abnormality detection. While the preceding publicati o n focused on time-frequenc y approaches and deep learning for representation learning, our resear ch focuses on the construction of XAI models. W e combine di v erse machine learning algorithms with e xplainable AI approaches such as LIME and SHAP , resulting in impro v ed accurac y and clear e xplanations for model predictions. The potential applications of ECG (Electro- cardiograph y) data analys is in healthcare, wellness monitoring, and be yond are v ast and promising. Lik e wise, e xplainable machine learning models are poised to be pi v otal in guaranteeing trans p a renc y , trustw orthiness, and accountability in AI-dri v en ECG analysis systems. Figure 9. Summary plot of SHAP using GBoost De velopment of e xplainable mac hine intellig ence models ... (J ee vakala Siva Ramakrishna) Evaluation Warning : The document was created with Spire.PDF for Python.
852 ❒ ISSN: 2502-4752 4. CONCLUSION Our study successfully created machine intelligence models for heart sound anomaly identi cation utilising methods such as random forest, GBoost, XGBoost, and decision trees. The use of e xplainable AI approaches such as LIME and SHAP impro v ed model interpretability , of fering insights into predictions. These models present a viable method for automated and transparent heart sound analysis, with potential applications in early identication and m on i toring of cardiac diseases. Future research m ight concentrate on increasing the dataset and conducting real w orld trials to conrm their benecial ef fects. Ov erall, our ef fort highlights the utility of e xplainable machine intelligence models in cardiac diagnosis. REFERENCES [1] M . A. H. Islam, S. M. Shahriyar , M. J. Alam, M. Rahman, and M. R. K. R. Sark er , “Skin disease detection emplo ying transfer learning approach- a ne-tune visual geometry group-19, ” Indonesian Journal of Electrical Engineering and Computer Science (IJEECS) , v ol. 31, no. 1, pp. 321–328, Jul. 2023, doi: 10.11591/ijeecs.v31.i1.pp321-328. [2] R . Battur and J. Narayana, “Classication of medical X-ray images using supervised and unsupervised learning ap- proaches, ” Indonesian Journal of Electrical Engineering and Computer Science (IJEECS) , v ol. 30, no. 3, p. 1713, Jun. 2023, doi: 10.11591/ijeecs.v30.i3.pp1713-1721. [3] B. J. Khadhim, Q. K. Kadhim, W . K. Shams, S. T . Ahmed, and W . A. W ahab Alsiadi, “Diagnose CO VID-19 by using h ybrid CNN- RNN for chest X-ray , ” Indonesian Journal of Electrical Engineering and Computer Science (IJEECS) , v ol. 29, no. 2, pp. 852–860, Feb . 2023, doi: 10.11591/ijeecs.v29.i2.pp852-860. [4] N. Chinnamadha, R. Z. Ahmed, and K. Kale go wda, “De v elopment of health monitori ng system using smart intelligent de- vice, ” Indonesian Journal of Electrical Engineering and Computer Science (I JEECS) , v ol. 28, no. 3, p. 1381, Dec. 2022, doi: 10.11591/ijeecs.v28.i3.pp1381-1387. [5] S. C. V enkatesw arlu, S. R. Jee v akala, N. U. K umar , P . Munas w amy , and D. Pendyala, “Emotion recognition from speech and te xt using long short-term memory , ” Engineering, T echnology and Applied Science Research , v ol. 13, no. 4, pp. 11166–11169, Aug. 2023, doi: 10.48084/etasr .6004. [6] F . Renna, J. Oli v eira, and M. T . C oimbra, “Deep con v olutional neural netw orks for heart sound se gmentation, ” IEEE Journal of Biomedical and Health Informatics , v ol. 23, no. 6, pp. 2435–2445, No v . 2019, doi: 10.1109/JBHI.2019.2894222. [7] A. Rath, D. Mishra, G. P anda, and M. P al, “De v elopment and assessment of machine learning based heart disease de- tection using imbalanced heart sound signal, ” Biomedical Signal Processing and Control , v ol. 76, p. 103730, Jul. 2022, doi: 10.1016/j.bspc.2022.103730. [8] A. Holzinger , A. Sarant, C. Molnar , P . Biecek, and W . Samek, “Explainable AI methods-a brief o v ervie w , ” in International w orkshop on e xtending e xplainable AI be yond deep models and classiers , 2022, pp. 13–38, doi: 10.1007/978-3-031-04083-2 2. [9] V . Maknickas and A. Maknickas, “Recognition of normal-abnormal phonocardiographic signals using deep con v olutional neu- ral netw orks and mel-frequenc y spectral coef cients, ” Ph ysiological Measurement , v ol. 38, no. 8, pp. 1671–1684, Jul. 2017, doi: 10.1088/1361-6579/aa7841. [10] T . Al af, M. Boulares, A. Barna wi, T . Alaf, H. Althobaiti, and A. Alferaidi, “Normal and abnormal heart rates recognition using transfer learning, ” in Proceedings - 2020 12th International Conference on Kno wledge and Systems Engineering, KSE 2020 , No v . 2020, pp. 275–280, doi: 10.1109/KSE50997.2020.9287514. [11] M. Deng, T . Meng, J. Cao, S. W ang, J. Zhang, and H. F an, “Heart sound classication based on impro v ed MFCC features and con v olutional recurrent neural netw orks, ” Neural Netw orks , v ol. 130, pp. 22–32, Oct. 2020, doi: 10.1016/j.neunet.2020.06.015. [12] Z. Abduh, E. A. Nehary , M. A. W ahed, and Y . M. Kadah, “Classication of heart sounds using fractional fourier transform based mel-frequenc y spectral coef cients and traditional classiers, ” Biomedical Signal Processing and Control , v ol. 57, p. 101788, Mar . 2020, doi: 10.1016/j.bspc.2019.101788. [13] S. Latif, M. Usman, R. Rana, and J. Qadir , “Phonocardiographic sensing using deep learning for abnormal heartbeat detection, ” IEEE Sensors Journal , v ol. 18, no. 22, pp. 9393–9400, No v . 2018, doi: 10.1109/JSEN.2018.2870759. [14] T . C. I. Y ang and H. Hsieh, “Classication of acoustic ph ysiologica l signals based on deep learning neural netw orks with augmented features, ” Computing in Cardiology , v ol. 43, pp. 569–572, 2016, doi: 10.22489/cinc.2016.163-228. [15] F . A. Khan, A. Abid, A. Abid, M. S. Khan, and M. S. Khan, “ Automatic heart sound classication from se gmented/unse gmented phonocardiogram signals using time and frequenc y features, ” Ph ysiological Measurement , v ol. 41, no. 5, p. 055006, Jun. 2020, doi: 10.1088/1361-6579/ab8770. [16] A. Raza, A. Mehmood, S. Ullah, M. Ahmad, G. S. Choi, and B. W . On, “Heartbeat sound signal classication us ing deep learning, ” Sensors (Switzerland) , v ol. 19, no. 21, p. 4819, No v . 2019, doi: 10.3390/s19214819. [17] J. M. T . W u et al. , “ Applying an ensemble con v olutional neural netw ork with Sa vitzk y–Golay lter to construct a phonocardiogram prediction model, ” Applied Soft Computing Journal , v ol. 78, pp. 29–40, May 2019, doi: 10.1016/j.asoc.2019.01.019. [18] C. Potes, S. P arv aneh, A. Rahman, and B. Conro y , “Ensemble of feature-based and deep learning-based classiers for detection of abnormal heart sounds, ” in Computing in Cardiology , Sep. 2016, v ol. 43, pp. 621–624, doi: 10.22489/cinc.2016.182-399. [19] F . Li et al., “Feature e xtraction and classication of heart sound using 1D con v olutional neural netw orks, ” Eurasip Journal on Adv ances in Signal Processing , v ol. 2019, no. 1, p. 59, Dec. 2019, doi: 10.1186/s13634-019-0651-3. [20] F . Li, H. T ang, S. Shang, K. Mathiak, and F . Cong, “Classica tion of heart sounds using con v olutional neural netw ork, ” Applied Sciences (Switzerland) , v ol. 10, no. 11, p. 3956, Jun. 2020, doi: 10.3390/app10113956. [21] B. Xiao, Y . Xu, X. Bi, J. Zhang, and X. Ma, “Heart sounds classication using a no v el 1-D con v olutional neural netw ork with e xtremely lo w parameter consumption, ” Neurocomputing , v ol. 392, pp. 153–159, Jun. 2020, doi: 10.1016/j.neucom.2018.09.101. [22] A. I. Humayun, S. Ghaf f arzade g an, M. I. Ansari, Z. Feng, and T . Hasan, “T o w ards domain in v ariant heart sound abnormal- ity detection using learnable lterbanks, ” IEEE Journal of Biomedical and Health Informatics , v ol. 24, no. 8, pp. 2189–2198, Aug. 2020, doi: 10.1109/JBHI.2020.2970252. Indonesian J Elec Eng & Comp Sci, V ol. 36, No. 2, No v ember 2024: 846–853 Evaluation Warning : The document was created with Spire.PDF for Python.
Indonesian J Elec Eng & Comp Sci ISSN: 2502-4752 ❒ 853 [23] S. R. Jee v akala and H. Ramasangu, “Identication of signicant instants of v ox els for cogniti v e state classication using in- terpretable machine learning models, ” Journal of Medicinal and Chemical Sciences , v ol. 6, no. 6, pp. 1291–1301, 2023, doi: 10.26655/JMCHEMSCI.2023.6.9. [24] Z. W ang, K. Qian, H. Liu, B. Hu, B. W . Schuller , and Y . Y amamoto, “Exploring interpretable representations for heart sound abnormality detection, ” Biomedical Signal Processing and Control , v ol. 82, p. 104569, Apr . 2023, doi: 10.1016/j.bspc.2023.104569. [25] “Ph ysioNet Challenge2016:Heart sound classication, ” Kaggle , 2016. https://www .kaggle.com/datasets/bjoernjostein/ph ysionet- challenge (accessed Aug. 05, 2022). BIOGRAPHIES OF A UTHORS J ee v akala Si v a Ramakrishna is associate professor in the Department of CSE (A rticial Intelligence and Machine Learning), Institute of Aeronautical Engineeri ng, Hyderabad, India. He Holds a Ph.D. de gree in Electronics and Communication Engineering with specialization in biomedi- cal signal, image processing and Machine Learning. His research areas include image and signal pro- cessing, medic al image analysis, and FMRI data analysis. Dr . J. Si v a Ramakrishna has o v er 14 years of e xperience in teaching, including 4 years as a researcher . He published se v eral research papers in international journals and conferences. He can be contacted at email: j.si v aramakrishna@iare.ac.in. Sonagiri China V enkateswarlu professor in the Department of Electronics and Commu- nication Engineering at the Institute of Aeronautical Engineering (IARE). He holds a Ph.D. de gree in Electronics and Communication Engineering with a specialization in Digital Speech Processing. Dr . S. China V enkatesw arlu has more than 40 citations and paper publications ac ross v arious pub- lishing platforms, and e xpertise in teaching subjects such as microprocessors and microcontrollers, digital signal processing, digital image processing, and speech process ing. W ith 20 years of teaching e xperience, he can be contacted at email: c.v enkatesw arlu@iare.ac.in. K ommu Na v een K umar is a professor in the Department of Electronics and Communi- cation Engineering, MLR ITM, Hyderabad, India. He hol ds a Ph.D. de gree in Electronics and Com- munication Enginee ring with specialization in Digital Image Processing. His research areas include digital image processing, and embedded systems. Dr . K. Na v een K umar has o v er 15 years of e xperi- ence in teaching. He published paper in se v eral national and international journals and conferences. He can be contacted at email: na v eenkarun ya@gmail.com. P arikipandla Sh r eya is a student pursuing bachelor’ s de gree in Electronics and Com- munication Engineering in Institute of Aeronautical engineering. She has strong interest in Articial Intelligence and Machine Learning as well as cloud computing. She is v ery k een in research and al w ays eager to learn and apply ne w concepts. She is determined to contrib ute to the adv ancements of technology and e xcited about the opportunities that li e ahead. She can be contacted at email: shre yaparikipandlla@gmail.com. De velopment of e xplainable mac hine intellig ence models ... (J ee vakala Siva Ramakrishna) Evaluation Warning : The document was created with Spire.PDF for Python.