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2.
M
E
T
H
O
D
T
h
is
r
esear
ch
p
r
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ts
th
e
i
m
p
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tatio
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f
a
s
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I
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T
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b
ased
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ea
r
t
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E
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G
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n
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is
,
in
teg
r
atin
g
th
r
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r
im
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m
p
o
n
e
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ts
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s
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h
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to
v
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s
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m
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u
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d
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is
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d
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T
m
o
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ito
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tem
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e
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elty
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b
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ig
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ip
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ac
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m
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at
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t
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ig
n
if
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tly
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lin
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h
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B
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p
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th
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h
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m
s
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al
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o
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u
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u
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.
Mo
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3.
RE
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D
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r
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ased
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icien
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ated
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if
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th
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ith
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r
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h
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w
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ely
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et
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ted
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m
atch
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e
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s
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en
s
u
r
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le
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er
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m
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ce
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ab
le
3
s
h
o
ws
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r
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ef
f
icien
ts
f
o
r
R
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p
ea
k
an
d
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R
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ter
v
al
d
e
tectio
n
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o
s
s
h
ea
r
t
r
ates
(
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0
,
8
0
,
1
2
0
B
PM)
.
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p
litu
d
e
R
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ef
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0
.
9
9
9
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in
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icatin
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e
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ag
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ee
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etwe
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d
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lated
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u
es.
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h
e
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ter
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tio
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o
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d
s
a
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er
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0
0
co
r
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c
o
n
f
i
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m
in
g
its
ac
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h
e
R
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ter
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v
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im
p
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ata,
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with
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s
o
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h
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r
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s
T
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n
ea
r
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ate
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ito
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g
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r
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o
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e
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atasets
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ed
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er
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ce
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itio
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h
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tu
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y
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itatio
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g
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u
s
e
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f
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im
u
lat
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E
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G
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ig
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als,
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ich
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t
f
u
lly
r
ep
licate
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ea
l
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r
ld
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ar
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a
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ited
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am
p
le
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ize
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f
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9
9
s
am
p
les
ac
r
o
s
s
th
r
ee
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ea
r
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r
ates.
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tu
r
e
r
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s
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u
ld
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n
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G
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s
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ess
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ally
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in
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o
r
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ad
v
an
ce
d
s
ig
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al
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r
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iq
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u
n
d
er
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itio
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s
.
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r
th
er
v
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in
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s
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is
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s
s
en
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s
u
r
e
r
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r
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r
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tical
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.
T
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3
.
Am
p
litu
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e
R
an
d
R
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R
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r
r
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n
co
ef
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ic
ien
t
P
a
r
a
me
t
e
r
s
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mp
l
i
t
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d
e
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R
-
R
4
0
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P
M
0
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9
9
9
1
.
0
0
(
o
v
e
r
a
l
l
)
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0
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P
M
0
.
9
9
8
1
2
0
B
P
M
0
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7
3
.
3
.
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CG
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h Io
T
B
ased
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th
e
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etec
ted
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el
in
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ab
le
4
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e
co
n
d
itio
n
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ar
e
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t
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ec
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tim
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i
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elo
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ased
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T
h
e
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r
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eter
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u
t
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u
r
th
e
r
an
aly
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is
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d
test
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m
ay
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m
th
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ce
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tu
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ith
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with
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e
to
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th
e
r
ass
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th
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r
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s
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ess
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d
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ar
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s
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m
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ce
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o
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ith
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s
f
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d
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ter
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ated
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h
ac
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en
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lin
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ly
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o
f
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n
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m
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r
t
r
h
y
th
m
s
an
d
im
p
r
o
v
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n
g
p
atien
t
o
u
tco
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es.
W
ith
its
p
o
ten
tial
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o
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g
lo
b
al
h
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lth
im
p
ac
t,
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ar
tic
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lar
ly
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n
d
e
r
s
er
v
ed
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g
y
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lim
ited
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e
g
io
n
s
,
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is
s
y
s
tem
r
ep
r
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ts
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n
o
v
el,
m
u
ltid
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cip
lin
ar
y
ap
p
r
o
ac
h
to
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ex
t
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g
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m
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