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419
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CC B
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co
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1.
I
NT
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N
Ma
lar
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o
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tality
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ates
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in
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I
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[
1
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-
[
3
]
.
Pap
u
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Pro
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th
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af
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Plas
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p
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lim
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lab
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test
in
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f
ac
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4
]
,
[
5
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,
th
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s
ca
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s
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m
alar
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s
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ly
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Data
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
5
0
2
-
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7
52
In
d
o
n
esian
J
E
lec
E
n
g
&
C
o
m
p
Sci
,
Vo
l.
41
,
No
.
1
,
J
an
u
ar
y
20
2
6
:
419
-
4
2
9
420
E
lly
Uy
o
C
o
m
m
u
n
ity
Hea
lth
C
en
ter
g
en
er
ally
b
e
g
in
s
with
r
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is
tr
atio
n
,
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am
n
esis
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p
h
y
s
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am
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,
a
n
d
lab
o
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co
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test
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a
r
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DT
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.
Alth
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th
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s
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en
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s
.
[
6
]
,
[
7
]
.
I
n
tech
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ev
elo
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tific
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ased
ex
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tem
s
[
8
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,
[
9
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.
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in
f
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ajo
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ity
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(
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Ho
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h
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1
2
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s
with
r
ec
o
m
m
en
d
atio
n
s
f
o
r
ap
p
r
o
p
r
iate
p
r
o
b
lem
-
s
o
lv
in
g
ac
tio
n
s
.
W
ith
in
th
e
m
ed
ical
f
ield
,
ex
p
er
t
s
y
s
tem
s
ca
n
b
e
ap
p
lied
to
an
aly
ze
d
ata
an
d
p
r
ed
ict
h
ea
lth
co
n
d
itio
n
s
,
s
u
ch
as
id
e
n
tify
in
g
d
is
ea
s
es
b
ased
o
n
p
atien
t
s
y
m
p
to
m
s
.
B
y
lev
er
ag
in
g
a
k
n
o
wled
g
e
b
ase
an
d
an
in
f
er
e
n
ce
en
g
in
e
co
m
p
o
s
ed
o
f
p
r
ed
e
f
in
ed
r
u
les,
ex
p
e
r
t
s
y
s
tem
s
ca
n
ef
f
ec
tiv
ely
s
u
p
p
o
r
t
th
e
d
iag
n
o
s
tic
p
r
o
ce
s
s
.
T
h
e
in
teg
r
atio
n
o
f
th
e
f
o
r
wa
r
d
ch
ain
in
g
a
p
p
r
o
ac
h
w
ith
th
e
CF
m
eth
o
d
allo
ws
th
e
s
y
s
tem
to
p
r
o
ce
s
s
b
o
th
clin
ical
an
d
lab
o
r
ato
r
y
d
a
ta,
th
er
eb
y
im
p
r
o
v
in
g
t
h
e
ac
cu
r
ac
y
o
f
m
alar
ia
d
iag
n
o
s
is
[
1
3
]
,
[
1
4
]
.
Var
io
u
s
p
r
ev
io
u
s
s
tu
d
ies
h
av
e
im
p
lem
en
ted
f
o
r
war
d
ch
ain
in
g
an
d
CF
in
ca
s
e
s
o
f
in
f
ec
tio
u
s
d
is
ea
s
e
s
an
d
o
th
er
in
f
ec
tio
n
s
.
Fo
r
ex
a
m
p
le,
r
esear
ch
o
n
th
e
d
ia
g
n
o
s
is
o
f
d
en
g
u
e
h
em
o
r
r
h
ag
ic
f
e
v
er
(
DHF)
,
m
alar
ia,
an
d
c
h
ik
u
n
g
u
n
y
a
s
h
o
wed
8
0
%
–
9
8
%
ac
cu
r
ac
y
f
o
r
f
o
r
war
d
ch
ain
in
g
an
d
t
h
e
s
u
p
e
r
io
r
ity
o
f
CF
in
h
a
n
d
lin
g
u
n
ce
r
tain
ty
.
An
o
th
er
s
tu
d
y
o
n
th
e
d
iag
n
o
s
is
o
f
ea
r
in
f
ec
tio
n
s
p
r
o
d
u
ce
d
9
4
%
ac
cu
r
ac
y
b
u
t
was
lim
ited
to
o
n
e
ty
p
e
o
f
d
is
ea
s
e
[
1
5
]
,
wh
ile
r
es
ea
r
ch
in
Mim
ik
a
R
eg
en
c
y
r
ec
o
r
d
ed
9
8
.
2
%
ac
c
u
r
ac
y
f
o
r
m
al
ar
ia
d
iag
n
o
s
is
,
b
u
t
was
o
n
ly
av
ailab
le
f
o
r
lo
ca
l
ac
ce
s
s
[
1
6
]
.
An
o
th
er
s
tu
d
y
d
etec
ted
th
r
ee
f
eb
r
ile
d
is
ea
s
es
(
DH
F,
m
alar
ia,
ty
p
h
o
id
)
ea
r
ly
with
9
5
%
ac
c
u
r
ac
y
,
b
u
t
th
e
c
o
m
p
lex
ity
o
f
s
im
ilar
s
y
m
p
to
m
s
m
ad
e
th
e
m
eth
o
d
less
th
an
o
p
tim
al
o
p
tim
izatio
n
[
1
7
]
.
T
o
d
ate,
n
o
m
alar
ia
d
iag
n
o
s
tic
s
y
s
tem
h
as
b
ee
n
f
o
u
n
d
th
at
s
p
ec
if
ically
in
teg
r
ates
cli
n
ical
d
ata
(
s
u
b
jectiv
e
s
y
m
p
to
m
s
)
an
d
la
b
o
r
ato
r
y
d
ata
(
o
b
jectiv
e
r
esu
l
ts
)
in
a
h
y
b
r
id
f
o
r
war
d
ch
ain
in
g
an
d
CF
mod
e
l
.
T
h
e
r
e
f
o
r
e
,
t
h
i
s
s
t
u
d
y
a
i
m
s
t
o
d
e
v
e
l
o
p
a
n
d
o
p
t
i
m
i
ze
a
h
y
b
r
i
d
f
o
r
w
a
r
d
c
h
a
i
n
i
n
g
a
n
d
CF
m
o
d
e
l
t
h
a
t
i
n
t
e
g
r
at
es
c
l
i
n
i
c
al
a
n
d
l
a
b
o
r
a
t
o
r
y
d
a
t
a
t
o
im
p
r
o
v
e
t
h
e
a
c
c
u
r
a
c
y
o
f
m
a
l
a
r
ia
d
i
a
g
n
o
s
i
s
[
1
8
]
,
[
1
9
].
T
h
e
n
o
v
elty
o
f
th
is
s
tu
d
y
lies
in
th
e
in
teg
r
atio
n
o
f
clin
ical
s
y
m
p
to
m
s
with
lab
o
r
ato
r
y
d
ata
,
o
f
f
er
in
g
m
o
r
e
co
m
p
r
eh
en
s
iv
e
in
f
o
r
m
at
io
n
an
d
en
h
a
n
cin
g
th
e
ac
cu
r
ac
y
o
f
d
iag
n
o
s
is
.
Op
tim
izatio
n
o
f
th
e
h
y
b
r
id
m
o
d
el
allo
ws
f
o
r
m
o
r
e
f
lex
ib
le
in
f
e
r
en
ce
p
r
o
ce
s
s
in
g
in
th
e
f
ac
e
o
f
p
atien
t
d
ata
u
n
ce
r
tain
ty
.
Sy
s
t
em
v
alid
atio
n
was
co
n
d
u
cte
d
d
ir
ec
tly
o
n
f
ield
d
ata
in
m
alar
ia
-
en
d
em
ic
ar
e
as
in
Pap
u
a,
t
h
u
s
s
tr
en
g
th
e
n
in
g
th
e
s
y
s
tem
’
s
ef
f
ec
tiv
en
ess
an
d
ac
ce
p
tab
ili
ty
in
a
r
ea
l
-
wo
r
l
d
co
n
tex
t
a
n
d
s
u
p
p
o
r
tin
g
co
m
m
u
n
ity
h
ea
lth
in
d
ep
e
n
d
en
ce
p
r
o
g
r
a
m
s
.
Fu
r
th
er
m
o
r
e,
d
u
r
i
n
g
th
e
im
p
le
m
en
tatio
n
p
h
ase,
th
is
r
esear
ch
u
s
ed
th
e
Py
th
o
n
p
r
o
g
r
a
m
m
in
g
lan
g
u
ag
e.
T
h
e
s
y
s
tem
was
im
p
lem
en
ted
u
s
in
g
Py
t
h
o
n
w
ith
s
u
p
p
o
r
t
f
r
o
m
lib
r
ar
ies
s
u
ch
as
Nu
m
Py
an
d
Py
Kn
o
w,
wh
ich
s
er
v
ed
as
t
h
e
b
asis
f
o
r
s
y
s
tem
d
ev
elo
p
m
e
nt
[
2
0
]
,
b
ec
a
u
s
e
it
s
u
p
p
o
r
ts
v
ar
io
u
s
a
r
tific
ial
in
tellig
en
ce
lib
r
ar
ies
an
d
ex
p
e
r
t
s
y
s
tem
s
th
at
f
ac
ilit
ate
th
e
ef
f
icien
t
im
p
lem
en
tatio
n
o
f
f
o
r
war
d
ch
ain
in
g
an
d
CF
m
eth
o
d
s
.
2.
M
E
T
H
O
D
2
.
1
.
Resea
rc
h
d
esig
n
T
h
i
s
r
e
s
e
a
r
c
h
u
s
e
s
a
n
e
x
p
e
r
t
s
y
s
te
m
d
e
v
e
l
o
p
m
e
n
t
a
p
p
r
o
a
c
h
b
a
s
e
d
o
n
t
h
e
f
o
r
w
a
r
d
c
h
a
i
n
i
n
g
a
n
d
CF
m
e
t
h
o
d
s
o
p
t
i
m
i
z
e
d
f
o
r
m
a
l
a
r
ia
d
i
a
g
n
o
s
i
s
.
T
h
e
r
e
s
e
a
r
c
h
p
r
o
c
e
s
s
b
e
g
i
n
s
w
i
t
h
f
i
e
l
d
o
b
s
e
r
v
a
t
i
o
n
s
a
n
d
l
i
t
e
r
at
u
r
e
r
e
v
i
e
w
,
f
o
ll
o
w
e
d
b
y
k
n
o
wl
e
d
g
e
b
a
s
e
d
e
s
i
g
n
,
i
n
f
e
r
e
n
c
e
r
u
l
e
f
o
r
m
u
l
a
t
i
o
n
,
u
n
c
e
r
t
ai
n
t
y
c
al
c
u
la
t
i
o
n
u
s
i
n
g
CF
,
a
n
d
h
y
b
r
i
d
m
o
d
e
l
o
p
t
i
m
i
z
a
t
i
o
n
t
o
im
p
r
o
v
e
t
h
e
a
c
c
u
r
a
c
y
o
f
m
a
l
a
r
ia
d
i
a
g
n
o
s
i
s
b
as
e
d
o
n
c
li
n
i
c
a
l
an
d
l
a
b
o
r
a
t
o
r
y
d
a
t
a
.
2
.
2
.
Resea
rc
h
p
ro
ce
du
re
T
h
e
r
esear
ch
s
tag
es
ca
n
b
e
s
e
en
in
Fig
u
r
e
1
.
R
ef
er
r
in
g
to
Fig
u
r
e
1
w
h
ich
d
escr
ib
es
th
e
s
ta
g
es
o
f
th
e
r
esear
ch
,
th
is
s
tu
d
y
ap
p
lies
an
ex
p
er
t
s
y
s
tem
d
ev
elo
p
m
en
t
a
p
p
r
o
ac
h
b
y
co
m
b
in
in
g
th
e
f
o
r
war
d
ch
ain
in
g
an
d
CF
m
eth
o
d
s
to
im
p
r
o
v
e
th
e
ac
cu
r
ac
y
o
f
m
alar
ia
d
ia
g
n
o
s
is
.
T
h
e
r
esear
ch
p
r
o
ce
s
s
b
eg
in
s
with
f
ield
o
b
s
er
v
atio
n
at
th
e
P
u
s
ke
s
ma
s
an
d
liter
a
tu
r
e
r
e
v
iew
to
o
b
tain
th
e
latest
in
f
o
r
m
atio
n
an
d
th
e
o
r
etica
l
f
o
u
n
d
atio
n
s
.
Fu
r
th
er
m
o
r
e
,
th
e
id
en
tific
atio
n
o
f
ter
tian
a
an
d
tr
o
p
ical
m
alar
ia
ty
p
es
was
ca
r
r
ied
o
u
t,
th
en
a
k
n
o
wled
g
e
b
ase
was
co
m
p
iled
th
at
c
o
n
tain
ed
th
e
r
elatio
n
s
h
ip
b
et
wee
n
clin
ical
s
y
m
p
t
o
m
s
an
d
lab
o
r
ato
r
y
d
ata.
T
h
e
f
o
r
war
d
ch
ain
i
n
g
m
eth
o
d
is
u
s
ed
to
f
o
r
m
u
late
d
ia
g
n
o
s
i
s
r
u
les
b
ased
o
n
I
F
–
T
HE
N
r
u
les
[
2
1
]
,
wh
ile
t
h
e
CF
i
s
ap
p
lied
to
d
ea
l
with
u
n
ce
r
tain
ty
b
y
g
iv
i
n
g
weig
h
t
to
th
e
m
ea
s
u
r
e
o
f
b
elief
(
MB)
an
d
m
ea
s
u
r
e
o
f
d
is
b
elief
(
MD
)
v
alu
es.
T
h
e
t
wo
d
ata
wer
e
co
m
b
in
ed
to
g
en
er
ate
a
le
v
el
o
f
co
n
f
id
en
ce
in
th
e
d
iag
n
o
s
is
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
d
o
n
esian
J
E
lec
E
n
g
&
C
o
m
p
Sci
I
SS
N:
2
5
0
2
-
4
7
52
Op
timiz
a
tio
n
o
f a
h
y
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r
id
fo
r
w
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r
d
ch
a
in
in
g
a
n
d
ce
r
ta
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ty
fa
c
to
r
mo
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el
fo
r
…
(
P
a
tma
w
a
ti
Ha
s
a
n
)
421
T
h
e
co
m
b
in
atio
n
o
f
t
h
ese
two
m
eth
o
d
s
was o
p
tim
ized
in
to
a
h
y
b
r
id
m
o
d
el
th
at
was te
s
ted
o
n
1
0
0
r
esp
o
n
d
e
n
ts
with
clin
ical
d
ata
an
d
1
0
0
m
alar
ia
ca
s
es
u
s
in
g
clin
ical
an
d
lab
o
r
ato
r
y
d
ata.
T
h
e
d
at
a
an
aly
ze
d
in
clu
d
ed
clin
ical
s
y
m
p
to
m
s
(
f
e
v
er
,
c
h
i
lls
,
h
ea
d
ac
h
e,
m
u
s
cle
p
ain
,
n
au
s
ea
,
an
d
v
o
m
itin
g
)
as
well
as
lab
o
r
ato
r
y
test
r
esu
lts
(
m
icr
o
s
co
p
ic
an
d
R
DT
)
.
Acc
u
r
ac
y
test
s
wer
e
co
n
d
u
c
ted
b
y
co
m
p
ar
in
g
r
esu
lts
f
r
o
m
clin
ical
d
ata
w
ith
co
m
b
in
ed
clin
ical
an
d
lab
o
r
at
o
r
y
d
ata.
Fig
u
r
e
1
.
R
esear
ch
s
tag
es
I
n
th
is
s
tu
d
y
,
th
e
in
teg
r
atio
n
o
f
clin
ical
an
d
lab
o
r
ato
r
y
d
ata
is
a
cr
u
cial
f
o
u
n
d
atio
n
f
o
r
g
en
er
atin
g
m
o
r
e
ac
cu
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ate
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ec
is
io
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s
.
T
h
is
s
y
s
tem
r
el
ies
n
o
t
o
n
ly
o
n
f
o
r
war
d
ch
ain
i
n
g
-
b
ased
ex
p
er
t
r
u
les
b
u
t
also
s
tr
en
g
th
en
s
th
e
r
ea
s
o
n
in
g
r
esu
lts
with
a
CF
m
eth
o
d
to
m
ea
s
u
r
e
th
e
ce
r
tain
ty
o
f
th
e
h
y
p
o
t
h
eses
f
o
r
m
ed
.
T
h
is
ap
p
r
o
ac
h
allo
ws th
e
co
m
b
in
ati
o
n
o
f
p
atien
t c
lin
ical
s
y
m
p
to
m
s
an
d
lab
o
r
ato
r
y
test
r
esu
lts
,
al
lo
win
g
th
e
s
y
s
tem
to
p
r
o
v
id
e
m
o
r
e
c
o
m
p
r
e
h
en
s
iv
e
r
ec
o
m
m
e
n
d
atio
n
s
.
T
o
cl
ar
if
y
th
e
m
o
d
el
’
s
p
o
s
itio
n
with
in
th
e
r
e
s
ea
r
ch
p
ip
elin
e,
Fig
u
r
e
2
p
r
o
v
id
es a
c
o
n
ce
p
tu
al
d
iag
r
am
d
ep
ictin
g
t
h
e
r
elatio
n
s
h
ip
s
b
etwe
en
th
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m
ain
co
m
p
o
n
en
ts
.
2
.
3
.
Da
t
a
T
h
e
r
esear
ch
d
ata
was
o
b
tain
ed
f
r
o
m
th
e
m
e
d
ical
r
ec
o
r
d
s
o
f
m
alar
ia
p
atien
ts
at
th
e
E
lly
Uy
o
C
o
m
m
u
n
ity
Hea
lth
C
en
ter
,
J
a
y
ap
u
r
a
O
f
f
ice.
T
h
e
clin
ical
d
ata
u
s
ed
in
clu
d
e
d
th
e
b
asic
s
y
m
p
to
m
s
o
f
ter
tian
an
d
tr
o
p
ical
m
alar
ia,
as d
escr
i
b
ed
b
y
d
r
.
Nu
r
u
l A
m
ir
a
h
Su
d
i
r
m
an
:
i)
.
T
er
tian
m
alar
ia,
ch
ar
ac
ter
ize
d
b
y
a
f
ev
er
p
atter
n
th
at
r
ec
u
r
s
ev
er
y
4
8
h
o
u
r
s
,
h
ig
h
f
ev
er
a
cc
o
m
p
an
ied
b
y
ch
ills
an
d
s
wea
tin
g
,
with
ch
i
lls
p
r
esen
t
(
ea
r
ly
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e
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er
)
,
p
r
o
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u
s
e
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tin
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af
ter
th
e
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e
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er
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ase,
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en
e
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h
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s
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o
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ate
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/v
o
m
itin
g
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ild
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e
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ate
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em
ia,
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r
eq
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e
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iar
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h
ea
,
an
d
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er
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r
eq
u
e
n
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s
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ap
p
etite.
ii).
T
r
o
p
ic
al
m
alar
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,
ch
a
r
ac
ter
ize
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y
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ir
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eg
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lar
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ev
er
p
atter
n
th
at
r
ec
u
r
s
ev
er
y
2
4
h
o
u
r
s
,
h
i
g
h
f
e
v
er
t
h
at
is
co
n
tin
u
o
u
s
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d
ir
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e
g
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lar
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il
ls
th
at
ar
e
o
f
ten
m
o
r
e
s
ev
er
e,
s
wea
tin
g
th
at
m
ay
o
cc
u
r
f
r
e
q
u
en
tly
,
s
ev
er
e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
5
0
2
-
4
7
52
In
d
o
n
esian
J
E
lec
E
n
g
&
C
o
m
p
Sci
,
Vo
l.
41
,
No
.
1
,
J
an
u
ar
y
20
2
6
:
419
-
4
2
9
422
h
ea
d
ac
h
e,
m
u
s
cle/jo
in
t
p
ain
th
at
is
m
o
r
e
s
ev
er
e,
f
r
eq
u
en
t
n
au
s
ea
/v
o
m
itin
g
,
s
ev
er
e
a
n
e
m
ia,
o
cc
asio
n
al
d
iar
r
h
ea
,
a
n
d
f
r
eq
u
e
n
t lo
s
s
o
f
ap
p
etite.
L
ab
o
r
ato
r
y
d
ata
b
ased
o
n
b
l
o
o
d
r
esu
lts
o
b
tain
ed
b
y
Mr
s
.
Su
k
m
awa
ti
’
s
L
ab
o
r
ato
r
y
T
ec
h
n
ician
wer
e
as
f
o
llo
ws:
i)
.
T
er
tian
m
alar
ia
with
p
o
s
itiv
e
R
DT
d
ata
f
o
r
P.
v
iv
ax
/o
v
ale,
m
icr
o
s
co
p
ically
ty
p
ical
s
ch
izo
n
ts
/tro
p
h
o
zo
ites
,
f
ew
p
ar
asit
es,
lo
w
p
ar
asit
em
ia
(
<1
%),
n
o
r
m
al/s
lig
h
tly
d
ec
r
e
ased
h
em
o
g
lo
b
in
,
a
n
d
n
o
r
m
al
b
lo
o
d
s
u
g
ar
.
ii).
T
r
o
p
ical
m
alar
ia
with
p
o
s
itiv
e
R
DT
d
ata
f
o
r
P.
f
alcip
ar
u
m
,
m
icr
o
s
co
p
ically
m
u
ltip
le
r
in
g
ed
tr
o
p
h
o
z
o
ites
,
s
ick
led
g
am
eto
cy
tes,
h
ig
h
p
ar
asit
em
ia
(
>5
%,
ca
n
b
e
>2
0
%),
s
h
ar
p
ly
d
ec
r
ea
s
ed
h
em
o
g
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in
(
s
ev
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e
an
em
ia)
,
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d
lo
w
b
lo
o
d
s
u
g
ar
(
h
y
p
o
g
ly
ce
m
ia)
.
Fig
u
r
e
2
.
C
o
n
ce
p
tu
al
d
iag
r
am
2
.
4
.
F
o
rwa
rd
cha
ini
ng
m
et
h
o
d
T
h
e
f
o
r
war
d
c
h
ain
in
g
m
eth
o
d
f
u
n
ctio
n
s
as
a
r
u
le
-
b
ased
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f
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en
ce
m
ec
h
an
is
m
in
wh
ich
ex
i
s
tin
g
f
ac
ts
ar
e
co
m
p
ar
ed
with
th
e
IF
co
m
p
o
n
e
n
t
o
f
an
I
F
–
T
HE
N
r
u
le
.
W
h
en
a
f
ac
t
co
r
r
esp
o
n
d
s
to
th
e
I
F
co
n
d
itio
n
,
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e
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le
is
tr
ig
g
er
ed
,
an
d
its
o
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tco
m
e
(
T
HE
N
p
ar
t)
is
s
to
r
ed
a
s
a
n
ew
f
ac
t
in
th
e
k
n
o
wled
g
e
b
ase.
T
h
e
p
r
o
ce
s
s
b
eg
in
s
with
th
e
to
p
-
lev
el
r
u
l
e,
an
d
ea
ch
r
u
le
is
ex
ec
u
ted
o
n
ly
o
n
ce
.
Fig
u
r
e
3
is
th
e
in
f
er
en
ce
p
r
o
ce
s
s
co
n
tin
u
es u
n
til n
o
ad
d
itio
n
al
r
u
les ca
n
b
e
ap
p
lied
,
at
wh
ich
p
o
in
t th
e
m
atc
h
in
g
p
r
o
ce
s
s
ter
m
in
ates
[
2
2
]
.
Fig
u
r
e
3
.
Fo
r
wa
r
d
ch
ai
n
in
g
s
t
a
ge
2
.
5
.
Cer
t
a
inty
f
a
ct
o
r
m
et
ho
d
T
h
e
CF
m
eth
o
d
is
an
ap
p
r
o
ac
h
u
s
ed
to
m
an
ag
e
u
n
ce
r
tain
ty
in
d
ec
is
i
o
n
-
m
ak
i
n
g
.
A
CF
r
ep
r
esen
ts
th
e
d
e
g
r
ee
o
f
co
n
f
id
en
ce
ass
o
ciate
d
with
a
p
ar
ticu
lar
f
ac
t.
T
h
e
C
F
v
alu
e
r
an
g
es
f
r
o
m
+1
.
0
(
co
m
p
letely
ce
r
tain
)
to
–
1
.
0
(
co
m
p
letely
u
n
ce
r
tai
n
)
.
Po
s
itiv
e
v
alu
es
r
ef
lect
th
e
lev
el
o
f
b
elief
,
wh
e
r
ea
s
n
eg
ativ
e
v
alu
es
in
d
icate
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e
d
eg
r
ee
o
f
d
is
b
elief
.
T
h
e
i
m
p
lem
en
tatio
n
o
f
th
is
m
eth
o
d
ca
n
b
e
ex
p
r
ess
ed
m
ath
em
atica
lly
th
r
o
u
g
h
t
h
e
f
o
llo
win
g
f
o
r
m
u
la
[
2
3
]
-
[
2
5
]
:
a.
T
h
e
n
et
b
elief
m
eth
o
d
p
r
o
p
o
s
e
d
b
y
E
.
H.
Sh
o
r
tliff
e
a
n
d
B
.
G.
B
u
ch
an
an
:
[
,
]
=
[
,
]
−
[
,
]
(
1
)
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
d
o
n
esian
J
E
lec
E
n
g
&
C
o
m
p
Sci
I
SS
N:
2
5
0
2
-
4
7
52
Op
timiz
a
tio
n
o
f a
h
y
b
r
id
fo
r
w
a
r
d
ch
a
in
in
g
a
n
d
ce
r
ta
in
ty
fa
c
to
r
mo
d
el
fo
r
…
(
P
a
tma
w
a
ti
Ha
s
a
n
)
423
b.
C
o
m
b
in
in
g
CF
v
alu
es
CF
f
o
r
r
u
les with
s
im
ilar
ly
co
n
clu
d
ed
r
u
les:
=
[
H
,
]
+
[
,
]
∗
(
1
−
[
,
]
)
(
2
)
3.
RE
SU
L
T
S AN
D
D
I
SCU
SS
I
O
N
T
h
e
an
al
y
s
is
r
esu
lts
ar
e
b
as
ed
o
n
d
ata
co
m
p
iled
t
o
g
eth
er
with
m
e
d
ical
ex
p
er
ts
(
d
o
cto
r
s
an
d
lab
o
r
ato
r
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p
er
s
o
n
n
el)
to
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b
tai
n
a
k
n
o
wled
g
e
b
ase
f
r
o
m
i
n
teg
r
ated
s
y
m
p
t
o
m
d
ata
+
la
b
r
es
u
lts
.
3
.
1
.
K
no
wledg
e
b
a
s
e
T
h
e
k
n
o
wled
g
e
b
ase
(
r
u
le
b
a
s
e)
was
d
ev
elo
p
ed
with
a
r
ep
r
esen
tatio
n
o
f
th
e
r
elatio
n
s
h
i
p
b
etwe
en
s
y
m
p
to
m
s
,
lab
o
r
ato
r
y
r
esu
lts
,
an
d
th
e
t
y
p
es
o
f
m
alar
ia
s
tu
d
ied
,
n
am
el
y
ter
tian
m
alar
ia
a
n
d
tr
o
p
ical
m
alar
ia
.
T
h
e
weig
h
ts
f
o
r
MB
an
d
MD
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d
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m
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ed
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ased
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ex
p
er
t
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.
T
h
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wer
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s
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C
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y
m
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ase
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h
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T
ab
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1
.
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.
Kn
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f
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MB
MD
M
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1
Te
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M
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TH
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2
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Evaluation Warning : The document was created with Spire.PDF for Python.
I
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52
In
d
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J
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&
C
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p
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Vo
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41
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1
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T
h
e
C
F
s
c
a
l
e
i
n
d
i
c
a
t
e
s
th
e
d
e
g
r
e
e
o
f
c
e
r
ta
i
n
ty
o
f
a
m
a
la
r
i
a
d
i
ag
n
o
s
i
s
:
a
C
F
>
0
.
5
m
e
a
n
s
v
er
y
l
i
k
e
l
y
,
0
.
2
–
0
.
5
n
ee
d
s
co
n
f
ir
m
a
t
i
o
n
,
a
n
d
<
0
.
2
in
d
i
ca
t
e
s
a
we
a
k
i
n
d
i
c
a
t
io
n
.
T
h
e
f
o
l
l
o
w
in
g
T
a
b
l
e
6
d
e
ta
i
l
s
t
h
e
i
n
t
e
r
p
r
e
t
a
t
io
n
o
f
e
a
ch
C
F
r
a
n
g
e
to
a
id
m
ed
i
c
a
l
d
e
c
i
s
io
n
-
m
a
k
i
n
g
.
T
ab
l
e
6
.
I
n
ter
p
r
etatio
n
s
ca
le
R
a
n
g
e
C
F
I
n
t
e
r
p
r
e
t
a
t
i
o
n
I
n
f
o
r
mat
i
o
n
C
F
>
0
.
5
S
t
r
o
n
g
p
o
si
t
i
v
e
D
i
a
g
n
o
si
s
i
s
v
e
r
y
l
i
k
e
l
y
0
.
2
≤
C
F
≤
0
.
5
P
o
ssi
b
l
e
m
a
l
a
r
i
a
(
t
e
r
t
i
a
n
a
n
d
t
r
o
p
i
c
a
l
)
D
i
a
g
n
o
si
s
n
e
e
d
c
o
n
f
i
r
ma
t
i
o
n
C
F
<
0
.
2
N
o
st
r
o
n
g
i
n
d
i
c
a
t
i
o
n
s
D
i
a
g
n
o
si
s
sma
l
l
t
h
e
p
o
ssi
b
i
l
i
t
y
T
h
e
r
esu
lts
o
f
th
e
in
te
g
r
atio
n
o
f
th
e
f
o
r
war
d
c
h
ain
in
g
an
d
CF
m
eth
o
d
s
ca
n
b
e
f
o
r
m
u
lated
i
n
th
e
f
o
r
m
o
f
an
alg
o
r
ith
m
as f
o
llo
ws:
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
d
o
n
esian
J
E
lec
E
n
g
&
C
o
m
p
Sci
I
SS
N:
2
5
0
2
-
4
7
52
Op
timiz
a
tio
n
o
f a
h
y
b
r
id
fo
r
w
a
r
d
ch
a
in
in
g
a
n
d
ce
r
ta
in
ty
fa
c
to
r
mo
d
el
fo
r
…
(
P
a
tma
w
a
ti
Ha
s
a
n
)
425
1.
E
n
ter
th
e
p
atien
t
’
s
f
ac
ts
(
s
y
m
p
to
m
s
+
lab
r
esu
lts
)
.
2.
C
alcu
late
th
e
C
F o
f
ea
ch
s
y
m
p
to
m
: CF
=
M
B
-
MD
.
3.
I
n
itialize
C
F_
to
tal
=
0
f
o
r
ea
c
h
h
y
p
o
th
esis
.
4.
Fo
r
ea
ch
s
y
m
p
to
m
th
at
m
atch
es th
e
h
y
p
o
t
h
etica
l r
u
le:
5.
C
F_
to
tal
=
C
F_
to
tal
+
C
F_
g
ejala
*
(
1
-
C
F_
to
tal)
.
6.
C
o
m
p
ar
e
T
er
tian
a
v
s
T
r
o
p
ical
C
F_
to
tal.
7.
C
h
o
o
s
e
th
e
h
y
p
o
th
esis
with
th
e
lar
g
est C
F.
8.
I
n
ter
p
r
etasik
an
h
asil
: >
0
.
5
Str
o
n
g
Po
s
itiv
e,
0
.
2
–
0
.
5
Po
s
s
ib
le,
<0
.
2
No
I
n
d
icatio
n
.
3
.
7
.
F
ina
l
d
ia
g
no
s
is
B
ased
o
n
th
e
r
esu
lts
o
f
m
an
u
al
ca
lcu
latio
n
s
,
th
e
d
iag
n
o
s
is
o
f
ter
tian
a
m
alar
ia
was
o
b
tain
ed
with
a
“
s
tr
o
n
g
p
o
s
itiv
e
”
in
ter
p
r
etatio
n
.
T
h
e
r
esear
ch
e
r
im
p
lem
en
te
d
a
h
y
b
r
id
m
et
h
o
d
in
to
th
e
p
y
th
o
n
p
r
o
g
r
am
m
in
g
lan
g
u
ag
e
with
th
e
s
am
e
r
esu
lts
as
m
an
u
al
ca
lcu
latio
n
s
an
d
ca
n
b
e
s
ee
n
in
F
ig
u
r
e
4
wh
ic
h
d
is
p
lay
s
th
e
lis
t
of
ter
tian
a
an
d
tr
o
p
ical
s
y
m
p
to
m
s
as
well
as
th
e
in
p
u
t
of
s
y
m
p
t
o
m
s
th
at
g
et
t
he
d
ia
g
n
o
s
is
r
esu
lt
.
Fig
u
r
e
4
.
C
alcu
latio
n
r
esu
lts
u
s
in
g
Py
th
o
n
3
.
8
.
Acc
ura
cy
t
esting
I
n
th
e
test
in
g
s
tag
e,
u
s
in
g
1
0
0
s
am
p
les
f
r
o
m
r
esp
o
n
s
es
f
o
r
clin
ical
d
ata
an
d
1
0
0
r
esp
o
n
d
en
ts
f
o
r
clin
ical
d
ata
+
lab
o
r
ato
r
y
,
th
e
r
esu
lts
o
f
th
e
d
iag
n
o
s
is
ca
n
b
e
s
ee
n
in
T
a
b
les
7
an
d
8
.
B
ased
o
n
th
e
clin
ical
d
iag
n
o
s
is
o
f
1
0
0
r
esp
o
n
d
en
ts
alo
n
e,
t
h
e
r
esu
lts
w
er
e
o
b
tai
n
ed
th
at
8
1
%
wer
e
id
en
tifie
d
as
h
av
in
g
m
alar
ia.
Of
th
ese,
3
4
%
s
tr
o
n
g
p
o
s
itiv
e
s
u
f
f
er
e
d
f
r
o
m
ter
tian
a
m
alar
ia,
wh
ile
4
7
%
s
tr
o
n
g
p
o
s
itiv
e
s
u
f
f
er
ed
f
r
o
m
tr
o
p
ical
m
alar
ia.
I
n
ad
d
itio
n
,
t
h
er
e
wer
e
1
1
%
wh
o
wer
e
ca
t
eg
o
r
ized
as
lik
ely
to
b
e
m
alar
ia
p
r
o
n
e
to
ter
tiar
y
,
an
d
4
r
esp
o
n
d
en
ts
w
h
o
wer
e
lik
ely
to
b
e
m
ala
r
ia
ten
d
i
n
g
t
o
b
e
tr
o
p
ical.
On
ly
4
r
esp
o
n
d
en
ts
d
id
n
o
t
s
h
o
w
s
tr
o
n
g
in
d
icatio
n
s
o
f
m
alar
ia.
Me
an
wh
ile,
b
ased
o
n
th
e
r
e
s
u
lts
o
f
clin
ical
an
d
lab
o
r
ato
r
y
d
iag
n
o
s
is
o
f
1
0
0
r
esp
o
n
d
en
ts
,
it
was
f
o
u
n
d
t
h
at
9
8
p
eo
p
le
wer
e
id
e
n
tifie
d
as
h
av
in
g
m
alar
ia.
T
h
e
d
etails
s
h
o
wed
th
at
5
9
s
tr
o
n
g
p
o
s
itiv
e
r
esp
o
n
d
e
n
ts
h
ad
ter
tian
a
m
alar
ia,
wh
ile
3
9
s
tr
o
n
g
p
o
s
itiv
e
r
esp
o
n
d
en
ts
h
a
d
tr
o
p
ical
m
alar
ia.
On
ly
2
r
esp
o
n
d
en
ts
s
h
o
wed
n
o
s
tr
o
n
g
in
d
icatio
n
s
o
f
m
alar
ia
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
5
0
2
-
4
7
52
In
d
o
n
esian
J
E
lec
E
n
g
&
C
o
m
p
Sci
,
Vo
l.
41
,
No
.
1
,
J
an
u
ar
y
20
2
6
:
419
-
4
2
9
426
T
ab
le
7
.
C
lin
ical
d
ata
test
in
g
R
e
s
p
o
n
d
S
y
mp
t
o
m c
o
d
e
C
F
r
e
s
u
l
t
s
S
t
a
t
u
s
M
a
l
a
r
i
a
t
e
r
t
i
a
n
a
Tr
o
p
i
c
a
l
ma
l
a
r
i
a
M
a
l
a
r
i
a
t
e
r
t
i
a
n
a
Tr
o
p
i
c
a
l
ma
l
a
r
i
a
1
G
1
;
G
2
;
G
5
;
G
6
;
G
1
7
0
.
8
0
2
0
.
6
0
0
S
t
r
o
n
g
p
o
si
t
i
v
e
2
G
5
;
G
8
;
G
9
;
G
2
4
0
.
2
0
0
0
.
0
0
0
N
o
st
r
o
n
g
i
n
d
i
c
a
t
i
o
n
o
f
m
a
l
a
r
i
a
3
G
2
;
G
6
;
G
8
;
G
1
0
;
G
1
9
0
.
6
0
4
0
.
2
0
0
S
t
r
o
n
g
p
o
si
t
i
v
e
4
G
3
;
G
7
;
G
9
;
G
1
0
;
G
20
0
.
3
0
0
0
.
1
5
0
P
o
ssi
b
l
e
m
a
l
a
r
i
a
(
t
e
r
t
i
a
n
a
i
n
c
l
i
n
e
d
)
…
…………
……
…….
…………
….
…………
…
98
G
1
;
G
2
5
;
G
2
1
;
G
5
;
G
1
8
;
G
1
0
0
.
6
0
0
0
.
5
8
7
S
t
r
o
n
g
p
o
si
t
i
v
e
99
G
1
6
;
G
2
3
;
G
4
;
G
2
2
0
.
1
5
0
0
.
8
1
8
S
t
r
o
n
g
p
o
si
t
i
v
e
1
0
0
G
2
;
G
7
;
G
9
;
G
2
0
;
G6
0
.
5
0
5
0
.
1
5
0
S
t
r
o
n
g
p
o
si
t
i
v
e
T
ab
le
8
.
C
lin
ical
an
d
lab
o
r
ato
r
y
d
ata
test
in
g
R
e
s
p
o
n
d
e
n
t
S
y
mp
t
o
m c
o
d
e
C
F
r
e
s
u
l
t
s
S
t
a
t
u
s
M
a
l
a
r
i
a
t
e
r
t
i
a
n
a
Tr
o
p
i
c
a
l
ma
l
a
r
i
a
M
a
l
a
r
i
a
t
e
r
t
i
a
n
a
M
a
l
a
r
i
a
t
r
o
p
i
k
a
1
G
1
;
G
2
;
G
3
;
G
4
;
G
1
1
0
.
9
9
3
0
S
t
r
o
n
g
p
o
si
t
i
v
e
2
G
1
;
G
7
;
G
8
;
G
9
;
G
1
0
;
G
1
1
0
.
9
8
4
0
S
t
r
o
n
g
p
o
si
t
i
v
e
3
G
2
;
G
3
;
G
9
;
G
1
6
;
G
1
1
;
G
1
2
0
.
9
9
6
0
.
5
5
S
t
r
o
n
g
p
o
si
t
i
v
e
….
…….
.
….
….
.
……
…….
.
98
G
1
8
;
G
1
9
;
G
2
0
;
G
2
1
;
G
2
5
;
G
2
6
;
G
2
9
0
0
.
9
9
8
S
t
r
o
n
g
p
o
si
t
i
v
e
99
G
1
6
;
G
2
0
;
G
2
3
;
G
2
4
;
G
2
6
0
0
.
9
9
7
S
t
r
o
n
g
p
o
si
t
i
v
e
1
0
0
G
4
;
G
5
;
G
7
;
G
2
1
;
G
2
4
;
G
2
6
;
G
2
9
0
.
1
5
0
.
9
9
4
S
t
r
o
n
g
p
o
si
t
i
v
e
Fig
u
r
e
5
is
a
co
m
p
ar
is
o
n
o
f
th
e
ac
cu
r
ac
y
o
f
m
alar
ia
p
o
s
itiv
e
clin
ical
d
ata
was
o
b
tain
ed
f
o
r
81
%
a
n
d
clin
ical
an
d
lab
o
r
ato
r
y
d
ata
f
o
r
98
%
wh
o
s
tated
an
i
n
cr
e
ase
of
17%
m
alar
ia
p
o
s
itiv
e
ac
cu
r
ac
y
,
if
u
s
in
g
clin
ical
an
d
lab
o
r
at
o
r
y
d
ata
s
tatin
g
th
at
th
e
o
p
tim
izatio
n
of
th
e
h
y
b
r
id
f
o
r
war
d
c
h
ain
in
g
m
o
d
el
an
d
CF
f
o
r
m
alar
ia
d
iag
n
o
s
is
b
ased
on
cli
n
ical
an
d
lab
o
r
ato
r
y
d
ata
was
s
u
cc
ess
f
u
lly
d
iag
n
o
s
es
9
8
%
o
f
m
alar
ia
p
o
s
itiv
e.
T
h
e
n
ee
d
f
o
r
v
alid
atio
n
b
y
an
ex
p
er
t
o
r
d
o
cto
r
to
test
th
e
ac
cu
r
ac
y
o
f
clin
ical
d
ata
an
d
lab
o
r
ato
r
y
d
ata
b
y
d
r
.
Nu
r
u
l A
m
ir
ah
Su
d
ir
m
an
as sh
o
wn
in
T
ab
le
9
.
Fig
u
r
e
5
.
Acc
u
r
ac
y
c
o
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Evaluation Warning : The document was created with Spire.PDF for Python.