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p
u
le
s
h
o
we
d
th
e
p
r
esen
ce
o
f
d
o
m
in
a
n
t
alk
alo
id
-
s
p
ec
if
ic
co
m
p
o
u
n
d
co
m
p
o
n
en
ts
in
th
e
f
o
r
m
o
f
v
illals
to
n
in
e
(
4
4
.
6
1
0
1
%),
v
in
ca
d
if
f
o
r
m
in
e
(
2
2
.
2
5
0
9
%),
an
d
p
leio
ca
r
p
am
in
e
(
1
0
.
2
8
5
5
%)
,
wh
ich
ar
e
well
k
n
o
wn
to
s
u
p
p
r
ess
an
tim
alar
ial
ac
tiv
ity
[
6
]
.
C
o
n
s
is
ten
t
with
th
is
ch
em
ical
p
r
o
f
ile,
a
n
tip
lasmo
d
ial
ass
ay
s
r
ev
ea
led
s
tr
o
n
g
in
h
ib
itio
n
o
f
th
e
P
la
s
mo
d
iu
m
fa
lcip
a
r
u
m
3
D
7
s
tr
ain
with
an
I
C
5
0
v
alu
e
o
f
1
.
2
3
μ
g
/m
L
[
7
]
.
T
h
ese
f
in
d
in
g
s
p
r
o
v
i
d
e
s
cien
tific
v
alid
atio
n
f
o
r
th
e
lo
n
g
-
s
tan
d
i
n
g
tr
ad
itio
n
al
u
s
e
o
f
b
lack
p
u
le
in
eth
n
o
m
ed
icin
e
f
o
r
th
e
tr
ea
tm
en
t
o
f
m
alar
ia,
th
er
eb
y
estab
lis
h
in
g
th
e
p
la
n
t
as
a
p
r
o
m
is
in
g
ca
n
d
id
at
e
f
o
r
th
e
d
e
v
elo
p
m
e
n
t
o
f
s
tan
d
ar
d
ized
an
d
co
m
m
er
cially
v
ia
b
le
an
tim
alar
ial
p
r
o
d
u
cts.
Desp
ite
p
r
o
m
is
in
g
p
h
ar
m
ac
o
l
o
g
ical
ev
id
e
n
ce
,
co
n
s
u
m
e
r
ac
ce
p
tan
ce
an
d
m
ar
k
et
s
tr
ateg
y
f
o
r
b
lack
p
u
le
tab
lets
r
em
ain
u
n
e
x
p
lo
r
ed
.
T
h
is
is
a
cr
itical
g
a
p
in
th
e
d
o
wn
s
tr
ea
m
p
r
o
ce
s
s
o
f
h
er
b
al
p
r
o
d
u
ct
co
m
m
er
cializa
tio
n
.
T
o
ad
d
r
ess
th
is
g
ap
,
th
e
p
r
esen
t
s
tu
d
y
ev
alu
ates
co
n
s
u
m
e
r
p
r
ef
er
e
n
c
es
th
r
o
u
g
h
h
ed
o
n
ic
an
d
h
ed
o
n
ic
q
u
ality
test
s
an
d
f
u
r
th
er
ass
ess
es
m
ar
k
et
v
iab
ilit
y
u
s
in
g
a
SW
OT
an
aly
s
is
.
T
h
e
o
b
jectiv
e
o
f
th
is
s
tu
d
y
is
to
p
r
o
v
id
e
ac
ti
o
n
ab
l
e
in
s
ig
h
ts
f
o
r
th
e
d
ev
el
o
p
m
e
n
t
o
f
e
f
f
ec
tiv
e
m
a
r
k
etin
g
s
tr
ateg
ies
f
o
r
h
e
r
b
al
an
tim
alar
ial
p
r
o
d
u
ct
s
in
m
alar
ia
-
en
d
em
ic
r
e
g
io
n
s
,
with
a
p
a
r
ticu
lar
f
o
cu
s
o
n
th
e
So
u
t
h
-
C
en
tr
al
T
im
o
r
co
n
tex
t.
I
n
t
h
is
s
t
u
d
y
,
c
o
n
s
u
m
er
a
cc
e
p
ta
n
ce
was
ass
ess
e
d
t
h
r
o
u
g
h
tw
o
s
e
n
s
o
r
y
e
v
a
lu
ati
o
n
m
e
t
h
o
d
s
.
T
h
e
h
e
d
o
n
ic
t
est wa
s
a
d
m
i
n
is
t
er
e
d
to
1
0
0
u
n
t
r
a
in
e
d
p
a
n
el
is
ts
,
wh
o
e
v
a
lu
at
ed
at
t
r
i
b
u
t
es
s
u
c
h
as sh
a
p
e
,
c
o
l
o
r
,
f
la
v
o
r
,
ar
o
m
a,
s
i
ze
,
a
n
d
o
v
e
r
a
ll
i
m
p
r
e
s
s
io
n
.
T
o
co
m
p
le
m
e
n
t
t
h
is
,
a
h
ed
o
n
ic
q
u
al
it
y
test
u
s
i
n
g
2
5
s
e
m
i
-
tr
ai
n
e
d
p
a
n
el
is
ts
p
r
o
v
i
d
e
d
a
m
o
r
e
s
p
e
cif
ic
ass
ess
m
e
n
t
o
f
k
e
y
c
h
a
r
a
ct
er
is
tic
s
,
i
n
cl
u
d
in
g
s
h
a
p
e
,
c
o
l
o
r
,
f
l
a
v
o
r
,
a
n
d
a
r
o
m
a.
I
n
ad
d
it
io
n
,
th
e
m
a
r
k
et'
s
v
i
ab
ilit
y
was
e
v
al
u
ate
d
t
h
r
o
u
g
h
a
SW
OT
an
al
y
s
is
,
w
h
i
c
h
w
as
em
p
l
o
y
e
d
t
o
asc
e
r
ta
in
t
h
e
r
es
p
o
n
d
e
n
ts
'
ass
ess
m
e
n
ts
o
f
t
h
e
p
r
o
d
u
ct
,
wit
h
th
e
o
b
j
ec
t
iv
e
o
f
e
n
h
a
n
ci
n
g
th
e
e
f
f
ici
en
c
y
a
n
d
ef
f
e
cti
v
e
n
ess
o
f
p
r
o
d
u
ct
m
a
r
k
et
i
n
g
.
T
h
e
SW
O
T
a
n
al
y
s
is
m
e
th
o
d
i
n
t
h
is
s
tu
d
y
was
c
o
n
d
u
c
te
d
t
o
d
et
er
m
i
n
e
th
e
e
x
te
r
n
al
s
tr
ate
g
ic
f
a
ct
o
r
a
n
al
y
s
is
s
u
m
m
a
r
y
(
E
F
AS)
,
wh
ic
h
in
cl
u
d
es
s
t
r
e
n
g
t
h
an
d
we
a
k
n
ess
p
ar
am
ete
r
s
t
o
d
e
v
e
lo
p
t
h
e
i
n
t
er
n
al
s
tr
a
te
g
ic
f
ac
t
o
r
a
n
a
ly
s
is
s
u
m
m
a
r
y
(
I
FAS
)
,
w
h
ic
h
i
n
c
l
u
d
es
o
p
p
o
r
t
u
n
it
y
a
n
d
t
h
r
ea
t
i
n
t
h
e
m
ar
k
e
ti
n
g
o
f
t
h
e
p
r
o
d
u
ct
[
8
]
.
C
o
m
p
a
n
i
es th
at
a
p
p
l
y
SW
O
T
a
n
a
ly
s
is
a
r
e
e
x
p
e
c
ted
to
b
e
s
u
c
ce
s
s
f
u
l
i
n
p
r
o
d
u
ct
co
m
p
eti
ti
o
n
s
o
t
h
a
t
th
e
y
c
an
o
u
tp
e
r
f
o
r
m
c
o
m
p
eti
n
g
c
o
m
p
a
n
i
es
an
d
t
h
e
c
o
m
p
an
y
ca
n
co
n
t
in
u
o
u
s
l
y
d
e
v
el
o
p
[
9
]
.
2.
M
E
T
H
O
D
T
h
is
s
tu
d
y
was
ap
p
r
o
v
ed
b
y
th
e
E
th
ics
C
o
m
m
ittee
f
o
r
Hea
lth
R
e
s
ea
r
ch
,
I
s
lam
ic
Un
iv
er
s
ity
Ho
s
p
ital
Ma
lan
g
with
letter
n
u
m
b
er
3
6
/KE
PK/R
SI
-
U/I
X/2
0
2
4
.
T
h
e
r
esear
ch
was
d
esig
n
e
d
u
s
in
g
a
s
u
r
v
ey
m
eth
o
d
an
d
a
d
escr
ip
tiv
e
q
u
a
n
titativ
e
ap
p
r
o
ac
h
.
I
n
o
r
d
er
to
o
b
tain
a
p
r
e
-
m
ar
k
etin
g
an
al
y
s
is
o
f
th
e
b
lack
p
u
le
tab
let
alter
n
ativ
e
m
alar
ia
m
ed
icin
e
p
r
o
d
u
ct,
th
e
liter
atu
r
e
was
co
m
p
iled
t
o
d
escr
ib
e
th
e
ta
r
g
ete
d
co
n
s
u
m
er
p
er
s
p
ec
tiv
es
o
n
th
e
p
r
o
d
u
ct
th
r
o
u
g
h
d
escr
ip
tiv
e
s
tatis
tical
as
s
es
s
m
en
t.
T
h
is
allo
wed
f
o
r
th
e
d
eter
m
in
atio
n
o
f
w
h
eth
er
t
h
e
p
r
o
d
u
ct
is
s
u
ita
b
le
f
o
r
th
e
t
ar
g
eted
co
n
s
u
m
er
m
ar
k
et
co
n
d
itio
n
s
an
d
th
e
s
elec
tio
n
o
f
th
e
b
est m
ar
k
etin
g
s
tr
ateg
y
f
o
r
th
e
s
u
b
s
eq
u
e
n
t stag
e
o
f
p
r
o
d
u
ct
co
m
m
er
cializa
tio
n
.
2
.
1
.
L
o
ca
t
io
n a
nd
p
a
rt
icipa
nt
T
h
is
s
tu
d
y
was
co
n
d
u
cted
in
Sep
tem
b
er
2
0
2
4
in
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
c
y
,
I
n
d
o
n
esia,
wh
ich
is
an
ar
ea
with
m
o
d
er
ate
m
alar
i
a
en
d
em
icity
[
1
0
]
.
T
h
e
tar
g
et
r
esp
o
n
d
e
n
ts
o
f
th
is
s
tu
d
y
we
r
e
1
0
0
p
eo
p
le
with
in
clu
s
io
n
cr
iter
ia
of
r
esid
en
ts
of
C
en
tr
al
So
u
th
T
im
o
r
R
e
g
en
cy
ag
ed
15
-
65
y
ea
r
s
with
g
o
o
d
a
n
d
n
o
r
m
al
s
en
s
o
r
y
ab
ilit
ies
as
r
ep
r
esen
tativ
es
o
f
th
e
tar
g
et
co
n
s
u
m
er
s
o
f
B
PAT
m
ar
k
etin
g
.
T
h
e
lo
c
atio
n
an
d
tar
g
et
o
f
th
is
s
tu
d
y
wer
e
p
u
r
p
o
s
iv
ely
d
eter
m
in
ed
,
with
a
to
tal
o
f
3
s
u
b
-
d
is
tr
icts
s
elec
ted
u
s
in
g
clu
s
ter
an
d
p
u
r
p
o
s
iv
e
s
am
p
lin
g
tech
n
i
q
u
es.
Am
o
n
g
th
e
s
u
b
-
d
is
tr
icts
in
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
cy
,
So
E
Su
b
-
d
is
tr
ict,
So
u
th
Am
an
u
b
an
Su
b
-
d
is
tr
ict,
an
d
B
o
k
in
g
Su
b
-
d
is
tr
ict
wer
e
s
el
ec
ted
o
n
th
e
b
asis
o
f
th
e
a
r
e
as
with
th
e
h
ig
h
est
in
cid
en
ce
o
f
m
ala
r
ia
in
2
0
1
9
[
1
0
]
.
T
h
er
e
f
o
r
e,
th
ese
th
r
ee
s
u
b
-
d
is
tr
icts
wer
e
ch
o
s
en
as
th
e
lo
ca
tio
n
a
n
d
p
lace
fo
r
s
am
p
lin
g
d
ata
b
ec
au
s
e
with
an
ar
ea
th
at
s
till
h
as
q
u
ite
a
lo
t
of
m
alar
ia
en
d
e
m
icity
,
th
e
p
eo
p
le
of
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
c
y
a
r
e
s
u
i
tab
le
if
th
e
y
a
r
e
u
s
ed
as
tar
g
e
t
co
n
s
u
m
er
s
f
o
r
th
e
s
ale
o
f
B
PAT
p
r
o
d
u
cts.
T
h
e
ex
clu
s
io
n
cr
iter
ia
en
co
m
p
ass
ed
in
d
iv
id
u
als
cu
r
r
en
tly
e
x
p
er
i
en
cin
g
s
en
s
o
r
y
im
p
air
m
en
ts
,
r
esid
en
ts
o
u
ts
id
e
th
e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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I
n
t J Pu
b
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Hea
lth
Sci
,
Vo
l.
15
,
No
.
2
,
J
u
n
e
20
26
:
34
6
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348
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ted
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u
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icts
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m
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th
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ased
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n
ee
d
ed
f
r
o
m
ea
c
h
s
u
b
-
d
is
tr
ict
was
ca
lcu
lated
b
ased
o
n
th
e
p
o
p
u
latio
n
s
tr
u
ctu
r
e
o
f
So
u
th
-
C
en
tr
al
T
im
o
r
R
eg
en
cy
.
T
h
e
r
esu
ltin
g
s
am
p
le
allo
ca
tio
n
s
f
o
r
ea
ch
d
is
tr
ict
ar
e
s
u
m
m
ar
ized
in
T
ab
le
1
.
T
ab
le
1.
Fre
q
u
en
cy
d
is
tr
ib
u
tio
n
tab
le
o
f
r
esear
ch
r
esp
o
n
d
e
n
ts
s
am
p
les b
ased
o
n
d
o
m
icile
S
u
b
-
d
i
s
t
r
i
c
t
F
r
e
q
u
e
n
c
y
(
N
)
P
e
r
c
e
n
t
a
g
e
(
%)
To
t
a
l
S
o
e
54
5
4
%
S
o
u
t
h
A
ma
n
u
b
a
n
32
3
2
%
1
0
0
%
B
o
k
i
n
g
14
1
4
%
2
.
2
.
Study
p
ro
ce
du
re
Prio
r
to
d
ata
co
llectio
n
,
all
p
a
r
ticip
an
ts
r
ec
eiv
ed
an
e
x
p
lan
a
tio
n
o
f
th
e
s
tu
d
y
'
s
p
u
r
p
o
s
e,
p
r
o
ce
d
u
r
es,
p
o
ten
tial
r
is
k
s
,
a
n
d
th
eir
r
ig
h
t
to
with
d
r
aw
at
a
n
y
tim
e
with
o
u
t
p
e
n
alty
.
I
n
f
o
r
m
ed
co
n
s
en
t
was
o
b
tain
ed
f
r
o
m
ea
ch
p
ar
ticip
an
t
in
th
e
s
tu
d
y
.
T
o
en
s
u
r
e
co
n
f
id
en
tiality
,
n
o
p
er
s
o
n
al
id
en
tifie
r
s
wer
e
co
lle
cted
.
All
r
esp
o
n
s
es
wer
e
co
d
ed
a
n
o
n
y
m
o
u
s
ly
,
s
t
o
r
ed
s
ec
u
r
ely
,
an
d
ac
ce
s
s
ed
o
n
ly
b
y
th
e
r
esear
ch
team
.
All
p
r
o
ce
d
u
r
es
wer
e
ap
p
r
o
v
ed
b
y
th
e
Hea
lth
R
e
s
ea
r
ch
E
th
ics C
o
m
m
ittee
o
f
th
e
I
s
lam
ic
Un
iv
er
s
ity
Ho
s
p
ital o
f
Ma
lan
g
.
R
esp
o
n
d
en
ts
ar
e
ask
ed
to
p
r
o
v
id
e
a
lik
in
g
ass
ess
m
en
t
o
f
th
e
s
en
s
o
r
y
attr
ib
u
tes
o
f
th
e
B
P
AT
p
r
o
d
u
ct
by
o
b
s
er
v
in
g
,
to
u
c
h
in
g
,
e
x
am
i
n
in
g
,
s
m
ellin
g
,
an
d
tast
in
g
th
e
p
r
o
d
u
ct
as
a
s
o
u
r
ce
of
in
f
o
r
m
atio
n
d
ata
to
o
b
tain
r
esear
ch
d
ata
r
esu
lts
in
th
e
f
o
r
m
of
p
a
n
elis
ts
'
p
r
ef
er
en
ce
lev
els
f
o
r
th
e
p
r
o
d
u
ct
an
d
to
ass
es
s
th
e
p
r
o
d
u
ct'
s
q
u
ality
ac
cu
r
ately
.
R
esp
o
n
d
e
n
ts
will
b
e
p
r
o
v
id
ed
with
m
in
e
r
al
wate
r
to
n
eu
tr
alize
th
eir
tast
e
b
u
d
s
b
ef
o
r
e
th
e
test
in
g
p
r
o
ce
s
s
is
co
n
d
u
cte
d
.
Nex
t,
th
e
r
esp
o
n
d
en
ts
f
ill
o
u
t
a
f
o
llo
w
-
u
p
q
u
esti
o
n
n
air
e
to
e
v
alu
ate
th
e
p
r
o
d
u
ct
in
m
o
r
e
d
etail.
I
n
th
e
h
ed
o
n
ic
test
,
th
e
1
-
4
L
ik
er
t scale
i
s
d
es
cr
ib
ed
in
s
tatem
en
ts
r
an
g
in
g
f
r
o
m
"Ve
r
y
L
ik
e"
to
"Ve
r
y
Dis
lik
e.
"
T
h
e
r
esu
lts
o
f
th
is
s
tu
d
y
will
d
eter
m
in
e
th
e
p
an
elis
ts
'
p
r
ef
er
en
ce
lev
els,
wh
ich
will
b
e
d
escr
ib
ed
b
y
th
e
a
v
er
ag
e
v
a
lu
e
an
d
d
ev
iatio
n
o
f
ea
c
h
h
ed
o
n
ic
test
p
ar
am
eter
.
C
o
n
c
u
r
r
en
tly
,
with
in
th
e
f
r
am
ewo
r
k
o
f
th
e
SW
OT
an
aly
s
is
,
th
e
1
-
4
L
ik
er
t
s
ca
le
is
d
el
in
ea
ted
in
s
tatem
en
ts
r
an
g
in
g
f
r
o
m
"Ve
r
y
Ag
r
ee
"
to
"Ve
r
y
Dis
ag
r
ee
.
"
Su
b
s
eq
u
en
t
to
th
e
co
llectio
n
o
f
d
at
a,
th
e
r
esu
lts
ar
e
p
r
o
ce
s
s
ed
b
y
ca
lcu
latin
g
th
e
ar
ith
m
etic
m
ea
n
an
d
th
e
n
d
iv
i
d
in
g
b
y
th
e
n
u
m
b
er
o
f
r
esp
o
n
d
en
ts
.
T
h
is
ca
lc
u
latio
n
y
ield
s
co
o
r
d
in
ates
th
at
ar
e
th
en
an
aly
ze
d
u
s
in
g
a
SW
OT
C
ar
tesi
an
d
iag
r
am
.
T
h
e
d
a
ta
o
b
tain
ed
f
r
o
m
t
h
e
r
esp
o
n
d
en
t'
s
a
s
s
es
s
m
en
t
is
s
u
b
s
eq
u
en
tly
s
u
b
jecte
d
t
o
s
tatis
tical
an
aly
s
is
u
tili
zin
g
Mic
r
o
s
o
f
t E
x
ce
l
an
d
SPSS
.
Af
ter
wh
ich
,
th
e
r
esu
lts
will
b
e
d
escr
ib
ed
t
h
r
o
u
g
h
d
escr
ip
tiv
e
d
ata
in
ter
p
r
etatio
n
.
2
.
3
.
P
r
o
du
ct
d
escript
io
n
T
h
e
p
r
o
d
u
ct
u
s
ed
in
t
h
is
s
tu
d
y
was
an
h
er
b
al
ta
b
let
m
ad
e
f
r
o
m
b
lack
p
u
le
c
o
r
tex
e
x
t
r
ac
t.
T
h
is
p
r
o
d
u
ct
is
m
an
u
f
ac
tu
r
ed
b
y
PT.
Ag
ar
icu
s
Sid
o
Ma
k
m
u
r
Se
n
to
s
a
(
ASI
MA
S)
in
L
awa
n
g
,
Ma
lan
g
,
E
ast
J
av
a.
T
h
e
f
o
r
m
u
latio
n
in
1
ta
b
let
7
0
0
mg
co
n
s
is
ts
of
63
mg
b
la
ck
p
u
le
ex
tr
ac
t
as
an
ac
tiv
e
i
n
g
r
ed
ien
t
a
n
d
m
an
y
ex
cip
ien
t
in
g
r
ed
ie
n
ts
.
Descr
ip
tio
n
o
f
th
e
p
h
y
s
ical
ch
ar
ac
ter
is
tics
an
d
p
r
o
p
er
ties
th
at
th
e
p
r
o
d
u
ct
p
o
s
s
ess
es
,
ac
co
r
d
in
g
to
th
e
r
esear
ch
er
'
s
s
u
b
jectiv
e
o
p
i
n
io
n
,
ca
n
b
e
s
ee
n
in
T
ab
le
2
.
T
ab
le
2
.
B
lack
p
u
l
e
an
ti m
alar
ia
tab
let
ch
ar
ac
ter
is
tics
O
r
g
a
n
o
l
e
p
t
i
c
a
sp
e
c
t
D
e
scri
p
t
i
o
n
S
h
a
p
e
O
v
a
l
C
o
l
o
r
W
h
i
t
e
w
i
t
h
l
i
g
h
t
b
r
o
w
n
s
p
o
t
Ta
st
e
B
i
t
t
e
r
S
mel
l
Ty
p
i
c
a
l
b
l
a
c
k
p
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l
e
a
r
o
m
a
S
i
z
e
7
0
0
m
g
/
1
8
m
m
3.
RE
SU
L
T
S AN
D
D
I
SCU
SS
I
O
N
3
.
1
.
H
edo
nic
t
est
Par
am
eter
s
o
f
B
PAT
p
r
o
to
ty
p
e
ass
ess
ed
b
y
a
h
ed
o
n
ic
s
ca
le
b
y
1
0
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n
tr
ain
ed
p
an
elis
ts
with
g
o
o
d
s
en
s
o
r
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co
n
d
itio
n
,
co
v
er
in
g
a
s
p
ec
ts
o
f
s
h
ap
e,
co
lo
r
,
tast
e,
s
m
ell,
s
ize,
an
d
o
v
er
all.
E
ac
h
h
ed
o
n
ic
s
ca
le
s
co
r
e
s
elec
ted
b
y
p
a
n
elis
ts
will
b
e
p
r
o
ce
s
s
ed
with
d
escr
ip
tiv
e
s
tatis
t
ical
a
n
aly
s
is
to
d
eter
m
in
e
th
e
m
ea
n
an
d
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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b
lic
Hea
lth
Sci
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SS
N:
2252
-
8
8
0
6
C
o
n
s
u
mer p
r
eferen
ce
s
a
n
d
ma
r
ke
tin
g
s
tr
a
teg
y
fo
r
b
la
ck
p
u
le
(
A
ls
to
n
ia
s
p
ec
ta
b
ilis
)
…
(
N
o
v
ia
Ma
u
lin
a
)
349
p
er
ce
n
tag
e
of
each
p
ar
am
ete
r
f
r
o
m
a
c
h
o
ice
of
1
-
4
h
ed
o
n
ic
s
ca
les.
T
h
e
h
ed
o
n
ic
s
ca
le
is
d
escr
ib
ed
in
s
tatem
en
ts
r
an
g
in
g
f
r
o
m
“Ve
r
y
L
ik
e”
to
“Ve
r
y
Dis
lik
e”
r
at
in
g
s
th
at
ar
e
r
a
n
k
ed
th
r
o
u
g
h
L
ik
er
t
s
ca
le
v
alu
es
[
1
1
]
.
T
h
e
r
esu
lts
o
f
th
e
v
alu
es
th
at
ap
p
ea
r
will
d
eter
m
in
e
th
e
lev
el
o
f
p
an
elis
t
p
r
ef
er
e
n
ce
as
a
r
ep
r
esen
tativ
e
o
f
th
e
lev
el
o
f
p
r
ef
er
e
n
ce
o
f
t
h
e
C
en
tr
al
So
u
th
T
im
o
r
R
eg
e
n
cy
s
o
ciety
f
o
r
B
PAT
tab
let
p
r
o
d
u
cts,
as
s
h
o
wn
in
T
ab
le
3
.
T
ab
le
4
s
h
o
ws
th
at
th
e
p
r
ef
er
en
ce
d
ata
s
ca
le
o
f
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
c
y
p
a
n
elis
ts
f
o
r
B
PAT
r
esu
lted
in
av
e
r
ag
e
v
al
u
es
o
n
s
h
ap
e
(
3
.
1
5
)
,
co
lo
r
(
3
.
2
5
)
,
ta
s
te
(
2
.
8
4
)
,
s
m
ell
(
3
.
1
9
)
,
s
ize
(
2
.
9
3
)
,
an
d
o
v
er
all
(
3
.
1
7
)
p
r
ef
er
e
n
ce
s
.
T
h
e
o
v
e
r
a
ll
m
ea
n
d
ata
o
f
th
e
o
r
g
an
o
le
p
tic
p
ar
am
eter
s
we
r
e
in
ter
p
r
e
ted
in
t
h
e
h
e
d
o
n
ic
r
an
g
e
with
a
"lik
e"
s
ca
le,
in
d
i
ca
tin
g
th
at
m
o
s
t
p
eo
p
le
in
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
cy
lik
ed
th
e
o
v
er
all
tab
let
p
r
o
to
ty
p
e.
T
h
e
s
tan
d
ar
d
d
ev
ia
tio
n
an
d
v
ar
ian
ce
v
alu
es
f
o
r
e
ac
h
p
ar
am
eter
d
em
o
n
s
tr
ate
n
o
ticea
b
le
d
ev
iatio
n
s
f
r
o
m
t
h
e
m
ea
n
,
s
u
g
g
esti
n
g
a
s
p
r
ea
d
o
f
in
d
iv
i
d
u
al
p
r
ef
er
e
n
ce
s
ac
r
o
s
s
s
am
p
les.
T
h
ese
r
esu
lts
ar
e
v
is
u
ally
s
u
m
m
ar
ized
in
Fig
u
r
e
1
,
w
h
ich
p
r
esen
ts
th
e
p
er
ce
n
tag
e
d
is
tr
ib
u
tio
n
o
f
h
ed
o
n
ic
r
esp
o
n
s
es
f
o
r
ea
ch
o
r
g
an
o
lep
tic
attr
ib
u
te.
T
h
e
r
esu
lts
o
f
th
e
m
ea
n
d
ata
o
n
th
e
l
ev
el
o
f
lik
in
g
o
f
th
e
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
cy
s
o
ciety
ar
e
r
ein
f
o
r
ce
d
b
y
th
e
h
e
d
o
n
ic
s
c
ale
p
er
ce
n
tag
e
v
alu
e
o
n
th
e
o
r
g
an
o
lep
tic
p
ar
am
eter
s
o
f
th
e
B
PAT
p
r
o
to
ty
p
e
p
r
o
d
u
ct.
B
ased
o
n
Fig
u
r
e
1
,
i
t
ca
n
b
e
s
ee
n
th
at
all
asp
ec
ts
h
av
e
th
e
h
ig
h
est
p
er
ce
n
tag
e
v
alu
e
o
n
th
e
“L
ik
e”
s
ca
le
f
o
r
th
e
m
ed
ici
n
al
p
r
o
d
u
c
t
u
n
d
e
r
s
tu
d
y
.
T
h
e
lar
g
est
p
er
c
en
tag
e
o
b
tain
ed
is
th
e
“L
ik
e”
h
ed
o
n
ic
s
ca
le
with
a
v
alu
e
7
7
%
f
o
r
s
h
ap
e,
7
3
%
f
o
r
co
lo
r
,
6
9
%
f
o
r
tast
e,
7
4
%
f
o
r
s
m
ell,
7
2
%
f
o
r
s
ize,
an
d
7
7
%
th
e
o
v
er
all
ta
b
let
o
r
g
an
o
lep
tic
asp
ec
t.
T
h
e
alig
n
m
en
t
o
f
th
e
p
r
ef
e
r
en
ce
r
atin
g
s
ac
r
o
s
s
all
asp
ec
ts
w
ill
in
f
l
u
en
ce
wh
eth
er
th
e
p
r
o
d
u
ct
is
ac
ce
p
ted
o
r
n
o
t
ac
co
r
d
in
g
to
co
n
s
u
m
er
p
r
ef
e
r
en
ce
s
.
Fro
m
th
e
p
er
ce
n
tag
e
d
ata
r
esu
lts
,
it
ca
n
b
e
co
n
clu
d
e
d
th
at
t
h
e
m
ajo
r
ity
o
f
p
an
elis
ts
f
r
o
m
th
e
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
cy
co
m
m
u
n
it
y
s
tated
"L
ik
e"
f
o
r
th
e
o
v
er
all
B
PAT
(
A
.
s
p
ec
ta
b
i
lis
).
T
ab
le
3
.
Hed
o
n
ic
s
ca
le
H
e
d
o
n
i
c
sca
l
e
N
u
meri
c
s
c
a
l
e
V
e
r
y
d
i
s
l
i
k
e
1
D
i
sl
i
k
e
2
Li
k
e
3
V
e
r
y
l
i
k
e
4
T
ab
le
4
.
Av
e
r
ag
e
p
a
n
elis
ts
p
r
ef
er
en
ce
s
co
r
e
f
o
r
t
h
e
p
u
le
b
lac
k
an
tim
alar
ial
tab
let
p
r
o
to
ty
p
e
P
a
r
a
me
t
e
r
M
e
a
n
S
t
d
.
S
h
a
p
e
3
.
1
5
0
.
4
6
C
o
l
o
r
3
.
2
5
0
.
4
6
Ta
st
e
2
.
8
4
0
.
6
1
S
mel
l
3
.
1
9
0
.
5
0
S
i
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e
2
.
9
3
0
.
5
5
O
v
e
r
a
l
l
3
.
1
7
0
.
3
8
Fig
u
r
e
1.
He
d
o
n
ic
test
p
er
ce
n
t
ag
e
g
r
ap
h
d
ata
a
n
a
l
y
s
i
s
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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2
2
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20
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6
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59
350
Alth
o
u
g
h
all
attr
ib
u
tes
r
ec
ei
v
ed
“L
ik
e”
as
th
e
h
ig
h
est
h
ed
o
n
ic
p
er
ce
n
tag
e
,
th
e
tast
e
p
ar
am
eter
s
h
o
wed
a
s
lig
h
tly
lo
wer
s
co
r
e
(
6
9
%)
co
m
p
a
r
ed
to
s
h
ap
e,
co
lo
r
,
s
m
ell,
s
ize,
an
d
o
v
er
al
l
im
p
r
ess
io
n
.
T
h
is
lo
wer
r
atin
g
m
ay
b
e
attr
ib
u
t
ed
to
th
e
in
h
e
r
en
t
b
itter
n
ess
o
f
A
.
s
p
ec
ta
b
ilis
,
as
h
er
b
al
an
tim
alar
ial
p
lan
ts
co
m
m
o
n
l
y
co
n
tain
alk
alo
i
d
co
m
p
o
u
n
d
s
th
at
n
atu
r
ally
im
p
ar
t
a
b
itter
tast
e.
E
v
en
th
o
u
g
h
th
e
B
PAT
f
o
r
m
u
latio
n
s
u
cc
ess
f
u
lly
r
e
d
u
ce
d
th
e
b
itter
n
ess
to
a
“less
b
itter
”
lev
el,
p
an
elis
ts
m
ay
s
till
h
av
e
p
er
ce
i
v
ed
m
ild
r
esid
u
al
b
itter
n
ess
,
m
ak
in
g
it l
ess
p
r
ef
er
r
ed
th
a
n
o
th
e
r
s
en
s
o
r
y
asp
ec
ts
.
T
h
e
r
esu
lts
o
f
th
is
s
tu
d
y
s
tate
th
at
attr
ac
tiv
e
an
d
co
n
v
en
ien
t
d
o
s
ag
e
f
o
r
m
s
ca
n
m
a
k
e
p
r
o
d
u
cts
m
o
r
e
ac
ce
p
tab
le
[
1
2
]
.
T
h
e
h
ed
o
n
ic
s
ca
le
s
elec
tio
n
o
f
“L
ik
e”
in
d
icate
s
th
e
o
v
al
s
h
ap
e
o
f
th
e
ta
b
let
is
f
av
o
r
ed
an
d
ac
ce
p
ted
b
y
th
e
tar
g
et
co
n
s
u
m
er
s
.
T
h
e
s
elec
tio
n
o
f
p
h
ar
m
ac
eu
tical
p
r
o
d
u
cts
in
f
o
r
m
s
p
r
ef
er
r
ed
b
y
c
o
n
s
u
m
er
s
is
u
s
u
ally
b
ased
o
n
elem
en
ts
o
f
p
r
ac
ticality
an
d
ea
s
e
o
f
u
s
e
[
1
3
]
.
C
o
lo
r
is
an
im
p
o
r
tan
t
co
m
p
o
n
en
t
in
co
m
m
er
cia
l
p
r
o
d
u
cts
th
at
will
b
e
th
e
f
ir
s
t
im
p
r
ess
io
n
m
o
s
t
l
ik
ely
to
b
e
ass
ess
ed
b
y
co
n
s
u
m
er
s
in
ac
ce
p
tan
ce
test
s
b
ec
au
s
e
th
is
p
ar
am
eter
i
s
v
is
u
ally
v
is
ib
le
d
ir
ec
tly
th
r
o
u
g
h
th
e
s
en
s
e
o
f
s
ig
h
t.
Go
o
d
co
lo
r
r
esu
lts
will
in
cr
ea
s
e
co
n
s
u
m
er
lik
in
g
f
o
r
a
p
r
o
d
u
ct
[
1
4
]
.
T
h
e
s
tatem
en
t
"L
ik
e,
"
c
h
o
s
en
b
y
m
an
y
p
an
elis
ts
,
in
d
icate
s
th
at
th
e
test
tab
let
p
r
o
d
u
ct
h
as a
g
o
o
d
co
lo
r
an
d
is
ac
ce
p
tab
le
to
c
o
n
s
u
m
er
s
.
T
h
e
q
u
ality
o
f
tast
e
in
a
p
r
o
d
u
ct
p
lay
s
a
s
ig
n
if
ica
n
t
r
o
le
in
d
eter
m
in
in
g
co
n
s
u
m
e
r
ac
ce
p
t
an
ce
.
T
aste
is
also
an
asp
ec
t
th
a
t
in
f
lu
en
ce
s
th
e
q
u
ality
lev
el
o
f
a
p
r
o
d
u
ct
[
1
5
]
.
T
h
e
asp
ec
t
o
f
s
m
ell
in
p
r
o
d
u
ct
m
ar
k
etin
g
r
esear
ch
is
v
er
y
im
p
o
r
tan
t
b
e
ca
u
s
e
th
is
p
ar
am
eter
is
c
o
n
s
id
er
ed
to
b
e
a
s
p
ec
ial
id
en
tity
o
f
a
p
r
o
d
u
ct
t
o
b
e
r
em
em
b
er
e
d
b
y
co
n
s
u
m
e
r
s
[
1
6
]
.
Acc
o
r
d
in
g
t
o
th
e
th
e
o
r
y
d
e
s
cr
ib
ed
b
y
Her
z
et
a
l.
[
1
7
]
,
th
e
s
ce
n
t
o
f
a
p
r
o
d
u
ct
ca
n
in
f
lu
en
ce
c
o
n
s
u
m
er
s
’
c
o
g
n
itiv
e
p
r
o
ce
s
s
es,
em
o
tio
n
s
,
an
d
b
eh
a
v
io
r
s
,
wh
er
e
a
p
leasan
t
ar
o
m
a
en
h
an
ce
s
p
er
ce
iv
ed
p
r
o
d
u
ct
q
u
ality
an
d
u
ltima
tely
s
h
ap
es c
o
n
s
u
m
er
p
r
ef
er
en
ce
s
an
d
d
ec
is
io
n
-
m
ak
i
n
g
.
B
ased
o
n
f
u
r
th
er
in
f
o
r
m
atio
n
g
ath
er
in
g
,
t
h
e
ac
ce
p
tab
ilit
y
o
f
th
e
1
8
m
m
d
iam
eter
tab
let
wei
g
h
in
g
7
0
0
m
g
b
y
t
h
e
p
an
elis
ts
f
r
o
m
C
en
tr
al
So
u
th
T
im
o
r
R
eg
en
cy
is
s
t
ill
q
u
ite
wel
l
r
ec
eiv
ed
an
d
alig
n
s
with
th
eir
g
en
er
al
p
r
ef
e
r
en
ce
f
o
r
m
ed
ic
atio
n
in
tab
let
f
o
r
m
,
as
ev
id
en
ce
d
b
y
th
e
s
elec
ted
"L
ik
e
"
s
ca
le
s
tatem
en
t.
Acc
o
r
d
in
g
to
th
e
Un
ited
States
Fo
o
d
an
d
Dr
u
g
Ad
m
in
is
tr
atio
n
(
FDA
US)
2
0
0
8
,
a
g
o
o
d
an
d
r
ec
o
m
m
en
d
e
d
tab
let
s
ize
s
h
o
u
ld
n
o
t
ex
ce
ed
2
2
m
m
.
Me
an
wh
ile,
th
e
f
o
r
m
u
lated
b
lack
p
u
le
an
tim
alar
ial
tab
let,
wh
ich
is
1
8
m
m
in
s
ize,
s
till
co
m
p
lies
wi
th
th
e
r
ec
o
m
m
en
d
atio
n
s
f
o
r
o
r
al
tab
lets
[
1
8
]
,
[
1
9
]
.
T
h
e
f
in
d
in
g
s
o
f
th
is
s
tu
d
y
alig
n
with
p
r
io
r
r
esear
ch
o
n
h
er
b
al
m
ed
icin
e,
wh
er
e
tab
lets
ar
e
g
en
er
ally
p
r
ef
e
r
r
ed
f
o
r
th
e
ir
co
n
v
en
ien
ce
an
d
d
o
s
in
g
ac
cu
r
ac
y
[
2
0
]
.
T
h
e
ac
ce
p
tan
ce
o
f
s
lig
h
t
b
it
ter
n
ess
an
d
m
ild
ar
o
m
a
r
ef
lects
cu
ltu
r
al
f
am
iliar
ity
with
tr
ad
itio
n
al
h
er
b
al
r
em
e
d
ies,
wh
er
e
s
u
ch
ch
a
r
ac
ter
is
tics
ar
e
o
f
ten
p
er
ce
iv
ed
as
m
ar
k
er
s
o
f
au
t
h
en
ticity
an
d
ef
f
icac
y
[
2
1
]
,
[
2
2
]
.
T
h
is
s
u
g
g
ests
th
at
th
e
b
lack
p
u
le
tab
let
f
o
r
m
u
latio
n
s
u
its
b
o
th
p
r
ac
ti
ca
l
an
d
cu
ltu
r
al
ex
p
ec
tatio
n
s
in
en
d
em
ic
r
eg
i
o
n
s
.
Nev
er
th
eless
,
th
e
s
tu
d
y
is
l
im
ited
b
y
its
s
m
all
s
am
p
le
s
iz
e,
g
eo
g
r
a
p
h
ic
s
co
p
e
r
estricte
d
to
So
u
th
C
en
tr
al
T
i
m
o
r
,
an
d
th
e
ab
s
en
ce
o
f
clin
ic
al
ef
f
icac
y
d
ata.
Fu
tu
r
e
r
esear
ch
s
h
o
u
ld
e
x
p
an
d
to
d
iv
er
s
e
p
o
p
u
latio
n
s
an
d
i
n
clu
d
e
clin
ical
ev
alu
atio
n
s
to
v
alid
ate
b
o
th
s
en
s
o
r
y
ac
ce
p
ta
n
ce
an
d
th
e
r
ap
eu
tic
ef
f
ec
tiv
en
ess
.
3
.
2
.
H
edo
nic qua
lity
t
est
T
h
e
h
ed
o
n
ic
q
u
ality
test
in
v
o
lv
ed
2
5
s
em
i
-
tr
ain
e
d
p
a
n
elis
ts
,
wh
o
wer
e
s
elec
ted
f
r
o
m
th
e
1
0
0
u
n
tr
ain
ed
p
a
n
elis
ts
o
f
th
e
h
ed
o
n
ic
test
.
T
h
ey
wer
e
s
elec
ted
b
ased
o
n
th
eir
s
en
s
o
r
y
f
am
ilia
r
ity
o
f
th
e
p
r
o
d
u
ct,
th
eir
k
n
o
wled
g
e,
an
d
t
h
eir
willin
g
n
ess
to
ass
e
s
s
th
e
p
r
o
d
u
ct
in
m
o
r
e
d
etail
[
2
3
]
.
T
h
er
e
f
o
r
e,
th
e
2
5
s
em
i
-
tr
ain
ed
p
an
elis
ts
wer
e
a
s
u
b
s
et
o
f
th
e
u
n
tr
ain
e
d
p
an
elis
ts
in
h
e
d
o
n
ic
test
.
T
h
e
s
ca
le
u
s
e
d
in
clu
d
es
4
L
ik
er
t
s
ca
les r
elate
d
to
th
e
r
an
g
e
o
f
o
r
g
an
o
lep
tic
v
a
r
iatio
n
s
in
ea
ch
asp
ec
t o
f
th
e
b
lack
p
u
le
h
er
b
al
an
tim
alar
ial
tab
let
p
r
o
d
u
ct.
T
h
e
p
ar
am
eter
s
o
f
th
e
B
PAT
test
ed
f
o
r
s
en
s
o
r
y
i
m
p
r
ess
io
n
s
in
clu
d
e
asp
ec
ts
o
f
s
h
ap
e,
co
lo
r
,
tast
e,
an
d
s
m
ell.
T
h
e
p
er
ce
n
tag
e
o
f
p
an
elis
t d
ata
f
r
o
m
t
h
e
h
ed
o
n
ic
q
u
ality
test
ca
n
b
e
s
ee
n
i
n
T
a
b
le
5
ab
o
v
e.
B
ased
on
T
ab
le
5,
m
o
s
t
p
a
n
e
lis
ts
lik
ed
th
e
B
PAT
with
o
v
al
s
h
ap
e
(
9
6
%),
wh
ite
co
lo
r
with
lig
h
t
b
r
o
wn
s
p
o
ts
(
8
4
%),
less
b
itter
(
7
6
%),
an
d
s
lig
h
tly
ty
p
ical
(
4
8
%).
T
h
ese
r
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lts
s
h
o
w
th
at
th
e
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elis
ts
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er
al
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ts
th
at
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ea
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y
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is
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th
e
p
r
o
d
u
ct
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d
ev
e
n
f
elt
th
at
th
e
p
r
o
d
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ct
in
th
e
asp
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ts
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f
tast
e
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d
ar
o
m
a
h
ad
b
etter
asp
ec
ts
th
an
th
e
r
esear
ch
er
'
s
s
u
b
jectiv
e
o
n
T
ab
le
2
,
n
am
ely
th
e
tast
e
o
f
"L
ess
b
itter
"
wh
ich
n
o
t to
o
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itter
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o
r
co
n
s
u
m
p
tio
n
an
d
th
e
ar
o
m
a
o
f
"Slig
h
tly
T
y
p
ical"
b
lack
p
u
le
wh
ich
is
n
o
t
p
u
n
g
e
n
t so
th
at
th
e
p
r
o
d
u
ct
ca
n
b
e
ac
ce
p
ted
b
y
m
o
s
t p
eo
p
le
in
C
en
tr
al
So
u
t
h
T
i
m
o
r
R
eg
en
cy
.
B
ased
o
n
th
e
r
esu
lts
of
th
e
h
e
d
o
n
ic
q
u
ality
a
n
aly
s
is
in
T
ab
le
6,
it
can
be
s
ee
n
th
at
th
e
s
h
a
p
e
of
B
PAT
h
av
e
s
co
r
e
of
m
ea
n
1
.
9
6
,
wh
ich
m
ea
n
s
o
v
al.
Du
e
to
th
e
s
elec
tio
n
of
q
u
ality
in
a
cc
o
r
d
an
ce
with
th
e
o
b
s
er
v
atio
n
s
o
f
th
e
p
r
o
d
u
ct
t
h
at
s
h
o
u
ld
b
e
with
th
e
ch
o
ice
o
f
f
o
r
m
in
ac
co
r
d
an
ce
with
th
e
tab
let
p
r
e
p
ar
atio
n
o
f
th
e
p
r
o
d
u
ct
b
ein
g
test
ed
.
T
h
er
ef
o
r
e
,
th
e
c
o
m
p
an
y
d
o
es
n
o
t
n
ee
d
to
re
-
m
o
d
if
y
th
e
s
h
ap
e
of
th
e
B
PAT
th
at
h
as
b
ee
n
d
esig
n
e
d
.
T
h
e
s
elec
t
io
n
o
f
th
e
o
v
al
s
h
ap
e
o
f
th
e
ta
b
let
was
m
ad
e
f
o
r
a
s
p
ec
if
ic
p
u
r
p
o
s
e.
B
lack
p
u
le
an
tim
alar
ial
tab
lets
ar
e
f
o
r
m
u
l
ated
with
a
f
air
ly
lar
g
e
weig
h
t
o
f
7
0
0
m
g
.
T
h
e
o
v
al
s
h
ap
e
o
f
lar
g
e
tab
lets
wil
l
m
ak
e
it e
asier
f
o
r
c
o
n
s
u
m
er
s
t
o
s
wallo
w
an
d
r
ed
u
ce
d
r
u
g
tr
a
n
s
it tim
e
in
th
e
eso
p
h
ag
u
s
[
2
4
]
.
Evaluation Warning : The document was created with Spire.PDF for Python.
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8
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T
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th
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is
o
f
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p
r
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d
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as a
n
av
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ag
e
o
f
2
.
1
6
,
wh
ich
m
ea
n
s
it is
wh
it
e
co
lo
r
with
lig
h
t
b
r
o
wn
s
p
o
t.
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ased
o
n
th
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an
al
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is
r
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it
ca
n
b
e
co
n
clu
d
ed
th
at
th
e
p
a
n
elis
ts
p
r
ef
er
r
ed
th
e
b
lack
p
u
le
an
tim
alar
ial
tab
lets
with
a
wh
ite
co
lo
r
an
d
lig
h
t
b
r
o
wn
s
p
ec
k
s
.
T
h
e
p
r
esen
ce
o
f
s
p
o
ts
o
n
th
e
tab
let
is
d
u
e
to
th
e
u
s
e
o
f
n
atu
r
al
in
g
r
ed
ien
ts
in
th
e
p
r
o
d
u
ct
m
a
n
u
f
ac
tu
r
in
g
p
r
o
ce
s
s
,
wh
er
e
n
atu
r
al
in
g
r
ed
ien
ts
h
a
v
e
th
e
d
r
awb
ac
k
o
f
ca
u
s
in
g
s
p
ec
k
les
o
n
th
e
r
esu
ltin
g
tab
lets
[
2
5
]
.
T
h
e
ap
p
ea
r
an
ce
o
f
th
ese
s
p
ec
k
led
s
p
o
ts
is
d
u
e
to
th
e
d
r
y
in
g
p
r
o
ce
s
s
o
f
th
e
ex
tr
ac
t,
wh
ich
r
esu
lts
in
lar
g
er
p
ar
ticle
s
izes
th
an
th
e
ex
cip
ien
ts
,
af
f
ec
tin
g
th
e
u
n
if
o
r
m
ity
of
t
h
e
g
r
an
u
le
m
ix
tu
r
e
b
e
f
o
r
e
co
m
p
r
ess
io
n
[
2
6
]
.
B
ut
th
is
d
i
d
n
o
t
r
ed
u
ce
th
e
p
an
elis
ts
'
p
r
ef
er
en
ce
in
ch
o
o
s
in
g
th
e
co
lo
r
im
p
r
ess
io
n
o
n
th
e
tab
let.
T
h
e
tast
e
o
f
t
h
e
B
PAT
p
r
o
d
u
c
t
h
as
an
a
v
er
ag
e
o
f
3
.
0
8
,
w
h
ich
m
ea
n
s
it
is
less
b
itter
.
T
h
is
b
lack
p
u
le
tab
let
p
r
o
d
u
ct
d
o
es
in
d
ee
d
h
a
v
e
a
d
is
tin
ctiv
e
ar
o
m
a
an
d
b
itt
er
tast
e.
T
h
is
is
b
ec
au
s
e
t
h
e
p
r
o
d
u
ct
is
m
a
d
e
f
r
o
m
n
atu
r
al
in
g
r
ed
ie
n
ts
with
a
n
atu
r
al
b
itter
n
ess
d
e
r
iv
ed
f
r
o
m
m
ed
icin
al
p
lan
t
m
ater
ials
with
o
u
t
an
y
ad
d
ed
ar
tific
ial
s
wee
ten
er
s
[
2
6
]
.
T
h
i
s
b
itter
tast
e
is
in
d
ee
d
less
s
u
i
tab
le
f
o
r
s
o
m
e
p
eo
p
le,
b
u
t
m
o
s
t
p
an
elis
ts
b
eliev
e
th
at
th
e
tast
e
of
th
is
tab
let
is
in
lin
e
with
th
e
g
en
er
al
tast
e
of
m
ed
icin
al
tab
lets
[
2
3
]
,
[
2
7
]
.
T
h
e
r
elativ
ely
m
ild
b
itter
n
ess
is
due
to
th
e
ad
d
itio
n
of
ex
ci
p
ien
ts
in
th
e
tab
let
f
o
r
m
u
latio
n
,
wh
ic
h
s
er
v
e
to
co
v
er
th
e
s
h
o
r
tco
m
i
n
g
s
of
th
e
p
la
n
t e
x
tr
ac
t a
s
th
e
ac
tiv
e
in
g
r
ed
ien
t
[
2
8
]
.
T
h
e
s
m
ell
of
th
e
B
PAT
p
r
o
d
u
ct
av
er
ag
es
2
.
4
0
,
wh
ich
m
ea
n
s
it
h
as
a
s
lig
h
tly
ty
p
ical
s
m
el
l
of
b
lack
p
u
le
ex
tr
ac
t.
T
h
e
f
o
r
m
u
latio
n
r
esu
lts
in
a
tab
let
ar
o
m
a
th
at
is
n
o
t
v
er
y
n
o
ticea
b
le,
b
u
t
th
er
e
is
s
till
a
s
lig
h
t
ch
ar
ac
ter
is
tic
ar
o
m
a
f
r
o
m
th
e
b
lack
p
u
le
p
lan
t.
T
h
e
s
o
m
ewh
at
d
is
tin
ctiv
e
ar
o
m
a
in
th
e
ta
b
let
in
f
lu
en
ce
s
th
e
p
an
elis
ts
'
p
r
ef
er
en
ce
in
e
x
p
r
ess
in
g
th
eir
lik
in
g
f
o
r
th
e
p
r
o
d
u
ct.
B
esid
es
b
ein
g
a
d
is
tin
ctiv
e
f
ea
tu
r
e
r
em
em
b
er
e
d
in
th
e
B
lack
Pu
le
tab
let
p
r
o
d
u
ct,
a
m
ild
h
er
b
al
ar
o
m
a
in
tr
ad
itio
n
al
m
e
d
icin
e
is
g
en
e
r
ally
p
r
ef
er
r
e
d
by
c
o
n
s
u
m
er
s
o
v
er
s
tr
o
n
g
-
s
m
ellin
g
h
er
b
al
p
r
o
d
u
c
ts
as
it
o
f
f
er
s
a
m
o
r
e
p
leasan
t
s
en
s
o
r
y
ex
p
er
ien
ce
an
d
im
p
r
o
v
es
p
r
o
d
u
ct
ac
ce
p
tan
ce
[
2
9
]
.
T
h
is
m
ild
ch
ar
ac
ter
is
tic
ar
o
m
a
m
ay
s
er
v
e
as
a
s
u
b
tle
p
r
o
d
u
ct
id
en
tifie
r
,
co
n
tr
ib
u
tin
g
p
o
s
itiv
ely
to
b
r
an
d
r
ec
o
g
n
itio
n
.
T
h
e
f
o
r
m
u
latio
n
p
r
o
d
u
ce
d
a
s
m
ell
th
at
is
n
o
t
p
u
n
g
en
t
y
et
r
etain
s
a
r
ec
o
g
n
izab
le
h
e
r
b
al
n
o
te
o
f
b
lack
p
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le,
alig
n
in
g
with
co
n
s
u
m
er
p
r
ef
e
r
en
ce
s
f
o
r
h
e
r
b
al
p
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o
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with
g
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tle,
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o
n
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o
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wer
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g
s
ce
n
ts
.
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o
r
e,
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in
d
er
th
e
p
r
o
d
u
ct’
s
i
d
en
t
ity
an
d
ac
ce
p
ta
b
ilit
y
.
In
th
is
s
tu
d
y
,
s
en
s
o
r
y
p
r
ef
e
r
en
ce
s
co
r
es
wer
e
p
r
esen
ted
as
f
r
eq
u
en
cy
p
er
ce
n
tag
es;
h
o
wev
er
,
v
ar
iatio
n
s
in
d
em
o
g
r
ap
h
ic
f
ac
t
o
r
s
m
ay
also
p
lay
a
r
o
le
in
s
h
a
p
in
g
co
n
s
u
m
er
r
esp
o
n
s
es.
Des
p
ite
th
e
ab
s
en
ce
o
f
s
tr
atif
icatio
n
by
ag
e
or
p
r
io
r
ex
p
er
ien
ce
with
h
er
b
al
p
r
o
d
u
cts
in
th
e
p
r
esen
t
s
tu
d
y
,
it
is
co
n
ce
iv
ab
le
th
at
y
o
u
n
g
er
r
esp
o
n
d
en
ts
,
wh
o
m
ay
h
a
v
e
less
f
am
iliar
ity
w
ith
tr
ad
itio
n
al
b
itter
h
er
b
al
p
r
ep
ar
atio
n
s
,
ex
h
i
b
it
m
ar
g
in
ally
d
im
in
is
h
ed
to
ler
a
n
ce
f
o
r
b
itter
n
ess
in
co
m
p
ar
i
s
o
n
to
o
ld
e
r
p
ar
ticip
a
n
ts
.
C
o
n
v
er
s
ely
,
in
d
iv
i
d
u
als
with
r
eg
u
lar
ex
p
o
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r
e
to
h
er
b
al
m
ed
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es
m
ay
ex
h
i
b
it
a
h
e
ig
h
ten
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ce
p
ta
n
ce
o
f
t
h
e
p
r
o
d
u
ct'
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m
ild
h
er
b
al
Evaluation Warning : The document was created with Spire.PDF for Python.
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J
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n
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20
26
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6
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3
59
352
ar
o
m
a.
C
o
n
s
eq
u
en
tly
,
f
u
t
u
r
e
r
esear
ch
s
h
o
u
ld
in
co
r
p
o
r
at
e
s
tr
atif
ied
an
aly
s
es
to
b
ett
er
u
n
d
er
s
tan
d
h
o
w
d
em
o
g
r
a
p
h
ic
ch
ar
ac
ter
is
tics
in
f
lu
en
ce
h
ed
o
n
ic
q
u
ality
p
e
r
c
ep
tio
n
s
.
T
o
im
p
r
o
v
e
clar
ity
an
d
f
ac
ilit
ate
d
ir
ec
t
co
m
p
ar
is
o
n
b
etwe
en
h
e
d
o
n
ic
an
d
h
ed
o
n
ic
q
u
ality
o
u
tco
m
es,
b
o
th
d
atasets
ar
e
co
m
b
in
ed
in
to
a
co
m
p
ar
ativ
e
s
u
m
m
ar
y
s
h
o
wn
in
T
ab
le
7
.
T
h
e
co
m
p
a
r
ativ
e
r
esu
lts
s
u
m
m
ar
ized
in
T
ab
le
7
p
r
o
v
id
e
a
m
o
r
e
co
m
p
r
eh
e
n
s
iv
e
u
n
d
er
s
tan
d
in
g
o
f
co
n
s
u
m
er
ac
ce
p
tan
ce
b
y
in
teg
r
atin
g
b
o
t
h
g
en
e
r
al
h
ed
o
n
ic
a
n
d
h
e
d
o
n
ic
q
u
ality
ass
ess
m
en
ts
.
T
h
e
h
ed
o
n
ic
test
r
esu
lts
d
em
o
n
s
tr
ate
th
at
all
s
en
s
o
r
y
p
ar
a
m
eter
s
wer
e
r
ated
with
in
th
e
“L
ik
e”
ca
teg
o
r
y
,
in
d
icatin
g
b
r
o
a
d
ac
ce
p
tan
ce
o
f
th
e
B
PAT
p
r
o
t
o
ty
p
e
am
o
n
g
th
e
g
en
e
r
al
p
an
eli
s
ts
.
Ho
wev
er
,
th
e
h
e
d
o
n
ic
q
u
a
lity
test
,
co
n
d
u
cted
with
s
em
i
-
tr
ain
ed
p
an
elis
ts
,
p
r
o
v
id
es
d
ee
p
er
in
s
ig
h
t
in
to
th
e
s
p
ec
if
ic
ch
ar
ac
ter
is
tics
th
at
in
f
lu
en
ce
d
th
ese
p
r
ef
er
en
ce
s
.
Fo
r
e
x
am
p
le,
alth
o
u
g
h
th
e
tast
e
p
ar
am
eter
r
ec
eiv
ed
th
e
lo
west
h
ed
o
n
ic
m
ea
n
s
co
r
e
(
2
.
8
4
)
,
th
e
h
ed
o
n
ic
q
u
ality
ev
alu
atio
n
s
h
o
ws
th
at
m
o
s
t
s
em
i
-
tr
ain
ed
p
an
elis
ts
p
er
ce
iv
ed
th
e
tast
e
as
“less
b
itter
,
”
s
u
g
g
esti
n
g
th
at
th
e
b
itter
n
ess
was
n
o
ticea
b
le
y
et
s
till
to
ler
ab
le
an
d
c
o
n
s
is
ten
t
with
ex
p
ec
tatio
n
s
f
o
r
h
e
r
b
al
m
ed
icin
al
p
r
o
d
u
cts.
Similar
ly
,
th
e
co
lo
r
p
ar
am
eter
r
ec
eiv
ed
h
ig
h
h
ed
o
n
ic
p
r
e
f
er
e
n
ce
,
wh
ich
alig
n
s
well
with
th
e
h
ed
o
n
ic
q
u
ality
f
in
d
in
g
th
at
m
o
s
t
p
an
elis
ts
id
en
tifie
d
th
e
tab
let
s
as
wh
ite
wi
th
lig
h
t
b
r
o
wn
s
p
ec
k
les,
an
attr
ib
u
te
co
m
m
o
n
l
y
ass
o
ciate
d
with
n
atu
r
al
p
lan
t
-
d
er
iv
e
d
p
r
o
d
u
cts.
T
h
is
co
n
s
is
ten
cy
b
etwe
en
lik
in
g
s
co
r
e
a
n
d
q
u
ality
p
er
ce
p
tio
n
s
u
g
g
ests
th
at
th
e
v
is
u
al
ap
p
ea
r
an
ce
of
B
PAT
s
u
p
p
o
r
ts
its
ac
ce
p
tan
ce
as
a
n
atu
r
al
h
er
b
al
f
o
r
m
u
latio
n
.
T
h
e
s
m
ell
p
ar
a
m
eter
als
o
s
h
o
wed
alig
n
m
en
t
b
e
twee
n
test
s
,
wh
er
e
th
e
g
en
er
al
“L
ik
e”
p
r
ef
er
e
n
ce
co
r
r
esp
o
n
d
s
to
th
e
id
e
n
tific
atio
n
of
a
“sli
g
h
tly
ty
p
ical”
a
r
o
m
a,
wh
ich
ap
p
ea
r
s
to
be
ac
ce
p
tab
le
to
co
n
s
u
m
er
s
an
d
n
o
t
o
v
er
ly
s
tr
o
n
g
.
I
n
c
o
m
b
in
atio
n
,
th
ese
f
in
d
in
g
s
d
em
o
n
s
tr
ate
th
at
in
teg
r
atin
g
o
f
th
e
two
d
atasets
h
ig
h
lig
h
ts
th
at
th
e
B
PAT
p
r
o
to
ty
p
e
h
as
f
av
o
r
a
b
le
s
en
s
o
r
y
attr
ib
u
tes
o
v
er
all,
with
tast
e
r
em
ain
in
g
th
e
m
o
s
t
ch
allen
g
in
g
ch
ar
ac
te
r
is
tic
b
u
t
s
till
with
in
ac
ce
p
tab
le
lim
its
f
o
r
h
er
b
al
m
e
d
icin
al
p
r
o
d
u
cts.
T
h
ese
r
esu
lts
co
n
f
ir
m
th
e
p
o
ten
tial
o
f
B
PAT
to
b
e
well
r
ec
eiv
ed
in
th
e
tar
g
et
m
ar
k
et
an
d
p
r
o
v
id
e
an
i
m
p
o
r
tan
t
f
o
u
n
d
atio
n
f
o
r
f
u
r
th
er
p
r
o
d
u
ct
d
e
v
elo
p
m
e
n
t,
p
o
s
itio
n
in
g
,
an
d
m
ar
k
etin
g
s
tr
ateg
ies.
T
ab
le
7.
C
o
m
p
ar
ativ
e
s
u
m
m
ar
y
of
h
ed
o
n
ic
an
d
h
ed
o
n
ic
q
u
ali
ty
test
r
e
s
u
l
ts
P
a
r
a
me
t
e
r
H
e
d
o
n
i
c
mea
n
I
n
t
e
r
p
r
e
t
a
t
i
o
n
H
e
d
o
n
i
c
q
u
a
l
i
t
y
me
a
n
I
n
t
e
r
p
r
e
t
a
t
i
o
n
S
h
a
p
e
3
.
1
5
Li
k
e
1
.
9
6
O
v
a
l
C
o
l
o
r
3
.
2
5
Li
k
e
2
.
1
6
W
h
i
t
e
w
i
t
h
l
i
g
h
t
b
r
o
w
n
s
p
o
t
s
Ta
st
e
2
.
8
4
Li
k
e
3
.
0
8
Le
ss
b
i
t
t
e
r
S
mel
l
3
.
1
9
Li
k
e
2
.
4
0
S
l
i
g
h
t
l
y
t
y
p
i
c
a
l
S
i
z
e
2
.
9
3
Li
k
e
-
-
O
v
e
r
a
l
l
3
.
1
7
Li
k
e
-
-
3.
3
.
SWO
T
a
na
ly
s
is
T
h
is
s
tu
d
y
u
tili
ze
d
two
ty
p
es
o
f
q
u
esti
o
n
n
air
es
f
o
r
th
e
S
W
OT
an
aly
s
is
,
n
am
ely
th
e
I
F
AS
an
d
th
e
E
FAS.
T
h
e
I
FAS
q
u
esti
o
n
n
air
e
was
ad
m
in
is
ter
ed
to
40
in
te
r
n
al
r
esp
o
n
d
en
ts
,
wh
o
wer
e
p
a
r
t
o
f
r
esear
ch
team
in
v
o
lv
ed
in
th
e
p
r
o
d
u
ct
d
e
v
elo
p
m
en
t,
p
r
o
d
u
ctio
n
,
q
u
ality
e
v
alu
atio
n
,
a
n
d
m
a
r
k
etin
g
p
lan
n
in
g
o
f
th
e
B
PAT.
T
h
ese
r
esp
o
n
d
e
n
ts
wer
e
s
elec
ted
b
ased
o
n
th
ei
r
d
ir
ec
t
i
n
v
o
lv
em
e
n
t
an
d
u
n
d
e
r
s
tan
d
i
n
g
of
t
h
e
in
ter
n
al
p
r
o
ce
s
s
es
of
B
PAT
d
ev
elo
p
m
en
t,
allo
win
g
th
e
m
to
ass
ess
in
ter
n
al
s
tr
en
g
th
s
an
d
we
ak
n
ess
es
ac
cu
r
ately
.
Me
an
wh
ile,
th
e
E
FAS
q
u
esti
o
n
n
air
e
was
d
is
tr
ib
u
ted
to
1
0
0
ex
ter
n
al
r
esp
o
n
d
en
ts
f
r
o
m
B
o
k
in
g
Dis
tr
ict,
So
e
C
ity
Dis
tr
ict
an
d
So
u
th
Am
an
u
b
an
Dis
tr
ict
in
So
u
th
C
en
tr
al
T
im
o
r
R
eg
en
cy
,
E
ast
Nu
s
a
T
en
g
g
ar
a
Pro
v
in
ce
.
T
h
ese
r
esp
o
n
d
en
ts
r
ep
r
esen
te
d
p
o
ten
tial
co
n
s
u
m
er
s
liv
in
g
i
n
m
alar
ia
-
en
d
em
ic
ar
ea
s
an
d
wer
e
s
elec
ted
b
ased
o
n
clu
s
ter
s
am
p
lin
g
.
T
h
e
to
tal
o
f
1
0
0
p
ar
ticip
a
n
ts
r
ef
lects th
e
tar
g
et
ex
ter
n
al
c
o
m
m
u
n
ity
ass
ess
m
e
n
t n
ee
d
ed
to
ev
alu
ate
m
ar
k
et
o
p
p
o
r
tu
n
ities
an
d
th
r
ea
ts
in
th
e
SW
OT
f
r
am
ewo
r
k
.
Ass
ess
m
en
t
at
a
s
ig
n
if
ican
t
lev
el
i
s
ca
r
r
ied
o
u
t
b
y
th
e
p
r
o
d
u
ct
o
w
n
er
b
y
d
eter
m
in
in
g
th
e
le
v
el
o
f
u
r
g
en
c
y
of
each
in
d
icato
r
or
s
tatem
en
t
in
th
e
q
u
esti
o
n
n
air
e
u
s
in
g
a
s
ca
le
of
1
(
not
im
p
o
r
tan
t)
,
2
(
less
im
p
o
r
tan
t)
,
3
(
im
p
o
r
tan
t)
,
a
n
d
4
(
v
er
y
im
p
o
r
tan
t
)
.
T
h
is
ass
es
s
m
en
t
is
u
s
ed
to
d
eter
m
in
e
th
e
weig
h
t
v
alu
e
in
th
e
SW
OT
an
aly
s
is
b
y
d
iv
id
i
n
g
th
e
s
ig
n
if
ican
ce
lev
el
o
f
ea
ch
s
tatem
en
t item
b
y
th
e
s
u
b
-
to
tal
n
u
m
b
er
o
f
ea
ch
f
ac
to
r
[
3
0
]
.
I
n
th
e
in
s
tr
u
m
en
t
ass
ess
m
en
t
in
th
e
f
o
r
m
o
f
a
q
u
esti
o
n
n
a
ir
e
g
iv
en
to
b
o
th
in
ter
n
al
an
d
ex
ter
n
al
r
esp
o
n
d
en
ts
,
t
h
e
an
s
wer
s
ar
e
o
b
tain
ed
in
th
e
f
o
r
m
of
a
L
ik
e
r
t
s
ca
le
ass
ess
m
en
t,
n
am
ely
:
1
=
v
er
y
d
is
ag
r
ee
,
2
=
d
is
ag
r
ee
,
3
=
ag
r
ee
,
4
=
v
er
y
ag
r
ee
.
T
h
e
to
tal
v
alu
e
o
b
ta
in
ed
is
u
s
ed
to
d
eter
m
in
e
th
e
r
atin
g
v
alu
e
in
th
e
SW
OT
an
aly
s
is
b
y
s
u
m
m
in
g
all
th
e
s
co
r
es
g
iv
en
b
y
th
e
r
esp
o
n
d
en
ts
f
o
r
ea
c
h
s
tatem
en
t
item
,
a
n
d
t
h
en
d
iv
id
in
g
by
th
e
n
u
m
b
er
o
f
r
es
p
o
n
d
e
n
ts
[
3
1
]
.
T
h
e
weig
h
t
an
d
r
atin
g
v
alu
es
o
b
tain
ed
ar
e
u
s
ed
to
f
in
d
th
e
s
co
r
e
v
alu
e
b
y
m
u
ltip
licatio
n
.
T
h
e
c
alcu
latio
n
o
f
I
FAS s
tatem
en
ts
in
th
is
s
tu
d
y
is
as
T
ab
le
8
.
B
ased
on
th
e
r
esu
lts
of
th
e
I
FAS
ca
lcu
latio
n
s
,
wh
ich
can
be
s
ee
n
in
T
ab
le
8
,
th
e
s
tr
en
g
th
s
co
r
e
is
2
,
2
5
9
,
a
n
d
th
e
wea
k
n
ess
s
co
r
e
is
1
,
0
5
1
.
T
h
is
s
h
o
ws
th
at
t
h
e
s
tr
en
g
th
f
ac
t
o
r
of
th
e
b
lac
k
p
u
le
an
tim
alar
ial
tab
let
p
r
o
d
u
ct
is
g
r
ea
ter
th
a
n
th
e
wea
k
n
ess
f
ac
to
r
.
I
f
th
e
s
co
r
e
of
th
e
s
tr
en
g
th
s
an
d
th
e
s
co
r
e
o
f
t
h
e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J Pu
b
lic
Hea
lth
Sci
I
SS
N:
2252
-
8
8
0
6
C
o
n
s
u
mer p
r
eferen
ce
s
a
n
d
ma
r
ke
tin
g
s
tr
a
teg
y
fo
r
b
la
ck
p
u
le
(
A
ls
to
n
ia
s
p
ec
ta
b
ilis
)
…
(
N
o
v
ia
Ma
u
lin
a
)
353
wea
k
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ess
es
ar
e
ad
d
ed
u
p
,
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e
f
in
al
to
tal
o
f
th
e
in
ter
n
al
f
ac
to
r
s
in
th
e
I
FAS
m
atr
ix
is
3
.
3
1
.
T
h
is
v
alu
e
is
ab
o
v
e
2
.
5
,
wh
ic
h
in
d
icate
s
th
at
t
h
e
co
m
p
an
y
'
s
in
ter
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al
p
o
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itio
n
is
q
u
ite
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tr
o
n
g
.
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h
is
is
b
ec
au
s
e
it
is
co
n
s
id
er
ed
to
h
av
e
an
ab
o
v
e
-
a
v
er
ag
e
a
b
ilit
y
to
tak
e
ad
v
a
n
tag
e
o
f
s
tr
en
g
th
s
an
d
an
ticip
ate
in
ter
n
al
wea
k
n
ess
es.
Me
an
wh
ile,
th
e
ca
lcu
latio
n
o
f
E
FAS s
tate
m
en
ts
in
th
is
s
tu
d
y
is
as
s
h
o
wn
in
T
ab
le
9
.
B
ased
o
n
th
e
r
esu
lts
o
f
th
e
E
F
AS c
alcu
latio
n
s
,
wh
ich
ca
n
b
e
s
ee
n
in
T
ab
le
9
,
th
e
o
p
p
o
r
tu
n
i
ty
s
co
r
e
is
1
.
7
4
6
,
an
d
th
e
th
r
ea
t
s
co
r
e
is
1
.
1
5
2
.
T
h
is
s
h
o
ws
th
at
th
e
o
p
p
o
r
tu
n
ity
f
ac
t
o
r
of
th
e
b
lac
k
p
u
le
an
tim
alar
ial
tab
let
p
r
o
d
u
ct
is
g
r
ea
ter
th
a
n
th
e
th
r
ea
t
f
ac
to
r
.
W
h
en
th
e
o
p
p
o
r
tu
n
ity
s
co
r
e
an
d
th
e
th
r
ea
t
s
co
r
e
a
r
e
s
u
m
m
e
d
u
p
,
t
h
e
f
i
n
al
to
tal
of
th
e
e
x
ter
n
a
l
f
ac
to
r
s
in
th
e
E
FAS
m
atr
ix
is
2
.
8
9
8
.
T
h
is
v
alu
e
is
ab
o
v
e
2
.
5
,
wh
ic
h
in
d
icate
s
th
at
th
e
co
m
p
an
y
'
s
ex
ter
n
al
p
o
s
itio
n
is
q
u
ite
s
tr
o
n
g
.
T
h
is
is
b
ec
au
s
e
it
is
co
n
s
id
er
ed
to
h
av
e
an
ab
o
v
e
-
a
v
er
ag
e
ab
ilit
y
to
tak
e
ad
v
an
tag
e
o
f
o
p
p
o
r
tu
n
ities
an
d
an
ticip
ate
th
r
e
ats f
r
o
m
th
e
in
ter
n
al
[
3
2
]
.
T
h
e
v
alu
e
th
at
h
as
b
ee
n
o
b
tai
n
ed
f
r
o
m
th
e
s
u
b
to
tal
o
f
ea
c
h
f
ac
to
r
ca
n
b
e
u
s
ed
to
o
b
tain
co
o
r
d
in
ate
p
o
in
ts
on
th
e
SW
OT
C
ar
tesi
a
n
d
iag
r
am
.
In
th
is
d
iag
r
am
,
it
can
d
escr
ib
e
th
e
s
itu
atio
n
an
d
co
n
d
itio
n
s
of
th
e
b
lack
p
u
le
a
n
tim
alar
ial
tab
let
m
ar
k
etin
g
s
tr
ateg
y
,
wh
ich
ca
n
b
e
s
ee
n
b
ased
o
n
th
e
p
o
s
itio
n
o
f
th
e
q
u
ad
r
an
ts
o
n
th
e
C
ar
tesi
an
d
iag
r
am
.
If
th
e
p
o
s
itio
n
o
f
th
e
co
o
r
d
in
ate
p
o
in
t
is
in
q
u
ad
r
a
n
t
I
,
it
m
ea
n
s
s
u
p
p
o
r
tin
g
a
n
ag
g
r
ess
iv
e
s
tr
ateg
y
;
q
u
ad
r
a
n
t
I
I
d
ev
elo
p
s
a
d
iv
e
r
s
if
icatio
n
s
tr
ateg
y
;
q
u
a
d
r
an
t
I
I
I
m
ak
es
a
t
u
r
n
ar
o
u
n
d
s
tr
ateg
y
,
an
d
q
u
ad
r
a
n
t
IV
m
ak
es
a
d
e
f
en
s
iv
e
s
tr
ateg
y
[
3
3
]
.
T
h
e
f
o
r
m
u
la
u
s
ed
to
ca
lcu
late
th
e
an
aly
s
is
of
in
ter
n
al
f
ac
to
r
s
an
d
e
x
ter
n
al
f
ac
to
r
s
to
o
b
tain
th
e
c
o
o
r
d
i
n
ate
p
o
in
ts
is
as f
o
llo
ws:
−
X
ax
is
=
I
FAS =
Stre
n
g
th
Sco
r
e
–
W
ea
k
n
ess
Sco
r
e
−
Y
ax
is
=
E
FAS
=
Op
p
o
r
tu
n
ity
Sco
r
e
-
T
h
r
ea
t
Sco
r
e
W
h
er
e
th
e
r
esu
lts
ar
e
o
b
tain
ed
,
n
am
ely
:
−
X
ax
is
=
2
.
2
5
9
–
1
.
0
5
1
=
1
.
2
0
8
−
Y
ax
is
=
1
.
7
4
6
-
1
.
1
5
2
=
0
.
5
9
4
T
ab
le
8
.
C
alcu
latio
n
of
I
FAS
s
t
a
t
e
m
e
n
ts
N
o
.
C
o
d
e
S
t
a
t
e
me
n
t
W
e
i
g
h
t
R
a
t
i
n
g
S
c
o
r
e
(
w
e
i
g
h
t
x
r
a
t
i
n
g
)
S
t
r
e
n
g
t
h
1.
S1
H
e
r
b
a
l
t
a
b
l
e
t
w
i
t
h
f
e
w
e
r
si
d
e
e
f
f
e
c
t
s
c
o
mp
a
r
e
d
t
o
sy
n
t
h
e
t
i
c
a
n
t
i
m
a
l
a
r
i
a
l
d
r
u
g
s
0
.
1
1
4
3
.
4
0
0
0
.
3
8
9
2.
S2
P
r
o
v
e
n
a
n
t
i
p
l
a
sm
o
d
i
a
l
a
c
t
i
v
i
t
y
f
r
o
m
i
n
v
i
v
o
a
n
d
i
n
v
i
t
r
o
st
u
d
i
e
s
0
.
1
1
4
3
.
7
2
5
0
.
4
2
6
3.
S3
M
a
n
u
f
a
c
t
u
r
e
d
b
y
a
n
I
o
T
-
c
e
r
t
i
f
i
e
d
i
n
d
u
st
r
y
i
mp
l
e
m
e
n
t
i
n
g
C
P
O
TB
0
.
1
1
4
3
.
7
0
0
0
.
4
2
3
4.
S4
P
r
o
d
u
c
t
i
o
n
f
a
c
i
l
i
t
y
c
e
r
t
i
f
i
e
d
w
i
t
h
I
S
O
9
0
0
1
:
2
0
1
5
0
.
0
8
6
3
.
7
0
0
0
.
3
1
7
5.
S5
A
t
t
r
a
c
t
i
v
e
a
n
d
e
l
e
g
a
n
t
p
a
c
k
a
g
i
n
g
0
.
1
1
4
3
.
5
0
0
0
.
4
0
0
6.
S6
P
a
c
k
a
g
i
n
g
r
e
ma
i
n
s
d
u
r
a
b
l
e
a
n
d
p
o
r
t
a
b
l
e
d
u
r
i
n
g
d
i
st
r
i
b
u
t
i
o
n
0
.
0
8
6
3
.
5
0
0
0
.
3
0
4
S
u
b
t
o
t
a
l
s
t
r
e
n
g
t
h
0
.
6
2
9
2
.
2
5
9
W
e
a
k
n
e
ss
1.
W1
Li
mi
t
e
d
p
u
b
l
i
c
a
w
a
r
e
n
e
ss
o
f
t
h
e
p
r
o
d
u
c
t
0
.
0
8
6
3
.
2
7
5
0
.
2
8
1
2.
W2
Th
e
t
a
b
l
e
t
si
z
e
i
s r
e
l
a
t
i
v
e
l
y
l
a
r
g
e
0
.
0
8
6
2
.
4
7
5
0
.
2
1
2
3.
W3
H
i
g
h
p
r
o
d
u
c
t
i
o
n
c
o
st
0
.
1
1
4
2
.
8
7
5
0
.
3
2
9
4.
W4
R
a
w
m
a
t
e
r
i
a
l
s
a
r
e
d
i
f
f
i
c
u
l
t
t
o
o
b
t
a
i
n
a
t
a
n
i
n
d
u
st
r
i
a
l
sc
a
l
e
0
.
0
5
7
2
.
6
5
0
0
.
1
5
1
5.
W5
R
a
w
m
a
t
e
r
i
a
l
s
u
p
p
l
y
d
e
p
e
n
d
s
o
n
a
si
n
g
l
e
p
a
r
t
n
e
r
0
.
0
2
9
2
.
7
3
5
0
.
0
7
8
S
u
b
t
o
t
a
l
w
e
a
k
n
e
ss
0
.
3
7
1
1
.
0
5
1
To
t
a
l
(
su
b
t
o
t
a
l
st
r
e
n
g
t
h
+
s
u
b
t
o
t
a
l
w
e
a
k
n
e
ss)
1
.
0
0
0
3
.
31
T
ab
le
9.
C
alcu
latio
n
of
I
FAS
s
t
a
t
e
m
e
n
ts
N
o
.
C
o
d
e
S
t
a
t
e
me
n
t
W
e
i
g
h
t
R
a
t
i
n
g
S
c
o
r
e
(
w
e
i
g
h
t
x
r
a
t
i
n
g
)
O
p
p
o
r
t
u
n
i
t
y
1.
O1
H
e
r
b
a
l
t
a
b
l
e
t
w
i
t
h
f
e
w
e
r
si
d
e
e
f
f
e
c
t
s
c
o
mp
a
r
e
d
t
o
sy
n
t
h
e
t
i
c
a
n
t
i
m
a
l
a
r
i
a
l
d
r
u
g
s
0
.
0
8
8
2
.
9
1
0
0
.
2
5
7
2.
O2
P
r
o
v
e
n
a
n
t
i
p
l
a
sm
o
d
i
a
l
a
c
t
i
v
i
t
y
f
r
o
m
i
n
v
i
v
o
a
n
d
i
n
v
i
t
r
o
st
u
d
i
e
s
0
.0
88
3
.
0
6
0
0
.
2
7
0
3.
O3
M
a
n
u
f
a
c
t
u
r
e
d
b
y
a
n
I
o
T
-
c
e
r
t
i
f
i
e
d
i
n
d
u
st
r
y
i
mp
l
e
m
e
n
t
i
n
g
C
P
O
TB
0
.
1
1
8
3
.
0
4
0
0
.
3
5
8
4.
O4
P
r
o
d
u
c
t
i
o
n
f
a
c
i
l
i
t
y
c
e
r
t
i
f
i
e
d
w
i
t
h
I
S
O
9
0
0
1
:
2
0
1
5
0
.
1
1
8
3
.
1
7
0
0
.
3
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SW
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ik
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)
,
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ir
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ath
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ap
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d
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f
r
o
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p
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F
UNDING
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NF
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h
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esia (
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d
i
k
b
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d
r
is
tek
)
u
n
d
er
Gr
an
t N
o
.
0
9
2
1
/E5
.
5
/AL
.
0
4
/
2
0
2
3
.
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