I
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t
er
na
t
io
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l J
o
urna
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f
Art
if
icia
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t
ellig
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I
J
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Vo
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13
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er
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//ij
a
i
.
ia
esco
r
e.
co
m
Im
plementa
tion o
f
fuz
zy
log
ic appr
o
a
ch f
o
r
thala
ss
e
mia
screening
in
child
ren
E
rliy
a
n Re
dy
Su
s
a
nto
1,
2
,
Adm
i Sy
a
rif
1
,
Wa
rsito
1
,
K
ha
iru
n N
is
a
B
er
a
wi
3
,
P
utu
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t
y
a
nin
g
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u Sa
ng
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ing
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Ag
us
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nto
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c
s
a
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r
a
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me
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o
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m,
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a
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a
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k
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t
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i
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r
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o
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e
p
a
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t
me
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o
f
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o
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l
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r
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i
o
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h
e
mi
st
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y
a
n
d
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h
y
s
i
o
l
o
g
y
,
F
a
c
u
l
t
y
o
f
M
e
d
i
c
a
l
,
L
a
m
p
u
n
g
U
n
i
v
e
r
si
t
y
,
B
a
n
d
a
r
L
a
mp
u
n
g
,
I
n
d
o
n
e
si
a
Art
icle
I
nfo
AB
S
T
RAC
T
A
r
ticle
his
to
r
y:
R
ec
eiv
ed
Ma
y
2
2
,
2
0
2
3
R
ev
is
ed
No
v
1
9
,
2
0
2
3
Acc
ep
ted
Dec
6
,
2
0
2
3
Th
a
las
se
m
ia
is
o
n
e
o
f
th
e
m
o
st
d
a
n
g
e
ro
u
s
b
lo
o
d
d
iso
rd
e
rs
th
a
t
c
a
n
lea
d
t
o
se
v
e
re
c
o
m
p
li
c
a
ti
o
n
s.
It
is
a
n
i
n
h
e
rit
e
d
d
ise
a
se
,
u
su
a
ll
y
d
e
tec
ted
a
f
ter
a
c
h
il
d
is
two
to
f
o
u
r
y
e
a
rs
o
ld
.
I
d
e
n
ti
f
ica
ti
o
n
o
f
th
a
las
se
m
ia
is
a
c
o
m
p
lex
tas
k
,
in
v
o
lv
i
n
g
m
a
n
y
v
a
riab
les
.
Do
c
t
o
r
s g
e
n
e
ra
ll
y
d
iag
n
o
se
t
h
a
las
se
m
ia
b
y
u
sin
g
a
c
o
m
p
lete
b
l
o
o
d
c
o
u
n
t
(CBC)
a
n
d
h
ig
h
-
p
e
rf
o
rm
a
n
c
e
li
q
u
id
c
h
r
o
m
a
to
g
ra
p
h
y
(HPL
C)
tes
t
re
su
lt
s.
Ho
we
v
e
r,
HPL
C
tes
ts
a
re
e
x
p
e
n
siv
e
a
n
d
ti
m
e
-
c
o
n
su
m
in
g
,
h
e
n
c
e
th
e
n
e
e
d
f
o
r
o
t
h
e
r
m
e
th
o
d
s
t
o
i
d
e
n
ti
f
y
th
a
las
se
m
ia
.
Th
e
re
a
re
m
a
n
y
stu
d
ies
o
n
t
h
e
a
p
p
li
c
a
ti
o
n
o
f
a
rti
ficia
l
i
n
telli
g
e
n
c
e
fo
r
m
e
d
ica
l
a
p
p
li
c
a
ti
o
n
s.
I
n
th
is
stu
d
y
,
we
d
e
v
e
lo
p
e
d
a
n
e
w
f
u
z
z
y
-
b
a
se
d
a
p
p
r
o
a
c
h
t
o
id
e
n
ti
f
y
t
h
a
las
se
m
ia
b
a
se
d
o
n
a
p
a
ti
e
n
t
’
s
b
lo
o
d
la
b
o
ra
to
r
y
re
su
lt
s
.
F
irst,
w
e
a
n
a
ly
z
e
d
t
h
e
CBC
d
a
ta fo
r
b
l
o
o
d
d
iso
rd
e
r
p
re
d
ictio
n
.
S
e
c
o
n
d
l
y
,
we
a
d
o
p
t
th
e
tes
t
re
su
lt
s
o
f
p
e
ri
p
h
e
ra
l
b
l
o
o
d
s
m
e
a
r
(P
BS
)
to
id
e
n
ti
fy
wh
e
t
h
e
r
t
h
e
p
e
rso
n
h
a
s th
a
las
se
m
ia
.
We co
n
d
u
c
ted
se
v
e
ra
l
e
x
p
e
rime
n
ts u
si
n
g
3
0
(t
h
irt
y
)
h
o
s
p
it
a
l
p
a
ti
e
n
t
d
a
ta
a
n
d
t
h
e
re
su
lt
s
we
r
e
c
o
m
p
a
re
d
with
t
h
e
re
s
u
lt
s
p
r
o
v
i
d
e
d
b
y
e
x
p
e
rts.
Th
e
e
x
p
e
rime
n
tal
re
su
lt
s
sh
o
w
th
a
t
th
e
sy
ste
m
c
a
n
d
e
term
in
e
b
lo
o
d
d
iso
rd
e
rs
wit
h
9
3
%
a
c
c
u
ra
c
y
a
n
d
1
0
0
%
p
re
c
isio
n
in
t
h
a
las
se
m
ia
p
re
d
ictio
n
.
Th
is
s
y
ste
m
is
v
e
ry
e
ffe
c
ti
v
e
t
o
h
e
lp
d
o
c
to
rs
in
d
iag
n
o
sin
g
t
h
a
las
se
m
ia
p
a
ti
e
n
ts.
K
ey
w
o
r
d
s
:
Ar
tific
ial
in
tellig
en
ce
B
lo
o
d
d
is
o
r
d
er
Fu
zz
y
ap
p
r
o
ac
h
I
n
h
er
ited
d
is
ea
s
e
T
h
alass
em
ia
T
h
is i
s
a
n
o
p
e
n
a
c
c
e
ss
a
rticle
u
n
d
e
r th
e
CC B
Y
-
SA
li
c
e
n
se
.
C
o
r
r
e
s
p
o
nd
ing
A
uth
o
r
:
Ad
m
i Sy
ar
if
Dep
ar
tm
en
t o
f
C
o
m
p
u
ter
Scie
n
ce
,
Facu
lty
o
f
Ma
th
em
atics a
n
d
Natu
r
al
Scien
ce
s
,
L
am
p
u
n
g
Un
iv
er
s
ity
St
.
Pro
f
.
Dr
.
Su
m
a
n
tr
i Bro
jo
n
e
g
o
r
o
N
o
.
1
,
B
an
d
a
r
L
am
p
u
n
g
,
L
am
p
u
n
g
3
5
1
4
5
,
I
n
d
o
n
esia
E
m
ail: a
d
m
i.sy
ar
if
@
f
m
ip
a.
u
n
i
la.
ac
.
id
1.
I
NT
RO
D
UCT
I
O
N
B
lo
o
d
d
is
o
r
d
er
s
ar
e
k
n
o
wn
to
r
eq
u
ir
e
v
e
r
y
ex
p
en
s
iv
e
m
e
d
ical
ex
p
en
s
es.
So
m
e
b
lo
o
d
d
is
o
r
d
er
s
,
s
u
ch
as
th
alass
em
ia,
h
em
o
p
h
ilia
,
b
lo
o
d
clo
ts
,
b
lo
o
d
ca
n
ce
r
,
leu
k
em
ia,
ly
m
p
h
o
m
a,
an
d
m
y
elo
m
a,
r
eq
u
ir
e
a
l
o
t
o
f
m
o
n
ey
.
Diag
n
o
s
in
g
th
alass
em
ia
is
a
ch
allen
g
in
g
task
.
I
n
ad
d
itio
n
to
ca
n
ce
r
,
it
is
co
n
s
id
er
ed
o
n
e
o
f
th
e
m
o
s
t
d
an
g
er
o
u
s
d
is
ea
s
es
in
th
e
wo
r
ld
[
1
]
.
T
h
alass
em
ia
is
o
n
e
ty
p
e
o
f
b
l
o
o
d
d
is
o
r
d
er
d
u
e
t
o
g
e
n
etic
ch
ar
ac
ter
is
tics
d
er
iv
ed
f
r
o
m
b
o
t
h
p
ar
en
ts
[
2
]
,
[
3
]
.
An
o
th
e
r
p
o
s
s
ib
ilit
y
th
at
it
ca
n
ca
u
s
e
is
wh
en
a
g
en
e
m
u
tatio
n
o
cc
u
r
s
[
4
]
.
T
h
is
d
is
ea
s
e
is
co
m
m
o
n
ly
k
n
o
wn
f
r
o
m
in
f
a
n
cy
[
5
]
,
[
6
]
.
I
n
s
o
m
e
ca
s
es,
th
ala
s
s
em
ia
is
d
is
co
v
er
ed
af
ter
a
p
er
s
o
n
g
r
o
ws
u
p
[
4
]
.
W
h
en
tr
ea
tm
en
t
is
g
iv
en
late,
th
e
d
is
e
ase
ca
n
ca
u
s
e
g
r
o
wth
d
elay
s
in
th
e
ch
ild
an
d
o
th
er
co
m
p
licatio
n
s
.
T
h
alass
em
ia
is
also
d
iv
id
ed
in
to
two
ca
teg
o
r
ies:
tr
an
s
f
u
s
io
n
-
d
e
p
en
d
e
n
t
an
d
n
o
n
tr
an
s
f
u
s
io
n
-
d
ep
en
d
e
n
t
[
7
]
.
T
h
e
ea
s
iest
way
to
p
e
r
f
o
r
m
a
b
l
o
o
d
t
r
an
s
f
u
s
io
n
is
b
y
k
n
o
win
g
t
h
e
h
em
o
g
lo
b
in
lev
els
in
th
e
b
lo
o
d
[
7
]
,
[
8
]
.
I
f
it
is
b
elo
w
th
e
s
tan
d
ar
d
v
al
u
e,
a
b
lo
o
d
tr
a
n
s
f
u
s
io
n
s
h
o
u
ld
b
e
in
i
tiated
im
m
ed
iately
.
T
h
alass
em
ia
p
atien
ts
o
f
ten
ex
p
er
ien
ce
a
n
em
ia
wh
ich
c
an
ca
u
s
e
f
atig
u
e,
wea
k
n
ess
,
an
d
d
i
f
f
icu
lty
in
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J Ar
tif
I
n
tell
I
SS
N:
2252
-
8
9
3
8
I
mp
leme
n
ta
tio
n
o
f f
u
z
z
y
lo
g
ic
a
p
p
r
o
a
c
h
fo
r
th
a
la
s
s
emia
s
creen
in
g
in
c
h
ild
r
en
(
E
r
liya
n
R
e
d
y
S
u
s
a
n
to
)
4063
p
er
f
o
r
m
in
g
p
h
y
s
ical
ac
tiv
ity
.
T
h
ey
m
ay
also
ex
p
e
r
ien
ce
d
e
lay
ed
g
r
o
wth
a
n
d
ab
n
o
r
m
al
b
o
n
e
d
ev
elo
p
m
en
t
.
Mo
s
t
o
f
th
ese
ca
s
es
ar
e
f
o
u
n
d
in
c
h
ild
r
en
o
v
e
r
th
e
a
g
e
o
f
two
y
ea
r
s
.
T
h
alass
em
ia
d
ete
ctio
n
ca
n
b
e
d
o
n
e
th
r
o
u
g
h
a
b
lo
o
d
test
in
a
l
ab
o
r
ato
r
y
,
c
o
m
m
o
n
ly
ca
lled
s
cr
ee
n
in
g
.
T
h
alass
em
ia
s
cr
ee
n
in
g
h
as
s
ev
er
al
co
m
p
o
n
en
ts
o
f
b
lo
o
d
test
s
,
in
clu
d
in
g
co
m
p
lete
b
lo
o
d
co
u
n
t
(
C
B
C
)
an
d
h
ig
h
-
p
er
f
o
r
m
a
n
ce
liq
u
id
ch
r
o
m
ato
g
r
ap
h
y
(
HPLC)
[
9
]
,
[
1
0
]
.
Do
cto
r
s
u
s
u
ally
u
s
e
C
B
C
to
p
r
ed
ict
a
b
l
o
o
d
d
is
o
r
d
er
[
1
1
]
,
[
1
2
]
.
So
m
e
o
f
th
e
C
B
C
co
m
p
o
n
en
ts
th
at
h
av
e
b
ee
n
u
s
ed
in
clu
d
e
h
em
o
g
lo
b
in
(
HGB),
m
ea
n
co
r
p
u
s
cu
lar
v
o
lu
m
e
(
MCV)
,
an
d
m
ea
n
co
r
p
u
s
cu
lar
h
e
m
o
g
l
o
b
in
(
MCH)
[
1
3
]
.
W
e
f
o
u
n
d
th
e
p
r
o
b
lem
t
h
at
HPLC
in
s
p
ec
tio
n
is
ex
p
en
s
iv
e,
a
n
d
th
e
co
n
s
u
m
p
tio
n
tim
e
is
p
r
o
lo
n
g
ed
[
1
0
]
,
[
1
4
]
,
[
1
5
]
.
T
h
u
s
,
o
u
r
s
tu
d
y
aim
s
to
u
s
e
a
n
ew
f
u
zz
y
-
b
ased
ap
p
r
o
ac
h
to
m
in
im
ize
co
s
ts
an
d
ac
ce
ler
a
te
th
e
s
cr
ee
n
in
g
tim
e
f
o
r
th
ala
s
s
em
ia
.
Ar
tific
ial
in
tellig
en
ce
(
AI
)
is
o
n
e
o
f
th
e
f
ield
s
o
f
co
m
p
u
ter
s
cien
ce
th
at
is
co
n
s
tan
tly
d
ev
elo
p
in
g
an
d
wid
ely
ap
p
lied
in
v
ar
io
u
s
f
ield
s
[
1
6
]
.
I
n
m
u
ltip
le
s
tu
d
ies,
AI
h
as
b
ee
n
wid
el
y
u
s
ed
to
s
o
lv
e
p
r
o
b
lem
s
r
elate
d
to
m
ed
icin
e,
ag
r
ic
u
ltu
r
e,
an
d
b
u
s
in
ess
[
1
7
]
,
[
1
8
]
.
I
t
is
also
u
s
ed
to
p
r
e
d
ict
th
e
p
r
esen
ce
o
f
b
lo
o
d
d
is
o
r
d
er
s
[
1
8
]
,
[
1
9
]
.
A
s
ig
n
if
ican
t
p
r
o
b
lem
in
AI
ap
p
licatio
n
s
is
d
ea
lin
g
with
n
o
n
-
d
eter
m
i
n
is
tic
d
ata
o
r
in
f
o
r
m
atio
n
.
On
e
p
o
p
u
lar
a
p
p
r
o
ac
h
to
th
is
is
s
u
e
is
to
ad
o
p
t
a
f
u
zz
y
ap
p
r
o
ac
h
.
Sin
ce
Z
ad
e
h
[
2
0
]
in
tr
o
d
u
ce
d
it,
f
u
zz
y
h
as
b
ee
n
wid
ely
u
s
ed
f
o
r
v
ar
io
u
s
ap
p
licatio
n
s
to
s
o
lv
e
v
ar
io
u
s
p
r
o
b
lem
s
o
f
d
is
ea
s
e
in
h
u
m
an
s
[
2
1
]
,
an
i
m
als
[
2
2
]
,
an
d
also
p
lan
ts
[
2
3
]
.
A
f
u
zz
y
ap
p
r
o
ac
h
to
p
r
e
d
ictin
g
th
alass
em
ia
in
c
h
ild
r
en
ca
n
o
v
e
r
co
m
e
s
ev
er
al
ch
alle
n
g
es
[
2
4
]
.
Fu
zz
y
lo
g
ic
ca
n
h
elp
a
n
a
ly
ze
in
ter
p
r
etatio
n
s
th
at
ar
e
in
co
m
p
lete,
am
b
i
g
u
o
u
s
,
o
r
s
u
b
je
ct
to
in
ter
p
r
etatio
n
.
T
h
is
p
r
o
b
lem
m
ak
es
th
e
m
s
u
i
tab
le
f
o
r
d
ea
lin
g
with
th
alass
em
ia
’
s
co
m
p
lex
an
d
d
iv
er
s
e
c
lin
ical
p
ictu
r
e.
T
h
e
p
r
o
p
o
s
ed
m
eth
o
d
u
s
es
a
f
u
z
zy
ap
p
r
o
ac
h
to
p
r
o
v
id
e
a
m
o
r
e
ac
cu
r
ate
an
d
e
f
f
icien
t
m
eth
o
d
f
o
r
p
r
e
d
ictin
g
th
alass
em
ia
in
ch
ild
r
en
.
T
h
alass
em
ia
is
v
er
y
im
p
o
r
tan
t
to
s
tu
d
y
an
d
m
an
y
s
tu
d
ies
o
n
th
e
u
s
e
o
f
AI
f
o
r
th
alass
em
ia
p
r
o
b
lem
s
h
av
e
b
ee
n
co
n
d
u
cte
d
.
T
h
e
u
s
e
o
f
AI
h
as
ad
d
r
ess
ed
a
n
u
m
b
e
r
o
f
ch
allen
g
es
ass
o
ciate
d
with
th
alass
em
ia.
W
e
h
av
e
s
u
m
m
ar
ize
d
s
o
m
e
AI
a
p
p
r
o
ac
h
es to
s
o
lv
e
s
o
m
e
p
r
o
b
le
m
s
in
th
alass
em
ia
p
r
esen
ted
in
T
ab
le
1
.
T
ab
le
1
.
AI
r
esear
ch
o
n
th
alass
em
ia
Y
ear
M
e
t
h
o
d
s
To
p
i
c
s
A
u
t
h
o
r
s
2
0
1
0
M
u
l
t
i
-
l
a
y
e
r
p
e
r
c
e
p
t
r
o
n
,
k
-
n
e
a
r
e
st
n
e
i
g
h
b
o
r
s,
b
a
y
e
s
i
a
n
n
e
t
w
o
r
k
s
,
n
a
ï
v
e
-
B
a
y
e
s,
a
n
d
mu
l
t
i
n
o
mi
a
l
l
o
g
i
st
i
c
r
e
g
r
e
ssi
o
n
Th
e
e
f
f
e
c
i
e
n
c
y
o
f
d
a
t
a
t
y
p
e
s
f
o
r
c
l
a
ssi
f
i
c
a
t
i
o
n
p
e
r
f
o
r
m
a
n
c
e
o
f
mac
h
i
n
e
l
e
a
r
n
i
n
g
t
e
c
h
n
i
q
u
e
s
f
o
r
scree
n
i
n
g
β
-
T
h
a
l
a
sse
mi
a
P
a
o
k
a
n
t
a
e
t
a
l
.
[
2
5
]
2
0
1
6
F
u
z
z
y
l
o
g
i
c
D
e
si
g
n
o
f
a
f
u
z
z
y
m
o
d
e
l
f
o
r
t
h
a
l
a
sse
mi
a
d
i
se
a
se
d
i
a
g
n
o
si
s
:
u
si
n
g
mam
d
a
n
i
t
y
p
e
f
u
z
z
y
i
n
f
e
r
e
n
c
e
sy
st
e
m (F
I
S
)
Th
a
k
u
r
e
t
a
l
.
[
1
1
]
2
0
1
7
F
u
z
z
y
l
o
g
i
c
Th
a
l
a
ss
e
mi
a
r
i
s
k
p
r
e
d
i
c
t
i
o
n
mo
d
e
l
u
si
n
g
f
u
z
z
y
i
n
f
e
r
e
n
c
e
s
y
s
t
e
ms
:
a
n
a
p
p
l
i
c
a
t
i
o
n
o
f
f
u
z
z
y
l
o
g
i
c
Th
a
k
u
r
a
n
d
R
a
w
[
1
2
]
2
0
1
7
F
u
z
z
y
l
o
g
i
c
U
si
n
g
f
u
z
z
y
l
o
g
i
c
f
o
r
i
mp
r
o
v
i
n
g
d
a
i
l
y
c
l
i
n
i
c
a
l
c
a
r
e
o
f
β
-
T
h
a
l
a
ss
e
mi
a
p
a
t
i
e
n
t
s
S
a
n
t
i
n
i
e
t
a
l
.
[
2
3
]
2
0
1
8
S
u
p
p
o
r
t
v
e
c
t
o
r
ma
c
h
i
n
e
D
e
t
e
c
t
i
o
n
o
f
β
t
h
a
l
a
ssem
i
a
c
a
r
r
i
e
r
s
b
y
r
e
d
c
e
l
l
p
a
r
a
m
e
t
e
r
s
o
b
t
a
i
n
e
d
f
r
o
m
a
u
t
o
m
a
t
i
c
c
o
u
n
t
e
r
s
u
si
n
g
ma
t
h
e
ma
t
i
c
a
l
f
o
r
mu
l
a
s
R
o
t
h
e
t
a
l
.
[
1
3
]
2
0
1
9
K
-
n
e
a
r
e
s
t
n
e
i
g
h
b
o
r
a
n
d
n
a
ï
v
e
B
a
y
e
s
C
l
a
s
si
f
i
c
a
t
i
o
n
o
f
t
h
a
l
a
s
sem
i
a
d
a
t
a
u
si
n
g
k
-
n
e
a
r
e
st
n
e
i
g
h
b
o
r
a
n
d
n
a
ï
v
e
B
a
y
e
s
S
i
sw
a
n
t
i
n
i
n
g
e
t
a
l
.
[
2
4
]
2
0
2
0
R
a
n
d
o
m
f
o
r
e
s
t
C
l
a
s
si
f
i
c
a
t
i
o
n
o
f
t
h
a
l
a
ss
e
mi
a
d
a
t
a
u
s
i
n
g
r
a
n
d
o
m
f
o
r
e
st
a
l
g
o
r
i
t
h
m
A
szh
a
r
i
e
t
a
l
.
[
1
7
]
2
0
2
0
M
a
c
h
i
n
e
l
e
a
r
n
i
n
g
a
n
d
d
e
e
p
l
e
a
r
n
i
n
g
A
r
t
i
f
i
c
i
a
l
i
n
t
e
l
l
i
g
e
n
c
e
i
n
h
e
m
a
t
o
l
o
g
y
:
c
u
r
r
e
n
t
c
h
a
l
l
e
n
g
e
s a
n
d
o
p
p
o
r
t
u
n
i
t
i
e
s
R
a
d
a
k
o
v
i
c
h
e
t
a
l
.
[
1
8
]
2
0
2
1
En
se
mb
l
e
c
l
a
ssi
f
i
e
r
s
C
l
a
s
si
f
i
c
a
t
i
o
n
o
f
β
-
t
h
a
l
a
ssem
i
a
c
a
r
r
i
e
r
s
f
r
o
m
r
e
d
b
l
o
o
d
c
e
l
l
i
n
d
i
c
e
s
u
si
n
g
e
n
se
mb
l
e
c
l
a
s
si
f
i
e
r
S
a
d
i
q
e
t
a
l
.
[
1
6
]
2
0
2
2
M
a
c
h
i
n
e
l
e
a
r
n
i
n
g
a
n
d
d
e
e
p
l
e
a
r
n
i
n
g
A
r
e
v
i
e
w
o
f
a
r
t
i
f
i
c
i
a
l
i
n
t
e
l
l
i
g
e
n
c
e
a
p
p
l
i
c
a
t
i
o
n
s
i
n
h
e
m
a
t
o
l
o
g
y
m
a
n
a
g
e
m
e
n
t
:
c
u
r
r
e
n
t
p
r
a
c
t
i
c
e
s
a
n
d
f
u
t
u
r
e
p
r
o
s
p
e
c
t
s
A
l
a
o
u
i
e
t
a
l
.
[
1
9
]
T
ab
le
1
s
h
o
ws
th
at
v
ar
io
u
s
t
h
alass
em
ia
p
r
o
b
lem
s
wo
r
k
ed
a
lo
t
with
AI
.
So
m
e
s
tu
d
ies
o
n
AI
with
f
u
zz
y
lo
g
ical
ap
p
r
o
ac
h
es
h
av
e
ex
ce
llen
t
p
r
ed
ictio
n
ac
cu
r
ac
y
[
2
3
]
,
[
2
6
]
,
[
2
7
]
.
T
h
er
ef
o
r
e,
w
e
u
s
e
th
is
ap
p
r
o
ac
h
to
s
o
lv
e
p
r
o
b
le
m
s
in
th
alass
em
ia.
T
h
is
ar
ticle
aim
s
to
p
r
ed
ict
b
lo
o
d
d
is
o
r
d
er
i
n
a
c
h
ild
,
f
o
cu
s
in
g
o
n
th
alass
em
ia
with
a
f
u
zz
y
ap
p
r
o
ac
h
.
Ou
r
s
y
s
tem
s
r
eq
u
ir
e
d
ata
f
r
o
m
lab
o
r
ato
r
y
test
s
s
u
ch
as
C
B
C
an
d
p
er
ip
h
er
al
b
lo
o
d
s
m
ea
r
(
PB
S).
T
h
alass
em
ia,
r
ef
er
r
ed
to
in
th
is
ar
ticle,
is
a
b
eta
(
β)
t
y
p
e.
T
h
is
ty
p
e
o
f
T
h
alass
em
ia
is
m
o
s
t
co
m
m
o
n
in
I
n
d
o
n
esia
an
d
o
th
er
Asi
an
c
o
u
n
tr
ies.
T
h
is
ar
ticle
p
er
f
ec
ted
p
r
ev
io
u
s
r
esear
ch
o
n
class
if
y
in
g
T
h
alass
em
ia
[
1
1
]
,
[
2
8
]
b
y
ad
d
in
g
PB
S a
s
a
n
e
w
p
ar
am
eter
.
T
h
is
ar
ticle
co
n
s
is
ts
o
f
two
s
tag
es.
First,
th
e
s
y
s
tem
d
etec
ts
b
lo
o
d
d
is
o
r
d
er
s
b
y
an
aly
zin
g
C
B
C
lab
o
r
ato
r
y
r
esu
lts
co
n
tain
in
g
HGB,
M
C
V,
an
d
MCH.
Sec
o
n
d
,
th
e
C
B
C
an
aly
s
is
r
esu
lt
s
th
at
d
etec
t
b
lo
o
d
ab
n
o
r
m
alities
ar
e
t
h
en
m
atc
h
ed
with
ex
p
er
t
k
n
o
wled
g
e
o
f
th
alass
em
ia
s
y
m
p
to
m
s
o
n
PB
S.
Ou
r
s
y
s
tem
will
p
r
o
v
id
e
a
p
r
e
d
ictio
n
o
f
th
e
p
atien
t
’
s
co
n
d
itio
n
b
ased
o
n
t
h
e
an
aly
s
is
p
er
f
o
r
m
e
d
u
s
in
g
C
B
C
an
d
PB
S
d
ata.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8
9
3
8
I
n
t J Ar
tif
I
n
tell
,
Vo
l.
13
,
No
.
4
,
Dec
em
b
er
2
0
2
4
:
4
0
6
2
-
4
0
7
0
4064
T
h
u
s
,
th
e
s
y
s
tem
ca
n
r
ec
o
m
m
en
d
th
e
p
atien
t
’
s
d
iag
n
o
s
is
r
esu
lt
to
th
e
d
o
cto
r
.
I
n
th
is
ca
s
e,
we
u
s
e
f
u
zz
y
m
eth
o
d
to
m
ak
e
t
h
alass
em
ia
p
r
ed
ictio
n
u
s
in
g
C
B
C
an
d
PB
S
d
ata
as
an
alter
n
ativ
e
to
C
B
C
an
d
HPL
C
d
ata.
W
e
p
r
o
p
o
s
e
a
n
ew
ap
p
r
o
ac
h
o
f
u
s
in
g
C
B
C
an
d
P
B
S
to
p
r
ed
ict
th
alass
em
ia
a
s
an
alter
n
ativ
e
to
C
B
C
an
d
HPLC
wh
ich
ar
e
co
m
m
o
n
ly
u
s
ed
b
y
d
o
cto
r
s
to
d
ay
.
W
e
e
v
alu
ate
it
b
y
co
m
p
ar
in
g
th
e
p
er
f
o
r
m
an
ce
o
f
o
u
r
d
ev
elo
p
e
d
s
y
s
tem
with
th
e
o
p
in
io
n
o
f
an
ex
p
er
t
(
c
lin
ical
p
ath
o
lo
g
is
t)
an
d
ass
ess
it
i
s
p
o
ten
tial.
W
e
h
av
e
co
n
d
u
cte
d
a
s
tu
d
y
u
s
in
g
lab
o
r
ato
r
y
d
ata
with
a
n
d
with
o
u
t
th
alass
em
ia
to
d
ev
el
o
p
a
n
d
ev
alu
ate
a
f
u
zz
y
p
r
ed
ictio
n
m
eth
o
d
f
o
r
th
alass
e
m
ia.
T
h
alass
em
ia
s
cr
ee
n
in
g
u
s
in
g
f
u
zz
y
ap
p
r
o
ac
h
with
C
B
C
an
d
PB
S
d
ata
in
p
u
t
is
o
u
r
co
n
tr
i
b
u
tio
n
i
n
th
i
s
s
tu
d
y
.
T
h
e
s
tu
d
y
r
esu
lts
s
h
o
w
th
at
o
u
r
m
o
d
el
h
as
a
v
er
y
g
o
o
d
p
er
f
o
r
m
an
ce
i
n
id
en
tify
in
g
t
h
alass
em
ia
.
2.
M
E
T
H
O
D
2
.
1
.
F
r
a
m
ewo
r
k
s
T
h
e
class
if
icatio
n
o
f
d
is
ea
s
e
s
with
a
f
u
zz
y
ap
p
r
o
ac
h
is
d
esig
n
ed
ac
co
r
d
i
n
g
to
a
p
r
e
d
eter
m
in
ed
f
r
am
ewo
r
k
.
T
h
e
f
r
am
ewo
r
k
is
a
wo
r
k
in
g
co
n
ce
p
tu
al
d
escr
ip
tio
n
o
f
th
e
th
alass
em
ia
class
if
i
ca
tio
n
s
y
s
tem
.
T
h
e
f
r
am
ewo
r
k
th
at
we
h
av
e
d
ev
e
lo
p
ed
is
p
r
esen
te
d
in
Fig
u
r
e
1
.
T
h
e
m
ai
n
p
ar
ts
o
f
Fig
u
r
e
1
ar
e
th
e
k
n
o
wled
g
e
b
ase,
in
f
er
en
ce
e
n
g
in
e,
an
d
u
s
er
in
ter
f
ac
e.
T
h
e
k
n
o
wle
d
g
e
b
ase
is
b
u
ilt
o
n
th
e
cl
in
ical
p
ath
o
lo
g
is
t
’
s
k
n
o
wled
g
e
o
f
b
lo
o
d
d
is
o
r
d
e
r
s
an
d
th
alass
em
ia.
T
h
e
in
f
er
en
ce
en
g
in
e
d
r
aws
co
n
clu
s
io
n
s
b
ased
o
n
th
e
in
f
o
r
m
atio
n
s
to
r
ed
in
t
h
e
k
n
o
wled
g
e
b
ase.
T
h
e
i
n
f
er
e
n
ce
en
g
in
e
is
r
esp
o
n
s
ib
le
f
o
r
r
e
aso
n
in
g
ab
o
u
t
th
e
k
n
o
wled
g
e
b
ase
an
d
u
s
in
g
it
to
s
o
lv
e
p
r
o
b
lem
s
o
r
an
s
wer
q
u
esti
o
n
s
.
T
h
e
in
f
er
en
ce
en
g
in
e
f
o
llo
ws
a
s
et
o
f
r
u
les
o
r
l
o
g
ical
s
tep
s
p
r
o
g
r
am
m
ed
in
to
th
e
s
y
s
tem
.
T
h
e
u
s
er
in
ter
f
ac
e
is
in
th
e
f
o
r
m
o
f
a
p
r
o
g
r
am
d
is
p
lay
t
h
at
is
d
esig
n
ed
ac
co
r
d
i
n
g
to
its
f
u
n
ctio
n
.
Do
cto
r
s
u
s
e
th
e
u
s
er
in
ter
f
ac
e
to
p
r
o
v
id
e
C
B
C
an
d
PB
S
in
p
u
t.
Fu
r
th
er
m
o
r
e
,
th
e
d
o
ct
o
r
will
g
et
in
f
o
r
m
atio
n
o
n
p
r
ed
ictio
n
s
o
f
b
lo
o
d
d
is
o
r
d
e
r
s
an
d
T
h
alas
s
em
ia
ac
co
r
d
in
g
to
th
e
k
n
o
wled
g
e
o
f
a
clin
ical
p
a
th
o
lo
g
is
t.
K
n
o
w
l
e
d
g
e
b
a
s
e
I
n
f
e
r
e
n
c
e
e
n
g
i
n
e
Th
a
l
a
s
s
e
m
i
a
p
r
e
d
i
c
t
i
o
n
B
l
o
o
d
d
i
s
o
r
d
e
r
p
r
e
d
i
c
t
i
o
n
U
s
e
r
i
n
t
e
r
f
a
c
e
D
o
c
t
o
r
C
B
C
P
B
S
c
l
i
n
i
c
a
l
p
a
t
h
o
l
o
g
i
s
t
Fig
u
r
e
1
.
Fra
m
ewo
r
k
o
f
th
alas
s
em
i
a
s
cr
ee
n
in
g
2
.
2
.
P
re
dict
io
n
o
f
blo
o
d dis
o
rder
s
Do
cto
r
s
u
s
u
ally
p
er
f
o
r
m
a
n
a
n
am
n
esis
,
a
p
h
y
s
ical
ex
am
in
a
tio
n
o
f
th
e
p
atien
t,
an
d
ar
e
s
u
p
p
o
r
ted
b
y
th
e
r
esu
lts
o
f
b
lo
o
d
test
s
,
i.e
.
,
C
B
C
.
T
h
is
s
ec
tio
n
u
s
es
a
f
u
zz
y
a
p
p
r
o
ac
h
to
d
eter
m
in
e
t
h
e
s
u
s
p
ec
ted
b
lo
o
d
d
is
o
r
d
er
.
T
h
e
f
u
zz
y
ap
p
r
o
ac
h
is
u
s
ed
b
ec
au
s
e
th
e
o
p
in
io
n
o
f
d
o
cto
r
s
ab
o
u
t
t
h
e
s
tan
d
ar
d
th
r
esh
o
ld
v
alu
es
o
n
th
e
C
B
C
r
e
s
u
lts
h
as
a
to
ler
an
ce
.
B
ased
o
n
p
r
ev
i
o
u
s
liter
atu
r
e
[
1
1
]
,
[
1
6
]
,
C
B
C
d
ata:
HGB
,
MCV,
an
d
MCH.
B
ased
o
n
o
u
r
in
ter
v
iews,
clin
ical
p
ath
o
lo
g
is
ts
b
eliev
e
th
a
t
HGB
is
th
e
f
ir
s
t
in
d
icato
r
u
s
ed
to
s
u
s
p
ec
t
th
e
p
r
esen
ce
o
f
b
lo
o
d
d
is
o
r
d
e
r
s
,
th
en
to
ass
ess
o
th
er
in
d
icato
r
s
.
2
.
3
.
T
ha
la
s
s
em
ia
predict
io
n
T
h
e
d
o
cto
r
’
s
d
iag
n
o
s
is
lead
s
to
a
b
lo
o
d
d
is
o
r
d
er
o
r
n
o
t
b
lo
o
d
d
is
o
r
d
er
.
I
f
th
e
d
iag
n
o
s
is
lead
s
to
b
lo
o
d
d
is
o
r
d
er
s
,
p
r
o
ce
ed
with
a
m
o
r
e
d
etailed
b
l
o
o
d
test
,
n
a
m
ely
PB
S.
B
a
s
ed
o
n
th
e
r
esu
lts
o
f
th
e
PB
S,
it wil
l
th
en
b
e
co
m
p
ar
ed
with
th
e
ch
a
r
ac
ter
is
tics
o
f
th
alass
em
ia
d
is
e
ase.
I
n
g
en
er
al,
th
e
ch
ar
ac
te
r
is
tics
o
f
th
alass
em
ia
b
ased
o
n
PB
S
in
clu
d
e
m
icr
o
c
y
tic,
p
o
ly
c
h
r
o
m
asia,
h
y
p
o
ch
r
o
m
ic,
tear
d
r
o
p
,
a
n
d
tar
g
et
ce
lls
[
7
]
,
[
2
9
]
,
[
3
0
]
.
T
h
e
th
alass
em
ia
p
r
ed
ictio
n
s
ec
tio
n
will
p
r
o
v
id
e
o
u
tp
u
t
in
th
e
f
o
r
m
o
f
p
atien
t
i
n
f
o
r
m
atio
n
in
d
icate
d
b
y
th
alass
em
ia
o
r
n
o
t t
h
alass
em
ia
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J Ar
tif
I
n
tell
I
SS
N:
2252
-
8
9
3
8
I
mp
leme
n
ta
tio
n
o
f f
u
z
z
y
lo
g
ic
a
p
p
r
o
a
c
h
fo
r
th
a
la
s
s
emia
s
creen
in
g
in
c
h
ild
r
en
(
E
r
liya
n
R
e
d
y
S
u
s
a
n
to
)
4065
2.
4
.
K
no
wledg
e
ba
s
ed
T
h
is
s
tu
d
y
u
s
es
C
B
C
,
in
clu
d
in
g
HGB,
MCV,
an
d
M
C
H.
T
h
e
s
u
s
p
ec
ted
p
r
esen
ce
o
f
b
lo
o
d
d
is
o
r
d
er
s
s
u
ch
as
th
alass
em
ia
ca
n
b
e
k
n
o
wn
b
ased
o
n
th
ese
v
alu
es
[
3
1
]
.
T
ab
le
2
is
a
k
n
o
wled
g
e
b
a
s
e
o
n
th
e
p
r
ed
ictio
n
o
f
b
lo
o
d
d
is
o
r
d
er
s
b
ased
o
n
C
B
C
.
T
ab
le
2
.
Kn
o
wled
g
e
-
b
ased
f
o
r
b
lo
o
d
d
is
o
r
d
er
s
b
ased
o
n
C
B
C
No
P
a
r
a
me
t
e
r
s
R
e
f
e
r
e
n
c
e
s
D
i
so
r
d
e
r
s
u
n
i
t
s
1
HGB
1
0
.
8
-
1
2
.
8
<
1
0
.
8
o
r
>
1
2
.
8
g
/
d
L
2
M
C
V
73
-
1
0
1
<
7
3
o
r
>
1
0
1
fL
3
M
C
H
23
-
31
<
2
3
o
r
>
3
1
Pg
C
B
C
v
alu
es
th
at
d
o
n
o
t
m
atch
th
e
r
ef
er
en
ce
v
al
u
es
in
d
icate
th
at
p
atien
ts
ar
e
s
tr
o
n
g
ly
s
u
s
p
ec
ted
o
f
h
av
in
g
b
lo
o
d
d
is
o
r
d
er
s
.
Do
ct
o
r
s
r
ec
o
m
m
en
d
th
at
t
h
e
p
atie
n
t
u
n
d
er
g
o
f
u
r
th
er
ex
am
i
n
atio
n
,
n
am
ely
PB
S,
to
en
s
u
r
e
th
at
th
er
e
a
r
e
s
u
s
p
ec
ted
b
lo
o
d
d
is
o
r
d
er
s
.
B
ased
o
n
PB
S
[
2
9
]
,
[
3
0
]
,
[
3
2
]
,
th
alass
em
ia
h
as sev
er
al
u
n
iq
u
e
ch
ar
ac
ter
is
tics
:
m
icr
o
cy
tic,
h
y
p
o
ch
r
o
m
ic,
tear
d
r
o
p
,
p
o
ly
c
h
r
o
m
asia,
an
d
tar
g
et
ce
lls
.
T
h
e
o
p
in
io
n
o
f
e
x
p
er
t
s
tates
th
at
th
e
p
atien
t
will
b
e
ca
lled
a
ca
r
r
ier
if
h
e
is
m
icr
o
cy
tic
an
d
h
y
p
o
c
h
r
o
m
ic.
At
t
h
e
s
am
e
tim
e,
it
is
ca
lled
th
alass
em
ia
if
it h
as o
th
er
s
ig
n
s
,
s
u
ch
as tea
r
d
r
o
p
s
,
p
o
l
y
ch
r
o
m
asia,
a
n
d
tar
g
et
ce
lls
.
2.
5
.
F
uzzy
m
e
m
bersh
ip f
un
c
t
io
n
B
ased
o
n
th
e
k
n
o
wled
g
e
b
ase
o
n
b
lo
o
d
d
is
o
r
d
er
s
,
d
eter
m
in
e
th
e
p
ar
am
eter
s
u
s
ed
an
d
cr
ea
te
a
m
ath
em
atica
l
f
u
n
ctio
n
in
a
f
u
zz
y
m
em
b
er
s
h
ip
f
u
n
ctio
n
[
3
3
]
.
T
h
e
ex
is
ten
ce
o
f
ex
p
er
t
to
ler
an
ce
f
o
r
th
e
r
ef
er
en
ce
v
alu
e
o
f
ea
c
h
p
a
r
a
m
eter
u
s
ed
is
wh
y
we
u
s
e
a
f
u
zz
y
a
p
p
r
o
ac
h
.
W
e
c
o
n
s
tr
u
c
t
f
u
zz
y
m
em
b
er
s
h
i
p
f
u
n
ctio
n
s
a
n
d
c
u
r
v
es
f
o
r
ea
ch
C
B
C
p
ar
am
eter
[
1
1
]
b
ased
o
n
lab
o
r
ato
r
y
d
ata
on
b
lo
o
d
d
is
o
r
d
er
s
p
r
esen
ted
i
n
T
ab
le
3
.
T
ab
le
3
.
Me
m
b
er
s
h
ip
f
u
n
ctio
n
an
d
cu
r
v
es
P
a
r
a
me
t
e
r
M
e
m
b
e
r
s
h
i
p
f
u
n
c
t
i
o
n
C
u
r
v
e
s
HGB
[
7
.
2
]
=
{
1
≤
10
10
.
8
−
10
.
8
−
10
10
≤
≤
10
.
8
0
>
10
.
8
M
C
V
[
72
]
=
{
1
≤
71
73
−
73
−
71
71
≤
≤
73
0
>
73
M
C
H
[
22
.
2
]
=
{
1
≤
21
23
−
23
−
21
21
≤
≤
23
0
>
23
Fo
r
ex
am
p
le,
we
co
n
s
id
er
p
at
ien
t
x
with
C
B
C
d
ata
with
H
GB
v
alu
es
o
f
7
.
2
0
,
MCV
o
f
7
2
.
0
0
,
an
d
MCH
o
f
2
2
.
2
0
.
B
ased
o
n
th
e
m
em
b
er
s
h
ip
f
u
n
ctio
n
in
T
ab
le
2
,
t
h
e
f
u
zz
y
v
alu
es
f
o
r
b
lo
o
d
d
is
o
r
d
er
s
ar
e
HGB:
1
.
0
0
,
MCV:
1
.
0
0
,
an
d
MCH:
0
.
4
0
.
As
f
o
r
n
o
t
b
lo
o
d
d
is
o
r
d
er
s
,
th
e
v
alu
es
ar
e
HGB:
0
.
0
0
,
MCV:
0
.
0
0
,
a
n
d
MCH:0
.
6
0
.
T
h
e
n
we
cr
ea
te
f
u
zz
y
weig
h
ts
f
o
r
4
0
%
HGB,
3
0
%
MCV,
an
d
3
0
%
MCH.
So
,
we
g
et
a
f
u
zz
y
weig
h
t
f
o
r
b
lo
o
d
d
is
o
r
d
er
s
o
f
0
.
8
2
a
n
d
f
o
r
n
o
t
b
lo
o
d
d
is
o
r
d
er
s
o
f
0
.
1
8
.
B
ased
o
n
t
h
e
f
u
zz
y
weig
h
ts
,
it
ca
n
b
e
co
n
clu
d
e
d
th
at
th
er
e
is
a
s
u
s
p
i
cio
n
th
at
th
e
p
atien
t h
as a
b
lo
o
d
d
is
o
r
d
er
.
Fu
r
th
er
m
o
r
e
,
a
PB
S
-
b
ased
ex
am
in
atio
n
was
ca
r
r
ie
d
o
u
t
o
n
p
atien
ts
s
u
s
p
ec
ted
o
f
h
av
in
g
b
lo
o
d
d
is
o
r
d
er
s
.
W
e
p
u
t
a
“
1
”
if
th
e
m
ar
k
is
f
o
u
n
d
an
d
a
“
0
”
if
it
is
n
o
t
f
o
u
n
d
.
Sig
n
s
in
q
u
esti
o
n
in
clu
d
e
m
icr
o
c
y
tic,
h
y
p
o
c
h
r
o
m
ic,
tear
d
r
o
p
,
p
o
ly
c
h
r
o
m
asia,
an
d
tar
g
et
ce
lls
[
3
0
]
.
T
h
e
PB
S d
ata
o
f
p
atien
t x
s
h
o
wed
m
icr
o
cy
tic: 1
,
h
y
p
o
c
h
r
o
m
ic:
1
,
tear
d
r
o
p
:
1
,
p
o
ly
ch
r
o
m
asia:
1
,
a
n
d
tar
g
et
ce
lls
:
1
.
B
ased
o
n
th
e
liter
atu
r
e
[
2
9
]
an
d
ex
p
er
t
k
n
o
wled
g
e,
PB
S
is
a
m
eth
o
d
co
m
m
o
n
ly
u
s
ed
b
y
d
o
cto
r
s
to
d
iag
n
o
s
e
b
lo
o
d
d
is
o
r
d
er
s
.
T
h
er
ef
o
r
e
,
th
e
co
n
clu
s
io
n
o
f
th
e
d
iag
n
o
s
is
b
a
s
ed
o
n
th
e
PB
S v
alu
e
is
th
at
th
e
p
atien
t
s
u
f
f
er
s
f
r
o
m
th
alass
em
ia
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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:
2
2
5
2
-
8
9
3
8
I
n
t J Ar
tif
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n
tell
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Vo
l.
13
,
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4
,
Dec
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b
er
2
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4
:
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3.
RE
SU
L
T
S AN
D
D
I
SCU
SS
I
O
N
3
.
1
.
E
v
a
lua
t
i
o
n
T
h
e
s
y
s
tem
s
we
h
a
v
e
d
e
v
elo
p
ed
h
a
v
e
b
ee
n
test
ed
t
o
ev
alu
a
te
th
e
r
esu
lts
o
f
th
is
s
tu
d
y
.
W
e
h
av
e
as
m
an
y
as
3
0
lab
d
ata
s
ets
o
f
C
B
C
an
d
P
B
S
d
ata.
T
h
e
tr
ial
w
as
co
n
d
u
cted
u
s
in
g
p
atien
t
d
at
a
o
b
tain
ed
f
r
o
m
th
e
h
o
s
p
ital.
T
h
e
r
esu
lts
ar
e
co
m
p
ar
ed
to
th
e
o
p
in
i
o
n
s
o
f
e
x
p
er
ts
(
c
lin
ical
p
ath
o
lo
g
is
t
at
a
p
u
b
lic
h
o
s
p
ital
in
L
am
p
u
n
g
I
n
d
o
n
esia)
.
T
h
e
r
esu
lts
o
f
th
is
ex
p
er
im
en
t a
r
e
p
r
es
en
ted
in
T
ab
le
4
.
T
ab
le
4
.
T
est r
esu
lts
p
r
ed
ictiv
e
o
f
b
lo
o
d
d
is
o
r
d
er
s
No
P
a
r
a
me
t
e
r
Ex
p
e
r
t
P
r
o
p
o
se
d
s
y
st
e
m
R
e
s
u
l
t
s
HGB
M
C
V
M
C
H
1
1
2
.
9
0
7
3
.
7
0
2
5
.
9
0
N
o
t
N
o
t
Tr
u
e
2
5
.
9
0
4
9
.
3
0
1
2
.
0
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
3
7
.
2
0
7
2
.
0
0
2
2
.
2
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
4
9
.
2
0
9
8
.
3
0
3
0
.
8
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
5
1
3
.
0
0
8
2
.
3
0
2
9
,
1
0
N
o
t
N
o
t
Tr
u
e
6
1
1
.
7
0
5
9
.
9
0
1
8
.
8
0
N
o
t
N
o
t
Tr
u
e
7
1
1
.
8
0
7
4
.
3
0
2
7
.
6
0
N
o
t
N
o
t
Tr
u
e
8
8
.
8
0
9
0
.
5
0
2
8
.
9
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
9
4
.
5
0
8
5
.
7
0
2
9
,
2
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
10
1
3
.
7
0
7
9
.
2
0
2
7
,
6
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
11
1
1
.
2
0
8
3
.
5
0
2
8
.
0
0
N
o
t
N
o
t
Tr
u
e
12
1
2
.
6
0
7
8
.
8
0
2
6
.
8
0
N
o
t
N
o
t
Tr
u
e
13
1
1
.
3
0
7
6
.
4
0
2
5
.
5
0
N
o
t
N
o
t
Tr
u
e
14
1
5
.
5
0
8
3
.
6
0
2
9
.
9
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
15
1
3
.
8
0
8
2
.
2
0
2
8
.
6
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
16
1
2
.
5
0
7
7
.
5
0
2
7
.
6
0
N
o
t
N
o
t
Tr
u
e
17
7
.
3
0
5
3
.
5
0
1
4
.
9
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
18
8
.
7
0
7
2
.
9
0
2
3
.
3
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
19
9
.
7
0
8
2
.
1
0
2
6
,
4
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
20
1
6
.
7
0
6
5
.
9
0
2
1
.
7
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
21
3
.
6
0
9
1
.
7
0
2
7
.
3
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
22
1
1
.
3
0
6
9
.
0
0
1
0
:
6
0
N
o
t
N
o
t
Tr
u
e
23
1
0
.
0
0
9
2
.
2
0
3
0
.
1
0
B
l
o
o
d
d
i
so
r
d
e
r
s
N
o
t
F
a
l
se
24
1
3
.
9
0
8
4
.
0
0
2
8
.
9
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
25
4
.
9
0
1
1
0
.
1
0
3
8
.
0
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
26
6
.
7
0
7
7
.
2
0
2
5
.
0
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
27
3
.
5
0
8
0
.
2
0
2
7
.
8
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
28
5
.
0
0
6
6
.
7
0
2
0
.
3
0
B
l
o
o
d
d
i
so
r
d
e
r
s
B
l
o
o
d
d
i
so
r
d
e
r
s
Tr
u
e
29
1
0
.
8
0
6
2
.
5
0
1
9
.
9
0
N
o
t
N
o
t
Tr
u
e
30
1
4
.
0
0
7
4
.
0
0
2
5
.
6
0
N
o
t
B
l
o
o
d
D
i
so
r
d
e
r
s
F
a
l
se
T
ab
le
4
s
h
o
ws
th
at
clin
ical
p
ath
o
lo
g
is
ts
b
eliev
e
th
at
8
p
atie
n
ts
h
av
e
b
lo
o
d
d
is
o
r
d
e
r
s
an
d
1
1
d
o
n
o
t.
T
h
e
s
y
s
tem
we
d
ev
elo
p
e
d
als
o
p
r
e
d
icts
th
e
s
am
e
n
u
m
b
er
.
Ho
wev
er
,
th
e
r
e
ar
e
d
if
f
er
en
ce
s
in
p
r
e
d
ictio
n
s
f
r
o
m
d
ata
2
3
an
d
3
0
.
T
h
e
p
r
ed
icti
o
n
s
f
r
o
m
th
e
two
d
ata
s
ets
ar
e
co
n
tr
ad
icto
r
y
t
o
ea
ch
o
th
er
.
T
h
e
class
if
icatio
n
s
y
s
tem
f
o
r
b
lo
o
d
d
is
o
r
d
er
s
th
at
we
d
ev
elo
p
ed
g
a
v
e
r
esu
lts
in
clu
d
in
g
1
8
p
atien
ts
id
en
tifie
d
as
h
av
in
g
b
lo
o
d
d
is
o
r
d
er
s
(
tr
u
e
p
o
s
itiv
e
)
,
1
p
a
tien
t
with
n
o
t
b
lo
o
d
d
is
o
r
d
er
id
en
tifie
d
as
a
b
lo
o
d
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p
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in
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o
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o
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r
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is
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o
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W
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ill
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s
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ate
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er
all
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alu
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etr
ic
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y
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i
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Fig
u
r
e
2
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W
e
co
n
d
u
cted
an
o
th
er
ex
p
er
i
m
en
t
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ate
th
e
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o
f
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e
p
r
e
d
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ased
o
n
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o
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o
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t
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e
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atien
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W
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m
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h
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a
r
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o
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r
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ted
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T
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le
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.
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I
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icatio
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atien
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ativ
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d
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p
atien
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wh
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.
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e
s
h
o
w
th
e
co
n
f
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s
io
n
m
atr
ix
in
T
ab
le
7
.
T
ab
le
7
.
C
o
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f
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s
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f
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r
p
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ed
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n
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f
th
alass
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e
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t
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8
B
ased
o
n
ex
p
er
t
o
p
in
io
n
s
as
s
h
o
wn
in
T
ab
le
7
,
th
e
ac
c
u
r
a
cy
o
f
th
e
test
r
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o
f
th
e
s
y
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we
d
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d
to
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tif
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h
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s
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s
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g
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i
s
1
0
0
%.
Ho
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f
ee
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th
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f
o
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am
p
le
with
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u
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en
s
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b
les
[
3
4
]
,
[
3
5
]
.
W
e
h
o
p
e
th
at
th
is
wo
r
k
ca
n
b
e
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o
n
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u
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d
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y
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s
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al
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ata
to
test
th
e
q
u
ali
ty
an
d
ac
cu
r
ac
y
o
f
th
e
s
y
s
tem
th
at
h
as b
ee
n
d
e
v
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o
p
ed
.
93%
95%
91%
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8
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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4
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4068
4.
CO
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N
T
h
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ased
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p
p
r
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f
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th
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s
cr
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g
.
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t
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ts
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f
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ased
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h
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ased
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C
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d
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ata.
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h
e
k
n
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g
e
u
s
ed
in
th
is
r
esear
c
h
is
also
b
a
s
ed
o
n
in
f
o
r
m
atio
n
f
r
o
m
clin
ical
p
ath
o
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ts
.
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h
e
s
y
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tem
h
as
b
ee
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alu
ated
u
s
in
g
th
e
h
o
s
p
ital
’
s
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tu
al
p
atien
t
d
ata
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d
co
m
p
ar
in
g
th
e
r
esu
lts
with
th
o
s
e
p
r
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v
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e
d
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y
ex
p
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ts
.
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ased
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C
B
C
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d
PB
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ata,
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r
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y
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tem
h
as
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er
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ig
h
ac
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ac
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i
n
p
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ed
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b
lo
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d
is
o
r
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er
s
(
9
3
%
ac
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r
ac
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)
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d
th
alass
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ia
(
1
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%
ac
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r
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)
.
Ho
we
v
er
,
m
o
r
e
d
ata
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ets
ar
e
n
ee
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ed
to
test
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is
m
o
d
el.
I
n
th
e
f
u
tu
r
e,
t
h
is
m
o
d
el
ca
n
ad
a
p
t
th
e
f
u
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y
en
s
em
b
le
to
im
p
r
o
v
e
m
o
d
el
p
er
f
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r
m
a
n
ce
.
ACK
NO
WL
E
DG
E
M
E
NT
S
W
e
th
an
k
to
Un
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er
s
itas
T
ek
n
o
k
r
at
I
n
d
o
n
esia
f
o
r
s
u
p
p
o
r
tin
g
th
is
r
esear
ch
.
W
e
also
th
an
k
th
e
I
m
m
an
u
el
Ho
s
p
ital
B
an
d
ar
L
am
p
u
n
g
,
I
n
d
o
n
esia,
esp
ec
ially
Mr
.
Ns.
Dw
ian
to
r
o
,
f
o
r
p
r
o
v
i
d
in
g
th
e
lab
o
r
ato
r
y
d
ata.
RE
F
E
R
E
NC
E
S
[
1
]
J.
I
.
Jo
h
n
se
n
,
C
.
D
y
b
e
r
g
,
a
n
d
M
.
W
i
c
k
st
r
ö
m,
“
N
e
u
r
o
b
l
a
st
o
ma
—
A
n
e
u
r
a
l
c
r
e
s
t
d
e
r
i
v
e
d
e
mb
r
y
o
n
a
l
m
a
l
i
g
n
a
n
c
y
,
”
Fr
o
n
t
i
e
rs
i
n
Mo
l
e
c
u
l
a
r
N
e
u
r
o
sc
i
e
n
c
e
,
v
o
l
.
1
2
,
p
p
.
1
–
1
1
,
2
0
1
9
,
d
o
i
:
1
0
.
3
3
8
9
/
f
n
mo
l
.
2
0
1
9
.
0
0
0
0
9
.
[
2
]
S
.
P
e
r
e
r
a
e
t
a
l
.
,
“
G
e
n
o
t
y
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id
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